1.
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16 p, 1.1 MB |
Multimorbidity patterns in COVID-19 patients and their relationship with infection severity : MRisk-COVID study
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Lleal, Marina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corral-Vazquez, Celia (Instituto de Salud Carlos III) ;
Bare Mañas, Montserrat (Institut Català de la Salut) ;
Comet Monte, Ricard (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Herranz, Susana (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Baigorri, Francisco (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gimeno-Miguel, Antonio (Instituto de Salud Carlos III) ;
Raurich, Maria (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Fortià, Cristina (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Navarro, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Poblador-Plou, Beatriz (Instituto de Salud Carlos III) ;
Baré i Mañas, Marisa (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Several chronic conditions have been identified as risk factors for severe COVID-19 infection, yet the implications of multimorbidity need to be explored. The objective of this study was to establish multimorbidity clusters from a cohort of COVID-19 patients and assess their relationship with infection severity/mortality. [...]
2023 - 10.1371/journal.pone.0290969
PloS one, Vol. 18 (august 2023)
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2.
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9 p, 319.4 KB |
Effectiveness of risk minimization measures for the use of cilostazol in United Kingdom, Spain, Sweden, and Germany
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Castellsague, Jordi (RTI Health Solutions) ;
Poblador-Plou, Beatriz (University of Zaragoza) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona) ;
Linder, Marie (Karolinska Institutet (Estocolm, Suècia). Department of Medicine) ;
Scholle, Oliver (Leibniz Institute for Prevention Research and Epidemiology. Department of Clinical Epidemiology) ;
Calingaert, Brian (RTI Health Solutions) ;
Bui, Christine (RTI Health Solutions) ;
Arana, Alejandro (RTI Health Solutions) ;
Laguna, Clara (University of Zaragoza) ;
Gonzalez Rubio, Francisca (University of Zaragoza) ;
Roso-Llorach, Albert (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Prados-Torres, Alexandra (University of Zaragoza) ;
Perez-Gutthann, S. (RTI Health Solutions)
The purpose of the study is to evaluate the effectiveness of risk minimization measures-labeling changes and communication to health care professionals-recommended by the European Medicines Agency for use of cilostazol for the treatment of intermittent claudication in Europe. [...]
2018 - 10.1002/pds.4584
Pharmacoepidemiology and Drug Safety, Vol. 27 (july 2018) , p. 953-961
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3.
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11 p, 1.2 MB |
Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014 : Incidence and comorbidities of antidepressant initiators
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Forns, Joan (RTI Health Solutions. Epidemiology) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Morros, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions) ;
Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital)
Background: We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009-2014 in Denmark, Germany, Spain, and Sweden. Methods: Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. [...]
2019 - 10.1016/j.jad.2019.02.010
Journal of Affective Disorders, Vol. 249 (April 2019) , p. 242-252
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4.
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13 p, 786.0 KB |
Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users in Four European Countries : A Cohort and Nested Case-Control Study Using Automated Health Data Sources
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Pladevall-Vila, Manel (Epidemiology. RTI Health Solutions) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Schink, Tania (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Reutfors, Johan (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Morros, Rosa. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Timmer, Antje (Division of Epidemiology and Biometry. Medical Faculty. Carl von Ossietzky University) ;
Forns, Joan (Epidemiology. RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Reinders, Tammo (Leibniz Institute for Prevention Research and Epidemiology-BIPS) ;
Hägg, David (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Giner-Soriano, Maria (Institut Català de la Salut) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Cainzos-Achirica, Miguel (Epidemiology. RTI Health Solutions) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Brandt, Lena (Centre for Pharmacoepidemiology. Department of Medicine. Solna. Karolinska Institutet. Karolinska University Hospital) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Aguado, Jaume (Epidemiology. RTI Health Solutions) ;
Perlemuter, Gabriel (INSERM U996) ;
Falissard, Bruno (CESP INSERM U1018. Université Paris-Saclay. Université Paris-Sud. UVSQ. APHP) ;
Castellsague, Jordi (Epidemiology. RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Servier) ;
Perez-Gutthann, S. (Epidemiology. RTI Health Solutions)
Background: Agomelatine is a melatonin receptor agonist and serotonin 5-HT receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. [...]
2019 - 10.1007/s40263-019-00611-9
CNS Drugs, Vol. 33 Núm. 4 (april 2019) , p. 383-395
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5.
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11 p, 536.7 KB |
Validity of ICD-9 and ICD-10 codes used to identify acute liver injury : A study in three European data sources
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Forns, Joan (RTI Health Solutions) ;
Cainzos-Achirica, Miguel (RTI Health Solutions) ;
Hellfritzsch, Maja (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Morros, Rosa (Universitat Autònoma de Barcelona) ;
Poblador-Plou, Beatriz (Instituto de Investigación Sanitaria de Aragón) ;
Hallas, Jesper (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona) ;
Prados-Torres, Alexandra (Instituto de Investigación Sanitaria de Aragón) ;
Pottegård, Anton (Clinical Pharmacology and Pharmacy. Department of Public Health. University of Southern Denmark) ;
Cortés, Jordi (Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa) ;
Castellsague, Jordi (RTI Health Solutions) ;
Jacquot, Emmanuelle (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Deltour, Nicolas (Pharmacoepidemiology Department. Les Laboratoires Servier) ;
Perez-Gutthann, S. (RTI Health Solutions) ;
Pladevall-Vila, Manel (RTI Health Solutions)
Purpose: Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs). Methods: Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. [...]
2019 - 10.1002/pds.4803
Pharmacoepidemiology and Drug Safety, Vol. 28 Núm. 7 (july 2019) , p. 965-975
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