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45 p, 10.5 MB |
Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats
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Steinberg, Pablo (University of Veterinary Medicine Hannover, Institute for Food Toxicology (Germany)) ;
van der Voet, Hilko (Wageningen University and Research. Biometris (The Netherlands)) ;
Goedhart, Paul W. (Wageningen University and Research. Biometris (The Netherlands)) ;
Kleter, Gijs (RIKILT Wageningen University & Research (The Netherlands)) ;
Kok, Esther J. (RIKILT Wageningen University & Research (The Netherlands)) ;
Pla, Maria (Centre de Recerca en Agrigenòmica) ;
Nadal Matamala, Anna (Universitat de Girona. Institut de Tecnologia Agroalimentària) ;
Zeljenková, Dagmar. (Slovak Medical University (Slovakia)) ;
Aláčová, Radka (Slovak Medical University (Slovakia)) ;
Babincová, Júlia (Slovak Medical University (Slovakia)) ;
Rollerová, Eva (Slovak Medical University (Slovakia)) ;
Jaďuďová, Soňa (Slovak Medical University (Slovakia)) ;
Kebis, Anton (Slovak Medical University (Slovakia)) ;
Szabova, Elena (Slovak Medical University (Slovakia)) ;
Tulinská, Jana (Slovak Medical University (Slovakia)) ;
Líšková, Aurélia (Slovak Medical University (Slovakia)) ;
Takácsová, Melinda (Slovak Medical University (Slovakia)) ;
Mikušová, Miroslava Lehotská (Slovak Medical University (Slovakia)) ;
Krivošíková, Zora (Slovak Medical University (Slovakia)) ;
Spök, Armin (Alpen-Adria Universität Klagenfurt (Austria)) ;
Racovita, Monica (Alpen-Adria Universität Klagenfurt (Austria)) ;
de Vriend, Huib (LIS Consult (The Netherlands)) ;
Alison, Roger (Roger Alison Ltd. (UK)) ;
Alison, Clare (Roger Alison Ltd. (UK)) ;
Baumgärtner, Wolfgang (University of Veterinary Medicine Hannover. Department of Pathology (Germany)) ;
Becker, Kathrin (University of Veterinary Medicine Hannover. Department of Pathology (Germany)) ;
Lempp, Charlotte (University of Veterinary Medicine Hannover. Department of Pathology (Germany)) ;
Schmicke, Marion (University of Veterinary Medicine Hannover. Clinic for Cattle (Germany)) ;
Schrenk, Dieter (University of Kaiserslautern. Food Chemistry and Toxicology (Germany)) ;
Pöting, Annette (Federal Institute for Risk Assessment (Germany)) ;
Schiemann, Joachim (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology. Federal Research Centre for Cultivated Plants (Germany)) ;
Wilhelm, Ralf (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology. Federal Research Centre for Cultivated Plants (Germany))
In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested the potential subchronic and chronic toxicity as well as the carcinogenicity of the glyphosate-resistant genetically modified maize NK603 by performing two 90-day feeding trials, one with GM maize inclusion rates of 11 and 33% and one with inclusion rates of up to 50%, as well as a 2-year feeding trial with inclusion rates of 11 and 33% in male and female Wistar Han RCC rats by taking into account OECD Guidelines for the testing of chemicals and EFSA recommendations on the safety testing of whole-food/feed in laboratory animals. [...]
