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18 p, 6.6 MB |
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
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López de Maturana, Evangelina (CIBERONC, Madrid, Spain) ;
Rodríguez, Juan Antonio (Barcelona Institute of Science and Technology (BIST). CNAG-CRG, Centre for Genomic Regulation (CRG)) ;
Alonso, Lola (CIBERONC, Madrid, Spain) ;
Lao, Oscar (Barcelona Institute of Science and Technology (BIST). CNAG-CRG, Centre for Genomic Regulation (CRG)) ;
Molina-Montes, Esther (CIBERONC, Madrid, Spain) ;
Martín-Antoniano, Isabel Adoración (CIBERONC, Madrid, Spain) ;
Gómez-Rubio, Paulina (CIBERONC, Madrid, Spain) ;
Lawlor, Rita (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Carrato, Alfredo (IRYCIS, Alcala University. Department of Oncology, Ramón y Cajal University Hospital) ;
Hidalgo, Manuel (Weill Cornell Medicine) ;
Iglesias, Mar (Parc de Salut Mar (Barcelona, Catalunya)) ;
Molero, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Löhr, Matthias (Gastrocentrum, Karolinska Institutet and University Hospital) ;
Michalski, Christopher (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Perea, José (Fundación Jiménez Díaz. Department of Surgery, Hospital 12 de Octubre, and Department of Surgery and Health Research Institute) ;
O'Rorke, Michael (The University of Iowa. College of Public Health) ;
Barberà, Victor Manuel (Molecular Genetics Laboratory, General University Hospital of Elche, Elche, Spain) ;
Tardón, Adonina (CIBERESP) ;
Farré, Antoni (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz-Bellvís, Luís (Universidad de Salamanca. Department of Surgery, Hospital Universitario de Salamanca - IBSAL) ;
Crnogorac-Jurcevic, Tanja (Queen Mary University of London. Barts Cancer Institute, Centre for Molecular Oncology) ;
Domínguez-Muñoz, Enrique (University Clinical Hospital of Santiago de Compostela. Department of Gastroenterology) ;
Gress, Thomas (University Hospital of Giessen and Marburg. Department of Gastroenterology) ;
Greenhalf, William (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Sharp, Linda (Newcastle University, Institute of Health & Society) ;
Arnes, Luís (Columbia University Medical Center. Department of Systems Biology) ;
Cecchini, Lluís (Parc de Salut Mar (Barcelona, Catalunya)) ;
Balsells, Joaquim (Universitat Autònoma de Barcelona and CIBEREHD) ;
Costello, Eithne (University of Liverpool. Department of Molecular and Clinical Cancer Medicine) ;
Ilzarbe, Lucas (Parc de Salut Mar (Barcelona, Catalunya)) ;
Kleeff, Jörg (Martin-Luther-University Halle-WittenberHalle (Saale). Department of Visceral, Vascular and Endocrine Surgery) ;
Kong, Bo (Technical University of Munich. Department of Surgery) ;
Márquez, Mirari (CIBERONC, Madrid, Spain) ;
Mora Brugués, Josefina (Institut d'Investigació Biomèdica Sant Pau) ;
O'Driscoll, Damian (University College Cork. National Cancer Registry Ireland and HRB Clinical Research Facility) ;
Scarpa, Aldo (University and Hospital Trust of Verona. ARC-Net Centre for Applied Research on Cancer and Department of Pathology and Diagnostics) ;
Ye, Weimin (Karolinska Institutet. Department of Medical Epidemiology and Biostatistics) ;
Yu, Jingru (Karolinska Institutet. Department of Medical Epidemiology and Biostatistics) ;
García-Closas, Montserrat (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Kogevinas, M. (Hospital del Mar (Barcelona)) ;
Rothman, Nathaniel (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Silverman, Debra T (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Albanes, Demetrius (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Arslan, Alan A (New York University School of Medicine. Department of Population Health) ;
Beane-Freeman, Laura (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Bracci, Paige M (University of California. Department of Epidemiology and Biostatistics) ;
Brennan, Paul (International Agency for Research on Cancer (IARC)) ;
Bueno-de-Mesquita, Bas (National Institute for Public Health and the Environment (RIVM). Deparment for Determinants of Chronic Diseases (DCD)) ;
Buring, Julie (Brigham and Women's Hospital. Division of Preventive Medicine) ;
Canzian, Federico (German Cancer Research Center (DKFZ. Genomic Epidemiology Group) ;
Du, Margaret (Memorial Sloan Kettering Cancer Center. Department of Epidemiology and Biostatistics) ;
