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9 p, 742.8 KB The Genome in a Three-Dimensional Context : Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood Cancer / Rovirosa Mulet, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ramos-Morales, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Javierre, B. M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Associations between blood cancer and genetic predisposition, including both inherited variants and acquired mutations and epimutations, have been well characterized. However, the majority of these variants affect noncoding regions, making their mechanisms difficult to hypothesize and hindering the translation of these insights into patient benefits. [...]
2020 - 10.3389/fimmu.2020.592087
Frontiers in immunology, Vol. 11 (july 2020) , p. 592087  
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