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8 p, 826.6 KB |
Levodopa-carbidopa intestinal gel in advanced Parkinson's : Final results of the GLORIA registry
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Antonini, Angelo (University of Padua) ;
Poewe, Werner (Medical University of Innsbruck) ;
Chaudhuri, K.Ray (King's College and King's College Hospital) ;
Jech, Robert (General University Hospital in Prague) ;
Pickut, Barbara (Michigan State University) ;
Pirtošek, Zvezdan (University Medical Center Ljubljana) ;
Szasz, Jozsef (University of Medicine and Pharmacy Tirgu-Mures) ;
Valldeoriola, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Winkler, Christian (Lindenbrunn Hospital) ;
Bergmann, Lars (AbbVie Inc.) ;
Yegin, Ashley (AbbVie Inc.) ;
Onuk, Koray (AbbVie Inc.) ;
Barch, David (AbbVie Inc.) ;
Odin, Per (Lund University) ;
Amalia, Ene (University Emergency Hospital) ;
Arnold, Guy (Sindelfingen Hospital) ;
Bajenaru, Ovidiu (University of Medicine and Pharmacy "Carol Davila") ;
Bergmans, Bruno (AZ St-Jan Brugge-Oostende AV) ;
Bjornara, Kari Anne (Drammen Hospital) ;
Blackie, Jeff (John Hunter Hospital) ;
Bode, Matthias (Odense University Hospital (Dinamarca)) ;
Bourgeois, Paul (Department of Neurology AZ Groeninge) ;
Bohlhalter, Stephan (Neurology and Neurorehabilitation Center) ;
Buraga, Ioan (Colentina Hospital) ;
Burkhard, Pierre R. (Geneva University Hospitals) ;
Busson, Philippe (Centre Hospitalier Avranches Granvilles) ;
Calopa, Matilde (Hospital Universitari de Bellvitge) ;
Clausen, Jesper (Rigshospitalet/Glostup) ;
Danielsen, Erik Hvid (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Defebvre, Luc (Université of Lille) ;
Delvaux, Valerie (University of Liege) ;
Dethy, Sophie (Chu-Tivoli) ;
Dietrichs, Espen (University of Oslo) ;
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron) ;
Gerhard, Ransmayr (Kepler University Hospital) ;
Gusmaroli, Graziano (Ospedale degli Infermi di Biella) ;
Hahn, Kirsten ;
Hauptmann, Björn (Neurologisches Zentrum) ;
Henriksen, Tove (University Hospital of Bispebjerg) ;
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron) ;
Jeanjean, A. (Université catholique de Louvain) ;
Kaiserova, Michaela (Palacky University) ;
Kassubek, Jan (University of Ulm) ;
Kimber, Thomas (University of Adelaide) ;
Konitsiotis, Spyridon (University of Ioannina) ;
Krüger, Rejko (University of Tübingen) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Leenders, Jo (Sint-Dimpa Ziekenhuis) ;
Lundqvist, Christofer (Akershus University Hospital) ;
Ory Magne, F. (Toulouse University Hospital) ;
Marano, Pietro (Nuova Casa di Cura D'Anna) ;
Milanov, Ivan (University Neurological Hospital "St. Naum") ;
Modugno, Nicola (IRCCS Neuromed) ;
Misbahuddin, Anjum (Essex Centre for Neurological Sciences) ;
Nevrly, Martin (University Hospital and Faculty of Medicine and Dentistry of Palacky University) ;
Panayiotis, Zikos (251 Hellenic Air Force Hospital) ;
Pedersen, Kenn Freddy (Stavanger University Hospital) ;
Pedersen, Stephen W. (Glostrup Hospital University of Copenhagen) ;
Perju-Dumbrava, Lacramioara (University of Medicine and Pharmacy "Iuliu Hatieganu") ;
Ponsen, M.M. (Meander Medical Center) ;
Popescu, Bogdan O. (Carol Davila University of Medicine and Pharmacy) ;
Rijntjes, Michel (University Clinic Freiburg) ;
Puente, V. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Redecker, Christoph (Jena University Hospital (Alemania)) ;
Schrader, Christoph (Hannover Medical School) ;
Sensi, Mariachiara (Arcispedale S.Anna) ;
Simu, Michaela (UMF"Victor Babes") ;
Spanaki, Cleanthe (University of Crete) ;
Storch, Alexander (University of Rostock) ;
Storstein, Anette (Haukeland University Hospital (Bergen, Noruega)) ;
Tomantschger, Volker (Gailtal-Klinik Hermagor) ;
van der Linden, Chris (St. Lucas Hospital Ghent) ;
van Laar, T. (University Medical Center Groningen) ;
Viallet, F. (CH du pays d'Aix) ;
Witjas, Tatiana (University Hospital Timone) ;
Wolz, Martin (Elblandklinikum Meissen) ;
Zibetti, Maurizio (University of Torino) ;
Van Zandijcke, Michel (AZ Sint-Jan Brugge) ;
Universitat Autònoma de Barcelona
This registry evaluated the 24-month safety and efficacy of levodopa-carbidopa intestinal gel (LCIG) treatment in advanced Parkinson's disease (PD) patients under routine clinical care. Motor fluctuations, dyskinesia, non-motor symptoms, quality of life, and safety were evaluated. [...]
