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10 p, 482.9 KB |
Improved adipose tissue function with initiation of protease inhibitor-only ART
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Maughan, Robert T. (University College Dublin) ;
Feeney, Eoin R. (University College Dublin) ;
Capel, Emilie (Sorbonne Universities) ;
Capeau, Jacqueline (Sorbonne Universities) ;
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau) ;
Giralt, Marta (CIBER Fisiopatologia de la Obesidad y Nutrición) ;
Lange, Joep M.A. (Thai Red Cross Aids Research Center (TRCARC)) ;
Phanuphak, Praphan (Chulalongkorn University) ;
Cooper, David A. (University of New South Wales) ;
Reiss, Peter (Thai Red Cross Aids Research Center (TRCARC)) ;
Mallon, Patrick W.G. (University College Dublin) ;
Autar, Saskia R. ;
van der Lugt, Jasper ;
Avihingsanon, Anchalee ;
Klungklang, Supalak ;
Ubolyam, Sasiwimol ;
Universitat Autònoma de Barcelona
Use of ART containing HIV PIs has previously been associated with toxicity in subcutaneous adipose tissue (SAT), potentially contributing to the development of lipodystrophy and insulin resistance. However, the effect of PIs on SAT function in ART-naive patients independent of other ART classes is unknown. [...]
2016 -  10.1093/jac/dkw301
Journal of antimicrobial chemotherapy, Vol. 71 Núm. 11 (january 2016) , p. 3212-3221
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2.
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11 p, 299.2 KB |
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes : A prospective study of HIV-positive individuals
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Cain, Lauren E. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Caniglia, Ellen C. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Phillips, Andrew (University College London) ;
Olson, Ashley ;
Muga, Roberto (Institut Germans Trias i Pujol) ;
Pérez Hoyos, Santiago ;
Abgrall, Sophie ;
Costagliola, Dominique ;
Rubio, Rafael ;
Jarrín, Inma ;
Bucher, Heiner ;
Fehr, Jan ;
van Sighem, Ard ;
Reiss, Peter ;
Dabis, François ;
Vandenhende, Marie-Anne ;
Logan, Roger ;
Robins, James ;
Sterne, Jonathan A C ;
Justice, Amy ;
Tate, Janet ;
Touloumi, Giota ;
Paparizos, Vasilis ;
Esteve, Anna ;
Casabona-Barbarà, Jordi ;
Seng, Rémonie ;
Meyer, Laurence ;
Jose, Sophie ;
Sabin, Caroline A ;
Hernán, Miguel A ;
HIV CAUSAL Collaboration ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective: To compare regimens consisting of either ritonavir-boosted atazanavir or efavirenz and a nucleoside reverse transcriptase inhibitor (NRTI) backbone with respect to clinical, immunologic, and virologic outcomes. [...]
2016 - 10.1097/MD.0000000000005133
Medicine, Vol. 95 Núm. 41 (2016) , art. e5133
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3.
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16 p, 1.2 MB |
Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers
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Chereau, Fanny (Université Paris-Saclay) ;
Madec, Yoann (Institut Pasteur) ;
Sabin, Caroline A (Research Department of Infection and Population Health (Regne Unit)) ;
Obel, Niels (Copenhagen University Hospital Rigshospitalet) ;
Ruiz-Mateos, Ezequiel (Instituto de Biomedicina de Sevilla) ;
Chrysos, Georgios (Tzaneio General Hospital of Piraeus) ;
Fidler, Sarah (Imperial College (Regne Unit)) ;
Lehmann, Clara (University of Cologne and German Center for Infection Research) ;
Zangerle, Robert (DMedical University Innsbruck) ;
Wittkop, Linda (University Bordeaux) ;
Reiss, Peter (Stichting HIV Monitoring) ;
Hamouda, Osamah (Robert Koch Institute) ;
Estrada Perez, Vicente (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Leal, Manuel (Instituto de Biomedicina de Sevilla) ;
Mocroft, Amanda (Research Department of Infection and Population Health (Regne Unit)) ;
García de Olalla, Patricia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Ammassari, Adriana (Istituto Nazionale Malattie Infettive) ;
D'Arminio Monforte, Antonella (University Hospital (Itàlia)) ;
Mussini, Cristina (University of Modena and Reggio Emilia) ;
Segura, Ferran (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Castagna, Antonella (San Raffaele Vita Salute University) ;
Cavassini, Matthias (Lausanne University Hospital) ;
Grabar, Sophie (Institut Pierre Louis d'Epidémiologie et de Santé Publique) ;
Morlat, Philippe (Université de Bordeaux) ;
De Wit, Stéphane (Université Libre de Bruxelles) ;
Lambotte, Olivier (Université Paris Sud) ;
Meyer, Laurence (Université Paris-Saclay) ;
Universitat Autònoma de Barcelona
HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. [...]