2019 -  10.1007/s00204-019-02400-1
Archives of Toxicology, Vol. 93 (February 2019) , p. 1095-1139
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32 p, 2.6 MB |
One-year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
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Zeljenková, Dagmar (Slovak Medical University in Bratislava) ;
Aláčová, Radka (Slovak Medical University in Bratislava) ;
Ondrejková, Júlia (Slovak Medical University in Bratislava) ;
Ambrušová, Katarína (Slovak Medical University in Bratislava) ;
Bartušová, Mária (Slovak Medical University in Bratislava) ;
Kebis, Anton (Slovak Medical University in Bratislava) ;
Kovrižnych, Jevgenij (Slovak Medical University in Bratislava) ;
Rollerova, Eva (Slovak Medical University in Bratislava) ;
Szabová, Elena (Slovak Medical University in Bratislava) ;
Wimmerová, Sona (Slovak Medical University in Bratislava) ;
Černák, Martin (Slovak Medical University in Bratislava) ;
Krivošíková, Zora (Slovak Medical University in Bratislava) ;
Kuricová, Miroslava (Slovak Medical University in Bratislava) ;
Líšková, Aurélia (Slovak Medical University in Bratislava) ;
Spustová, Viera (Slovak Medical University in Bratislava) ;
Tulinská, Jana (Slovak Medical University in Bratislava) ;
Levkut, Mikuláš (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB) ;
Révajová, Viera (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB) ;
Ševčíková, Zuzana (University of Veterinary Medicine and Pharmacy in Košice and TOPALAB) ;
Schmidt, Kerstin (BioMath GmbH (Germany)) ;
Schmidtke, Jörg (BioMath GmbH (Germany)) ;
Schmidt, Paul (BioMath GmbH (Germany)) ;
La Paz, Jose Luis (Centre de Recerca en Agrigenòmica) ;
Corujo, Maria (Centre de Recerca en Agrigenòmica) ;
Pla, Maria (Universitat de Girona) ;
Kleter, Gijs A. (Wageningen University and Research Centre. RIKILT Wageningen UR) ;
Kok, Esther J. (Wageningen University and Research Centre. RIKILT Wageningen UR) ;
Sharbati, Jutta (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Bohmer, Marc (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Bohmer, Nils (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Einspanier, Ralf (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Adel-Patient, Karine (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire) ;
Spök, Armin (IFZ-Inter-University Research Centre for Technology. Work and Culture) ;
Pöting,Annette (Federal Institute for Risk Assessment) ;
Kohl, Christian (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology) ;
Wilhelm, Ralf (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology) ;
Schiemann, Joachim (Julius Kühn-Institut. Institute for Biosafety in Plant Biotechnology) ;
Steinberg, Pablo (University of Veterinary Medicine Hannover. Institute for Food Toxicology and Analytical Chemistry)
The GRACE (GMO Risk Assessment and Communication of Evidence; www. grace-fp7. eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. [...]
2016 - 10.1007/s00204-016-1798-4
Archives of Toxicology, Vol. 90, Issue 10 (October 2016) , p. 2531-2562
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3.
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26 p, 1.5 MB |
Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
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Zeljenková, Dagmar (Slovak Medical University) ;
Ambrušová, Katarína (Slovak Medical University) ;
Bartušová, Mária (Slovak Medical University) ;
Kebis, Anton (Slovak Medical University) ;
Kovrižnych, Jevgenij (Slovak Medical University) ;
Krivošíková, Miroslava (Slovak Medical University) ;
Líšková, Aurélia (Slovak Medical University) ;
Rollerová, Eva (Slovak Medical University) ;
Spustová, Viera (Slovak Medical University) ;
Szabová, Elena (Slovak Medical University) ;
Tulinská, Jana (Slovak Medical University) ;
Wimmerová, Sona (Slovak Medical University) ;
Levkut, Mikuláš (TOPALAB) ;
Révajová, Viera (TOPALAB) ;
Ševčíková, Zuzana (TOPALAB) ;
Schmidt, Kerstin (BioMath GmbH) ;
Schmidtke, Jörg (BioMath GmbH) ;
La Paz, Jose Luis (Centre de Recerca en Agrigenòmica) ;
Corujo, Maria (Centre de Recerca en Agrigenòmica) ;
Pla, Maria (Universitat de Girona) ;
Kleter, Gijs A. (Wageningen University and Research Centre) ;
Kok, Esther J. (Wageningen University and Research Centre) ;
Sharbati, Jutta (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Hanisch, Carlos (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Einspanier, Ralf (Freie Universität Berlin. Institute of Veterinary Biochemistry) ;
Adel-Patient, Karine (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire) ;
Wal, Jean‑Michel (Institut national de la recherche agronomique. Unité d'Immuno-Allergie Alimentaire) ;
Spök, Armin (IFZ-Inter-University Research Centre for Technology. Work and Culture) ;
Pöting, Annette (Federal Institute for Risk Assessment) ;
Kohl, Christian (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology) ;
Wilhelm, Ralf (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology) ;
Schiemann, Joachim (Julius Kühn Institute. Institute for Biosafety in Plant Biotechnology) ;
Steinberg, Pablo (University of Veterinary Medicine Hannover. Institute for Food Toxicology and Analytical Chemistry)
The GMO Risk Assessment and Communication of Evidence (GRACE; www. grace-fp7. eu) project is funded by the European Commission within the 7th Framework Programme. A key objective of GRACE is to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. [...]