2017 -  10.1016/j.parkreldis.2017.09.018
Parkinsonism and Related Disorders, Vol. 45 (december 2017) , p. 13-20
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A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA) : Rationale, Design, and Baseline Data
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Pagano, Gennaro (F Hoffmann-La Roche AG Research and Development Division) ;
Boess, Frank (Roche Pharma Research and Early Development) ;
Taylor, Kirsten I. (Faculty of Psychology. University of Basel) ;
Ricci, Benedicte (Roche Pharma Research and Early Development) ;
Mollenhauer, Brit ;
Poewe, Werner ;
Boulay, Anne ;
Anzures-Cabrera, Judith (Roche Products Ltd) ;
Vogt, Annamarie ;
Marchesi, Maddalena ;
Post, Anke ;
Nikolcheva, Tania ;
Kinney, Gene G. (Prothena Biosciences Inc. South San Francisco) ;
Zago, Wagner M. ;
Ness, Daniel K. ;
Svoboda, Hanno (F. Hoffmann-La Roche) ;
Britschgi, Markus ;
Ostrowitzki, Susanne ;
Simuni, Tanya ;
Marek, Kenneth (Institute for Neurodegenerative Disorders) ;
Koller, Martin ;
Sevigny, Jeff ;
Doody, Rachelle ;
Fontoura, Paulo ;
Umbricht, Daniel ;
Bonni, Azad ;
Altendorf, Claudia ;
Anandan, Chareyna ;
Andrews, Giulia ;
Ansquer, Solène ;
Arrouasse, Raphaele ;
Aslam, Sana ;
Azulay, Jean-Philippe ;
Baker, Jeanette ;
Balaguer Martinez, Ernest ;
Barbu, Shadi ;
Bardram, Kara ;
Bega, Danny ;
Bejr-kasem, Helena (Institut d'Investigació Biomèdica Sant Pau) ;
Benatru, Isabelle ;
Benchetrit, Eve ;
Bernhard, Felix ;
Besharat, Amir ;
Bette, Sagari ;
Bichon, Amelie ;
Billnitzer, Andrew ;
Blondeau, Sophie ;
Boraud, Thomas ;
Borngräber, Freiderike ;
Boyd, James ;
Brockmann, Kathrin ;
Brodsky, Matthew ;
Brown, Ethan ;
Bruecke, Christof ;
Calvas, Fabienne ;
Canelo, Monica ;
Carbone, Federico ;
Carroll, Claire ;
Casado Fernandez, Laura ;
Cassé-Perrot, Catherine ;
Castrioto, Anna ;
Catala, Helene ;
Chan, Justine ;
Cheriet, Samia ;
Ciabarra, Aanthony ;
Classen, Joseph ;
Coleman, Juliana ;
Coleman, Robert ;
Compta, Yaroslau ;
Corbillé, Anne-Gaëlle ;
Corvol, Jean-Christophe ;
Cosgaya, Marina ;
Dahodwala, Nabila ;
Damier, Philippe ;
David, Elodie ;
Davis, Thomas ;
Dean, Marissa ;
Debilly, Berengere ;
DeGiorgio, Janell ;
Deik, Andres ;
Delaby, Laure ;
Delfini, Marie-Helene ;
Derkinderen, Pascal ;
Derost, Philipp ;
de Toledo, María ;
Deuel, Lisa ;
Diaz-Hernandez, Ann Marie ;
Dietiker, Cameron ;
Dimenshteyn, Karina ;
Dotor, Julio ;
Durif, Franck ;
Ebentheuer, Jens ;
Eggert, Karla Maria ;
Eichau Madueño, Sara ;
Eickhoff, Claudia ;
