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11 p, 912.1 KB |
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing
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Corominas, Jordi (Radboud University Medical Center) ;
Klein, Marieke (Radboud University Medical Center) ;
Zayats, Tetyana (University of Bergen) ;
Rivero, Olga (University of Würzburg) ;
Ziegler, Georg C. (University of Würzburg) ;
Pauper, Marc (Radboud University Medical Center) ;
Neveling, Kornelia (Radboud University Medical Center) ;
Poelmans, Geert (Radboud University Medical Center) ;
Jansch, Charline (University of Würzburg) ;
Svirin, Evgeniy (I.M. Sechenov First Moscow State Medical University) ;
Geissler, Julia (University Hospital of Würzburg) ;
Weber, Heike (University Hospital Frankfurt) ;
Reif, Andreas (University Hospital Frankfurt) ;
Arias Vasquez, Alejandro (Radboud University Medical Center) ;
Galesloot, Tessel E. (Radboud University Medical Center) ;
Kiemeney, Lambertus A. L. M. (Radboud University Medical Center) ;
Buitelaar, Jan K. (Radboud University Medical Center) ;
Ramos Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Cormand, Bru (Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat) ;
Ribasés, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hveem, Kristian (Norwegian University of Science and Technology) ;
Gabrielsen, Maiken Elvestad (Norwegian University of Science and Technology) ;
Hoffmann, Per (University of Basel) ;
Cichon, Sven (University Hospital Basel) ;
Haavik, Jan (Haukeland University Hospital) ;
Johansson, Stefan (University of Bergen) ;
Jacob, Christian P. (University of Würzburg) ;
Romanos, Marcel (University Hospital of Würzburg) ;
Franke, Barbara (Radboud University Medical Center) ;
Lesch, Klaus-Peter (Maastricht University)
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of underlying genetic risk factors. We hypothesized that combining linkage analysis and whole-exome sequencing (WES) in multi-generation pedigrees with multiple affected individuals can point toward novel ADHD genes. [...]
2018 -  10.1038/s41380-018-0210-6
Molecular Psychiatry, Vol. 25 (august 2018) , p. 2047-2057
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10 p, 2.1 MB |
Shared genetic background between children and adults with attention deficit/hyperactivity disorder
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Rovira, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Demontis, Ditte (Center for Genomics and Personalized Medicine, Aarhus, Denmark) ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zayats, Tetyana (Broad Institute of MIT, and Harvard. Stanley Center for Psychiatric Research) ;
Klein, Marieke (University Medical Center Utrecht, UMC Utrecht Brain Center, Department of Psychiatry) ;
Mota, Nina Roth (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Weber, Heike (University Hospital Frankfurt. Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy) ;
Garcia-Martínez, Iris (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pagerols, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilar-Ribó, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arribas, Lorena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Richarte, Vanesa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Corrales, Montserrat (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fadeuilhe, Christian (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Bosch, Rosa (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Martin, Gemma Español (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Almos, Peter (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Doyle, Alysa E. (Harvard Medical School. Department of Psychiatry) ;
Grevet, Eugenio Horacio (Universidade Federal do Rio Grande do Sul. Department of Psychiatry, Faculty of Medicine) ;
Grimm, Oliver (University Hospital Frankfurt. Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy) ;
Halmøy, Anne (Haukeland University Hospital. Division of Psychiatry) ;
Hoogman, Martine (Radboud University Medical Center. Department of Human Genetics, Donders Institute for Brain, Cognition, and Behaviour) ;
Hutz, Mara (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Jacob, Christian P. (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Kittel-Schneider, Sarah (University Hospital Frankfurt. Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy) ;
Knappskog, Per M. (University of Bergen. Department of Clinical Science) ;
Lundervold, Astri J. (University of Bergen. Department of Biological and Medical Psychology) ;
Rivero, Olga (University of Würzburg. Division of Molecular Psychiatry, Center of Mental Health) ;
