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1.
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17 p, 4.0 MB |
Pharmacokinetics, biodistribution, and biosafety of PEGylated gold nanoparticles in vivo
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Kozics, Katarina (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Sramkova, Monika (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Kopecka, Kristina (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Begerova, Patricia (Biomedical Research Center SAS (Bratislava, Eslovàquia). Department of Nanobiology) ;
Manova, Alena (Slovak University of Technology in Bratislava. Institute of Analytical Chemistry) ;
Krivosikova, Zora (Slovak Medical University in Bratislava. Department of Clinical and Experimental Pharmacotherapy) ;
Sevcikova, Zuzana (University of Veterinary Medicine and Pharmacy in Kosice. Department of Morphological Disciplines) ;
Liskova, Aurelia (Slovak Medical University in Bratislava. Laboratory of Immunotoxicology) ;
Rollerova, Eva (Slovak Medical University in Bratislava. Laboratory of Toxicology) ;
Dubaj, Tibor (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Puntes, Victor (Institut Català de Nanociència i Nanotecnologia) ;
Wsolova, Ladislava (Slovak Medical University in Bratislava. Laboratory of Toxicology) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Tulinska, Jana (Slovak Medical University in Bratislava. Laboratory of Immunotoxicology) ;
Gabelova, Alena (Biomedical Research Center SAS. Department of Nanobiology)
Despite the obvious advantages of gold nanoparticles for biomedical applications, controversial and incomplete toxicological data hamper their widespread use. Here, we present the results from an in vivo toxicity study using gold nanoparticles coated with polyethylene glycol (PEG-AuNPs). [...]
2021 -  10.3390/nano11071702
Nanomaterials, Vol. 11, issue 7 (July 2021) , art. 1702
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2.
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12 p, 1.1 MB |
Pharmacokinetics of PEGylated gold nanoparticles : in vitro-in vivo correlation
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Dubaj, Tibor (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Kozics, Katarina (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Sramkova, Monika (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Manova, Alena (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia) ;
Kohl, Yvonne (Fraunhofer Institute for Biomedical Engineering) ;
Dusinska, Maria (Norwegian Institute for Air Research. Health Effects Laboratory) ;
Rundén-Pran, Elise (Norwegian Institute for Air Research. Health Effects Laboratory) ;
Puntes, Victor (Institut Català de Nanociència i Nanotecnologia) ;
Nelson, Andrew (University of Leeds. School of Chemistry) ;
Gabelova, Alena (Biomedical Research Center SAS. Cancer Research Institute (Bratislava, Eslovàquia)) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics)
Data suitable for assembling a physiologically-based pharmacokinetic (PBPK) model for nanoparticles (NPs) remain relatively scarce. Therefore, there is a trend in extrapolating the results of in vitro and in silico studies to in vivo nanoparticle hazard and risk assessment. [...]
2022 - 10.3390/nano12030511
Nanomaterials, Vol. 12, issue 3 (Feb. 2022) , art. 511
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3.
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17 p, 1.5 MB |
Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance
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Swartzwelter, Benjamin J. (Institute of Biochemistry and Cell Biology) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Verde, Alessandro (Institute of Biochemistry and Cell Biology) ;
Mangini, Maria (Institute of Biochemistry and Cell Biology) ;
Pirozzi, Marinella (Institute of Biochemistry and Cell Biology) ;
De Luca, Anna Chiara (Institute of Biochemistry and Cell Biology) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Leite, Luciana C. C. (Instituto Butantan. Laboratório de Desenvolvimento de Vacinas) ;
Italiani, Paola (Institute of Biochemistry and Cell Biology) ;
Boraschi, Diana (Institute of Biochemistry and Cell Biology)
Innate immune memory is characterized by a modulation in the magnitude with which innate immune cells such as monocytes and macrophages respond to potential dangers, subsequent to previous exposure to the same or unrelated agents. [...]
2020 - 10.3390/cells9020284
Cells, Vol. 9, Issue 2 (February 2020) , art. 284
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4.
