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1.
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18 p, 1.8 MB |
Serum DNA methylome of the colorectal cancer serrated pathway enables non-invasive detection
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Gallardo-Gómez, María (Universidade de Vigo) ;
Costas-Ríos, Lara (Universidade de Vigo) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Rodríguez, Lara (Universidade de Vigo) ;
Bujanda, Luis (Universidad del País Vasco (UPV/EHU)) ;
Barrero, Maialen (Hospital Universitario Donostia) ;
Castells, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Balaguer, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Jover, Rodrigo (Universidad Miguel Hernández, Alicante) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tardío Baiges, Antoni (Instituto de Investigación Biomédica Galicia Sur) ;
González-Carreró Fojón, Joaquín (Instituto de Investigación Biomédica Galicia Sur) ;
Cubiella, Joaquín (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Ourense) ;
De Chiara, Loretta (Universidade de Vigo)
The clinical relevance of the colorectal cancer serrated pathway is evident, but the screening of serrated lesions remains challenging. We aimed to characterize the serum methylome of the serrated pathway and to evaluate circulating cell-free DNA (cfDNA) methylomes as a potential source of biomarkers for the non-invasive detection of serrated lesions. [...]
2023 -  10.1002/1878-0261.13573
Molecular Oncology, 2023
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2.
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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, Manel (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 - 10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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3.
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15 p, 4.7 MB |
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
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Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Janin, Maxime (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Setien, Fernando (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Rebollo, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Zhang, Pei Hong (Fudan University, Shanghai, China) ;
Yang, Li (Fudan University, Shanghai, China) ;
Guarnacci, Marco (Australian National University, Canberra, Australia) ;
Schumann, Ulrike (Australian National University, Canberra, Australia) ;
Preiss, Thomas (Australian National University, Canberra, Australia) ;
Balaseviciute, Ugne (Hospital Clínic i Provincial de Barcelona) ;
Montal, Robert (Universitat de Lleida) ;
Llovet, Josep M. (Hospital Clínic i Provincial de Barcelona) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Background: RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. [...]
2023 - 10.1186/s12943-023-01785-z
Molecular cancer, Vol. 22 Núm. 1 (may 2023)
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4.
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11 p, 4.4 MB |
Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome
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Salz, Lucia (RWTH Aachen University Medical School, Germany) ;
Seitz, Alexander (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Schäfer, Daniel (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Franzen, Julia (RWTH Aachen University Medical School, Germany) ;
Holzer, Tatjana (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bürger, Iris (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Hardt, Olaf (Miltenyi Biotec B.V. & Co. KG, Gladbach, Germany) ;
Esteller, Manel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wagner, Wolfgang (RWTH Aachen University Medical School, Germany)
Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity and therapeutic outcome. [...]
2023 - 10.1038/s41375-023-01966-1
Leukemia, Vol. 37 Núm. 9 (july 2023) , p. 1868-1878
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5.
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4 p, 1.4 MB |
Remodeling of the m6A RNA landscape in the conversion of acute lymphoblastic leukemia cells to macrophages
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Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Prieto, Carlos A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortiz-Barahona, Vanessa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez-Verbo, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Webster, Natalie A. (STORM Therapeutics Ltd, UK) ;
Andrews, Byron (STORM Therapeutics Ltd, UK) ;
Kol, Nitzan (Tel Aviv University, Israel) ;
Avrahami, Chen (Tel Aviv University, Israel) ;
Moshitch-Moshkovitz, Sharon (Tel Aviv University, Israel) ;
Rechavi, Gideon (Tel Aviv University, Israel) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2022 - 10.1038/s41375-022-01621-1
Leukemia, Vol. 36 Núm. 8 (august 2022) , p. 2121-2124
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6.
