Resultados globales: 15 registros encontrados en 0.02 segundos.
Artículos, Encontrados 9 registros
Documentos de investigación, Encontrados 3 registros
Materiales académicos, Encontrados 3 registros
Artículos Encontrados 9 registros  
1.
10 p, 1.4 MB Reliable resolution of ambiguous hepatitis C virus genotype 1 results with the Abbott HCV Genotype Plus RUO assay / Saludes, Verónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Antuori Torres, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Reinhardt, B. (Abbott GmbH & Co. KG) ; Viciana, I. (Microbiology Service. Hospital Virgen de la Victoria) ; Clavijo, E. (Microbiology Service. Hospital Virgen de la Victoria) ; Schreiber, L. (Maccabi Mega-Lab) ; Tenenbaum, M. (Maccabi Mega-Lab) ; Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matas, L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martró, Elisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Accurate subtyping of hepatitis C virus genotype 1 (HCV-1) remains clinically and epidemiologically relevant. The Abbott HCV Genotype Plus RUO (GT Plus) assay, targeting the core region, was evaluated as a reflex test to resolve ambiguous HCV-1 results in a challenging sample collection. [...]
2019 - 10.1038/s41598-019-40099-3
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 3678  
2.
10 p, 2.2 MB Evidence for positive selection of hepatitis A virus antigenic variants in vaccinated men-having-sex-with men patients : Implications for immunization policies / Sabrià, Aurora (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Gregori, Josep (Roche Diagnostics, S.L., Sant Cugat del Vallés, Barcelona, Spain) ; Garcia-Cehic, Damir (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Guix, Susana (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Manzanares-Laya, Sandra (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp) del Instituto de Salud Carlos III, Madrid, Spain) ; Caylà, Joan A. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBEResp) del Instituto de Salud Carlos III, Madrid, Spain) ; Bosch, Albert (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Quer Sivila, Josep (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Pintó, Rosa M. (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
A huge outbreak in the men-having-sex-with-men (MSM) has hit Europe during the years 2016-2018. Outbreak control has been hampered by vaccine shortages in many countries, and to minimize their impact, reduction of antigen doses has been implemented. [...]
2018 - 10.1016/j.ebiom.2018.11.023
EBioMedicine, Vol. 39 (november 2018) , p. 348-357  
3.
4 p, 131.8 KB Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant / Perales, Celia (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Chen, Qian (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Soria, Maria Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gregori, Josep (Roche Diagnostics SL, Sant Cugat del Vallès, Barcelona, Spain) ; Garcia-Cehic, Damir (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Nieto-Aponte, Leonardo (Liver Pathology Unit, Department of Biochemistry and Microbiology, HUVH, Barcelona, Spain) ; Castells, Lluis (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Imaz, Arkaitz (Hospital Universitari de Bellvitge) ; Llorens-Revull, Meritxell (Hospital Universitari Vall d'Hebron) ; Domingo, Esteban (Virology and Microbiology Department, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus de Cantoblanco, Madrid, Spain) ; Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ; Esteban, Juan Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodriguez Frias, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ; Quer Sivila, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
Controversy is ongoing about whether a minority mutant present at frequencies below 15% may be clinically relevant and should be considered to guide treatment. Resistance-associated substitution (RAS) studies were performed in patients before and at failure of antiviral treatments using Next-generation hepatitis C virus (HCV) sequencing (NGS). [...]
2018 - 10.2147/IDR.S172226
Infection and drug resistance, Vol. 11 (november 2018) , p. 2207-2210  
4.
14 p, 1.3 MB Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy / González, Carolina (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; Gregori i Font, Josep (Roche Diagnostics SL) ; Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ; Godoy, Cristina (Hospital Universitari Vall d'Hebron) ; Sopena, Sara (Hospital Universitari Vall d'Hebron) ; Rando, Ariadna (Hospital Universitari Vall d'Hebron) ; Yll, Marçal (Hospital Universitari Vall d'Hebron) ; Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ; Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodríguez-Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 - 10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107  
5.
14 p, 1.3 MB Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population / Casillas, Rosario (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Belmonte, Irene (Hospital Universitari Vall d'Hebron) ; Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ; González, Carolina (Hospital Universitari Vall d'Hebron) ; Riveiro-Barciela, Mar ; López, Rosa Maria (Hospital Universitari Vall d'Hebron) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael ; Buti, Maria ; Rodríguez-Frías, Francisco (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. [...]
2018 - 10.3748/wjg.v24.i6.680
World Journal of Gastroenterology, Vol. 24 (february 2018) , p. 680-692  
6.
17.3 KB Hepatitis C virus deep sequencing for sub-genotype identification in mixed infections : A real-life experience / del Campo, José A. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Parra-Sánchez, Manuel (UCM Infectious Diseases and Microbiology, Valme University Hospital, Seville, Spain) ; Figueruela, Blanca (UCM Digestive Diseases, Valme University Hospital, Seville, Spain) ; García-Rey, Silvia (UCM Infectious Diseases and Microbiology, Valme University Hospital, Seville, Spain) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bernal, Samuel (UCM Infectious Diseases and Microbiology, Valme University Hospital, Seville, Spain) ; Grande, Lourdes (UCM Digestive Diseases, Valme University Hospital, Seville, Spain) ; Palomares, José C. (UCM Infectious Diseases and Microbiology, Valme University Hospital, Seville, Spain) ; Romero-Gómez, Manuel (Hospital Universitario Virgen del Rocío, Instituto de Investigación Biomédica de Sevilla (IBiS), Seville, Spain) ; Universitat Autònoma de Barcelona
The effectiveness of the new generation of hepatitis C treatments named direct-acting antiviral agents (DAAs) depends on the genotype, subtype, and resistance-associated substitutions present in individual patients. [...]
2018 - 10.1016/j.ijid.2017.12.016
International journal of infectious diseases, Vol. 67 (february 2018) , p. 114-117  
7.
6 p, 168.2 KB Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice : Comparison with Massive Sequencing / Nieto-Aponte, Leonardo (Hospital Universitari Vall d'Hebron) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ruiz-Ripa, Alicia (Hospital Universitari Vall d'Hebron) ; Tabernero, David (Hospital Universitari Vall d'Hebron) ; Gonzalez, Carolina (Hospital Universitari Vall d'Hebron) ; Gregori, Josep (Hospital Universitari Vall d'Hebron) ; Vila, Marta (Hospital Universitari Vall d'Hebron) ; Asensio, Miriam (Hospital Universitari Vall d'Hebron) ; Garcia-Cehic, Damir (Hospital Universitari Vall d'Hebron) ; Ruiz, Gerardo (Hospital Universitari Vall d'Hebron) ; Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ordeig, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Saez, Montserrat (Hospital Universitari Vall d'Hebron) ; Esteban, Juan I. (Hospital Universitari Vall d'Hebron) ; Esteban, Rafael (Hospital Universitari Vall d'Hebron) ; Buti, Maria (Hospital Universitari Vall d'Hebron) ; Pumarola, Tomas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
The unequivocal identification of hepatitis C virus (HCV) subtypes 1a/1b and genotypes 2 to 6 is required for optimizing the effectiveness of interferon-free, direct-acting antiviral therapies. We compared the performance of a new real-time HCV genotyping assay used on the Cobas 4800 system (C4800) with that of high-resolution HCV subtyping (HRCS). [...]
2017 - 10.1128/JCM.01960-16
Journal of Clinical Microbiology, Vol. 55 (january 2017) , p. 504-509  
8.
21 p, 1.8 MB Resistance of Hepatitis C Virus to Inhibitors : Complexity and Clinical Implications / Perales, Celia (Hospital Universitari Vall d'Hebron) ; Quer Sivila, Josep (Hospital Universitari Vall d'Hebron) ; Gregori, Josep (Hospital Universitari Vall d'Hebron) ; Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron) ; Domingo, Esteban (Centro de Biologia Molecular Severo Ochoa (Madrid, Espanya))
Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent results on drug resistance in HCV, with emphasis on resistance to the newly-developed, directly-acting antiviral agents, as they are increasingly employed in the clinic. [...]
2015 - 10.3390/v7112902
Viruses, Vol. 7 N. 11 (November 2015) , p. 5746-5766  
9.
2 p, 122.6 KB Canvis en l'epidemiologia de l'Hepatitis C a Europa / Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ; Sauleda Oliveras, Sílvia (Institut Català de la Salut) ; Quer Sivila, Josep (Instituto de Salud Carlos III) ; Institut Català de la Salut
Els paràmetres epidemiològics de la infecció pel virus de l'Hepatitis C (VHC) han canviat substancialment a Europa els darrers 15 anys. Les mesures de seguretat han reduït el risc de transmissió, però s'estima que el VHC encara s'expandeix pel continent. [...]
2008
UAB divulga, Maig 2008, p. 1-2  