2014 - 10.1007/s00204-014-1374-8
Archives of Toxicology, Vol. 88, Issue 12 (December 2014) , p. 2289-2314
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18 p, 2.7 MB |
Detecting un-authorized genetically modified organisms (GMOs) and derived materials
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Holst-Jensen, Arne (Norwegian Veterinary Institute) ;
Bertheau, Yves (Institut National de la Recherche Agronomique (France)) ;
de Loose, Marc (Institute for Agricultural and Fisheries Research (Belgium)) ;
Grohmann, Lutz (Bundesamt für Verbraucherschutz und Lebensmittelsicherheit) ;
Hamels, Sandrine (Eppendorf Array Technologies) ;
Hougs, Lotte (Danish Plant Directorate) ;
Morisset, Dany (National Institute of Biology (Slovenia)) ;
Pecoraro, Sven (Bavarian Health and Food Safety Authority) ;
Pla, Maria (Centre de Recerca en Agrigenòmica) ;
Van den Bulcke, Marc (Institute of Health and Consumer Protection (Belgium)) ;
Wulff, Doerte (Eurofins GeneScan)
Genetically modified plants, in the following referred to as genetically modified organisms or GMOs, have been commercially grown for almost two decades. In 2010 approximately 10% of the total global crop acreage was planted with GMOs (James, 2011). [...]
2012 - 10.1016/j.biotechadv.2012.01.024
Biotechnology advances, Vol. 30, Issue 6 (November-December 2012) , p. 1318-1335
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7 p, 15.8 MB |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis
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Nuñez, Olivier (Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)) ;
Román, Antonio (Román Broto) (Hospital Universitari Vall d'Hebron) ;
Johnson, Simon R. (National Centre for Lymphangioleiomyomatosis, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, UK Division of Respiratory Medicine and Respiratory Research Unit, University of Nottingham) ;
Inoue, Yoshikazu (National Hospital Organization Kinki-Chuo Chest Medical Center) ;
Hirose, Masaki (National Hospital Organization Kinki-Chuo Chest Medical Center) ;
Casanova, Álvaro (Department of Pneumology, Henares Hospital) ;
de Garibay, Gorka Ruiz (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO) Institute for Biomedical Research (IDIBELL)) ;
Herranz-Ors, C. (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL)) ;
Bueno-Moreno, Gema (MD Anderson International Foundation) ;
Boni, Jacopo (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO) for Biomedical Research (IDIBELL), Gran via 199, L'Hospitalet del Llobregat) ;
Mateo, Francesca (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL)) ;
Petit Montserrat, Anna (Department of Pathology, University Hospital of Bellvitge, IDIBELL) ;
Climent, Fina (Department of Pathology, University Hospital of Bellvitge, IDIBELL) ;
Soler, Teresa (Department of Pathology, University Hospital of Bellvitge, IDIBELL) ;
Vidal, August (Department of Pathology, University Hospital of Bellvitge, IDIBELL) ;
Sánchez-Mut, José Vicente (Cancer Epigenetics and Biology Program, IDIBELL) ;
Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
López, José Ignacio (Cruces University Hospital, BioCruces Research Institute, University of the Basque Country) ;
García, Nadia (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO)Institute for Biomedical Research (IDIBELL), Gran via 199) ;
Gumà, Anna (Department of Radiology, University Hospital of Bellvitge, IDIBELLBarcelona, Catalonia Spain) ;
Ortega, Raúl (Department of Radiology, University Hospital of Bellvitge, IDIBELL) ;
Plà, María Jesús (Breast Cancer Functional Unit, Department of Gynecology, University Hospital of Bellvitge, ICO, IDIBELL) ;
Campos, Miriam (Breast Cancer Functional Unit, Department of Medical Oncology, ICO, IDIBELL) ;
Ansótegui, Emilio (Lung Transplant and Cystic Fibrosis Unit, Hospital Universitario y Politecnico La Fe) ;
