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13 p, 1.8 MB |
Integrated Genomic Analysis of Chromosomal Alterations and Mutations in B-Cell Acute Lymphoblastic Leukemia Reveals Distinct Genetic Profiles at Relapse
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Forero-Castro, Maribel (Escuela de Ciencias Biológicas, Universidad Pedagógica y Tecnológica de Colombia) ;
Montaño, Adrián (IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center) ;
Robledo, Cristina (IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center) ;
García de Coca, Alfonso (Servicio de Hematología, Hospital Clínico de Valladolid) ;
Fuster, José Luis (Servicio de Oncohematología Pediátrica, Hospital Universitario Virgen de la Arrixaca, Murcia) ;
de las Heras, Natalia (Servicio de Hematología, Hospital Virgen Blanca, León) ;
Queizán, José Antonio (Servicio de Hematología, Hospital General de Segovia) ;
Hernández-Sánchez, María (IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center) ;
Corchete-Sánchez, Luis A. (Servicio de Hematología, Hospital Universitario de Salamanca) ;
Martín-Izquierdo, Marta (IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center) ;
Ribera, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, José-María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benito, Rocío (IBSAL, IBMCC, Universidad de Salamanca-CSIC, Cancer Research Center) ;
Hernández-Rivas, Jesús M. (Departamento de Medicina, Universidad de Salamanca)
The clonal basis of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is complex and not fully understood. Next-generation sequencing (NGS), array comparative genomic hybridization (aCGH), and multiplex ligation-dependent probe amplification (MLPA) were carried out in matched diagnosis-relapse samples from 13 BCP-ALL patients to identify patterns of genetic evolution that could account for the phenotypic changes associated with disease relapse. [...]
2020 -  10.3390/diagnostics10070455
Diagnostics, Vol. 10 (july 2020)
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22 p, 4.3 MB |
Cerium oxide nanoparticles protect against oxidant injury and interfere with oxidative mediated kinase signaling in human-derived hepatocytes
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Carvajal, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Perramón, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Casals, Gregori (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Oró, Denise (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Ribera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Morales Ruiz, Manuel (Universitat de Barcelona. Departament de Biomedicina) ;
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences) ;
Casado, Pedro (Queen Mary University of London) ;
Melgar Lesmes, Pedro (Universitat de Barcelona. Departament de Biomedicina) ;
Fernández Varo, Guillermo (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Cutillas, Pedro (Queen Mary University of London) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)
Cerium oxide nanoparticles (CeO NPs) possess powerful antioxidant properties, thus emerging as a potential therapeutic tool in non-alcoholic fatty liver disease (NAFLD) progression, which is characterized by a high presence of reactive oxygen species (ROS). [...]
2019 - 10.3390/ijms20235959
International journal of molecular sciences, Vol. 20, Issue 23 (December 2019) , art. 5959
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12 p, 4.4 MB |
Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats
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Córdoba Jover, Bernat (Hospital Clínic de Barcelona) ;
Arce Cerezo, Altamira (Hospital Clínic de Barcelona) ;
Ribera, Jordi (Hospital Clínic de Barcelona) ;
Pauta, Montse (Hospital Clínic de Barcelona) ;
Oró, Denise (Hospital Clínic de Barcelona) ;
Casals, Gregori (Hospital Clínic de Barcelona) ;
Fernández Varo, Guillermo (Hospital Clínic de Barcelona) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina) ;
Morales Ruiz, Manuel (Universitat de Barcelona. Departament de Biomedicina)
Background and aims: Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of these nanoparticles on hepatic regeneration after liver injury by partial hepatectomy and acetaminophen overdose. [...]
2019 - 10.1186/s12951-019-0544-5
Journal of nanobiotechnology, Vol. 17 (October 2019) , art. 112
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4.
