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13 p, 1.8 MB |
Interleukin-6, a Major Cytokine in the Central Nervous System
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Erta, María (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Quintana Romero, Albert (University of Washington. Departament of Chemistry) ;
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell differentiation factor, capable of inducing the maturation of B cells into antibody-producing cells. As with many other cytokines, it was soon realized that IL-6 was not a factor only involved in the immune response, but with many critical roles in major physiological systems including the nervous system. [...]
2012 -  10.7150/ijbs.4679
International journal of biological sciences, Vol. 8, Num. 9 (2012) , p. 1254-1266
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9 p, 846.3 KB |
Striatal GPR88 modulates foraging efficiency
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Rainwater, Aundrea (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
The striatum is anatomically and behaviorally implicated in behaviors that promote efficient foraging. To investigate this function, we studied instrumental choice behavior in mice lacking GPR88, a striatum-enriched orphan G-protein-coupled receptor that modulates striatal medium spiny neuron excitability. [...]
2017 - 10.1523/JNEUROSCI.2439-16.2017
The Journal of neuroscience, Vol. 37, Núm. 33 (August 2017) , p. 7939-7947
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8 p, 2.2 MB |
Loss of mitochondrial Ndufs4 in striatal medium spiny neurons mediates progressive motor impairment in a mouse model of leigh syndrome
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Chen, Byron (University of Washington. Howard Hughes Medical Institute) ;
Hui, Jessica (Seattle Children's Research Institute (Seattle, Estats Units d'Amèrica)) ;
Montgomery, Kelsey S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. [...]
2017 - 10.3389/fnmol.2017.00265
Frontiers in molecular neuroscience, Vol. 10 (August 2017) , article 265
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9 p, 1.4 MB |
Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons
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Beutler, Lisa R. (University of Washington. Department of Genome Sciences) ;
Eldred, Kiara C. (Howard Hughes Medical Institute (Estats Units d'Amèrica)) ;
Quintana Romero, Albert (University of Washington. Department of Biochemistry) ;
Keene, C. Dirk (University of Washington. Department of Pathology) ;
Rose, Shannon E. (University of Washington. Department of Pathology) ;
Postupna, Nadia (University of Washington. Department of Pathology) ;
Montine, Thomas J. (University of Washington. Department of Pathology) ;
Palmiter, Richard D. (University of Washington. Department of Genome Sciences)
The striatum is composed predominantly of medium spiny neurons (MSNs) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. [...]
2011 - 10.1371/journal.pone.0028168
PloS one, Vol. 6 Num. 11 (November 2011) , p. e28168
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5 p, 216.6 KB |
Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I
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Quintana Romero, Albert (University of Washington. Howard Hughes Medical Institute and Department of Biochemistry) ;
Morgan, Philip G. (University of Washington. Department of Anesthesiology and Pain Medicine) ;
Kruse, Shane E. (University of Washington. Howard Hughes Medical Institute and Department of Biochemistry) ;
Sedensky, Margaret M. (Center for Developmental Therapeutics, Seattle Children's Research Institute)
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABAA and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role of these receptors as sole effectors of general anesthesia. [...]
2012 - 10.1371/journal.pone.0042904
PloS one, Vol. 7, Num. 8 (2012) , p. e42904
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16 p, 7.0 MB |
RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo
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Sanz Iglesias, Elisenda (University of Washington. Department of Pharmacology) ;
Evanoff, Ryan (Washington State University. School of Molecular Biosciences) ;
Quintana Romero, Albert (University of Washington. Department of Biochemistry) ;
Evans, Elizabeth (Washington State University. School of Molecular Biosciences) ;
Miller, Jeremy A. (Allen Institute for Brain Science (Seattle, Washington)) ;
Ko, Chemyong (University of Illinois. Department of Comparative Biosciences) ;
Amieux, Paul S. (University of Washington. Department of Pharmacology) ;
Griswold, Michael D. (Washington State University. School of Molecular Biosciences) ;
McKnight, G. Stanley (University of Washington. Department of Pharmacology)
Male spermatogenesis is a complex biological process that is regulated by hormonal signals from the hypothalamus (GnRH), the pituitary gonadotropins (LH and FSH) and the testis (androgens, inhibin). The two key somatic cell types of the testis, Leydig and Sertoli cells, respond to gonadotropins and androgens and regulate the development and maturation of fertilization competent spermatozoa. [...]
2013 - 10.1371/journal.pone.0066179
PloS one, Vol. 8, Num. 6 (2013) , p. e66179
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26 p, 2.1 MB |
Glutamatergic neurotransmission links sensitivity to volatile anesthetics with mitochondrial function
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Zimin, Pavel I. (Seattle Children's Research Institute. Center for Developmental Therapeutics (Seattle, Estats Units d'Amèrica)) ;
Woods, Christian B. (Seattle Children's Research Institute. Center for Developmental Therapeutics (Seattle, Estats Units d'Amèrica)) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ramirez, Jan-Marino (Seattle Children's Research Institute. Center for Integrative Brain Research (Seattle, Estats Units d'Amèrica)) ;
Morgan, Philip G. (Seattle Children's Research Institute. Center for Developmental Therapeutics (Seattle, Estats Units d'Amèrica)) ;
Sendensky, Margaret M. (Seattle Children's Research Institute. Center for Developmental Therapeutics (Seattle, Estats Units d'Amèrica))
An enigma of modern medicine has persisted for over 150 years. The mechanisms by which volatile anesthetics (VAs) produce their effects (loss of consciousness, analgesia, amnesia, and immobility) remain an unsolved mystery. [...]
2016 - 10.1016/j.cub.2016.06.020
Current biology, Vol. 26, Issue 16 (August 2016) , p. 2194-2201
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28 p, 14.2 MB |
Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state
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Padilla, Stephanie L. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Qiu, Jian (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ;
Soden, Marta E. (University of Washington (Seattle, Estats Units d'Amèrica)) ;
Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Nestor, Casey C. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ;
Barker, Forrest D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ;
Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Zweifel, Larry S. (University of Washington (Seattle, Estats Units d'Amèrica)) ;
Rønnekleiv, Oline K. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ;
Kelly, Martin J. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ;
Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica))
In the face of starvation, animals will engage in high-risk behaviors that would normally be considered maladaptive. Starving rodents, for example, will forage in areas that are more susceptible to predators and will also modulate aggressive behavior within a territory of limited or depleted nutrients. [...]
2016 - 10.1038/nn.4274
Nature neuroscience, Vol. 19, Num. 5 (May 2016) , p. 734-741
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