Rovaris, Diego Luiz (University of São Paulo. Department of Physiology and Biophysics, Institute of Biomedical Sciences) ;
Salatino-Oliveira, Angelica (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
da Silva, Bruna Santos (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Svirin, Evgeniy (IM Sechenov First Moscow State Medical University. Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine) ;
Sprooten, Emma (Radboud University Medical Centre. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour) ;
Strekalova, Tatyana (Maastricht University. Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS)) ;
Arias-Vasquez, Alejandro (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Sonuga-Barke, Edmund J. S. (Aarhus University. Department of Child and Adolescent Psychiatry) ;
Asherson, Philip (King's College London. Social Genetic and Developmental Psychiatry, Institute of Psychiatry Psychology and Neuroscience) ;
Bau, Claiton Henrique Dotto (Universidade Federal do Rio Grande do Sul. Department of Genetics, Institute of Biosciences) ;
Buitelaar, Jan K. (Karakter Child and Adolescent Psychiatry, Nijmegen, The Netherlands) ;
Cormand, Bru (Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Catalonia Spain) ;
Faraone, Stephen V. (SUNY Upstate Medical University. Departments of Psychiatry, of Neuroscience, and Physiology) ;
Haavik, Jan (Haukeland University Hospital. Division of Psychiatry) ;
Johansson, Stefan E. (University of Bergen. Department of Clinical Science) ;
Kuntsi, Jonna (King's College London. Social Genetic and Developmental Psychiatry, Institute of Psychiatry Psychology and Neuroscience) ;
Larsson, Henrik (Karolinska Institutet. Department of Medical Epidemiology and Biostatistics) ;
Lesch, Klaus-Peter (Maastricht University. Department of Neuroscience, School for Mental Health and Neuroscience (MHeNS)) ;
Reif, Andreas (University Hospital Frankfurt. Department of Psychiatry, Psychosomatic Medicine, and Psychotherapy) ;
Rohde, Luis Augusto (Federal University of Rio Grande do Sul. Division of Child Psychiatry, Hospital de Clinicas de Porto Alegre) ;
Casas, Miquel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Børglum, Anders D. (Center for Genomics and Personalized Medicine, Aarhus, Denmark) ;
Franke, Barbara (Radboud University Medical Center. Department of Psychiatry, Donders Institute for Brain, Cognition, and Behaviour) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Soler Artigas, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribasés, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. [...]
2020 - 10.1038/s41386-020-0664-5
Neuropsychopharmacology, Vol. 45 (april 2020) , p. 1617-1626
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15 p, 1010.8 KB |
Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome
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Lahrouchi, Najim (University of Amsterdam) ;
Tadros, Rafik (Université de Montréal) ;
Crotti, Lia (University of Milano-Bicocca) ;
Mizusawa, Yuka (University of Amsterdam) ;
Postema, Pieter G. (University of Amsterdam) ;
Beekman, Leander (University of Amsterdam) ;
Walsh, Roddy (University of Amsterdam) ;
Hasegawa, Kanae (Shiga University of Medical Science, Otsu, Japan) ;
Barc, Julien (Inserm, France) ;
Ernsting, Marko (University Hospital Muenster, Germany) ;
Turkowski, Kari L. (Mayo Clinic, Rochester) ;
Mazzanti, Andrea (University of Pavia) ;
Beckmann, Britt M. (University Hospital of the Ludwig Maximilians University, Munich) ;
Shimamoto, Keiko (National Cerebral and Cardiovascular Center, Osaka) ;
Diamant, Ulla-Britt (Umeå University, Sweden) ;
Wijeyeratne, Yanushi D. (St George's University of London) ;
Kucho, Yu (National Hospital Organization Kagoshima Medical Center, Japan) ;
Robyns, Tomas (University Hospitals Leuven) ;
Ishikawa, Taisuke (National Cerebral and Cardiovascular Center, Osaka) ;
Arbelo, Elena (IDIBAPS) ;
Christiansen, Michael (Statens Serum Institute, Copenhagen) ;
Winbo, Annika (The University of Auckland) ;
Jabbari, Reza (Copenhagen University Hospital) ;
Lubitz, Steven A. (Massachusetts General Hospital) ;
Steinfurt, Johannes (Heart Center University of Freiburg) ;
Rudic, Boris (University Medical Center Mannheim) ;
Loeys, Bart (Antwerp University Hospital, Belgium) ;
Shoemaker, M. Ben (Vanderbilt University Medical Center, Nashville) ;
Weeke, Peter E. (Vanderbilt University Medical Center, Nashville) ;
Pfeiffer, Ryan (Masonic Medical Research Institute, Utica, NY) ;
Davies, Brianna (University of British Columbia, Vancouver) ;