Molina-Molina, María (Consortium for Biomedical Research in Respiratory Diseases (CIBERES), 28029 Madrid, Spain) ;
Valenzuela, Claudia (Department of Pneumology, Instituto de Investigación Sanitaria La Princesa) ;
Ussetti, Piedad (Department of Pneumology, University Hospital Clínica Puerta del Hierro) ;
Laporta, Rosalía (Department of Pneumology, University Hospital Clínica Puerta del Hierro) ;
Ancochea, Julio (Department of Pneumology, Instituto de Investigación Sanitaria La Princesa, Hospital La Princesa) ;
Xaubet, Antoni (Department of Pneumology, Hospital Clinic of Barcelona, August Pi Suñer Biomedical Research Institute (IDIBAPS)) ;
Pollán, Marina (Cancer and Environmental Epidemiology Unit, National Center for Epidemiology, Carlos III Institute of Health, and Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP)) ;
Pujana, Miguel Angel (ProCURE, Breast Cancer and Systems Biology, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The online version of this article (doi:10. 1007/s10549-016-3737-8) contains supplementary material, which is available to authorized users.
2016 - 10.1007/s10549-016-3737-8
Breast Cancer Research and Treatment, Vol. 156 (march 2016) , p. 195-201
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3 p, 134.6 KB |
Libros: La didáctica de la geografía : una mirada actual
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Comes Solé, Pilar ;
Busquets Fàbregas, Jaume (Universitat de Barcelona) ;
Bovet Pla, Maria del Tura
La oferta de Guías Praxis para el profesorado de ESO, como la propia editorial indica en el prólogo, "pretende ofrecer todo tipo de recursos para la intervención docente del profesor en el aula". Para ello se ha diseñado una colección de carpetas, formato archivador con anillas de hojas intercambiables, a una sola tinta, para que con suma facilidad se pueda fotocopiar el material y también pueda actualizarse su contenido. [...]
1998
Aula de innovación educativa, Núm. 73-74 (1998) , p. 67-69
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22 p, 2.1 MB |
Constitutive expression of transgenes encoding derivatives of the synthetic antimicrobial peptide BP100 : impact on rice host plant fitness
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Nadal Matamala, Anna (Institut de Tecnologia Agroalimentaria) ;
Montero, Maria (Institut de Tecnologia Agroalimentaria) ;
Company, Nuri (Institut de Tecnologia Agroalimentaria) ;
Badosa Romañó, Esther (Institut de Tecnologia Agroalimentaria) ;
Messeguer, Joaquima (Centre de Recerca en Agrigenòmica) ;
Montesinos, Laura (Institut de Tecnologia Agroalimentaria) ;
Montesinos, Emilio (Institut de Tecnologia Agroalimentaria) ;
Pla, Maria (Institut de Tecnologia Agroalimentaria)
Background: the Biopeptide BP100 is a synthetic and strongly cationic α-helical undecapeptide with high, specific antibacterial activity against economically important plant-pathogenic bacteria, and very low toxicity. [...]
2012 - 10.1186/1471-2229-12-159
BMC plant biology, Vol. 12 (2012) , art. 159
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13 p, 701.8 KB |
The use of massive sequencing to detect differences between immature embryos of MON810 and a comparable non-GM maize variety
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La Paz, Jose Luis (Centre de Recerca en Agrigenòmica) ;
Pla, Maria (Centre de Recerca en Agrigenòmica) ;
Centeno Ortiz, Emilio (Centre de Recerca en Agrigenòmica) ;
Vicient Sánchez, Carlos M. (Centre de Recerca en Agrigenòmica) ;
Puigdomènech, Pere, 1948- (Centre de Recerca en Agrigenòmica)
The insect resistant maize YieldGard MON810 was studied to assess the extent to which introduction of a transgene may putatively alter the expression of endogenous genes by comparison of various GM lines vs. [...]
2014 - 10.1371/journal.pone.0100895
PloS one, Vol. 9, issue 6 (June 2014) , e100895
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