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23 p, 2.1 MB |
Next-Generation Sequencing for Confronting Virus Pandemics
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Quer, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Colomer-Castell, Sergi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Campos, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrés, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Piñana, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Sánchez, Alejandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, Damir (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ibáñez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pumarola Suñé, Tomàs (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rodriguez-Frias, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Antón, Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Tabernero, David (Hospital Universitari Vall d'Hebron)
Virus pandemics have happened, are happening and will happen again. In recent decades, the rate of zoonotic viral spillover into humans has accelerated, mirroring the expansion of our global footprint and travel network, including the expansion of viral vectors and the destruction of natural spaces, bringing humans closer to wild animals. [...]
2022 -  10.3390/v14030600
Viruses, Vol. 14 (march 2022)
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18 p, 6.4 MB |
Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients
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Toscano-Guerra, Emily (Hospital Universitari Vall d'Hebron) ;
Martínez Gallo, Mónica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Arrese-Muñoz, Iria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Giné Vilalta, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz-Troyano, Noelia (Hospital Universitari Vall d'Hebron) ;
Gabriel-Medina, Pablo (Hospital Universitari Vall d'Hebron) ;
Riveiro-Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Labrador Horrillo, Moises (Hospital Universitari Vall d'Hebron) ;
Martínez-Valle, Fernando (Hospital Universitari Vall d'Hebron) ;
Montalvá, Adrián Sánchez (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández-González, Manuel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Borrell, Ricardo Pujol (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Rodríguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron) ;
Thomson, Timothy M. (Plataforma Temática Interdisciplinar Salud Global (Madrid)) ;
Paciucci, Rosanna (Hospital Universitari Vall d'Hebron. Institut de Recerca)
SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities such as obesity, diabetes, and cardiovascular disease. [...]
2022 - 10.1186/s12916-022-02345-w
BMC Medicine, Vol. 20 (march 2022)
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18 p, 2.7 MB |
Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy
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Llorens-Revull, Meritxell (Universitat Autònoma de Barcelona) ;
Costafreda, Maria Isabel (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Rico, Angie (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Guerrero-Murillo, Mercedes (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soria, Maria Eugenia (Universidad Autónoma de Madrid) ;
Píriz-Ruzo, Sofía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vargas-Accarino, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gabriel-Medina, Pablo (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro-Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Perales, Celia (Universidad Autónoma de Madrid) ;
Quer, Josep (Universitat Autònoma de Barcelona) ;
Sauleda, Silvia (Banc de Sang i Teixits (Barcelona, Catalunya)) ;
Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron) ;
Bes, Marta (Banc de Sang i Teixits (Barcelona, Catalunya))
HCV CD4+ and CD8+ specific T cells responses are functionally impaired during chronic hepatitis C infection. DAAs therapies eradicate HCV infection in more than 95% of treated patients. However, the impact of HCV elimination on immune responses remain controversial. [...]
2021 - 10.1371/journal.pone.0254243
PloS one, Vol. 16 (july 2021)
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13 p, 1.5 MB |
Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1 : Conservation and Variability
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Pacin-Ruiz, Beatriz (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-García, Selene (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Najarro, Adrián (Hospital Universitari Vall d'Hebron) ;
Aldama, Unai (Hospital Universitari Vall d'Hebron) ;
Palom, Adriana (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Galán, Anna (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Aseguinolaza, Gloria (Univerdad de Pamplona) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The hepatitis delta virus (HDV) genome has an autocatalytic region called the ribozyme, which is essential for viral replication. The aim of this study was to use next-generation sequencing (NGS) to analyze the ribozyme quasispecies (QS) in order to study its evolution and identify highly conserved regions potentially suitable for a gene-silencing strategy. [...]
2022 - 10.3390/v14020215
Viruses, Vol. 14 (january 2022)
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13 p, 844.8 KB |
Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency
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Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Núñez, Alexa (Universitat Autònoma de Barcelona) ;
Esquinas, Cristina (Universitat Autònoma de Barcelona) ;
Torres-Durán, María (Complejo Universitario Hospital de Vigo) ;
Rodriguez Hermosa, Juan Luis (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Calle Rubio, Myriam (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Tubio-Pérez, Ramón (Pneumology Department, University Hospital Complex of Vigo, Instituto de Investigación Biomédica Galicia Sur, 36213 Vigo, Spain; (M.T.-D.); (R.T.-P.)) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Frías, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Rodríguez, Esther (Hospital Universitari Vall d'Hebron) ;
Genescà, J (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. [...]
