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11 p, 1.5 MB |
The role of IL-23 and the IL-23/TH17 immune axis in the pathogenesis and treatment of psoriasis
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Girolomoni, Giampiero (University of Verona) ;
Strohal, Robert (Federal Academic Teaching Hospital of Feldkirch) ;
Puig Sanz, Lluís (Universitat Autònoma de Barcelona) ;
Bachelez, Herve (Institut Imagine) ;
Barker, Jonathan (King's College London) ;
Boehncke, Wolf-Henning (University of Geneva) ;
Prinz, Joerg (University of Munich)
Psoriasis is a chronic, immune-mediated disease affecting more than 100 million people worldwide and up to 2. 2% of the population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. [...]
2017 -  10.1111/jdv.14433
Journal of the European Academy of Dermatology and Venereology, Vol. 31, Issue 10 (October 2017) , p. 1616-1626
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11 p, 255.5 KB |
Maintenance of clinical efficacy and radiographic benefit through two years of ustekinumab therapy in patients with active psoriatic arthritis : results from a randomized, placebo-controlled phase III trial
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Kavanaugh, Arthur (University of California) ;
Puig Sanz, Lluís (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gottlieb, Alice B. (Tufts Medical Center) ;
Ritchlin, Christopher (University of Rochester) ;
Li, Shu (Janssen Pharmaceutica) ;
Wang, Yuhua (Janssen Pharmaceutica) ;
Mendelsohn, Alan M. (Janssen Pharmaceutica) ;
Song, Michael (Janssen Pharmaceutica) ;
Zhu, Yaowei (Janssen Pharmaceutica) ;
Rahman, Proton (Memorial University of Newfoundland) ;
McInnes, Iain B. (University of Glasgow) ;
Universitat Autònoma de Barcelona
To evaluate the efficacy and safety of ustekinumab through 2 years in adult patients with active psoriatic arthritis (PsA). A total of 615 adult patients with active PsA were randomized to placebo, ustekinumab 45 mg, or ustekinumab 90 mg, at weeks 0, 4, and every 12 weeks through week 88 (last dose). [...]
2015 - 10.1002/acr.22645
Arthritis Care & Research, Vol. 67, issue 12 (Dec. 2015) , p. 1739-1749
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10 p, 285.5 KB |
Pimecrolimus in atopic dermatitis : Consensus on safety and the need to allow use in infants
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Luger, Thomas (University of Münster. Department of Dermatology) ;
Boguniewicz, Mark (Division of Pediatric Allergy-Immunology, Department of Pediatrics, National Jewish Health and University of Colorado School of Medicine) ;
Carr, Warner (Southern California Research) ;
Cork, Michael (Academic Unit of Dermatology Research, Department of Infection and Immunity, The University of Sheffield, K Floor, The Medical School (RHH Tower)) ;
Deleuran, Mette (Department of Dermatology, Aarhus University Hospital) ;
Eichenfield, Lawrence (Departments of Pediatrics and Medicine, University of California, San Diego School of Medicine, Rady Children's Hospital) ;
Eigenmann, Philippe (Pediatric Allergy Unit, Children's University Hospital) ;
Fölster-Holst, Regina (Department of Dermatology, University Clinics of Schleswig-Holstein) ;
Gelmetti, Carlo (Department of Pathophysiology and Transplantation, University of Milan, Clinica Dermatologica, Fondazione I.R.C.C.S. Ca' Granda "Ospedale Maggiore Policlinico") ;
Gollnick, Harald (Department of Dermatology & Venereology, Otto-von-Guericke University of Magdeburg) ;
Hamelmann, Eckard (Allergy Center Ruhr, Ruhr-University Bochum, & Evangelisches Krankenhaus Bielefeld, Klinik für Kinder und Jugendmedizin) ;
Hebert, Adelaide A (Departments of Dermatology and Pediatrics, The University of Texas Medical School-Houston) ;
Muraro, Antonella (Food Allergy Referral Centre, Department of Woman and Child Health, University Hospital of Padua) ;
Oranje, Arnold P (Intermedica Dermatology and Hair Clinic) ;
Paller, Amy S (Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine) ;
Paul, Carle (Dermatology Department, INSERM 1056, Paul Sabatier University, Larrey Hospital) ;
Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Ring, Johannes (Department of Dermatology and Allergology Biederstein, Christine Kühne-Center for Allergy Research and Education, Technische Universität München) ;
Siegfried, Elaine (Departments of Pediatrics and Dermatology, Saint Louis University School of Medicine) ;
Spergel, Jonathan M (Division of Allergy and Immunology, Department of Pediatrics, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania) ;
Stingl, Georg (Department of Dermatology, Medical University of Vienna) ;
Taieb, Alain (Service de Dermatologie et Dermatologie Pédiatrique Centre de référence pour les maladies rares de la peau, INSERM 1035, Université de Bordeaux) ;
Torrelo, Antonio (Department of Dermatology, Hospital Niño Jesus) ;
Werfel, Thomas (Department of Dermatology and Allergy, Hannover Medical School) ;
Wahn, Ulrich (Department of Pediatric Pneumology and Immunology, Charite)
Atopic dermatitis (AD) is a distressing dermatological disease, which is highly prevalent during infancy, can persist into later life and requires long-term management with anti-inflammatory compounds. [...]