2017 - 10.1371/journal.pone.0173893
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4.
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13 p, 1.2 MB |
Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine : A substudy of the NEAT001/ANRS143 randomised trial
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Bernardino, J. I. (Hospital Universitario La Paz (Madrid)) ;
Mocroft, Amanda (University College London) ;
Wallet, C. (University of Bordeaux) ;
De Wit, Stéphane (CHU Saint Pierre, Brussels) ;
Katlama, C. (Hôpital Pitié Salpétrière, Paris) ;
Reiss, Peter (University of Amsterdam) ;
Mallon, P. W. (University College Dublin) ;
Richert, L. (University of Bordeaux) ;
Molina, J. M. (University of Paris Diderot) ;
Knobel Freud, Hernando (Hospital del Mar (Barcelona, Catalunya)) ;
Morlat, Philippe (CHU Bordeaux) ;
Babiker, A. (University College London) ;
Pozniac, A. (Chelsea and Westminster Hospital NHS Foundation Trust) ;
Raffi, F. (CHU de Nantes) ;
Arribas, Jose (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Background Comparison of changes in body composition, adipokines and inflammatory markers after initial therapy with a nucleos(t)ide reverse transcriptase inhibitor (N(t)RTI)- sparing or containing regimen are scarce. [...]
2019 - 10.1371/journal.pone.0209911
PloS one, Vol. 14 Núm. 1 (january 2019) , p. e0209911
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5.
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18 p, 347.2 KB |
Comparing dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals on cART : a prospective observational study in high-income countries
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Caniglia, Ellen C (Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.) ;
Cain, Lauren E. ;
Sabin, Caroline A. ;
Robins, James M. ;
Logan, Roger ;
Abgrall, Sophie ;
Mugavero, Michael J. ;
Hernández-Díaz, Sonia ;
Meyer, Laurence ;
Seng, Remonie ;
Drozd, Daniel R. ;
Seage, George R. ;
Dabis, Francois ;
Fabrice, Bonnet ;
Richard, D. Moore ;
Reiss, Peter ;
van Sighem, Ard ;
Mathews, William C. ;
Del Amo, Julia ;
Moreno, Santiago ;
Deeks, Steven G. ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. ;
Ferrer, Elena ;
Eron, Joseph J. ;
Napravnik, Sonia ;
Jose, Sophie ;
Phillips, Andrew ;
Justice, Amy C. ;
Tate, Janet P. ;
Gill, John ;
Pacheco, Antonio ;
Veloso, Valdilea G. ;
Bucher, Heiner ;
Egger, Matthias ;
Furrer, Hansjakob ;
Kholoud, Porter ;
Touloumi, Giota ;
Crane, Heidi ;
Miró, José M ;
Sterne, Jonathan A. ;
Dominique, Costagliola ;
Saag, Michael ;
Hernán, Miguel A.
Clinical guidelines vary with respect to the optimal monitoring frequency of HIV-positive individuals. We compared dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals. [...]
