1.
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20 p, 4.6 MB |
Exploring the Long-Term Tissue Accumulation and Excretion of 3 nm Cerium Oxide Nanoparticles after Single Dose Administration
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Ernst, Lena M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramis, Joana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gustà, Muriel F. (Institut Català de Nanociència i Nanotecnologia) ;
Yudina, Tetyana (Institut Català de Nanociència i Nanotecnologia) ;
Casals, Eudald (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Fernández-Varo, Guillermo (Hospital Clínic i Provincial de Barcelona) ;
Casals, Gregori (Hospital Clínic i Provincial de Barcelona) ;
Jiménez, Wladimiro (Hospital Clínic i Provincial de Barcelona) ;
Puntes, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Nanoparticle (NP) pharmacokinetics significantly differ from traditional small molecule principles. From this emerges the need to create new tools and concepts to harness their full potential and avoid unnecessary risks. [...]
2023 - 10.3390/antiox12030765
Antioxidants, Vol. 12 (march 2023)
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2.
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9 p, 1.4 MB |
Heterogeneous rate constant for amorphous silica nanoparticle adsorption on phospholipid monolayers
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Vakurov, Alex (University of Leeds. School of Chemistry) ;
Drummond-Brydson, Rik (University of Leeds. School of Chemical and Process Engineering) ;
William, Nicola (University of Leeds. School of Chemistry) ;
Sanver, Didem (Necmettin Erbakan University. Department of Food Engineering) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Nelson, Andrew L. (University of Leeds. School of Chemistry)
The interaction of amorphous silica nanoparticles with phospholipid monolayers and bilayers has received a great deal of interest in recent years and is of importance for assessing potential cellular toxicity of such species, whether natural or synthesized for the purpose of nanomedical drug delivery and other applications. [...]
2022 - 10.1021/acs.langmuir.1c03155
Langmuir, Vol. 38, issue 18 (May 2022) , p. 5372-5380
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3.
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8 p, 1.3 MB |
Nanoceria dissolution at acidic pH by breaking off the catalytic loop
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Galyamin, Dmitry (Institut de Microelectrònica de Barcelona) ;
Ernst, Lena M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fitó-Parera, Aina (Institut de Microelectrònica de Barcelona) ;
Mira-Vidal, Guillem (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia) ;
Sabaté Vizcarra, Neus (Institució Catalana de Recerca i Estudis Avançats) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
This manuscript proves the reproducibility and robustness of cerium oxide nanoparticles, nanoceria, employed as a chemical reagent with oxidizing capacity (as an electron sink) at acidic pH. Unlike nanoceria multi-enzyme-mimetic capabilities at neutral or high pH, nanoceria can behave as a stoichiometric reagent at low pH where insoluble Ce4+ ions transform into soluble Ce3+ in the nanocrystal that finally dissolves. [...]
2022 - 10.1039/d2nr03586c
Nanoscale, Vol. 14, Issue 38 (August 2022) , p. 14223-14230
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4.
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26 p, 1.5 MB |
The Role of common cell culture media supplements on citrate-stabilized gold nanoparticle protein corona formation, aggregation state, and the consequent impact on cellular uptake
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Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Michelini, Sara (University of Salzburg. Department of Biosciences) ;
Moriones, Oscar Hernando (Universitat Autònoma de Barcelona) ;
Patarroyo, Javier (Institut Català de Nanociència i Nanotecnologia) ;
Rosell, Jordi 1955- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Freixenet Gusta, Muriel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vitali, Michele (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín, Luna (Vall d'Hebron Institut d'Oncologia) ;
Canals, Francesc (Vall d'Hebron Institut d'Oncologia) ;
Duschl, Albert (University of Salzburg. Department of Biosciences) ;
Horejs-Hoeck, Jutta (University of Salzburg. Department of Biosciences) ;
Mondragón, Laura (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Sodium citrate-stabilized gold nanoparticles (AuNPs) are destabilized when dispersed in cell culture media (CCMs). This may promote their aggregation and subsequent sedimentation, or under the proper conditions, their interaction with dispersed proteins can lead to the formation of a NP-stabilizing protein corona. [...]
2022 - 10.1021/acs.bioconjchem.2c00232
Bioconjugate chemistry, Vol. 33, issue 8 (Aug. 2022) , p. 1505-1514
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5.
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15 p, 2.3 MB |
Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles
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Della Camera, Giacomo (European Commission. Joint Research Centre) ;
Liu, Tinghao (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Yang, Wenjie (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Li, Yang (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Gioria, Sabrina (European Commission. Joint Research Centre) ;
Italiani, Paola (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation) ;
Boraschi, Diana (China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation)
We assessed whether concomitant exposure of human monocytes to bacterial agents and different engineered nanoparticles can affect the induction of protective innate memory, an immune mechanism that affords better resistance to diverse threatening challenges. [...]
2022 - 10.3390/ijms232314655
International journal of molecular sciences, Vol. 23, Issue 23 (November 2022) , art. 14655
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6.
