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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 -  10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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15 p, 739.8 KB |
Advances in diagnostic tools for respiratory tract infections : from tuberculosis to COVID-19 - changing paradigms?
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Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonçalves-Carvalho, Filipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marín, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Respiratory tract infections (RTIs) are one of the most common reasons for seeking healthcare, but are amongst the most challenging diseases in terms of clinical decision-making. Proper and timely diagnosis is critical in order to optimise management and prevent further emergence of antimicrobial resistance by misuse or overuse of antibiotics. [...]
2022 - 10.1183/23120541.00113-2022
ERJ Open Research, Vol. 8 (september 2022)
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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 - 10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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13 p, 3.5 MB |
Electrophysiological effects of adipose graft transposition procedure (AGTP) on the post-myocardial infarction scar : A multimodal characterization of arrhythmogenic substrate
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Adeliño, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Falguera, Daina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Curiel, Carolina (Boston Scientific Department. Barcelona Delegation) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marsal, Roger (Boston Scientific Department. Barcelona Delegation) ;
Rodríguez-Leor, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fadeuilhe, Edgar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Aranyó, Júlia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sarrias, Axel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bazán, Víctor (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Andrés-Cordón, Joan Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villuendas-Sabaté, Roger (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lupón, Josep (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bisbal, Felipe (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
To assess the arrhythmic safety profile of the adipose graft transposition procedure (AGTP) and its electrophysiological effects on post-myocardial infarction (MI) scar. Myocardial repair is a promising treatment for patients with MI. [...]
2022 - 10.3389/fcvm.2022.983001
Frontiers in Cardiovascular Medicine, Vol. 9 (september 2022)
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9 p, 1.2 MB |
BCG vaccination to reduce the impact of COVID-19 in healthcare workers : Protocol for a randomised controlled trial (BRACE trial)
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Pittet, Laure F (The Royal Children's Hospital Melbourne) ;
Messina, Nicole L (The University of Melbourne) ;
Gardiner, Kaya (Murdoch Children's Research Institute) ;
Orsini, Francesca (Murdoch Children's Research Institute) ;
Abruzzo, Veronica (Murdoch Children's Research Institute) ;
Bannister, Samantha (The Royal Children's Hospital Melbourne) ;
Bonten, Marc (Julius Center for Health Sciences and Primary Care) ;
Campbell, John L (University of Exeter Medical School) ;
Croda, Julio (Yale School of Public Health) ;
Dalcolmo, Margareth (Pontifical Catholic University of Rio de Janeiro) ;
Elia, Sonja (The Royal Children's Hospital Melbourne) ;
Germano, Susie (Murdoch Children's Research Institute) ;
Goodall, Casey (Murdoch Children's Research Institute) ;
Gwee, Amanda (The Royal Children's Hospital Melbourne) ;
Jamieson, Tenaya (Murdoch Children's Research Institute) ;
Jardim, Bruno (Fundação de Medicina Tropical Doutor Heitor Vieira Dourado) ;
Kollmann, Tobias R (Telethon Kids Institute) ;
Guimarães Lacerda, Marcus Vinícius (Fundação Oswaldo Cruz (Brasil)) ;
Lee, Katherine J (Murdoch Children's Research Institute) ;
Legge, Donna (Royal Children's Hospital Melbourne) ;
Lucas, Michaela (The University of Western Australia) ;
Lynn, David J (Flinders University) ;
McDonald, Ellie (Murdoch Children's Research Institute) ;
Manning, Laurens (Fiona Stanley Hospital (Perth, Austràlia)) ;
Munns, Craig F (The University of Sydney) ;
Perrett, Kirsten P (Murdoch Children's Research Institute) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Richmond, Peter (The University of Western Australia) ;
Shann, Frank (The Royal Children's Hospital Melbourne) ;
Sudbury, Eva (Murdoch Children's Research Institute) ;
Villanueva, Paola (The University of Melbourne) ;
Wood, Nicholas J (National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases) ;
Lieschke, Katherine (Murdoch Children's Research Institute) ;
Subbarao, Kanta (The Peter Doherty Institute for Infection and Immunity) ;
Davidson, Andrew (Murdoch Children's Research Institute) ;
Curtis, Nigel (The Royal Children's Hospital Melbourne) ;
Universitat Autònoma de Barcelona
BCG vaccination modulates immune responses to unrelated pathogens. This off-target effect could reduce the impact of emerging pathogens. As a readily available, inexpensive intervention that has a well-established safety profile, BCG is a good candidate for protecting healthcare workers (HCWs) and other vulnerable groups against COVID-19. [...]