Andorin, Antoine (St George's University of London) ;
Hofman, Nynke (University of Amsterdam) ;
Dagradi, Federica (Istituto Auxologico Italiano - IRCCS, Milan) ;
Pedrazzini, Matteo (Istituto Auxologico Italiano - IRCCS, Milan) ;
Tester, David J. (Mayo Clinic, Rochester) ;
Bos, J. Martijn (Mayo Clinic, Rochester) ;
Sarquella-Brugada, Georgia (Hospital Sant Joan de Déu. Institut de Recerca) ;
Campuzano, Óscar (Hospital Sant Joan de Déu. Institut de Recerca) ;
Platonov, Pyotr G. (Lund University, Sweden) ;
Stallmeyer, Birgit (University Hospital Muenster, Germany) ;
Zumhagen, Sven (University Hospital Muenster, Germany) ;
Nannenberg, Eline A. (University of Amsterdam) ;
Veldink, Jan H. (University Medical Center Utrecht) ;
van den Berg, Leonard H. (University Medical Center Utrecht) ;
Al-Chalabi, Ammar (King's College Hospital, London) ;
Shaw, Christopher E. (King's College London) ;
Shaw, Pamela J. (Istituto Auxologico Italiano - IRCCS, Milan) ;
Morrison, Karen E. (University of Southampton) ;
Andersen, Peter M. (Ulm University, Germany) ;
Müller-Nurasyid, Martina (University Hospital of the Ludwig Maximilians University, Munich) ;
Cusi, Daniele (University of Milan) ;
Barlassina, Cristina (University of Milan) ;
Galan, Pilar (Inserm, France) ;
Lathrop, Mark (McGill University and Génome Québec Innovation Centre, Montréal) ;
Munter, Markus (McGill University and Génome Québec Innovation Centre, Montréal) ;
Werge, Thomas (The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen) ;
Ribasés, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aung, Tin (Singapore Eye Research Institute) ;
Khor, Chiea C. (Genome Institute of Singapore) ;
Ozaki, Mineo (Ozaki Eye Hospital, Miyazaki, Japan) ;
Lichtner, Peter (Helmholtz Zentrum München, Neuherberg, Germany) ;
Meitinger, Thomas (Helmholtz Zentrum München, Neuherberg, Germany) ;
van Tintelen, J. Peter (University of Amsterdam) ;
Hoedemaekers, Yvonne (University Medical Centre Groningen) ;
Denjoy, Isabelle (Université de Paris Inserm) ;
Leenhardt, Antoine (Université de Paris Inserm) ;
Napolitano, Carlo (ICS Maugeri - IRCCS, Pavia) ;
Shimizu, Wataru (National Cerebral and Cardiovascular Center, Osaka) ;
Schott, Jean-Jacques (Inserm, France) ;
Gourraud, Jean-Baptiste (Inserm, France) ;
Makiyama, Takeru (Kyoto University Graduate School of Medicine) ;
Ohno, Seiko (University of Milano-Bicocca) ;
Itoh, Hideki (Shiga University of Medical Science, Otsu, Japan) ;
Krahn, Andrew D. (University of British Columbia, Vancouver) ;
Antzelevitch, Charles (Lankenau Institute for Medical Research, Wynnewood, PA) ;
Roden, Dan M. (Vanderbilt University Medical Center, Nashville) ;
Saenen, Johan (Antwerp University Hospital, Belgium) ;
Borggrefe, Martin (University Medical Center Mannheim) ;
Odening, Katja E. (Heart Center University of Freiburg, Germany) ;
Ellinor, Patrick T. (Massachusetts General Hospital, Boston) ;
Tfelt-Hansen, Jacob (Copenhagen University Hospital) ;
Skinner, Jonathan R. (Starship Children's Hospital, Auckland) ;
van den Berg, Maarten P. (University Medical Center Groningen) ;
Olesen, Morten Salling (Copenhagen University Hospital) ;
Brugada, Josep (IDIBAPS) ;
Brugada, Ramón (IDIBAPS) ;
Makita, Naomasa (National Cerebral and Cardiovascular Center Research Institute, Osaka) ;
Breckpot, Jeroen (University Hospitals Leuven) ;
Yoshinaga, Masao (National Hospital Organization Kagoshima Medical Center, Japan) ;
Behr, Elijah R. (St George's University of London) ;
Rydberg, Annika (Umeå University, Sweden) ;
Aiba, Takeshi (National Cerebral and Cardiovascular Center, Osaka) ;
Kääb, Stefan (University Hospital of the Ludwig Maximilians University, Munich) ;
Priori, Silvia G. (ICS Maugeri - IRCCS, Pavia) ;
Guicheney, Pascale (Inserm, France) ;
Tan, Hanno L. (University of Amsterdam) ;
Newton-Cheh, Christopher (Massachusetts General Hospital, Boston) ;
Ackerman, Michael J. (Mayo Clinic, Rochester) ;
Schwartz, Peter J. (European Reference Network for Rare, Low Prevalence, and Complex Diseases of the Heart - ERN GUARD-Heart) ;
Schulze-Bahr, Eric (University Hospital Muenster) ;
Probst, Vincent (Inserm, France) ;
Horie, Minoru (Shiga University of Medical Science, Otsu, Japan) ;
Wilde, Arthur A. (University of Amsterdam) ;
Tanck, Michael W.T. (University of Amsterdam) ;
Bezzina, Connie R. (University of Amsterdam) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is available in the text. We conducted genome-wide association studies followed by transethnic meta-analysis in 1656 unrelated patients with LQTS of European or Japanese ancestry and 9890 controls to identify susceptibility single nucleotide polymorphisms. [...]