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32 p, 2.1 MB |
Programmed iron oxide nanoparticles disintegration in anaerobic digesters boosts biogas production
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Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Barrena Gómez, Raquel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
García, Ana (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
González, Edgar E. (Pontificia Universidad Javeriana) ;
Delgado Ramisa, Lucía (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Busquets-Fité, Martí (Applied Nanoparticles S.L.) ;
Font i Segura, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Arbiol i Cobos, Jordi (Institut de Ciència de Materials de Barcelona) ;
Glatzel, Pieter (European Synchrotron Radiation Facility) ;
Kvashnina, Kristina (European Synchrotron Radiation Facility) ;
Sanchez, Antoni (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
A novel concept of dosing iron ions using FeO engineered nanoparticles is used to improve biogas production in anaerobic digestion processes. Since small nanoparticles are unstable, they can be designed to provide ions in a controlled manner, and the highest ever reported improvement of biogas production is obtained. [...]
2014 - 10.1002/smll.201303703
Small, Vol. 10, issue 14 (Jul. 2014) , p. 2801-2808
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7.
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13 p, 7.0 MB |
Innate memory reprogramming by gold nanoparticles depends on the microbial agents that induce memory
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Swartzwelter, Benjamin J. (Paris Lodron University of Salzburg. Department Biosciences) ;
Michelini, Sara (Paris Lodron University of Salzburg. Department Biosciences) ;
Frauenlob, Tobias (Paris Lodron University of Salzburg. Department Biosciences) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Duschl, Albert (Paris Lodron University of Salzburg. Department Biosciences) ;
Horejs-Hoeck, Jutta (Paris Lodron University of Salzburg. Department Biosciences) ;
Italiani, Paola (Consiglio Nazionale delle Ricerche (Nàpols, Itàlia). Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Stazione Zoologica Anton Dohrn)
Innate immune memory, the ability of innate cells to react in a more protective way to secondary challenges, is induced by exposure to infectious and other exogeous and endogenous agents. Engineered nanoparticles are particulate exogenous agents that, as such, could trigger an inflammatory reaction in monocytes and macrophages and could therefore be also able to induce innate memory. [...]
2021 - 10.3389/fimmu.2021.751683
Frontiers in immunology, Vol. 12 (Nov. 2021) , art. 751683
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8.
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24 p, 2.6 MB |
Growth-promoting gold nanoparticles decrease stress responses in arabidopsis seedlings
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Ferrari, Eleonora (Universität Tübingen. Zentrum für Molekularbiologie der Pflanzen) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Busquets-Fité, Martí (Applied Nanoparticles. S.L.) ;
Franz-Wachtel, Mirita (c Proteom Centrum) ;
Köhler, Heinz-R. (Institut für Evolution und Ökologie. Institut für Evolution und Ökologie) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Kemmerling, Birgit (Universität Tübingen. Zentrum für Molekularbiologie der Pflanzen)
The global economic success of man-made nanoscale materials has led to a higher production rate and diversification of emission sources in the environment. For these reasons, novel nanosafety approaches to assess the environmental impact of engineered nanomaterials are required. [...]
2021 - 10.3390/nano11123161
Nanomaterials, Vol. 11, issue 12 (Dec. 2021) , art. 3161
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9.
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15 p, 4.8 MB |
Antibody cooperative adsorption onto AuNPs and its exploitation to force natural killer cells to kill HIV-infected T cells
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Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vitali, Michele (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borrajo, Mireya L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Suárez-López, Rosa (Universitat Autònoma de Barcelona. Departament de Química) ;
Jaime Cardiel, Carlos (Universitat Autònoma de Barcelona. Departament de Química) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Serra-Peinado, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Blanch-Lombarte, Oscar (Institut Germans Trias i Pujol) ;
Prado, Julia G. (Institut Germans Trias i Pujol) ;
Lorente, Juan (Hospital Universitari Vall d'Hebron) ;
Pumarola, Felix (Hospital Universitari Vall d'Hebron) ;
Pellicer, Marc (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
HIV represents a persistent infection which negatively alters the immune system. New tools to reinvigorate different immune cell populations to impact HIV are needed. Herein, a novel nanotool for the specific enhancement of the natural killer (NK) immune response towards HIV-infected T-cells has been developed. [...]
2021 - 10.1016/j.nantod.2020.101056
Nano Today, Vol. 36 (Feb. 2021) , art. 101056
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10.
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20 p, 3.3 MB |
Interaction of nanoparticles with endotoxin Importance in nanosafety testing and exploitation for endotoxin binding
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Mangini, MARIA (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Verde, Alessandro (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Boraschi, Diana (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Italiani, Paola (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia)) ;
De Luca, Anna Chiara (Istituto di Biochimica e Biologia Cellulare (Nàpols, Itàlia))
The interaction between engineered nanoparticles and the bacterial lipopolysaccharide, or endotoxin, is an event that warrants attention. Endotoxin is one of the most potent stimulators of inflammation and immune reactions in human beings, and is a very common contaminant in research labs. [...]
2021 - 10.1080/17435390.2021.1898690
Nanotoxicology, Vol. 15, issue 4 (2021) , p. 558-576
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