2021 - 10.1136/bmjopen-2021-052101
BMJ open, Vol. 11 (october 2021)
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12 p, 1.4 MB |
Study of CD27, CD38, HLA-DR and Ki-67 immune profiles for the characterization of active tuberculosis, latent infection and end of treatment
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Díaz-Fernández, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Stojanovic, Zoran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron) ;
Tolosa, Guillermo (Universidad de la Frontera) ;
Sánchez-Montalva, Adrián (Hospital Universitari Vall d'Hebron) ;
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron) ;
Safont Gonzalez, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romero i Andrada, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Sabrià, Josefina (Hospital de Sant Joan Despí Moisès Broggi) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Current blood-based diagnostic tools for TB are insufficient to properly characterize the distinct stages of TB, from the latent infection (LTBI) to its active form (aTB); nor can they assess treatment efficacy. [...]
2022 - 10.3389/fmicb.2022.885312
Frontiers in microbiology, Vol. 13 (july 2022)
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12 p, 2.7 MB |
Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination
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Villanueva, Paola (Department of General Medicine, Royal Children's Hospital Melbourne (Austràlia)) ;
Crawford, Nigel W. (Immunisation Service, Royal Children's Hospital Melbourne) ;
Croda, Mariana Garcia (Universidade Federal do Mato Grosso do Sul (Brasil)) ;
Collopy, Simone (Department of Pediatrics, Universidade Estadual do Rio de Janeiro) ;
Jardim, Bruno Araújo (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (Brasil)) ;
de Almeida Pinto Jardim, Tyane (Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (Brasil)) ;
Manning, Laurens (Fiona Stanley Hospital (Austràlia)) ;
Lucas, Michaela (QE2 Medical Centre (Austràlia)) ;
Marshall, Helen (The University of Adelaide and Department of Paediatrics (Austràlia)) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol) ;
Sawka, Alice (Royal Adelaide Hospital (Austràlia)) ;
Sharma, Ketaki (The Children's Hospital at Westmead (Austràlia)) ;
Troeman, Darren (University Medical Center Utrecht) ;
Wadia, Ushma (Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute (Austràlia)) ;
Warris, Adilia (Great Ormond Street Hospital, London, UK) ;
Wood, Nicholas (University of Sydney) ;
Messina, Nicole L. (Infection and Immunity, Murdoch Children's Research Institute, (Austràlia)) ;
Curtis, Nigel (The Royal Children's Hospital Melbourne) ;
Pittet, Laure F. (University of Geneva) ;
Universitat Autònoma de Barcelona
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. [...]
2023 - 10.1016/j.heliyon.2023.e15821
Heliyon, Vol. 9 (april 2023)
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11 p, 1.5 MB |
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
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Wheatley, Rachel M. (University of Oxford, Department of Biology) ;
Caballero, Julio Diaz (University of Oxford, Department of Biology) ;
van der Schalk, Thomas E. (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
De Winter, Fien H. R. (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Shaw, Liam P. (University of Oxford, Department of Biology) ;
Kapel, Natalia (University of Oxford, Department of Biology) ;
Recanatini, Claudia (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Timbermont, Leen (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Kluytmans, Jan (University Medical Center Utrecht, Utrecht University. Julius Center for Health Sciences and Primary Care, Utrecht) ;
Esser, Mark (Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA) ;
Lacoma, Alicia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Oliver, Antonio (Institut d'Investigació Sanitària Illes Balears, Hospital Universitari Son Espases) ;
Kumar-Singh, Samir (University of Antwerp. Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, Wilrijk, Belgium) ;
Malhotra-Kumar, Surbhi (University of Antwerp. Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, Wilrijk, Belgium) ;
Craig MacLean, R. (University of Oxford, Department of Biology)
Bacteria have the potential to translocate between sites in the human body, but the dynamics and consequences of within-host bacterial migration remain poorly understood. Here we investigate the link between gut and lung Pseudomonas aeruginosa populations in an intensively sampled ICU patient using a combination of genomics, isolate phenotyping, host immunity profiling, and clinical data. [...]
2022 - 10.1038/s41467-022-34101-2
Nature communications, Vol. 13 (november 2022)
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