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8 p, 830.0 KB Design of an enantioselective artificial metallo-hydratase enzyme containing an unnatural metal-binding amino acid / Drienovská, Ivana (Stratingh Institute for Chemistry) ; Alonso-Cotchico, Lur (Universitat Autònoma de Barcelona. Departament de Química) ; Vidossich, Pietro (Universitat Autònoma de Barcelona. Departament de Química) ; Lledós, Agustí (Lledós i Falcó) (Universitat Autònoma de Barcelona. Departament de Química) ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ; Roelfes, Gerard (Stratingh Institute for Chemistry)
Starting from biochemical knowledge followed by computational design, an artificial metallo-hydratase comprising an unnatural metal binding amino acid was created. The design of artificial metalloenzymes is a challenging, yet ultimately highly rewarding objective because of the potential for accessing new-to-nature reactions. [...]
2017 - 10.1039/c7sc03477f
Chemical science, Vol. 8 (Oct. 2017) , p. 7228-7235  

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