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12 p, 831.3 KB |
Preoperative CA125 Significantly Improves Risk Stratification in High-Grade Endometrial Cancer
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Lombaers, Marike S. (Radboud Institute of Health Sciences (Holanda)) ;
Cornel, Karlijn M. C. (Department of Obstetrics and Gynecology, University of Toronto) ;
Visser, Nicole C. M. (Department of Pathology, Eurofins PAMM (Països Baixos)) ;
Bulten, Johan (Radboud University Medical Center (Holanda)) ;
Küsters-Vandevelde, Heidi V. N. (Department of Pathology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
Amant, Frederic (The Netherlands Cancer Institute (Països Baixos)) ;
Boll, Dorry (Department of Gynecology, Catharina Hospital (Països Baixos)) ;
Bronsert, Peter (University Medical Center) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Geomini, Peggy M. A. J. (Department of Obstetrics and Gynecology, Maxima Medical Centre (Països Baixos)) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
van Hamont, Dennis (Department of Obstetrics and Gynecology, Amphia Hospital (Països Baixos)) ;
Huvila, Jutta (Department of Pathology, University of Turku (Països Baixos)) ;
Krakstad, Camilla (Department of Clinical Science, University of Bergen) ;
Kraayenbrink, Arjan A. (Department of Obstetrics and Gynaecology, Rijnstate Hospital (Països Baixos)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital (França)) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Matías-Guiu, Xavier (Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova) ;
Ngo, Huy (Department of Obstetrics and Gynecology, Elkerliek Hospital (Països Baixos)) ;
Pijlman, Brenda M. (Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, 5223 GZ 's-Hertogenbosch (Països Baixos)) ;
Vos, Maria Caroline (Department of Obstetrics and Gynecology, Elisabeth-TweeSteden Hospital (Països Baixos)) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, University Hospital Brno, Faculty of Medicine, Masaryk University (República Txeca)) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynecology, Canisius-Wilhelmina Hospital (Països Baixos)) ;
van Koeverden, Sebastiaan W. (Department of Radiology and Nuclear Medicine, Radboud University Medical Center (Països Baixos)) ;
Haldorsen, Ingfrid S. (Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, 5021 Bergen, Norway) ;
Reijnen, Casper (Department of Radiation Oncology, Radboud University Medical Center (Països Baixos)) ;
Pijnenborg, Johanna M. A. (Radboud Institute of Health Sciences (Països Baixos)) ;
Universitat Autònoma de Barcelona
Patients with high-grade uterine cancer (UC) have a risk of around 20% of the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-grade uterine cancer. CA125 is a marker that can be detected in blood and is associated with increased tumor spread. [...]
2023 -  10.3390/cancers15092605
Cancers, Vol. 15 (may 2023)
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10 p, 887.3 KB |
Relevance of Molecular Profiling in Patients With Low-Grade Endometrial Cancer
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Vrede, Stephanie W. (Canisius-Wilhelmina Hospital) ;
Kasius, Jenneke (Amsterdam Medical Centers and Center of Gynecologic Oncology Amsterdam) ;
Bulten, Johan (Radboud University Medical Center) ;
Teerenstra, Steven (Radboud University Medial Center) ;
Huvila, Jutta (University of Turku) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Boll, Dorry (Catharina Hospital Eindhoven, the Netherlands) ;
Vos, Maria Caroline (Elisabeth-Tweesteden Hospital) ;
van Altena, Anne M. (Radboud University Medical Center) ;
Asberger, Jasmin (Medical Center-University of Freiburg) ;
Sweegers, Sanne (Radboud University Medical Center) ;
van Weelden, Willem Jan (Canisius-Wilhelmina Hospital) ;
van der Putten, Louis J. M. (Radboud University Medical Center) ;
Amant, Frederic (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Visser, Nicole C. M. (Stichting Laboratory for Pathology and Medical Microbiology) ;
Snijders, Marc P. L. M. (Canisius-Wilhelmina Hospital) ;
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Hospital) ;
Kruitwagen, Roy (Maastricht University Medical Center) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Weinberger, Vit (University Hospital in Brno and Masaryk University) ;
Reijnen, Casper (Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Is tumor molecular profile associated with outcomes among patients with low-grade endometrial cancer? In this retrospective multicenter cohort study of 393 patients, outcomes for patients with low-grade endometrial cancer were not associated with molecular subgroup. [...]