2017 - 10.1016/S2352-3018(17)30043-7
The lancet. HIV, Vol. 4 (april 2017) , p. e251-e259
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6.
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7 p, 259.3 KB |
Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study
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May, Margaret T. ;
Vehreschild, Jorg-Janne ;
Trickey, Adam ;
Obel, Niels ;
Reiss, Peter ;
Bonnet, Fabrice ;
Mary-Krause, Murielle ;
Samji, Hasina ;
Cavassini, Matthias ;
Gill, Michael John ;
Shepherd, Leah C. ;
Crane, Heidi ;
D'Arminio Monforte, Antonella ;
Burkholder, Greer A. ;
Johnson, Margaret M. ;
Sobrino-Vegas, Paz ;
Domingo, Pere (Domingo Pedrol) ;
Zangerle, Robert (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Justice, Amy C. ;
Sterling, Timothy R. ;
Miró, José M. ;
Sterne, Jonathan A. C.
The strong association of CD4 count at start of combination therapy with subsequent survival in HIV-infected patients diminished during the first 5 years of treatment. After 5 years, lower baseline CD4 counts were not associated with higher mortality. [...]
2016 - 10.1093/cid/ciw183
Clinical Infectious Diseases, Vol. 62 (march 2016) , p. 1571-1577
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7.
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8 p, 283.7 KB |
When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries : A Prospective Observational Study
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Caniglia, Ellen C. (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA) ;
Sabin, Caroline A. (University College London, London, United Kingdom) ;
Robins, James M. (Department of Biostatistics, Harvard T.H. Chan School of Public Health) ;
Logan, Roger (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Cain, Lauren E. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Abgrall, Sophie (Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Antoine Béclère, Service de Médecine Interne) ;
Mugavero, Michael J. (University of Alabama at Birmingham) ;
Hernandez-Diaz, Sonia (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Meyer, Laurence (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Seng, Remonie (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Drozd, Daniel R. (Division of Allergy and Infectious Diseases, School of Medicine, University of Washington) ;
Seage, George R. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Bonnet, Fabrice (Bordeaux University, ISPED, INSERM U897 CHU de Bordeaux) ;
Dabis, Francois (INSERM U897, Centre Inserm Epidémiologie et Biostatistique, Université de Bordeaux, and Department of Internal Medicine, Bordeaux University Hospital) ;
Moore, Richard R. (School of Medicine, Johns Hopkins University, Baltimore, MD) ;
Reiss, Peter (Stichting HIV Monitoring, Amsterdam, Netherlands; Academic Medical Center, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, and Amsterdam Institute for Global Health and Development) ;
van Sighem, Ard (Stichting HIV Monitoring, Amsterdam, Netherlands) ;
Mathews, William C. (Internal Medicine, Johns Hopkins University) ;
Del Amo, Julia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Deeks, Steven G. (Positive Health Program, San Francisco General Hospital) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. (Fenway Health) ;
Ferrer, Elena (Institut d'Investigació Biomèdica de Bellvitge) ;
Eron, Joseph J. (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Napravnik, Sonia (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Jose, Sophie (University College London) ;
Phillips, Andrew (University College London, London, United Kingdom) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London) ;
Justice, Amy C. (VA Connecticut Healthcare System) ;
Tate, Janet P. (VA Connecticut Healthcare System) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Egger, Matthias (University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland) ;
Touloumi, Giota (Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School) ;
Sterne, Jonathan A. (School of Social and Community Medicine, University of Bristol) ;
Costagliola, Dominique (Institute Pierre Louis d'Épidémiologie et de Santé Publique) ;
Saag, Michael (Department of Medicine, University of Alabama at Birmingham) ;
Hernán, Miguel A. (Department of Medicine, University of Alabama at Birmingham) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). [...]
2016 - 10.1097/QAI.0000000000000956
Journal of acquired immune deficiency syndromes (1999), Vol. 72 (may 2016) , p. 214-221
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