Resultados globales: 8 registros encontrados en 0.02 segundos.
Artículos, Encontrados 6 registros
Documentos de investigación, Encontrados 2 registros
Artículos Encontrados 6 registros  
1.
13 p, 1.5 MB Impaired Phagocytosis in Dendritic Cells From Pediatric Patients With Type 1 Diabetes Does Not Hamper Their Tolerogenic Potential / Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Murillo, Marta (Hospital Universitari Germans Trias i Pujol) ; Villalba Felipe, Adrián (Hospital Universitari Germans Trias i Pujol) ; Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Bel, Joan (Hospital Universitari Germans Trias i Pujol) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) are crucial as immune response orchestrators. In fact, they contribute to maintaining tolerance to self-antigens, but they can also prompt an immunogenic response against them, leading to autoimmunity. [...]
2019 - 10.3389/fimmu.2019.02811
Frontiers in immunology, Vol. 10 (November 2019) , art. 2811  
2.
12 p, 2.5 MB Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Perna Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242  
3.
17 p, 2.4 MB Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry / Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol) ; Pujol Autonell, Irma (Institut Germans Trias i Pujol) ; Brianso, Ferran (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Perna Barrull, David (Institut Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ; Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ; Sanchez, Alex (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ; Aguilera, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Vazquez, Federico (Hospital Universitari Germans Trias i Pujol. Servei d'Endocrinologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Maspoch Comamala, Daniel (Institució Catalana de Recerca i Estudis Avançats) ; Vives-Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. [...]
2018 - 10.3389/fimmu.2018.00253
Frontiers in immunology, Vol. 9 (Feb. 2018) , art. 253  
4.
10 p, 841.0 KB How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes : a review / Vives-Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is a metabolic disease that results from the autoimmune attack against insulin-producing β-cells in the pancreatic islets of Langerhans. Currently, there is no treatment to restore endogenous insulin secretion in patients with autoimmune diabetes. [...]
2015 - 10.1007/s10495-015-1090-8
Apoptosis, Vol. 20 (january 2015) , p. 263-272  
5.
22 p, 1.1 MB Type 1 diabetes prevention in NOD mice by targeting DPPIV/CD26 is associated with changes in CD8+T effector memory subset / Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Carrascal, Jorge (Institut Germans Trias i Pujol) ; Colobrán Oriol, Roger (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Teniente Serra, Aina (Institut Germans Trias i Pujol) ; Fernández Sanmartin, Marco Antonio (Institut Germans Trias i Pujol) ; Miñarro Alonso, Antoni (Universitat de Barcelona. Departament d'Estadística) ; Ruiz de Villa, María del Carmen (Universitat de Barcelona. Departament d'Estadística) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona. Departament de Medicina
CD26 is a T cell activation marker consisting in a type II transmembrane glycoprotein with dipeptidyl peptidase IV (DPPIV) activity in its extracellular domain. It has been described that DPPIV inhibition delays the onset of type 1 diabetes and reverses the disease in non-obese diabetic (NOD) mice. [...]
2015 - 10.1371/journal.pone.0142186
PloS one, Vol. 10, Issue 11 (Novembre 2015) , p. e0142186  
6.
19 p, 1.2 MB Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes / Pujol Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Serracant Prat, Arnau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Ampudia, Rosa Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Rodriguez Fernandez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Sànchez, Àlex (Sànchez Pla) (Universitat de Barcelona. Departament d'Estadística) ; Izquierdo Castro, Cristina (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Stratmann, Thomas (Universitat de Barcelona. Departament de Fisiologia i Immunologia) ; Puig Domingo, Manuel Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Verdaguer, Joan (Universitat de Lleida. Departament de Medicina Experimental) ; Vives Pi, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona
INTRODUCTION: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. [...]
2015 - 10.1371/journal.pone.0127057
PloS one, Vol. 19, Issue 6 (June 2015) , p. e0127057  

Documentos de investigación Encontrados 2 registros  
1.
280 p, 7.9 MB Phosphatidylserine-rich liposomes to tackle autoimmunity: route to translationality= / Rodríguez Fernández, Silvia, autor. ; Vives Pi, Marta, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Les malalties autoimmunitàries estan causades per defectes en la tolerància immunològica, i afecten a gairebé un 10% de la població. Darrerament, diverses intervencions mèdiques han convertit aquestes malalties en cròniques, però el seu diagnòstic encara comporta morbiditat i mortalitat elevades. [...]
Autoimmune diseases are caused by defective immunological tolerance, and reportedly affect up to 10% of the global population. In the last years, current medical interventions have transformed these disorders into chronic and manageable, but they still entail high rates of morbidity and mortality. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
2.
1 p, 4.9 MB A study in grey : effects of cocaine and nicotine on the organism in the novel / Rodríguez Fernández, Silvia ; Vila Calsina, Elisabet, dir. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2014
Grau en Ciències Biomèdiques [832]  

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