Resultats globals: 6 registres trobats en 0.01 segons.
Articles, 6 registres trobats
Articles 6 registres trobats  
1.
12 p, 653.9 KB HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy / Blanch Lombarte, Oscar (Institut Germans Trias i Pujol) ; Santos, José Ramón (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Jiménez Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Virological failure (VF) to boosted PIs with a high genetic barrier is not usually linked to the development of resistance-associated mutations in the protease gene. From a cohort of 520 HIV-infected subjects treated with lopinavir/ritonavir or darunavir/ritonavir monotherapy, we retrospectively identified nine patients with VF. [...]
2020 - 10.1093/jac/dkaa228
Journal of Antimicrobial Chemotherapy, Vol. 75 (june 2020) , p. 2535-2546  
2.
16 p, 2.5 MB Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa / Cantero-Pérez, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Grau-Expósito, J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Serra-Peinado, C. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rosero, D.A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Luque-Ballesteros, L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castellvi, Josep. (Hospital Universitari Vall d'Hebron. Centre d'Esclerosi Mútiple de Catalunya) ; Sanhueza, T. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Tapia Melendo, Gustavo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lloveras, B. (Parc de Salut Mar (Barcelona, Catalunya)) ; Fernández, Marco A. (Institut Germans Trias i Pujol) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Solé-Sedeno, J.M. (Institut Hospital del Mar d'Investigacions Mèdiques) ; Tarrats, A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Lecumberri, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mañalich-Barrachina, L. (Hospital Universitari Vall d'Hebron) ; Centeno-Mediavilla, C. (Hospital Universitari Vall d'Hebron) ; Falcó, V. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Buzon, M.J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
HIV viral reservoirs are established very early during infection. Resident memory T cells (T) are present in tissues such as the lower female genital tract, but the contribution of this subset of cells to the pathogenesis and persistence of HIV remains unclear. [...]
2019 - 10.1038/s41467-019-12732-2
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4739  
3.
0 p, 5.4 MB Antigen production after latency reversal and expression of inhibitory receptors in CD8+ T cells limit the killing of HIV-1 reactivated cells / Ruiz, A. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Jimenez-Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Peña, R. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Goulder, P. (Department of Paediatrics. University of Oxford) ; Barnard, R. (Department of Infectious Disease. Merck and Co. Inc.) ; Howell, B. (Department of Infectious Disease. Merck and Co. Inc.) ; Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Universitat Autònoma de Barcelona
The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. [...]
2019 - 10.3389/fimmu.2018.03162
Frontiers in immunology, Vol. 10 Núm. JAN (2019) , p. 3162  
4.
14 p, 2.0 MB Differential Immunodominance Hierarchy of CD8 + T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection / Adland, Emily ; Hill, Matilda ; Lavandier, Nora ; Csala, Anna ; Edwards, Anne ; Chen, Fabian ; Radkowski, Marek ; Kowalska, Justyna D. ; Paraskevis, Dimitrios ; Hatzakis, Angelos ; Valenzuela-Ponce, Humberto ; Pfafferott, Katja ; Williams, Ian ; Pellegrino, Pierre ; Borrow, Persephone ; Mori, Masahiko ; Rockstroh, Jürgen ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Tudor-Williams, Gareth ; Frater, John ; Stryhn, Anette ; Buus, Soren ; Teran, Gustavo Reyes ; Mallal, Simon ; John, Mina ; Buchbinder, Susan ; Kirk, Gregory ; Martin, Jeffrey ; Michael, Nelson ; Fellay, Jacques ; Deeks, Steve ; Walker, Bruce ; Avila-Rios, Santiago ; Cole, David ; Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Carrington, Mary ; Goulder, Philip ; Universitat Autònoma de Barcelona
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and polymerase (Pol) KY9 (residues 901 to 909) epitopes. [...]
2018 - 10.1128/JVI.01685-17
Journal of Virology, Vol. 92 (january 2018)  
5.
15 p, 1.4 MB Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1 / Izquierdo Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Lorizate, Maier (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Contreras, F. Xabier (Heidelberg University Biochemistry Center (BZH), Heidelberg) ; Rodríguez Plata, María T. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Glass, Bärbel (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Casas, Josefina (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Fabriàs, Gemma (Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain) ; Kräusslich, Hans Georg (Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany) ; Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
An accessible sialyllactose moiety on viral membrane gangliosides is shown to be essential for HIV-1 uptake into mature dendritic cells, thereby promoting viral transfer and infection of bystander CD4+ T lymphocytes. [...]
2012 - 10.1371/journal.pbio.1001315
PLoS biology, Vol. 10 (april 2012)  
6.
26 p, 2.7 MB Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection / Adland, Emily (University of Oxford) ; Paioni, Paolo (University of Oxford) ; Thobakgale, Christina (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Laker, Leana (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Mori, Luisa (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Muenchhoff, Maximilian (University of Oxford) ; Csala, Anna (University of Oxford) ; Clapson, Margaret (Saint Hospital for Children (London, Gran Bretanya)) ; Flynn, Jacquie (Saint Hospital for Children (London, Gran Bretanya)) ; Novelli, Vas (Saint Hospital for Children (London, Gran Bretanya)) ; Hurst, Jacob (University of Oxford) ; Naidoo, Vanessa (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Shapiro, Roger (Botswana Harvard AIDS Institute Partnership (Gaborone, Botswana)) ; Gary, Kuan-Hsiang Huang (University of Oxford) ; Frater, John (University of Oxford) ; Prendergast, Andrew (Queen Mary University of London) ; Prado, Julia G. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Ndung'u, Thumbi (University of KwaZulu-Natal (Durban, Sud-àfrica)) ; Walker, Bruce D. (University of Oxford) ; Carrington, Mary (National Cancer Institute (Maryland, Estats Units d'Amèrica)) ; Jooste, Pieter (Kimberley Hospital (Northern Cape, Sud-àfrica)) ; Goulder, Philip J. R. (University of Oxford)
Abstract. HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted CD8+ T-cell responses. [...]
2015 - 10.1371/journal.ppat.1004954
PLoS pathogens, Vol. 11 Núm. 6 (June 2015)  

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