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8 p, 801.4 KB |
Epigenetic clocks in relapse after a first episode of schizophrenia
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Segura, Àlex González (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Prohens, Llucia (Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)) ;
Mezquida, Gisela (Centro de Investigación Biomédica en Red de Salud Mental) ;
Amoretti, Silvia (Centro de Investigación Biomédica en Red de Salud Mental) ;
Bioque, Miquel (Universitat de Barcelona) ;
Ribeiro, María (Instituto de Investigación Sanitaria de Navarra) ;
Gurriarán-Bas, Xaquin (Hospital General Universitario Gregorio Marañón) ;
Rementería, Lide (Instituto de Investigación Sanitaria Bioaraba) ;
Bergé Baquero, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid) ;
Roldán, Alejandra (Institut d'Investigació Biomèdica Sant Pau) ;
Pomarol-Clotet, Edith (FIDMAG Germanes Hospitalàries Research Foundation) ;
Ibáñez, Angela (Universidad de Alcalá) ;
Usall, Judith (Institut de Recerca Sant Joan de Déu) ;
García-Portilla, Maria Paz (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)) ;
Cuesta, Manuel J. (Instituto de Investigación Sanitaria de Navarra) ;
Parellada, Mara (Hospital General Universitario Gregorio Marañón) ;
González-Pinto, Ana (Instituto de Investigación Sanitaria Bioaraba) ;
Berrocoso, Esther (Hospital Universitario Puerta del Mar) ;
Bernardo, Miquel (Universitat de Barcelona) ;
Mas, Sergi (Centro de Investigación Biomédica en Red de Salud Mental) ;
González-Díaz, Jairo (Hospital Clínic i Provincial de Barcelona) ;
Arbelo, Néstor (Hospital Clínic i Provincial de Barcelona) ;
González-Peñas, Jairo (Hospital General Universitario Gregorio Marañón) ;
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón) ;
Diestre, Alba (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Selma Gonzalez, Judit (Institut d'Investigació Biomèdica Sant Pau) ;
Zorrilla, Iñaki (Instituto de Investigación Sanitaria Bioaraba) ;
López, Purificación (Instituto de Investigación Sanitaria Bioaraba) ;
Trabsa, Amira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Monserrat, Clara (Parc de Salut MAR de Barcelona) ;
Sanchez-Pastor, Luis (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Nuñez-Doyle, Aggie (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Fatjó-Vilas, Mar (Universitat de Barcelona) ;
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation) ;
Butjosa, Anna (Institut de Recerca Sant Joan de Déu) ;
Pardo, Marta (Institut de Recerca Sant Joan de Déu) ;
López-Ilundain, Jose M. (Instituto de Investigación Sanitaria de Navarra) ;
Sánchez Torres, Ana M. (Instituto de Investigación Sanitaria de Navarra) ;
Saiz-Ruiz, Jerónimo (Hospital Universitario Ramón y Cajal) ;
Ochoa-Mangado, Enriqueta (Hospital Universitario Ramón y Cajal) ;
Rlevero, Olga (Universidad de Valencia) ;
De-la-Cámara, Concepción (Universidad de Zaragoza) ;
Echevarría, Rafael Segarra (Universidad del País Vasco) ;
González-Blanco, Leticia (Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)) ;
Universitat Autònoma de Barcelona
The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. [...]
2022 -  10.1038/s41537-022-00268-2
Schizophrenia, Vol. 8 Núm. 1 (december 2022) , p. 61
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19 p, 7.4 MB |
Exportin 1-mediated nuclear/cytoplasmic trafficking controls drug sensitivity of classical Hodgkin's lymphoma
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Caillot, Mélody (Normandie Université) ;
Miloudi, Hadjer (Normandie Université) ;
Taly, Antoine (IPSL Research University) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos, Juliana C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribeiro, Marcelo L. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Maitre, Elsa (CHU Côte de Nacre) ;
Saule, Simon (Université Paris-Sud) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jardin, Fabrice (Centre de lutte contre le cancer Henri Becquerel) ;
Sola, Brigitte (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Miloudi, Hadjer (Normandie Université)
Exportin 1 (XPO1) is the main nuclear export receptor that controls the subcellular trafficking and the functions of major regulatory proteins. XPO1 is overexpressed in various cancers and small inhibitors of nuclear export (SINEs) have been developed to inhibit XPO1. [...]
2023 - 10.1002/1878-0261.13386
Molecular Oncology, Vol. 17 Núm. 12 (december 2023) , p. 2546-2564
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29 p, 401.7 KB |
Epigenetic targets in B- and T-cell lymphomas : latest developments
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Ribeiro, Marcelo L. (Sao Francisco University Medical School) ;
Sánchez Vinces, Salvador (Sao Francisco University Medical School) ;
Mondragón, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Non-Hodgkin's lymphomas (NHLs) comprise a diverse group of diseases, either of mature B-cell or of T-cell derivation, characterized by heterogeneous molecular features and clinical manifestations. While most of the patients are responsive to standard chemotherapy, immunotherapy, radiation and/or stem cell transplantation, relapsed and/or refractory cases still have a dismal outcome. [...]