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12 p, 3.0 MB |
Sustained effect of zero-valent iron nanoparticles under semi-continuous anaerobic digestion of sewage sludge : Evolution of nanoparticles and microbial community dynamics
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Barrena Gómez, Raquel (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Vargas-García, María del Carmen (Universidad de Almería. Departamento de Biología y Geología) ;
Capell, Georgina (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Barańska, Maja (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Moral Vico, Javier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Sanchez, Antoni (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ;
Font, Xavier (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental)
The effects of adding zero-valent iron nanoparticles (nZVI) on the physicochemical, biological and biochemical responses of a semi-continuous anaerobic digestion of sewage sludge have been assessed. Two sets of consecutive experiments of 103 and 116 days, respectively, were carried out in triplicate. [...]
2021 - 10.1016/j.scitotenv.2021.145969
Science of the total environment, Vol. 777 (July 2021) , art. 145969
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5.
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18 p, 13.4 MB |
Stressor-dependant changes in immune parameters in the terrestrial isopod crustacean, porcellio scaber : a focus on nanomaterials
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Mayall, Craig (University of Ljubljana. Biotechnical Faculty) ;
Dolar, Andraz (University of Ljubljana. Biotechnical Faculty) ;
Kokalj, Anita Jemec (University of Ljubljana. Biotechnical Faculty) ;
Novak, Sara (University of Ljubljana. Biotechnical Faculty) ;
Razinger, Jaka (Agricultural Institute of Slovenia. Plant Protection Department) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Drobne, Damjana (University of Ljubljana. Biotechnical Faculty)
We compared the changes of selected immune parameters of Porcellio scaber to different stressors. The animals were either fed for two weeks with Au nanoparticles (NPs), CeO2 NPs, or Au ions or body-injected with Au NPs, CeO2 NPs, or lipopolysaccharide endotoxin. [...]
2021 - 10.3390/nano11040934
Nanomaterials, Vol. 11 Núm. 4 (April 2021) , art. 934
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6.
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15 p, 4.6 MB |
Microfluidic in vitro platform for (nano)safety and (nano)drug efficiency screening
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Kohl, Yvonne (Fraunhofer Institute for Biomedical Engineering) ;
Biehl, Margit (Fraunhofer Institute for Biomedical Engineering) ;
Spring, Sarah (Fraunhofer Institute for Biomedical Engineering) ;
Hesler, Michelle (Fraunhofer Institute for Biomedical Engineering) ;
Ogourtsov, Vladimir (University College Cork. Tyndall National Institute) ;
Todorovic, Miomir (University College Cork. Tyndall National Institute) ;
Owen, Joshua (University of Leeds. Institute of Thermofluids) ;
Elje, Elisabeth (University of Oslo. Department of Molecular Medicine) ;
Kopecka, Kristina (Slovak Academy of Sciences. Biomedical Research Center) ;
Moriones, Oscar Hernando (Institut Català de Nanociència i Nanotecnologia) ;
Bastús, Neus G. (Institut Català de Nanociència i Nanotecnologia) ;
Šimon, Peter (Slovak University of Technology in Bratislava. Institute of Physical Chemistry and Chemical Physics) ;
Dubaj, Tibor (Institute of Physical Chemistry and Chemical Physicsof SUT) ;
Rundén-Pran, Elise (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
William, Nicola (University of Leeds. School of Chemistry) ;
von Briesen, Hagen (Fraunhofer Institute for Biomedical Engineering) ;
Wagner, Sylvia (Fraunhofer Institute for Biomedical Engineering) ;
Kapur, Nikil (University of Leeds. Institute of Thermofluids) ;
Mariussen, Espen (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Nelson, Andrew (University of Leeds. School of Chemistry) ;
Gabelova, Alena (Slovak Academy of Sciences. Biomedical Research Center) ;
Dusinska, Maria (Norwegian Institute for Air Research. Department for Environmental Chemistry) ;
Velten, Thomas (Fraunhofer Institute for Biomedical Engineering) ;
Knoll, Thorsten (Fraunhofer Institute for Biomedical Engineering)
Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses for rapid and animal-free risk assessment of new chemicals and drugs. Microfluidic cell-based devices allow high-throughput screening and flexible automation while lowering costs and reagent consumption due to their miniaturization. [...]