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9 p, 6.4 MB |
Reporte del hallazgo de árboles culturalmente modificados en bosques costeros de Nothofagus Betuloides (Mirb.) Oerst 1871 (Nothofagaceae) por pueblos canoeros de la Patagonia austral y Tierra del Fuego
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Zegers, Gabriel (Asociación de Investigadores del Museo de Historia Natural Río Seco) ;
Fernández, Macarena (Centro de Estudios del Cuaternario Fuego Patagonia y Antártica Chilena) ;
Cáceres, Benjamín (Centro de Estudios del Cuaternario Fuego Patagonia y Antártica Chilena) ;
Prieto, Alfredo (Universidad de Magallanes) ;
Carracedo Recasens, Robert (Universitat Autònoma de Barcelona. Departament de Prehistòria) ;
Östlund, Lars (Swedish University of Agricultural Sciences)
Los bosques templados costeros pluviales de la Patagonia austral y Tierra del Fuego cons- tituyen una expresión florística y ecológica de características propias y muy distintas al resto de las formaciones vegetales del continente americano (Pisano, 1997). [...]
2020 - 10.25074/rantros.v7i13.1726
Antropologías del Sur, Vol. 7 Núm. 13 (2020) , p. 245-253
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7.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulen, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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9.
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11 p, 1.3 MB |
Detection of oncogenic and clinically actionable mutations in cancer genomes critically depends on variant calling tools
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Jiménez, Francisco (Institute for Research in Biomedicine (IRB Barcelona)) ;
Valencia, Alfonso (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Motivation: The analysis of cancer genomes provides fundamental information about its etiology, the processes driving cell transformation or potential treatments. While researchers and clinicians are often only interested in the identification of oncogenic mutations, actionable variants or mutational signatures, the first crucial step in the analysis of any tumor genome is the identification of somatic variants in cancer cells (i. [...]
2022 - 10.1093/bioinformatics/btac306
Bioinformatics, Vol. 38 Núm. 12 (15 2022) , p. 3181-3191
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10.
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10 p, 481.8 KB |
Towards new recommendations to reduce the burden of alcohol-induced hypertension in the European Union
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Rehm, Jürgen (Technische Universität Dresden) ;
Anderson, Peter (Maastricht University) ;
Prieto, Jose Angel (Primary Care Spanish Society SEMERGEN) ;
Armstrong, Iain (Health and Wellbeing Directorate. Public Health England) ;
Aubin, Henri-Jean (University Paris-Sud) ;
Bachmann, Michael (Copentown Healthcare Consultants) ;
Bastida Bastus, Nuria (Raval Nord) ;
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Burton, Robyn (Public Health England) ;
Cardoso, Mabnuel (General Directorate for Intervention on Addictive Behaviours and Dependencies (SICAD)) ;
Colom, Joan (Generalitat de Catalunya) ;
Duprez, Daniel (University of Minnesota) ;
Gmel, Gerrit (University of New South Wales) ;
Gual, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Kraus, Ludwig (Stockholm University) ;
Kreutz, Reinhold (Charité - Universitätsmedizin Berlin) ;
Liira, Helena (University of Helsinki) ;
Manthey, Jakob (Technische Universität Dresden) ;
Møller, Lars (WHO Regional Office for Europe) ;
Okruhlica, Lubomír (Centrum pre Liecbu Drogovych Zavislosti) ;
Roerecke, Michael (University of Toronto) ;
Scafato, Emanuele (Società Italiana di Alcologia (SIA)) ;
Schulte, Bernd (Hamburg University) ;
Segura-Garcia, Lidia (Generalitat de Catalunya) ;
Shield, Kevin David (Institute for Mental Health Policy Research) ;
Sierra, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Vyshinskiy, Konstantin (Federal Medical Research Centre for Psychiatry and Narcology n.a. V. Serbsky) ;
Wojnar, Marcin (Medical University of Warsaw) ;
Zarco, José (Ibiza Primary Health Care Center) ;
Universitat Autònoma de Barcelona
Hazardous and harmful alcohol use and high blood pressure are central risk factors related to premature non-communicable disease (NCD) mortality worldwide. A reduction in the prevalence of both risk factors has been suggested as a route to reach the global NCD targets. [...]
2017 - 10.1186/s12916-017-0934-1
BMC Medicine, Vol. 15 Núm. 1 (28 2017) , p. 173
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