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Resultats globals: 7 registres trobats en 0.02 segons.
Articles, 7 registres trobats
Articles 7 registres trobats  
1.
27 p, 3.9 MB The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks / Pereira, Quélita Cristina (Sao Francisco University Medical School, Brazil) ; dos Santos, Tanila Wood (Sao Francisco University Medical School, Brazil) ; Fortunato, Isabela Monique (Sao Francisco University Medical School, Brazil) ; Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. [...]
2023 - 10.3390/ijms24065508
International journal of molecular sciences, Vol. 24 Núm. 6 (march 2023)  
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2.
13 p, 2.5 MB G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy / Ribeiro, Marcelo Lima (Sao Francisco University Medical School. Laboratory of Immunopharmacology and Molecular Biology) ; Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Reyes Garau, Diana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Armengol, Marc Antoni (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Serrano, Miranda (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Miskin, Hari P. (TG Therapeutics (New York)) ; Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ; Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ; Normant, Emmanuel (TG Therapeutics (New York)) ; Roué, Gaël (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Immunotherapy-based regimens have considerably improved the survival rate of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decades; however, most disease subtypes remain almost incurable. TG-1801, a bispecific antibody that targets CD47 selectively on CD19+ B-cells, is under clinical evaluation in relapsed/refractory (R/R) B-NHL patients either as a single-agent or in combination with ublituximab, a new generation CD20 antibody. [...]
2023 - 10.3389/fimmu.2023.1130052
Frontiers in immunology, Vol. 14 (April 2023) , art. 1130052  
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3.
11 p, 1.4 MB Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non-Hodgkin Lymphoma / Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Reyes, Diana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Armengol, Marc Antoni (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Serrano, Miranda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Sedó Mor, Alícia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bech-Serra, Joan-Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Miskin, Hari (TG Therapeutics (Nova York)) ; Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Bosch José, Francesc Xavier 1947- (Vall d'Hebron Institut d'Oncologia) ; Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Normant, Emmanuel (TG Therapeutics (Nova York)) ; Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Despite the remarkable activity of BTK inhibitors (BTKi) in relapsed B-cell non-Hodgkin lymphoma (B-NHL), no clinically-relevant biomarker has been associated to these agents so far. The relevance of phosphoproteomic profiling for the early identification of BTKi responders remains underexplored. [...]
2021 - 10.1158/1078-0432.CCR-21-1067
Clinical Cancer Research, Vol. 27 (september 2021) , p. 6591-6601  
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4.
12 p, 989.8 KB The Impact of Polyphenols-Based Diet on the Inflammatory Profile in COVID-19 Elderly and Obese Patients / Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ribeiro, Marcelo Lima (Sao Francisco University) ; Gambero, Alessandra (Pontifical Catholic University of Campinas)
The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 - COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation-related pathology and already kills more than 1. [...]
2020 - 10.3389/fphys.2020.612268
Frontiers in physiology, Vol. 11 (december 2020) , p. 612268  
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5.
22 p, 1.0 MB Regulation of B-Cell Receptor Signaling and Its Therapeutic Relevance in Aggressive B-Cell Lymphomas / Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Marín-Niebla, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The proliferation and survival signals emanating from the B-cell receptor (BCR) constitute a crucial aspect of mature lymphocyte's life. Dysregulated BCR signaling is considered a potent contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B-NHLs). [...]
2022 - 10.3390/cancers14040860
Cancers, Vol. 14 Núm. 4 (2-2 2022) , p. 860  
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6.
13 p, 1.2 MB Effect of polyphenols intake on obesity-induced maternal programming / Fortunato, Isabela Monique (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ; Dos Santos, Tanila Wood (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ; Ferraz, Lucio Fábio Caldas (Post Graduate Program in Health Science. Universidade São Francisco (USF)) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ribeiro, Marcelo Lima (Post Graduate Program in Health Science. Universidade São Francisco (USF))
Excess caloric intake and body fat accumulation lead to obesity, a complex chronic disease that represents a significant public health problem due to the health-related risk factors. There is growing evidence showing that maternal obesity can program the offspring, which influences neonatal phenotype and predispose offspring to metabolic disorders such as obesity. [...]
2021 - 10.3390/nu13072390
Nutrients, Vol. 13 Núm. 7 (july 2021) , p. 2390  
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7.
12 p, 1.1 MB The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders / Leite, Camila Dos Santos (São Francisco University Medical School) ; Bonafé, Gabriel Alves (São Francisco University Medical School) ; Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Martínez, Carlos Augusto (São Francisco University) ; Ortega, Manoela Marques (São Francisco University Medical School) ; Ribeiro, Marcelo Lima (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. [...]
2022 - 10.3390/ijms23084121
International journal of molecular sciences, Vol. 23 Núm. 8 (4-2 2022) , p. 4121  
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