2021 - 10.1002/smll.202006012
Small, Vol. 17, issue 15 (April 2021) , art. 2006012
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13 p, 1.8 MB |
Interaction between macrophages and nanoparticles : in vitro 3d cultures for the realistic assessment of inflammatory activation and modulation of innate memory
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Swartzwelter, Benjamin (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Verde, Alessandro (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Rehak, Laura (Athena Biomedical Innovations (Roma, Itàlia)) ;
Madej, Mariusz (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
De Luca, Anna Chiara (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Boraschi, Diana (Consiglio Nazionale delle Ricerche. Istituto di Biochimica e Biologia Cellulare) ;
Italiani, Paola (Stazione Zoologica Anton Dohrn)
Understanding the modes of interaction between human monocytes/macrophages and engineered nanoparticles is the basis for assessing particle safety, in terms of activation of innate/inflammatory reactions, and their possible exploitation for medical applications. [...]
2021 - 10.3390/nano11010207
Nanomaterials, Vol. 11, issue 1 (Jan. 2021) , art. 207
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9.
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19 p, 7.4 MB |
Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures
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Michelini, Sara (Paris-Lodron University Salzburg) ;
Barbero, Francesco (Institut Català de Nanociència i Nanotecnologia) ;
Prinelli, Alessandra (AvantiCell Science Ltd) ;
Steiner, Philip (University Salzburg) ;
Weiss, Richard (Paris-Lodron University Salzburg) ;
Verwanger, Thomas (Paris-Lodron University Salzburg) ;
Andosch, Ancuela (Paris-Lodron University Salzburg) ;
Lütz-Meindl, Ursula (Paris-Lodron University Salzburg) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Drobne, Damjana (University of Ljubljana) ;
Duschl, Albert (Paris-Lodron University Salzburg) ;
Horejs-Hoeck, Jutta (Paris-Lodron University Salzburg)
Dendritic cells (DCs) shape immune responses by influencing T-cell activation. Thus, they are considered both an interesting model for studying nano-immune interactions and a promising target for nano-based biomedical applications. [...]
2021 - 10.1039/d0nr09153g
Nanoscale, Vol. 13, Issue 16 (April 2021) , p. 7648-7666
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10.
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16 p, 1.9 MB |
Bespoken Nanoceria : An Effective Treatment in Experimental Hepatocellular Carcinoma
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Fernández-Varo, Guillermo (Universitat de Barcelona) ;
Perramón, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Carvajal, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oró, Denise (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Casals, Eudald (Wuyi University) ;
Boix, Loreto (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Oller, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Macías-Muñoz, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Marfà, Santi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Casals, Gregori (Working Group for the Biochemical Assessment of Hepatic Disease-SEQC ML) ;
Morales-Ruiz, Manuel (Working Group for the Biochemical Assessment of Hepatic Disease-SEQC ML) ;
Casado, Pedro (Barts Cancer Institute (BCI)) ;
Cutillas, Pedro R. (Barts Cancer Institute (BCI)) ;
Bruix, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navasa, Miquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fuster, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
García-Valdecasas, Juan Carlos (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pavel, Mihai C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Puntes, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez, Wladimiro (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
Despite the availability of new-generation drugs, hepatocellular carcinoma (HCC) is still the third most frequent cause of cancer-related deaths worldwide. Cerium oxide nanoparticles (CeONPs) have emerged as an antioxidant agent in experimental liver disease because of their antioxidant, anti-inflammatory, and antisteatotic properties. [...]
2020 - 10.1002/hep.31139
Hepatology, Vol. 72 (october 2020) , p. 1267-1282
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