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7 p, 199.8 KB CA19-9 decrease at 8 weeks as a predictor of overall survival in a randomized phase III trial (MPACT) of weekly nab -paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic pancreatic cancer / Chiorean, E. G. (University of Washington. Department of Medicine) ; Von Hoff, D. D. (Translational Genomics Research Institute) ; Reni, M. (Ospedale San Raffaele. Servizio di Oncologia Medica) ; Arena, F. P. (NYU Langone Arena Oncology. Department of Oncology) ; Infante, J. R. (Sarah Cannon Research Institute) ; Bathini, V. G. (University of Massachusetts Medical School. Cancer Center of Excellence) ; Wood, T. E. (University of Alabama at Birmingham. Comprehensive Cancer Center) ; Mainwaring, P. N. (Centre for Haematology & Oncology (Brisbane, Austràlia)) ; Muldoon, R. T. (Genesis Cancer Center. Department of Oncology) ; Clingan, P. R. (Southern Medical Day Care Centre) ; Kunzmann, V. (Universitätsklinikum Würzburg. Medizinischen Klinik und Poliklinik II) ; Ramanathan, R. K. (Translational Genomics Research Institute) ; Tabernero Caturla, Josep (Hospital Universitari de la Vall d'Hebron) ; Goldstein, D. (Prince of Wales Hospital. Department of Oncology) ; McGovern, D. (Celgene Corporation) ; Lu, B. (Celgene Corporation) ; Ko, A. (Celgene Corporation) ; Universitat Autònoma de Barcelona
Any CA19-9 decline at week 8 and radiologic response by week 8 each predicted longer OS in both treatment arms. In the nab- P + Gem arm, the higher proportion of patients with week 8 CA19-9 decrease [82% (206/252); median OS 13. [...]
2016 - 10.1093/annonc/mdw006
Annals of oncology, Vol. 27, issue 4 (April 2016) , p. 654-660  

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