2023 - 10.1177/20406207231173485
Therapeutic Advances in Hematology, Vol. 14 (1-12 2023)
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27 p, 3.9 MB |
The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks
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Pereira, Quélita Cristina (Sao Francisco University Medical School, Brazil) ;
dos Santos, Tanila Wood (Sao Francisco University Medical School, Brazil) ;
Fortunato, Isabela Monique (Sao Francisco University Medical School, Brazil) ;
Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. [...]
2023 - 10.3390/ijms24065508
International journal of molecular sciences, Vol. 24 Núm. 6 (march 2023)
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5.
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35 p, 2.4 MB |
Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World
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Labbé, Frédéric (University of Notre Dame) ;
Abdeladhim, Maha (National Institutes of Health (United States of America)) ;
Abrudan, Jenica (Medical College of Wisconsin) ;
Araki, Alejandra Saori (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Araujo, Ricardo N. (Universidade Federal de Minas Gerais) ;
Arensburger, Peter (California State Polytechnic University) ;
Benoit, Joshua B. (University of Cincinnati) ;
Brazil, Reginaldo Pecanha (Instituto Oswaldo Cruz (Brazil)) ;
Bruno, Rafaela V. (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Bueno da Silva Rivas, Gustavo (Texas A&M University) ;
Carvalho de Abreu, Vinicius (Universidade Federal de Minas Gerais) ;
Charamis, Jason (University of Crete) ;
Coutinho-Abreu, Iliano V. (University of California) ;
da Costa-Latgé, Samara G. (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Darby, Alistair (The University of Liverpool) ;
Dillon, Viv M. (The University of Liverpool) ;
Emrich, Scott J. (University of Tennessee) ;
Fernandez-Medina, Daniela (Getulio Vargas Foundation) ;
Figueiredo Gontijo, Nelder (Universidade Federal de Minas Gerais) ;
Flanley, Catherine M. (University of Notre Dame) ;
Gatherer, Derek (Lancaster University) ;
Genta, Fernando A. (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Gesing, Sandra (University of Illinois Chicago) ;
Giraldo-Calderón, Gloria I. (Universidad Icesi) ;
Gomes, Bruno (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Aguiar, Eric Roberto Guimaraes Rocha (Universidade Federal de Minas Gerais) ;
Hamilton, James G. C. (Lancaster University) ;
Hamarsheh, Omar (Al-Quds University) ;
Hawksworth, Mallory (University of Notre Dame) ;
Hendershot, Jacob M. (University of Cincinnati) ;
Hickner, Paul V. (Knipling-Bushland U.S. Livestock Insects Research Laboratory) ;
Imler, Jean-Luc (Université de Strasbourg) ;
Ioannidis, Panagiotis (Foundation for Research and Technology Hellas) ;
Jennings, Emily C. (University of Cincinnati) ;
Kamhawi, Shaden (National Institutes of Health (United States of America)) ;
Karageorgiou, Charikleia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Kennedy, Ryan C. (University of Notre Dame) ;
Krueger, Andreas (Central Bundeswehr Hospital) ;
Latorre-Estivalis, José M. (Universidad de Buenos Aires) ;
Ligoxygakis, Petros (University of Oxford) ;
Meireles-Filho, Antonio Carlos A. (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Minx, Patrick (Donald Danforth Plant Science Center) ;
Miranda, Jose Carlos (Fundação Oswaldo Cruz) ;
Montague, Michael J. (University of Pennsylvania) ;
Nowling, Ronald J. (Milwaukee School of Engineering) ;
Oliveira, Fabiano (National Institutes of Health (United States of America)) ;
Ortigão-Farias, João (Instituto Oswaldo Cruz) ;
Pavan, Marcio G. (Laboratório de Transmissores de Hematozoários (Brazil)) ;
Horacio Pereira, Marcos (Universidade Federal de Minas Gerais) ;
Nobrega Pitaluga, Andre (Instituto Oswaldo Cruz) ;
Proveti Olmo, Roenick (Universidade Federal de Minas Gerais) ;
Ramalho-Ortigao, Marcelo (Uniformed Services University) ;
Ribeiro, José M. C. (National Institutes of Health (United States of America)) ;
Rosendale, Andrew J. (Texas A&M University) ;
Sant'Anna, Mauricio R. V. (Universidade Federal de Minas Gerais) ;
Scherer, Steven E. (Baylor College of Medicine) ;
Secundino, Nágila F. C. (René Rachou Institute-FIOCRUZ) ;
Shoue, Douglas A. (University of Notre Dame) ;
da Silva Moraes, Caroline (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Gesto, João Silveira Moledo (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Souza, Nataly Araujo (Laboratory Interdisciplinar em Vigilancia Entomologia em Diptera e Hemiptera) ;
Syed, Zainulabueddin (University of Kentucky) ;
Tadros, Samuel (University of Notre Dame) ;
Teles-de-Freitas, Rayane (Laboratório de Bioquímica e Fisiologia de Insetos (Brazil)) ;
Telleria, Erich L. (Charles University) ;
Tomlinson, Chad (Washington University School of Medicine) ;
Traub-Csekö, Yara M. (Instituto Oswaldo Cruz) ;
Marques, João Trindade (Texas A&M University) ;
Tu, Zhijian (Virginia Tech) ;
Unger, Maria F. (University of Notre Dame) ;
Valenzuela, Jesus (National Institutes of Health (United States of America)) ;
Ferreira, Flávia V. (Universidade Federal de Minas Gerais) ;
de Oliveira, Karla P. V. (Universidade Federal de Minas Gerais) ;
Vigoder, Felipe M. (Universidade Federal do Rio de Janeiro) ;
Vontas, John (Agricultural University of Athens) ;
Wang, Lihui (Donald Danforth Plant Science Center) ;
Weedall, Gareth D. (Liverpool John Moores University) ;
Zhioua, Elyes (Institut Pasteur de Tunis) ;
Richards, Stephen (Baylor College of Medicine) ;
Warren, Wesley C. (University of Missouri) ;
Waterhouse, Robert M. (University of Lausanne) ;
Dillon, Rod J. (Lancaster University) ;
McDowell, Mary Ann (University of Notre Dame)
Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. [...]