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20 p, 2.6 MB |
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease
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Carvajal, Silvia (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Perramón, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Oró, Denise (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Casals, Eudald (Wuyi University. School of Biotechnology and Health Sciences) ;
Fernández Varo, Guillermo (Universitat de Barcelona. Departament de Biomedicina) ;
Parra-Robert, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
González de la Presa, Bernardino. (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Ribera, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Pastor, Óscar (Hospital Universitario Ramón y Cajal. Servicio de Bioquímica Clínica) ;
Morales Ruiz, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina)
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO₂NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. [...]
2019 - 10.1038/s41598-019-49262-2
Scientific reports, Vol. 9 (2019) , art. 12848
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5.
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21 p, 2.7 MB |
Functionalized cerium oxide nanoparticles mitigate the oxidative stress and proinflammatory activity associated to the portal vein endothelium of cirrhotic rats
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Ribera, Jordi (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ;
Rodríguez Vita, Juan (German Cancer Research Center) ;
Cordoba, Bernat (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ;
Portolés, Irene (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ;
Casals, Gregori (Hospital Clínic de Barcelona. Departament de Bioquímica i Genètica Molecular) ;
Casals, Eudald (Institut Català de Nanociència i Nanotecnologia) ;
Jiménez, Wladimiro (Universitat de Barcelona. Departament de Biomedicina) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Morales Ruiz, Manuel (Universitat de Barcelona. Departament de Biomedicina)
Background and aims- The occurrence of endothelial alterations in the liver and in the splanchnic vasculature of cirrhotic patients and experimental models of liver diseases has been demonstrated. However, the pathological role of the portal vein endothelium in this clinical context is scarcely studied and, therefore, deserves attention. [...]
2019 - 10.1371/journal.pone.0218716
PloS one, Vol. 14, Num. 6 (June 2019) , art. e0218716
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20 p, 1.4 MB |
Genome-wide DNA copy number analysis of acute lymphoblastic leukemia identifies new genetic markers associated with clinical outcome
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Forero Castro, Maribel (Instituto de Investigación Biomédica de Salamanca (IBSAL)) ;
Robledo, Cristina (Instituto de Investigación Biomédica de Salamanca (IBSAL)) ;
Benito, Rocío (Instituto de Investigación Biomédica de Salamanca (IBSAL)) ;
Abáigar, María (Instituto de Investigación Biomédica de Salamanca (IBSAL)) ;
África Martín, Ana (Instituto de Investigación Biomédica de Salamanca (IBSAL)) ;
Arefi, Maryam (Hospital Clínico Universitario de Valladolid) ;
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Heras, Natalia de las (Hospital Universitario de León) ;
Rodríguez, Juan N. (Hospital Juan Ramón Jiménez (Huelva)) ;
Quintero, Jonathan (Hospital Universitario Miguel Servet (Saragossa)) ;
Riesco, Susana (Hospital Universitario de Salamanca) ;
Hermosín, Lourdes (Hospital Universitario de Jerez (Jerez de la Frontera)) ;
Fuente, Ignacio de la (Hospital Universitario Río Hortega (Valladolid)) ;
Recio, Isabel (Hospital Nuestra Señora de Sonsoles (Àvila)) ;
Ribera, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Labrador, Jorge (Hospital Universitario de Burgos) ;
Alonso, José M. (Hospital Río Carrión (Palència)) ;
Olivier, Carmen (Hospital General de Segovia) ;
Sierra, Magdalena (Hospital Virgen de la Concha (Zamora)) ;
Megido, Marta (Hospital del Bierzo (Ponferrada, Lleó)) ;
Corchete Sánchez, Luis A. (Hospital Universitario de Salamanca) ;
Ciudad Pizarro, Juana (Hospital Universitario de Salamanca) ;
García, Juan Luis (Instituto de Estudios de Ciencias de la Salud de Castilla y León (IESCYL)) ;
Ribera, José M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández Rivas, Jesús M. (Instituto de Investigación Biomédica de Salamanca (IBSAL))
Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of additional DNA copy number alterations (CNAs) in children and adults with ALL by whole-genome oligonucleotide array (aCGH) analysis, and to identify their associations with clinical features and outcome. [...]
2016 - 10.1371/journal.pone.0148972
PloS one, Vol. 11 Núm. 2 (February 2016)
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