2022 - 10.1001/jamanetworkopen.2022.47372
JAMA network open, Vol. 5 (december 2022)
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19 p, 1.5 MB |
Preoperative risk stratification in endometrial cancer (ENDORISK) by a Bayesian network model : A development and validation study
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Reijnen, Casper (Radboud University Medical Center) ;
Gogou, Evangelia (Radboud University) ;
Visser, Nicole C. M. (Radboud University Medical Center) ;
Engerud, Hilde (Haukeland University Hospital (Bergen, Noruega)) ;
Ramjith, Jordache (Radboud University Medical Center) ;
van der Putten, Louis J. M. (Radboud University Medical Center) ;
van de Vijver, Koen (Universitair Ziekenhuis Gent) ;
Santacana, Maria (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Bronsert, Peter (University Medical Center, Freiburg, Germany) ;
Bulten, Johan (Radboud University Medical Center) ;
Hirschfeld, Marc (University Medical Center, Freiburg, Germany) ;
Colás Ortega, Eva (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reques, Armando (Hospital Universitari Vall d'Hebron) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Krakstad, Camilla (Haukeland University Hospital (Bergen, Noruega)) ;
Trovik, Jone (Haukeland University Hospital (Bergen, Noruega)) ;
Haldorsen, Ingfrid S. (University of Bergen) ;
Huvila, Jutta (University of Turku) ;
Koskas, Martin (Bichat-Claude Bernard Hospital, Paris) ;
Weinberger, Vit (University Hospital Brno (República Txeca)) ;
Bednarikova, Marketa (University Hospital Brno (República Txeca)) ;
Hausnerova, Jitka (University Hospital Brno (República Txeca)) ;
van der Wurff, Anneke A. M. (Elisabeth-TweeSteden Hospital, Tilburg) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Amant, Frederic (The Netherlands Cancer Institute (Amsterdam, Països Baixos)) ;
Massuger, Leon F. A. G. (Radboud University Medical Center) ;
Snijders, Marc P. L. M. (Canisius-Wilhelmina Hospital) ;
Küsters-Vandevelde, Heidi V. N. (Canisius-Wilhelmina Hospital) ;
Lucas, Peter J. F. (University of Twente) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center)
Bayesian networks (BNs) are machine-learning-based computational models that visualize causal relationships and provide insight into the processes underlying disease progression, closely resembling clinical decision-making. [...]
2020 - 10.1371/journal.pmed.1003111
PLoS Medicine, Vol. 17 (may 2020)
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8 p, 6.1 MB |
Poor outcome in hypoxic endometrial carcinoma is related to vascular density
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Reijnen, Casper (Radboud University Medical Center) ;
van Weelden, Willem Jan (Radboud University Medical Center) ;
Arts, Martijn S. J. P. (Radboud University Medical Center) ;
Peters, Johan P. (Radboud University Medical Center) ;
Rijken, Paul F. (Radboud University Medical Center) ;
van de Vijver, Koen (Universitair Ziekenhuis Gent) ;
Santacana, Maria (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Bronsert, Peter (Universitätsklinikum Freiburg) ;
Bulten, Johan (Radboud University Medical Center) ;
Hirschfeld, Marc (Universitätsklinikum Freiburg) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Krakstad, Camilla (Haukeland universitetssjukehus) ;
Trovik, Jone (Haukeland universitetssjukehus) ;
Haldorsen, Ingfrid S. (Universitetet i Bergen) ;
Huvila, Jutta (Turun Yliopisto) ;
Koskas, Martin (Hôpital Bichat - Claude-Bernard) ;
Weinberger, Vit (Masarykova univerzita) ;
Minar, Lubos (Masarykova univerzita) ;
Jandakova, Eva (Masarykova univerzita) ;
Snijders, Marc P. L. M. (Canisius Wilhelmina Ziekenhuis) ;
van den Berg-van Erp, Saskia (Canisius Wilhelmina Ziekenhuis) ;
Küsters-Vandevelde, Heidi V. N. (Canisius Wilhelmina Ziekenhuis) ;
Matias-Guiu, Xavier (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Amant, Frederic (Katholieke Universiteit Leuven) ;
Massuger, Leon F. A. G. (Radboud University Medical Center) ;
Bussink, Johan (Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Radboud University Medical Center) ;
Universitat Autònoma de Barcelona
Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). [...]