2023 - 10.1371/journal.pntd.0010862
PLoS neglected tropical diseases, Vol. 17, Num. 4 (April 2023) , art. e0010862
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13 p, 2.5 MB |
G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy
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Ribeiro, Marcelo Lima (Sao Francisco University Medical School. Laboratory of Immunopharmacology and Molecular Biology) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Reyes Garau, Diana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Armengol, Marc Antoni (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Serrano, Miranda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Miskin, Hari P. (TG Therapeutics (New York)) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ;
Normant, Emmanuel (TG Therapeutics (New York)) ;
Roué, Gaël (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Immunotherapy-based regimens have considerably improved the survival rate of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decades; however, most disease subtypes remain almost incurable. TG-1801, a bispecific antibody that targets CD47 selectively on CD19+ B-cells, is under clinical evaluation in relapsed/refractory (R/R) B-NHL patients either as a single-agent or in combination with ublituximab, a new generation CD20 antibody. [...]
2023 - 10.3389/fimmu.2023.1130052
Frontiers in immunology, Vol. 14 (April 2023) , art. 1130052
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11 p, 1.4 MB |
Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non-Hodgkin Lymphoma
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Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Reyes, Diana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Armengol, Marc Antoni (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Serrano, Miranda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sedó Mor, Alícia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bech-Serra, Joan-Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Miskin, Hari (TG Therapeutics (Nova York)) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Normant, Emmanuel (TG Therapeutics (Nova York)) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Despite the remarkable activity of BTK inhibitors (BTKi) in relapsed B-cell non-Hodgkin lymphoma (B-NHL), no clinically-relevant biomarker has been associated to these agents so far. The relevance of phosphoproteomic profiling for the early identification of BTKi responders remains underexplored. [...]
2021 - 10.1158/1078-0432.CCR-21-1067
Clinical Cancer Research, Vol. 27 (september 2021) , p. 6591-6601
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1 p, 80.2 KB |
Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with MYD88 L265P mutation
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Dlouhy, Ivan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Armengol, Marc Antoni (Universitat Autònoma de Barcelona) ;
Recasens-Zorzo, Clara (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ribeiro, Marcelo L. (Universidade São Francisco) ;
Pérez-Galán, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ;
López Guillermo, Armando (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
2022 - 10.3324/haematol.2022.281988
Haematologica, Vol. 107 (december 2022) , p. 2990
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17 p, 293.4 KB |
Dependência do smartphone : relação entre procrastinação, saúde geral e valores humanos
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Soares, Ana Karla Silva (Universidade Federal do Mato Grosso do Sul) ;
Barros, Rosângela Cristina Ferreira (Universidade Federal do Mato Grosso do Sul) ;
Rezende, Alessandro Teixeira (Faculdade de Integração do Sertão) ;
Ribeiro, Maria Gabriela Costa (Universidade Federal da Paraíba)
Esta pesquisa objetivou conhecer o papel preditivo dos valores humanos, da procrastinação e da saúde geral com relação à dependência do smartphone. Contou-se com a participação de 390 pessoas da população geral, com idades variando de 18 a 69 anos (M = 27, DP = 8,91), sendo a maioria do sexo feminino (71%). [...]
This research aimed to understand the predictive role of human values, procrastination and general health in relation to smartphone dependence. Participated 390 people from the general, with ages ranging from 18 to 69 years old (M = 27, SD = 8. [...]
2023 - 10.5565/rev/qpsicologia.1834
Quaderns de psicologia, Vol. 25 Núm. 1 (2023) , p. e1834 (Artículos)
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