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10 p, 568.8 KB |
Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study
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Engelkes, Marjolein (ErasmusMC) ;
Baan, Esme J. (ErasmusMC) ;
de Ridder, Maria A. J. (ErasmusMC) ;
Svensson, Elisabeth (Aarhus University) ;
Prieto-Alhambra, Daniel (Institut d'Investigació en Atenció Primària Jordi Gol) ;
Lapi, Francesco (SIMG) ;
Giaquinto, Carlo (University of Padova) ;
Picelli, Gino ;
Boudiaf, Nada (GlaxoSmithKline) ;
Albers, Frank (Avillion US Inc) ;
Evitt, Lee A. (GlaxoSmithKline) ;
Cockle, Sarah (GlaxoSmithKline) ;
Bradford, Eric (GlaxoSmithKline) ;
Van Dyke, Melissa K. (GlaxoSmithKline) ;
Suruki, Robert (UCB Biosciences) ;
Rijnbeek, Peter (ErasmusMC) ;
Sturkenboom, Miriam C. J. M. (Utrecht University Medical Center) ;
Janssens, Hettie M. (University Medical Center Rotterdam) ;
Verhamme, Katia M. C. (OLV Hospital) ;
Universitat Autònoma de Barcelona
There are sparse real-world data on severe asthma exacerbations (SAE) in children. This multinational cohort study assessed the incidence of and risk factors for SAE and the incidence of asthma-related rehospitalization in children with asthma. [...]
2020 -  10.1111/pai.13237
Pediatric Allergy and Immunology, Vol. 31 (march 2020) , p. 496-505
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15 p, 1.4 MB |
Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on "real-world" data : a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database
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Khalid, Sara (Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom) ;
Calderon-Larrañaga, Sara (Family and Community Medicine Teaching Unit of Granada. Cartuja University Health Centre. Andalusian Health Service (SAS), Granada, Spain) ;
Hawley, Samuel (Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom) ;
Ali, M Sanni (London School of Hygiene and Tropical Medicine, London, United Kingdom) ;
Judge, Andrew (Bristol NIHR Biomedical Research Centre, Musculoskeletal Research Unit, Southmead Hospital, University of Bristol, Bristol, United Kingdom) ;
Arden, Nigel (Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, United Kingdom) ;
van Staa, Tjeerd (Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands) ;
Cooper, Cyrus (NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom) ;
Javaid, Muhammad Kassim (Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom) ;
Prieto-Alhambra, Daniel (Institut d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
This paper aims to compare the clinical effectiveness of oral anti-osteoporosis drugs based on the observed risk of fracture while on treatment in primary care actual practice. We investigated two primary care records databases covering UK National Health Service (Clinical Practice Research Datalink, CPRD) and Catalan healthcare (Information System for Research in Primary Care, SIDIAP) patients during 1995-2014 and 2006-2014, respectivey. [...]
2018 - 10.2147/CLEP.S164112
Clinical Epidemiology, Vol. 10 (october 2018) , p. 1417-1431
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3.
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9 p, 1.2 MB |
Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK : two prospective open cohorts using the UK Clinical Practice Research Datalink
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Yu, Dahai (Keele University) ;
Jordan, Kelvin P (Keele University) ;
Snell, Kym I E (Keele University) ;
Riley, Richard D (Keele University) ;
Bedson, John (Keele University) ;
Edwards, John James (Keele University) ;
Mallen, Christian D (Keele University) ;
Tan, Valerie (Keele University) ;
Ukachukwu, Vincent (Keele University) ;
Prieto-Alhambra, Daniel (Institut d'Investigació en Atenció Primària Jordi Gol) ;
Walker, Christine (Keele University) ;
Peat, George (Keele University) ;
Universitat Autònoma de Barcelona
The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate two models to estimate an individual's risk of primary THR and TKR in patients newly presenting to primary care. [...]
2018 - 10.1136/annrheumdis-2018-213894
Annals of the rheumatic diseases, Vol. 78 (october 2018) , p. 91-99
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4.
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5.
