Results overview: Found 4 records in 0.02 seconds.
Articles, 2 records found
Research literature, 2 records found
Articles 2 records found  
1.
19 p, 3.6 MB Insights into the Antimicrobial Mechanism of Action of Human RNase6 : Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation / Pulido Gomez, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Arranz Trullén, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Prats, Guillem, 1942- (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Velázquez, Diego (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Moussaoui, Mohammed (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. [...]
2016 - 10.3390/ijms17040552
International Journal of Molecular Sciences, Vol. 17 Núm. 4 (april 2016)  
2.
8 p, 1.8 MB Exploring new biological functions of amyloids : bacteria cell agglutination mediated by host protein aggregation / Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pulido Gomez, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Nogués i Bara, M. Victòria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Boix i Borràs, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Antimicrobial proteins and peptides (AMPs) are important effectors of the innate immune system that play a vital role in the prevention of infections. Recent advances have highlighted the similarity between AMPs and amyloid proteins. [...]
2012 - 10.1371/journal.ppat.1003005
PLoS Pathogens, Vol. 8, Issue 11 (November 2012) , p. e1003005  

Research literature 2 records found  
1.
264 p, 17.4 MB Unveiling the multifaceted antimicrobial mechanism of action of human host defence RNases / Arranz Trullén, Javier, autor ; Boix i Borràs, Esther, supervisor acadèmic (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pulido Gómez, David, supervisor acadèmic ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
La presente tesis doctoral se encuentra integrada dentro del estudio a gran escala de la estructura-función de las ribonucleasas antimicrobianas humanas. Estas proteínas catiónicas y de bajo peso molecular son secretadas por la mayoría de los organismos vertebrados agrupándose dentro la superfamilia de la ribonucleasa A, una de las enzimas mejor caracterizadas del siglo XX. [...]
The present doctoral thesis is integrated into the large-scale study of the structure and function of human antimicrobial ribonucleases. These cationic and low molecular weight proteins are grouped into the ribonuclease A superfamily, considered one of the best characterized enzymes of the twentieth century. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
2.
207 p, 3.8 MB Expanding the scope of the Ribonuclease A superfamily in the host immune defense system: Structural determinants of human RNases involved in antimicrobial host defense / Pulido Gómez, David ; Boix i Borràs, Esther, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torrent Burgas, Marc, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
El meu projecte de doctorat s'enmarca en l'estudi de l'estructura i la funció de les ribonucleases antimicrobianes humanes. Actualment, es coneixen vuit ribonucleases humanes funcionals pertanyents a la superfamília de ribonucleases secretades per vertebrats. [...]
My PhD project focuses on the structure-function analysis of human antimicrobial RNases, Currently eight functional members have been ascribed to the vertebrate secreted RNase superfamily. Together with their catalytic activity towards RNA substrates, other biological properties have been reported such as the antimicrobial activity of diverse members of the family, therefore suggesting that RNases could have an ancestral host-defence function. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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