2020 - 10.1161/CIRCULATIONAHA.120.045956
Circulation, Vol. 142 (may 2020) , p. 324-338
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30 p, 2.0 MB |
Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
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Franke, Barbara (Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands) ;
Michelini, Giorgia (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK) ;
Asherson, Philip (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK) ;
Banaschewski, Tobias (Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany) ;
Bilbow, Andrea (ADHD-Europe, Brussels, Belgium) ;
Buitelaar, Jan K. (Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands) ;
Cormand, Bru (Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Catalonia, Spain) ;
Faraone, Stephen V. (K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway) ;
Ginsberg, Ylva (Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden) ;
Haavik, Jan (Division of Psychiatry, Haukeland University Hospital, Bergen, Norway) ;
Kuntsi, Jonna (King's College London, Institute of Psychiatry, Psychology & Neuroscience, Social, Genetic & Developmental Psychiatry Centre, London, UK) ;
Larsson, Henrik (Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden) ;
Lesch, Klaus-Peter (Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands) ;
Ramos-Quiroga, J. Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Réthelyi, János M. (MTA-SE NAP-B Molecular Psychiatry Research Group, Hungarian Academy of Sciences, Budapest, Hungary) ;
Ribases, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Reif, Andreas (Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany)
Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. [...]
2018 - 10.1016/j.euroneuro.2018.08.001
European Neuropsychopharmacology, Vol. 28 (october 2018) , p. 1059-1088
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15 p, 2.4 MB |
Genome-wide analyses of aggressiveness in attention-deficit hyperactivity disorder
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Brevik, Erlend J. (Universitetet i Bergen) ;
van Donkelaar, Marjolein M. J. (Donders Institute for Brain, Cognition and Behaviour) ;
Weber, Heike (Goethe Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) ;
Sánchez Mora, Cristina (Hospital Universitari Vall d'Hebron) ;
Jacob, Christian (Klinik Nürtingen. Abteilung für Psychiatrie und Psychotherapie) ;
Rivero, Olga (Universität Würzburg. Zentrum fuer Psychische Gesundheit) ;
Kittel-Schneider, Sarah (Universität Würzburg. Zentrum fuer Psychische Gesundheit) ;
Garcia Martínez, Iris (Hospital Universitari Vall d'Hebron) ;
Aebi, Marcel (Psychiatrische Universitätsklinik Zürich) ;
van Hulzen, Kimm (Donders Institute for Brain, Cognition and Behaviour) ;
Cormand, Bru (Universitat de Barcelona. Departament de Genètica) ;
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Lesch, Klaus-Peter (Klinik Nürtingen. Abteilung für Psychiatrie und Psychotherapie) ;
Reif, Andreas (Goethe Universität Frankfurt am Main. Klinik für Psychiatrie, Psychosomatik und Psychotherapie) ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron) ;
Franke, Barbara (Donders Institute for Brain, Cognition and Behaviour) ;
Posserud, Maj-Britt (Universitetet i Bergen) ;
Johansson, Stefan (Haukeland universitetssykehus) ;
Lundervold, Astri J. (Universitetet i Bergen. Senter for nevropsykiatrisk forskning) ;
Haavik, Jan (Universitetet i Bergen) ;
Zayats, Tetyana (Universitetet i Bergen. Senter for nevropsykiatrisk forskning)
Aggressiveness is a behavioral trait that has the potential to be harmful to individuals and society. With an estimated heritability of about 40%, genetics is important in its development. We performed an exploratory genome-wide association (GWA) analysis of childhood aggressiveness in attention deficit hyperactivity disorder (ADHD) to gain insight into the underlying biological processes associated with this trait. [...]
2016 - 10.1002/ajmg.b.32434
American journal of medical genetics, Vol. 171, issue 5 (July 2016) , p. 733-747
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