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11 p, 619.1 KB |
In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture : the Spanish registry of osteoporotic femur fractures prospective cohort study
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Prieto-Alhambra, Daniel (Institut d'Investigació en Atenció Primària Jordi Gol) ;
Reyes, Carlen (Institut d'Investigació en Atenció Primària Jordi Gol) ;
Sainz, Miguel Sanz (Hospital Universitario Miguel Servet. IIS Aragón (Instituto de Investigación Sanitaria de Aragón)) ;
González-Macías, Jesús (UC (Universidad de Cantabria). IDIVAL (Instituto de Investigación Marqués de Valdecilla), HUMV (Hospital Universitario Marqués de Valdecilla)) ;
Delgado, Luis Gracia (Hospital Universitario Reina Sofía de Cordoba) ;
Bouzón, Cristina Alonso (Hospital Universitario de Getafe. Geriatric Unit) ;
Gañan, Sarah Mills (Hospital Universitario La Paz. Traumatology and Orthopaedics Unit) ;
Miedes, Damián Mifsut (Hospital Clínico de Valencia) ;
Vaquero-Cervino, Eduardo (Complejo Hospitalario de Pontevedra) ;
Bardaji, Manuel Francisco Bravo (Hospital Regional Universitario de Malaga) ;
Ezquerra, Laura (Hospital Clínico Universitario Lozano Blesa. F.E.A of the Traumatology and Orthopaedics Unit) ;
Baztán, Fátima Brañas (Hospital Universitario Infanta Leonor. Geriatric Unit) ;
Ferrer, Bartolomé Lladó (Hospital Son Llàtzer) ;
Perez-Coto, Ivan (Hospital Universitario San Agustín, Camino de Heros, 6, 33401 Avilés, Asturias Spain) ;
Bueno, Gaspar Adrados (Hospital Infanta Cristina. Internal Medicine Unit) ;
Mora-Fernandez, Jesús (Hospital Clínico San Carlos. Geriatric Unit) ;
Doñate, Teresa Espallargas (Hospital Obispo Polanco) ;
Blasco, Jorge Martínez-Iñiguez (Hospital San Pedro) ;
Aguado-Maestro, Ignacio (Hospital Universitario Rio Hortega) ;
Sáez-López, Pilar (Hospital Universitario Fundación Jiménez Díaz, IdiPAZ (Instituto de Investigación del Hospital La Paz), Madrid, Spain) ;
Doménech, Monica Salomó (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Climent-Peris, Vicente (Traumatology and Orthopaedics Unit, Hospital Públic Lluis Alcanyis de Xàtiva, Carretera Xátiva-Silla, Km 2, 46800 Xàtiva, Valencia Spain) ;
Rodríguez, Ángel Díez (Hospital Virgen del Puerto. Traumatology and Orthopaedics Unit) ;
Sardiñas, Humberto Kessel (Complejo Hospitalario Torrecárdenas. Geriatric Care Unit) ;
Gómez, Óscar Tendero (Hospital Universitari Son Espases) ;
Serra, Jordi Teixidor (Hospital Universitari Vall de Hebron) ;
Caeiro-Rey, José Ramón (Complejo Hospitalario Universitario de Santiago de Compostela. Traumatology and Orthopaedics Unit) ;
Cano, Ignacio Andrés (Hospital Puerta del Mar) ;
Carsi, Mariano Barrés (Hospital Universitari i Politècnic La Fe) ;
Etxebarria-Foronda, Iñigo (Department of Orthopaedic, Alto Deba Hospital, Arrasate-Mondragon, Gipuzkoa Spain) ;
Hernández, Juan Dionisio Avilés (Hospital Clínico Universitario Virgen de Arrixaca. Orthogeriatric Unit) ;
Solis, Juan Rodriguez (Hospital Universitario de Guadalajara. Geriatric Unit) ;
Suau, Oscar Torregrosa (Hospital General Universitari d'Elx. Bone Metabolism Unit, Internal Medicine Unit) ;
Nogués, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Herrera, Antonio (University of Zaragoza. Department of Surgery, Aragón Health Research Institute) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
We have characterised 997 hip fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59. 1 hours), in-hospital mortality was lower than in Northern European cohorts. [...]