Ellenbogen, Aaron ;
Ellmerer, Philipp ;
Esparragosa Vazquez, Inés ;
Eusebio, Alexandre ;
Ewert, Siobhan ;
Fang, John ;
Feigenbaum, Danielle ;
Fluchere, Frederique ;
Foubert-Samier, Alexandra ;
Fournier, Marie ;
Fradet, Anne ;
Fraix, Valerie ;
Frank, Samuel ;
Fries, Franca ;
Galitzky, Monique ;
Gallardo Pérez, Marisol ;
Moreno, Jose Manuel García ;
Gasca, Carmen ;
Gasser, Thomas ;
Gibbons, Joyce ;
Giordana, Caroline ;
González Martinez, Alicia ;
Goodman, Ira ;
Gorospe, Arantza ;
Goubeaud, Marie ;
Grabli, David ;
Graziella, Mangone ;
Grimaldi, Stephan ;
Gross, Jeffrey ;
Guimaraes-Costa, Raquel ;
Hartmann, Andreas ;
Hartmann, Christian ;
Hassell, Travis ;
Hauser, Robert ;
Hernandez, Antonio ;
Hernández-Vara, Jorge ;
Hoeglinger, Günter ;
Homedes, Christian ;
Horta, Andrea ;
Houeto, Jean-Luc ;
Huebl, Julius ;
Hui, Jennifer ;
Isaacson, Stuart ;
Jankovic, Joseph ;
Janzen, Annette ;
Jauregui, Junior ;
Jiao, Jocelyne ;
Martí Domenech, María José ;
Joseph, Xavier ;
Kadimi, Srinath ;
Kaminski, Pat ;
Kannenberg, Silja ;
Kassubek, Jan ;
Katz, Maya ;
Klos, Kevin ;
Klos, Shannon ;
Kobet, Christopher ;
Koebert, Jennifer ;
Krause, Patricia ;
Kuehn, Andrea ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Kumar, Rajeev ;
Kunz, Martin ;
Kurvits, Lille ;
Kwei, Kimberly ;
Laganiere, Simon ;
Laurens, Brice ;
Levin, Johannes ;
Levy, Oren ;
LeWitt, Peter ;
Cristóbal, Gurutz Linazasoro ;
Litvan, Irene ;
Lizarraga, Karlo ;
Longardner, Katherine ;
Lopez, Rocío ;
López Manzanares, Lydia ;
Lucas del Pozo, Sara ;
Luquín Pulido, María Rosario ;
Luthra, Nijee ;
Lyons, Kelly ;
Maass, Sylvia ;
Machetanz, Gerrit ;
Macías, Yolanda ;
Maltete, David ;
Manez Miro, Jorge Uriel ;
Mariani, Louise-Laure ;
Marin, Juan ;
Marini, Kathrin ;
Marques, Ana ;
Marti, Gloria ;
Martí Domenech, María José ;
Martinez, Saul ;
Meissner, Wassilios ;
Meoni, Sara ;
Mollenhauer, Brit ;
Martinez, Dunia Mon ;
Moon, Johnson ;
Moro, Elena ;
Morrison, Peter ;
Muehlberg, Christoph ;
Multani, Manpreet ;
Murphy, Christine ;
Nicholas, Anthony ;
Pahwa, Rajesh ;
Palasí Franco, Antoni ;
Pape, Heidi ;
Patel, Neepa ;
Patel, Prity ;
Peball, Marina ;
Peckham, Elizabeth ;
Peery, Terry ;
Perez, Rafael ;
Perez, Jesús ;
Petit, Alisa ;
Pinkhardt, Elmar ;
Poewe, Werner ;
Pomies, Elsa ;
Preterre, Cecile ;
Quinn, Joseph ;
Rascol, Olivier ;
Remy, Philippe ;
Richard, Irene ;
Roeben, Benjamin ;
Ruether, Emily ;
Rumpf, Jost-Julian ;
Russell, David ;
Salhi, Hayet ;
Samaniego-Toro, Daniela ;
Samier-Foubert, Alexandra ;