Documentos de investigación Encontrados 3 registros  
1.
123 p, 3.1 MB Caracterización molecular del perfil de resistencias del virus de la hepatitis C después del fallo terapéutico a antivirales de acción directa mediante secuenciación masiva / Chen, Qian ; Quer Sivila, Josep, dir. ; Perales Viejo, Celia, dir. ; Gregori i Font, Josep, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La infección crónica por el virus de la hepatitis C constituye un problema de salud pública a nivel mundial por su contribución al desarrollo de enfermedades hepáticas avanzadas y carcinoma hepatocelular. [...]
Chronic hepatitis C infection is considered as a major public health issue worldwide due to its linkage to the development of advanced liver diseases and hepatocellular carcinoma. Currently, the availability of highly efficient and well-tolerated antiviral therapies based on combinations of direct acting antivirals (DAAs) has provided sustained virological response (SVR) in nearly 95% of patients. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
2.
186 p, 13.1 MB Estudio de complejidad y evolución del gen NS3 del virus de la hepatitis C (VHC) mediante ultra-deep pyrosequencing (UDPS) en pacientes expuestos al mismo inóculo viral / Cubero León, María Dolores ; Quer Sivila, Josep, dir. ; Esteban Mur, Juan Ignacio, dir. ; Farrés i Vicén, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El objetivo principal del trabajo desarrollado en esta tesis doctoral ha sido el estudio de la variabilidad del virus de la hepatitis C (VHC) en diferentes situaciones clínicas y desarrollar técnicas de estudio adecuados para lograr este objetivo. [...]
The main topic in this thesis has been to study the variability of hepatitis C virus (HCV). This doctoral thesis has been developed in the Liver Disease Laboratory, Vall d'Hebron Institut de Recerca (VHIR). [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  
3.
228 p, 2.7 MB Propuesta de un modelo experimental para la monitorización de la respuesta inmunitaria en pacientes sometidos a transplante hepático / Cos Trullàs, Joan ; Bilbao Aguirre, Itxarone, dir. (Universitat Autònoma de Barcelona. Departament de Cirurgia) ; Quer Sivila, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona. Departament de Cirurgia
Actualmente, el trasplante hepático (TxH) es el tratamiento de numerosas enfermedades que abocan a una insuficiencia hepática aguda fulminante o, más frecuentemente, a una fase final de de una hepatopatía crónica irreversible. [...]
Currently, liver transplantation (LT) is the treatment of many diseases which lead to acute fulminant liver failure or, more commonly, to a final phase of irreversible chronic liver disease. Side effects associated with indiscriminate use of immunosuppressant drugs and the fact that 20% of patients develop tolerance to the transplanted graft after a complete withdrawal of immunosuppressant (operational tolerance) promotes research aimed at finding laboratory techniques with predictive of clinical outcome. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2011  

