Rivas-Santisteban, Rafael - Search Results - UAB Digital Repository of Documents

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Articles, 3 records found

Articles	3 records found

18 p, 1.7 MB

The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons / Rivas-Santisteban, Rafael (Universitat de Barcelona. Institut de Neurociències) ; Raïch, Iu (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Aguinaga Andrés, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Franco, Rafael (Universitat de Barcelona. Facultat de Química) ; Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia)
Background: The N-methyl-D-aspartate receptor (NMDAR) is a target in current treatments for Alzheimer's disease (AD). The human prion protein (PrPC) has an important role in the pathophysiology of AD. [...]
2023 - DOI (Digital Object Identifier)

10.3390/cells12020283
Cells, Vol. 12 (january 2023)

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16 p, 2.7 MB

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease / Franco, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Casanovas, Mireia (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Lillo, Alejandro (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer's disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. [...]
2020 - DOI (Digital Object Identifier)

10.3390/cells9051075
Cells, Vol. 9 Núm. 5 (april 2020)

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10 p, 2.0 MB

Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A receptor / Navarro Brugal, Gemma (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ; Gonzalez, Angel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Campanacci, Stefano (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Rivas-Santisteban, Rafael (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Reyes-Resina, Irene (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Casajuana-Martin, Nil (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Cordomí Montoya, Arnau (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Pardo Carrasco, Leonardo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ; Franco, Rafael (Universitat de Barcelona. Facultat de Química)
Biased agonism, the ability of agonists to differentially activate downstream signaling pathways by stabilizing specific receptor conformations, is a key issue for G protein-coupled receptor (GPCR) signaling. [...]
2020 - DOI (Digital Object Identifier)

10.1016/j.csbj.2020.09.028
Computational and Structural Biotechnology Journal, Vol. 18 (september 2020) , p. 2723-2732

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