2021 - 10.3390/jcm10081724
Journal of clinical medicine, Vol. 10 (april 2021)
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15 p, 703.1 KB |
Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
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Rodriguez-Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Juan I. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ortega, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Domingo, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cubero, María Dolores (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Camós Anguila, Sílvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Carles (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jardí, Rosendo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schaper, Melanie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Homs, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guardia, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. [...]
2012 - 10.1371/journal.pone.0037874
PloS one, Vol. 7 (may 2012)
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13 p, 974.8 KB |
Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing : Correlation between Natural Evolution and On-Treatment Evolution
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Homs, Maria (Hospital Universitari Vall d'Hebron) ;
Caballero, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto, Leonardo (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To evaluate HBV quasispecies (QA) complexity in the preCore/Core regions in relation to HBeAg status, and explore QA changes under natural evolution and nucleoside analogue (NUC) treatment. Ultra-deep pyrosequencing of HBV preCore/Core regions in 30 sequential samples (baseline [diagnosis], treatment-free, and treatment-nonresponse) from 10 retrospectively selected patients grouped according to HBeAg status over time: HBeAg+ (N = 4), HBeAg- (N = 2), and fluctuating HBeAg (transient seroreversion/seroconversion pattern) (N = 4). [...]
2014 - 10.1371/journal.pone.0112306
PloS one, Vol. 9 (november 2014)
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14 p, 618.6 KB |
Evidence of an Exponential Decay Pattern of the Hepatitis Delta Virus Evolution Rate and Fluctuations in Quasispecies Complexity in Long-Term Studies of Chronic Delta Infection
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Homs, Maria (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Frias, Francisco (Hospital Universitari Vall d'Hebron) ;
Gregori, Josep (Roche Diagnostics SL (Sant Cugat del Vallès, Barcelona)) ;
Ruiz, Alicia (Hospital Universitari Vall d'Hebron) ;
Reimundo, Pilar (Hospital Universitari Vall d'Hebron) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Barakat, Salma (National Centre for Gastrointestinal and Liver disease, Khartoum, Sudan) ;
Quer, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro-Barciela, Mar (Hospital Universitari Vall d'Hebron) ;
Roggendorf, Michael (Technische Universität München/Helmholtz Zentrum München) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Chronic HDV infection can cause a severe form of viral hepatitis for which there is no specific treatment. Characterization of the hepatitis B or C viral quasispecies has provided insight into treatment failure and disease recurrence following liver transplantation, has proven useful to understand hepatitis B e antigen seroconversion, and has helped to predict whether hepatitis C infection will resolve or become chronic. [...]
2016 - 10.1371/journal.pone.0158557
PloS one, Vol. 11 (june 2016)
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15 p, 3.3 MB |
Pipeline for specific subtype amplification and drug resistance detection in hepatitis C virus
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Soria, María Eugenia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gregori, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia-Cehic, Damir (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Ávila, Ana Isabel (Centro de Biología Molecular "Severo Ochoa") ;
Beach, Nathan M. (Centro de Biología Molecular "Severo Ochoa") ;
Domingo, Esteban (Centro de Biología Molecular "Severo Ochoa") ;
Rodríguez-Frías, Francisco (Universitat Autònoma de Barcelona) ;
Buti, Maria (Universitat Autònoma de Barcelona) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona) ;
Esteban Mur, Juan Ignacio (Universitat Autònoma de Barcelona) ;
Quer, Josep (Universitat Autònoma de Barcelona) ;
Perales Viejo, Celia (Centro de Biología Molecular "Severo Ochoa")
Despite the high sustained virological response rates achieved with current directly-acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 5-10% of treated patients do not respond to current antiviral therapies, and basal resistance to DAAs is increasingly detected among treatment-naïve infected individuals. [...]
2018 - 10.1186/s12879-018-3356-6
BMC Infectious diseases, Vol. 18 (september 2018)
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