2015 - 10.1111/pai.12331
Pediatric Allergy and Immunology, Vol. 26 (april 2015) , p. 306-315
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8 p, 307.5 KB |
Predictors of biologic treatment of psoriasis : a non-interventional study
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Puig Sanz, Lluís (Institut d'Investigació Biomèdica Sant Pau) ;
Fan, Tao (Merck and Co. Global Health Outcomes) ;
Ding, Qian (Merck and Co. Global Health Outcomes) ;
Smith, Nancy E (Merck and Co. Global Health Outcomes)
Biologic therapies represent a significant advance in the treatment of psoriasis. However, no studies have examined the patient characteristics predictive of biologic treatment of psoriasis. The purpose of this study was to ascertain the frequency and predictors of treatment of psoriasis with biologics in three European countries, ie, France, Spain, and the UK. [...]
2014 - 10.2147/CEOR.S54797
ClinicoEconomics and Outcomes Research: CEOR, Vol. 6 (february 2014) , p. 93-100
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12 p, 1.2 MB |
Urine metabolome profiling of immune-mediated inflammatory diseases
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Alonso, Arnald (Vall d'Hebron Institut de Recerca) ;
Julià, Antonio (Vall d'Hebron Institut de Recerca) ;
Vinaixa, Maria (Centre for Omic Sciences (Reus, Catalunya)) ;
Domènech i Morral, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández Nebro, Antonio (Instituto de Investigación Biomédica de Málaga) ;
Cañete, Juan D. (Hospital Clínic de Barcelona) ;
Ferrándiz Foraster, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tornero, Jesús (Hospital Universitario de Guadalajara) ;
Gisbert, Javier P. (Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd)(Madrid, Espanya)) ;
Nos Mateu, Pilar (Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd)(Madrid, Espanya)) ;
Gutiérrez Casbas, Ana (Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd)(Madrid, Espanya)) ;
Puig Sanz, Lluís (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
González-Alvaro, Isidoro (Hospital Universitario de la Princesa (Madrid)) ;
Pinto-Tasende, José A. (Complejo Hospitalario Universitario Juan Canalejo (La Corunya, Galícia)) ;
Blanco, Ricardo (Hospital Universitario Marqués de Valdecilla (Santander)) ;
Rodríguez, Miguel A. (Centre for Omic Sciences (Reus, Catalunya)) ;
Beltran, Antoni (Centre for Omic Sciences (Reus, Catalunya)) ;
Correig, Xavier (Centre for Omic Sciences (Reus, Catalunya)) ;
Marsal Barril, Sara (Vall d'Hebron Institut de Recerca) ;
IMID Consortium
BACKGROUND: Immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite profiles of biological samples is becoming a powerful approach to identify new biomarkers of clinical utility. [...]
2016 - 10.1186/s12916-016-0681-8
BMC Medicine, Vol. 14 (September 2016) , article 133
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