Gallinger, Steve (Sinai Health System. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute) ;
Gaziano, J Michael (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Goodman, Phyllis J (SWOG Statistical Center, Fred Hutchinson Cancer Research Center) ;
Gunter, Marc (International Agency for Research on Cancer (IARC)) ;
LeMarchand, Loic (University of Hawaii Cancer Center. Cancer Epidemiology Program) ;
Li, Donghui (University of Texas MD Anderson Cancer Center) ;
Neale, Rachael E (QIMR Berghofer Medical Research Institute. Population Health Department) ;
Peters, Ulrika (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Petersen, Gloria M (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Risch, Harvey A (Yale School of Public Health. Department of Chronic Disease Epidemiology) ;
Sánchez, Maria José (Universidad de Granada) ;
Shu, Xiao-Ou (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Thornquist, Mark D (Fred Hutchinson Cancer Research Center. Division of Public Health Sciences) ;
Visvanathan, Kala (Mayo Clinic College of Medicine. Department of Health Sciences Research) ;
Zheng, Wei (Vanderbilt University School of Medicine. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center) ;
Chanock, Stephen J (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Easton, Douglas (University of Cambridge. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care) ;
Wolpin, Brian M (Dana-Farber Cancer Institute. Department Medical Oncology) ;
Stolzenberg-Solomon, Rachael Z (National Institutes of Health. Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Klein, Alison P (Johns Hopkins School of Medicine. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center) ;
Amundadottir, Laufey T (National Institutes of Health. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute) ;
Marti-Renom, Marc A (National Centre for Genomic Analysis (CNAG), Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Universitat Pompeu Fabra (UPF), ICREA, Baldiri Reixac 4, 08028 Barcelona, Spain) ;
Real, Francisco X (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Malats, Núria (CIBERONC, Madrid, Spain)
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4. [...]
2021 -  10.1186/s13073-020-00816-4
Genome Medicine, Vol. 13 (february 2021)
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16 p, 1.4 MB |
Sampling time-dependent artifacts in single-cell genomics studies
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Massoni-Badosa, R. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Iacono, G. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Moutinho, C. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Kulis, M. (Institute of Biomedical Research August Pi i Sunyer (IDIBAPS)) ;
Palau, N. (Rheumatology Research Group. Vall d' Hebron Research Institute) ;
Marchese, D. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, E. (Hematopathology Unit. Hospital Clinic of Barcelona) ;
Rodriguez-Esteban, G. (CNAG-CRG. Centre for Genomic Regulation (CRG). Barcelona Institute of Science and Technology (BIST)) ;
Marsal, S. (Rheumatology Research Group. Vall d' Hebron Research Institute) ;
Aymerich, M. (Hematopathology Unit. Hospital Clinic of Barcelona) ;
Colomer, D. (Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)) ;
Campo, E. (Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)) ;
Julià, A. (Rheumatology Research Group. Vall d' Hebron Research Institute) ;
Martín-Subero, J.I. (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Universitat Autònoma de Barcelona
Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample acquisition can hinder solid, reproducible results, and a systematic benchmarking is required before entering large-scale data production. [...]
2020 - 10.1186/s13059-020-02032-0
Genome biology, Vol. 21 Núm. 1 (november 2020) , p. 112
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Characterisation of sperm piRNAs and their correlation with semen quality traits in swine
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Ablondi, Michela (University of Parma. Department of Veterinary Science (Italy)) ;
Gòdia, Marta (Centre de Recerca en Agrigenòmica) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ;
Clop, Alex (Centre de Recerca en Agrigenòmica) ;
Universitat Autònoma de Barcelona.