2019 - 10.1038/s41416-019-0461-2
British Journal of Cancer, Vol. 120 (april 2019) , p. 1037-1044
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9 p, 341.1 KB |
L1CAM expression in endometrial carcinomas : an ENITEC collaboration study
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van der Putten, Louis J. M. (Department of Obstetrics and Gynaecology, Radboud University Medical Center) ;
Visser, Nicole C. M. (Department of Pathology, Radboud University Medical Center) ;
van de Vijver, Koen (Department of Pathology, Anthoni van Leeuwenhoek Hospital) ;
Santacana, Maria (Institut de Recerca Biomèdica de Lleida) ;
Bronsert, Peter (Institute of Pathology, University Medical Center Freiburg) ;
Bulten, Johan (Department of Pathology, Radboud University Medical Center) ;
Hirschfeld, Marc (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia, Angel (Hospital Universitari Vall d'Hebron) ;
Mancebo, Gemma (Hospital del Mar (Barcelona, Catalunya)) ;
Alameda, Francesc (Hospital del Mar (Barcelona, Catalunya)) ;
Trovik, Jone (Haukeland University Hospital (Bergen, Noruega)) ;
Kopperud, Reidun K. (Center for Cancer Biomarkers (CCBIO), University of Bergen) ;
Huvila, Jutta (University of Turku. Department of Pathology) ;
Schrauwen, Stefanie (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Koskas, Martin (Department of Obstetrics and Gynecology, Bichat-Claude Bernard Hospital) ;
Walker, Francine (Department of Pathology, Bichat-Claude Bernard Hospital) ;
Weinberger, Vit (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University) ;
Minar, Lubos (Department of Gynecology and Obstetrics, Faculty of Medicine, Masaryk University) ;
Jandakova, Eva (Institute of Pathology, Faculty of Medicine, Masaryk University) ;
Snijders, Marc P. L. M. (Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital) ;
van den Berg-van Erp, Saskia (Department of Pathology, Canisius-Wilhelmina Hospital) ;
Matias-Guiu, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Salvesen, Helga B. (Haukeland University Hospital (Bergen, Noruega)) ;
Amant, Frederic (University Hospitals Gasthuisberg (Leuven, Bélgica)) ;
Massuger, Leon FAG (Department of Obstetrics and Gynaecology, Radboud University Medical Center) ;
Pijnenborg, Johanna M. A. (Department of Obstetrics and Gynaecology, TweeSteden Hospital) ;
Universitat Autònoma de Barcelona
Identification of aggressive endometrioid endometrial carcinomas (EECs) and non-endometrioid carcinomas (NEECs) is essential to improve outcome. L1 cell adhesion molecule (L1CAM) expression is a strong prognostic marker in stage I EECs, but less is known about L1CAM expression in advanced-stage EECs and NEECs. [...]
2016 - 10.1038/bjc.2016.235
British Journal of Cancer, Vol. 115 (08 2016) , p. 716-724
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