Materiales académicos Encontrados 3 registros  
1.
5 p, 81.2 KB Competències Bàsiques en Recerca Translacional i Clínica [42896] / Quer Sivila, Josep ; Genescà Ferrer, Juan ; Rodríguez Frías, Francisco ; Balibrea del Castillo, Jose Maria ; Universitat Autònoma de Barcelona. Facultat de Biociències
Aquest mòdul pretèn apropar a l'estudiant al funcionament de la recerca en un hospital terciari, mostrants les diferents fases clíniques i d'investigació entre el diagnòstic i el tractament de la malaltia. [...]
This module aims to approach the students to the functioning of research in a tertiary hospital, by showing the different medical states from diagnostic to care of diseases. The aim of the module is to enable students to acquire the basic knowledge on the ethical, methodological, regulatory and logistical aspects used in translational and clinical research, to be able to plan experiments in human pathology based on Genomics, Proteomics, Cytomics and Metabolomics, to acquire the knowledge to identify the transferability of the results of their research to the market, and to understand the bases and the application of new diagnostic tools (massive sequencing, magnetic resonance imaging, microarrays, nanotechnology, etc. [...]

2018-19
Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1153]
2 documentos
2.
6 p, 82.8 KB Competències Bàsiques en Recerca Translacional i Clínica [42896] / Quer Sivila, Josep ; Universitat Autònoma de Barcelona. Facultat de Biociències
Aquest mòdul pretèn apropar a l'estudiant al funcionament de la recerca en un hospital terciari, mostrants les diferents fases clíniques i d'investigació entre el diagnòstic i el tractament de la malaltia. [...]
This module aims to approach the students to the functioning of research in a tertiary hospital, by showing the different medical states from diagnostic to care of diseases. The aim of the module is to enable students to acquire the basic knowledge on the ethical, methodological, regulatory and logistical aspects used in translational and clinical research, to be able to plan experiments in human pathology based on Genomics, Proteomics, Cytomics and Metabolomics, to acquire the knowledge to identify the transferability of the results of their research to the market, and to understand the bases and the application of new diagnostic tools (massive sequencing, magnetic resonance imaging, microarrays, nanotechnology, etc. [...]

2016-17
Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1153]
2 documentos
3.
5 p, 30.1 KB Competències Bàsiques en Recerca Translacional i Clínica [42896] / Quer Sivila, Josep ; Universitat Autònoma de Barcelona. Facultat de Biociències
Aquest mòdul pretèn apropar a l'estudiant al funcionament de la recerca en un hospital terciari, mostrants les diferents fases clíniques i d'investigació entre el diagnòstic i el tractament de la malaltia. [...]
This module aims to approach the students to the functioning of research in a tertiary hospital, by showing the different medical states from diagnostic to care of diseases. The aim of the module is to enable students to acquire the basic knowledge on the ethical, methodological, regulatory and logistical aspects used in translational and clinical research, to be able to plan experiments in human pathology based on Genomics, Proteomics, Cytomics and Metabolomics, to acquire the knowledge to identify the transferability of the results of their research to the market, and to understand the bases and the 1 Basic Translational and Clinical Research Skills 2015 - 2016 application of new diagnostic tools (massive sequencing, magnetic resonance imaging, microarrays, nanotechnology, etc. [...]

2015-16
Màster Universitari en Bioquímica, Biologia Molecular i Biomedicina [1153]
2 documentos

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