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11 p, 4.3 MB |
Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. [...]
2020 -  10.1038/s41598-020-76041-1
Scientific reports, Vol. 10 (2020) , art. 18927
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2.
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14 p, 2.6 MB |
Repurposed analog of GLP-1 ameliorates hyperglycemia in type 1 diabetic mice through pancreatic cell reprogramming
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Aguilera, Eva (Institut Germans Trias i Pujol) ;
Coma, Mireia (Anaxomics Biotech SL) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Vives Pi, Marta (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. An ideal immunotherapy should combine the blockade of the autoimmune response with the recovery of functional target cell mass. [...]
2020 - 10.3389/fendo.2020.00258
Frontiers in Endocrinology, Vol. 11 (May 2020) , art. 258
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3.
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15 p, 4.1 MB |
Prenatal Betamethasone interferes with immune system development and alters target cells in autoimmune diabetes
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Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Gieras, A. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Glau, L. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Tolosa, E. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Vives Pi, Marta (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to medications in the prenatal period may influence the immune system maturation, thus altering self-tolerance. [...]
2019 - 10.1038/s41598-018-37878-9
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 1235
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4.
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12 p, 2.5 MB |
Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis
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Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mansilla Lopez, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242
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17 p, 2.4 MB |
Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry
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Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Brianso, Ferran (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Sánchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Maspoch Comamala, Daniel (Institució Catalana de Recerca i Estudis Avançats) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. [...]
2018 - 10.3389/fimmu.2018.00253
Frontiers in immunology, Vol. 9 (Feb. 2018) , art. 253
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8 p, 1.1 MB |
Expression of REG family genes in human inflammatory bowel diseases and its regulation
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Tsuchida, Chikatsugu (Saiseikai Nara Hospital, Japan) ;
Sakuramoto-Tsuchida, Sumiyo (Department of Biochemistry, Nara Medical University) ;
Taked, Maiko (Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center) ;
Itaya-Hironaka, Asako (Department of Biochemistry, Nara Medical University) ;
Yamauchi, Akiyo (Department of Biochemistry, Nara Medical University) ;
Misu, Masayasu (Department of Biochemistry, Nara Medical University) ;
Shobatake, Ryogo (Department of Biochemistry, Nara Medical University) ;
Uchiyama, Tomoko (Department of Diagnostic Pathology, Nara Medical University) ;
Makino, Mai (Department of Biochemistry, Nara Medical University) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ohbayashi, Chiho (Department of Diagnostic Pathology, Nara Medical University) ;
Takasawa, Shin (Department of Biochemistry, Nara Medical University)
The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. [...]
2017 - 10.1016/j.bbrep.2017.10.003
Biochemistry and Biophysics Reports, Vol. 12 (october 2017) , p. 198-205
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22 p, 1.1 MB |
Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset
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Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrascal, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ;
Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186
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19 p, 1.2 MB |
Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes
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Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez, Alex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ;
Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ;
Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ;
Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057
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