2018 - 10.1007/s11657-018-0515-8
Archives of Osteoporosis, Vol. 13 (september 2018)
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9 p, 1.3 MB |
Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis
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Losada-Grande, Eladio (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Hawley, Samuel (University of Oxford) ;
Soldevila, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez-Laguna, Daniel (Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina) ;
Nogues,Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Díez Pérez, Adolfo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Puig-Domingo, Manel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Mauricio, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prieto-Alhambra, Daniel (University of Oxford)
Despite normal to high bone mineral density, patients with type 2 diabetes (T2DM) have an increased fracture risk. T2DM medications could partially account for this excess risk. The aim of this study was to assess the association between insulin use and bone fracture risk in T2DM patients. [...]
2017 - 10.1038/s41598-017-03748-z
Scientific reports (Nature Publishing Group), Vol. 3 Núm. 378 (june 2017) , p. 1-9
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10 p, 1003.4 KB |
Trends and determinants of length of stay and hospital reimbursement following knee and hip replacement : evidence from linked primary care and NHS hospital records from 1997 to 2014
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Burn, Edward (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Edwards, Christopher J (University Hospital Southampton (UK)) ;
Murray, David W. (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Silman, Alan (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Cooper, Cyrus (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Arden, Nigel K (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Pinedo-Villanueva, Rafael (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (UK)) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona)
To measure changes in length of stay following total knee and hip replacement (TKR and THR) between 1997 and 2014 and estimate the impact on hospital reimbursement, all else being equal. Further, to assess the degree to which observed trends can be explained by improved efficiency or changes in patient profiles. [...]
2018 - 10.1136/bmjopen-2017-019146
BMJ open, Vol. 8, Issue 1 (January 2018) , article e019146
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8.
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17.3 KB |
The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee : a population-based cohort study
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Bayliss, Lee E (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford) ;
Culliford, David (NIHR CLAHRC Wessex Methodological Hub, University of Southampton, Southampton, UK) ;
Monk, A Paul (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford, Oxford, UK) ;
Glyn-Jones, Sion (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford, Oxford, UK) ;
Prieto-Alhambra, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK) ;
Carr, Andrew J (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford, Oxford, UK) ;
Arden, Nigel K (MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK) ;
Beard, David J (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford, Oxford, UK) ;
Price, Andrew J (Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, NIHR Biomedical Research Unit, University of Oxford, Oxford, UK)
Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective and demonstrate significant clinical improvement. However, robust population based lifetime-risk data for implant revision are not available to aid patient decision making, which is a particular problem in young patient groups deciding on best-timing for surgery. [...]
2017 - 10.1016/S0140-6736(17)30059-4
Lancet (London, England), Vol. 389 (april 2017) , p. 1424-1430
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11 p, 441.1 KB |
Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate : nationwide cohort and nested case-control study
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Abrahamsen, Bo (Department of Medicine, Holbæk Hospital, Smedelundsgade 60, 4300 Holbæk, Denmark) ;
Eiken, Pia (Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark, Pia Eiken) ;
Prieto-Alhambra, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Eastell, Richard (Academic Unit of Bone Metabolism (AUBM), Northern General Hospital and University of Sheffield, Sheffield S5 7AU, UK) ;
Universitat Autònoma de Barcelona
Objectives To determine the skeletal safety and efficacy of long term (≥10 years) alendronate use in patients with osteoporosis. Design Open register based cohort study containing two nested case control studies. [...]
2016 - 10.1136/bmj.i3365
The BMJ, Vol. 353 (june 2016)
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7 p, 376.1 KB |
Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients : population-based longitudinal study
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Hawley, Samuel (University of Oxford) ;
Javaid, M. Kassim (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Prieto-Alhambra, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lippett, Janet (Royal Berkshire NHS Foundation Trust, Reading) ;
Sheard, Sally (University of Oxford) ;
Arden, Nigel K. (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit, University of Southampton) ;
Universitat Autònoma de Barcelona
Objectives: to evaluate orthogeriatric and nurse-led fracture liaison service (FLS) models of post-hip fracture care in terms of impact on mortality (30 days and 1 year) and second hip fracture (2 years). [...]
2016 - 10.1093/ageing/afv204
Age and Ageing, Vol. 45 (january 2016) , p. 236-242
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