Sánchez, Antonio ;
Schmitt, Emmanuelle ;
Schnitzler, Alfons ;
Schorr, Oliver ;
Schwartzbard, Julie ;
Schweyer, Kerstin ;
Seppi, Klaus ;
Sergo, Victoria ;
Shill, Holly ;
Siderowf, Andrew ;
Simuni, Tanya ;
Spampinato, Umberto ;
Sriram, Ashok ;
Stover, Natividad ;
Tanner, Caroline ;
Tarakad, Arjun ;
Taylor, Carolyn ;
Thalamus, Claire ;
Toothaker, Thomas ;
Van Blercom, Nadege ;
Vanegas-Arrogave, Nora ;
Vela, Lydia ;
Vergnet, Sylvian ;
Vidal, Tiphaine ;
Vöglein, Jonathan ;
Walsh, Ryan ;
Waters, Cheryl ;
Wegscheider, Mirko ;
Weidinger, Endy ;
Weill, Caroline ;
Wenzel, Gregor ;
Witjas, Tatiana ;
Wurster, Isabel ;
Wright, Brenton ;
Zimmermann, Milan ;
Zuzuarregui, Rafael ;
Abt, Markus ;
Bamdadian, Atieh ;
Barata, Teresa ;
Barbet, Nicholas ;
Belli, Sara ;
Boess, Frank ;
Bonni, Azad ;
Borroni, Edilio ;
Boulay, Anne ;
Britschgi, Markus ;
Chague, Jerome ;
Cosson, Valerie ;
Czech, Christian ;
Deptula, Dennis ;
Diack, Cheikh ;
Doody, Rachelle ;
Dukart, Juergen ;
D'Urso, Giulia ;
Dziadek, Sebastian (F. Hoffmann-La Roche) ;
Eddleston, Hannah ;
Edgar, Chris ;
Essioux, Laurent ;
Farell, Morgan ;
Finch, Rebecca (Roche Products Ltd) ;
Fontoura, Paulo ;
Gruenbauer, Waltraud ;
Hahn, Andreas ;
Holiga, Stefan (F. Hoffmann-La Roche) ;
Honer, Michael ;
Jadidi, Shirin ;
Johnson-Wood, Kelly ;
Keller, Markus ;
Kilchenmann, Timothy ;
Koller, Martin ;
Kremer, Thomas ;
Kustermann, Thomas (F. Hoffmann-La Roche) ;
Landsdall, Claire ;
Lindemann, Michael (F. Hoffmann-La Roche) ;
Lipsmeier, Florian ;
Luzy, Cecile ;
Manchester, Marianne ;
Marchesi, Maddalena ;
Martenyi, Ferenc ;
Martin-Facklam, Meret ;
Mironova, Katerina ;
Monnet, Annabelle (F. Hoffmann-La Roche) ;
Moore, Emma ;
Ness, Daniel K. ;
Niggli, Markus ;
Nikolcheva, Tania (F. Hoffmann-La Roche) ;
Ostrowitzki, Susanne ;
Passmard, Benedicte ;
Poirier, Agnes ;
Post, Anke ;
Prasad, Megana ;
Pross, Nathalie (F. Hoffmann-La Roche) ;
Quock, Tiffany ;
Rose, Ellen ;
Sarry, Christoph ;
Schubert, Christine ;
Selkoe, Dennis ;
Sevigny, Jeff ;
Sink, Kaycee ;
Staunton, Hannah ;
Steven, Tim ;
Strasak, Alexander ;
Svoboda, Hanno ;
Tripuraneni, Radhika ;
Trundell, Dylan ;
Umbricht, Daniel ;
Verselis, Lynne ;
Vogt, Annamarie ;
Volkova-Volkmar, Ekaterina ;
Weber, Cornelia ;
Weber, Silke ;
Zago, Wagner (Prothena Biosciences Inc. (San Francisco))
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. [...]
2021 - 10.3389/fneur.2021.705407
Frontiers in neurology, Vol. 12 (january 2021) , p. 705407
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