Departament de Ciència Animal i dels Aliments
Piwi-interacting RNAs (piRNAs) are a class of non-coding RNAs that are essential in the transcriptional silencing of transposable elements and warrant genome stability in the mammalian germline. In this study, we have identified piRNAs in porcine sperm using male germline and zygote datasets from human, mice, cow and pig, and evaluated the relation between their abundances and sperm quality traits. [...]
2021 - 10.1111/age.13022
Animal Genetics, Vol. 52, Issue 1 (February 2021) , p. 114-120
3 documents
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17 p, 3.2 MB |
SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages
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Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Özkaramehmet, S. (Chromatin and Disease Group. Cancer Epigenetics and Biology Programme (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ;
Van Dijck, E. (Chromatin and Disease Group. Cancer Epigenetics and Biology Programme (PEBC). Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Sirtuins 1 and 2 (SIRT1/2) are two NAD-dependent deacetylases with major roles in inflammation. In addition to deacetylating histones and other proteins, SIRT1/2-mediated regulation is coupled with other epigenetic enzymes. [...]
2020 - 10.1093/nar/gkz1127
Nucleic acids research, Vol. 48 Núm. 2 (24 2020) , p. 665-681
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5 p, 653.8 KB |
Bone marrow clonogenic myeloid progenitors from NPM1-mutated AML patients do not harbor the NPM1 mutation : Implication for the cell-of-origin of NPM1+ AML
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Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-silva, L. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
López-Millán, Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Sevilla, Juan José (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Baroni, Matteo L. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Anguita, E. (Hematology and hemotherapy Department. Hospital Clínico San Carlos. IMDL. IdISSC. Departamento de Medicina. Universidad Complutense de Madrid) ;
Vives Polo, Susana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo Sanchís, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lapillonne, H. (Sorbonne Université. INSERM. Centre de recherche Saint-Antoine CRSA. AP-HP. Hôspital Armand Trousseau. Haematology Laboratory) ;
Varela, I. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The cell-of-origin of NPM1- and FLT3-mutated acute myeloid leukemia (AML) is still a matter of debate. Here, we combined in vitro clonogenic assays with targeted sequencing to gain further insights into the cell-of-origin of NPM1 and FLT3-ITD-mutated AML in diagnostic bone marrow (BM) from nine NPM1+/FLT3-ITD (+/−) AMLs. [...]
2020 - 10.3390/genes11010073
Genes, Vol. 11 Núm. 1 (2020) , p. 73
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28 p, 8.1 MB |
Los pastos de montaña de la Sierra del Aramo (Macizo Central Asturiano) : análisis geoecológico, evolución histórica y dinámica reciente
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Beato Bergua, Salvador (Universidad de Oviedo. Departamento de Geografía) ;
Marino Alfonso, José Luis (Universidad de Oviedo. Departamento de Geografía) ;
Poblete Piedrabuena, Miguel Ángel (Universidad de Oviedo. Departamento de Geografía) ;
Cunill Artigas, Raquel ;
Rodríguez Berdasco, José Manuel
Se analizan los pastizales montanos y subalpinos de la Sierra del Aramo, bastión calcáreo del Macizo Central Asturiano, centrándose no solo en el estado y la composición de las formaciones pratenses, sino también en su origen y devenir histórico, especialmente en la dinámica actual. [...]
S'analitzen les pastures montanes i subalpines de la Serra de l'Aramo, bastió calcari del Massís Central Asturià, centrant-se no només en l'estat i la composició dels prats, sinó també en el seu origen i esdevenir històric, especialment en la dinàmica actual. [...]
This article analyzes the montane and subalpine grasslands of the Sierra del Aramo, a limestone bastion of the Asturian Central Massif. The study focuses not only on the state and composition of the pasture formations, but also on their origin and historical evolution, especially in the current dynamics. [...]
Les prairies montagnardes et subalpines de la Sierra del Aramo, bastion calcaire du Massif Central Asturien, sont analysées en se focalisant non seulement sur l'état et la composition des formations prariales, mais aussi sur leur origine et leur évolution historique, en particulier dans la dynamique actuelle. [...]
2021 - 10.5565/rev/dag.654
Documents d'anàlisi geogràfica, Vol. 67 Núm. 1 (2021) , p. 5-32 (Articles)
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