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1.
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16 p, 12.4 MB |
H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells
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Testa, Erika. (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Nardozi, Daniela (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Antinozzi, Cristina (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Faieta, Monica (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Di Cecca, Stefano (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Caggiano, Cinzia (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Fukuda, Tomoyuki (Niigata University Graduate School of Medical and Dental Sciences. Department of Cellular Physiology) ;
Bonanno, Elena (Università degli Studi di Roma "Tor Vergata". Unità di Anatomia patologica) ;
Zhenkun, Lou (Mayo Clinic. Department of Oncology.) ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Di Giacomo, Monica (European Molecular Biology Laboratory) ;
Barchi, Marco (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione)
In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. [...]
2018 -  10.1242/jcs.214411
Journal of Cell Science, Vol. 131, issue 6 (2018) , p. jcs214411
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2.
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14 p, 6.4 MB |
ATR is required to complete meiotic recombination in mice
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Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rojas, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fuentes-Lazaro, Judit (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas.) ;
Garcia-Caldés, Montserrat (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature Communications, Vol. 9 (2018) , art. 2622
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3.
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12 p, 7.0 MB |
ATR is a multifunctional regulator of male mouse meiosis
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Widger, Alexander (The Francis Crick Institute) ;
Mahadevaiah, Shantha K. (Francis Crick Institute) ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Elinati, Elias (The Francis Crick Institute) ;
Zohren, Jasmin (The Francis Crick Institute) ;
Hirota, Takayuki (The Francis Crick Institute) ;
Pacheco Piñol, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Stanzione, Marcello (TU Dresden. Faculty of Medicine) ;
Ojarikre, Obah (The Francis Crick Institute) ;
Maciulyte, Valdone (The Francis Crick Institute) ;
De Rooij, Dirk G. (University of Amsterdam. Center for Reproductive Medicine) ;
Tóth, Attila (TU Dresden. Faculty of Medicine) ;
Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Turner, James M.A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature Communications, Vol. 9 (2018) , art. 2621
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4.
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13 p, 6.6 MB |
Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
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Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ;
Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ;
Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ;
Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature Communications, Vol. 9 (2018) , art. 3961
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5.
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19 p, 1001.5 KB |
The ATM signaling network in development and disease
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Stracker, Travis H. (Institut de Recerca Biomèdica) ;
Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Knobel, Philip A. (Institut de Recerca Biomèdica) ;
Marjanović, Marko (Institut de Recerca Biomèdica) ;
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the appropriate cellular programs to maintain genome integrity. This includes the coordination of cell cycle checkpoints, transcription, translation, DNA repair, metabolism, and cell fate decisions, such as apoptosis or senescence (Jackson and Bartek, 2009). [...]
2013 - 10.3389/fgene.2013.00037
Frontiers in genetics, Vol. 4 (March 2013) , art. 37
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6.
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31 p, 4.4 MB |
The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility
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Gomez Hernández, Laura (Centro de Investigación del Cáncer) ;
Felipe Medina, Natalia (Centro de Investigación del Cáncer) ;
Bejarano Condezo, Yazmine (Centro de Investigación del Cáncer) ;
Garcia Valiente, Rodrigo (Centro de Investigación del Cáncer) ;
Ramos, Isabel (Centro de Investigación del Cáncer) ;
Suja, José Ángel (Universidad Autónoma de Madrid. Unidad de Biologia Celular) ;
Barbero, José Luis (Centro de Investigaciones Biológicas (Madrid)) ;
Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez Martin, Manuel. (Universidad de Salamanca. Departamento de Medicina) ;
De Rooij, Dirk G. (Utrecht University. Departent of Biology) ;
Llano, Elena (Departamento de Fisiologia y Farmacologia. Universidad de Salamanca) ;
Martín Pendas, Alberto (Centro de Investigación del Cáncer)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [...]
2019 - 10.1371/journal.pgen.1008316
PLoS Genetics, Vol. 15, issue 8 (August 2019) , e1008316
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7.
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15 p, 565.4 KB |
A novel high-throughput in vivo molecular screen for shade avoidance mutants identifies a novel phyA mutation
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Wang, Xuewen (Royal Holloway University of London. School of Biological Sciences) ;
Roig-Villanova, Irma (Centre de Recerca en Agrigenòmica) ;
Khan, Safina (Royal Holloway University of London. School of Biological Sciences) ;
Shanahan, Hugh (Royal Holloway University of London. Department of Computer Science) ;
Quail, Peter H. (UC Berkeley. Department of Plant and Microbial Biology) ;
Martínez-García, Jaime F. (Centre de Recerca en Agrigenòmica) ;
Devlin, Paul F. (Royal Holloway University of London. School of Biological Sciences)
The shade avoidance syndrome (SAS) allows plants to anticipate and avoid shading by neighbouring plants by initiating an elongation growth response. The phytochrome photoreceptors are able to detect a reduction in the red:far red ratio in incident light, the result of selective absorption of red and blue wavelengths by proximal vegetation. [...]
2011 - 10.1093/jxb/err062
Journal of experimental botany, Vol. 62, Issue 8 (May 2011) , p. 2973-2987
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8.
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Photoreceptor Activity Contributes to Contrasting Responses to Shade in Cardamine and Arabidopsis Seedlings
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Molina-Contreras, Maria José (Centre de Recerca en Agrigenòmica) ;
Paulišić, Sandi (Centre de Recerca en Agrigenòmica) ;
Then, Christiane (Centre de Recerca en Agrigenòmica) ;
Moreno Romero, Jordi (Centre de Recerca en Agrigenòmica) ;
Pastor Andreu, Pedro (Centre de Recerca en Agrigenòmica) ;
Morelli, Luca (Centre de Recerca en Agrigenòmica) ;
Roig-Villanova, Irma (Centre de Recerca en Agrigenòmica) ;
Jenkins, Huw (University of Oxford) ;
Hallab, Asis (Max Planck Institute) ;
Gan, Xiangchao (Max Planck Institute) ;
Gómez-Cadenas, Aurelio (Universitat Jaume I) ;
Tsiantis, Miltos (Max Planck Institute) ;
Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica) ;
Martínez-García, Jaime F. (Centre de Recerca en Agrigenòmica)
Plants have evolved two major ways to deal with nearby vegetation or shade: avoidance and tolerance. Moreover, some plants respond to shade in different ways; for example, Arabidopsis thaliana undergoes an avoidance response to shade produced by vegetation, but its close relative Cardamine hirsuta tolerates shade. [...]
2019 - 10.1105/tpc.19.00275
The Plant Cell, Vol. 31 (Nov. 2019) , p. 2649-2663
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9.
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10.
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9 p, 3.0 MB |
DRACULA2 is a dynamic nucleoporin with a role in regulating the shade avoidance syndrome in Arabidopsis
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Gallemí Rovira, Marçal (Centre de Recerca en Agrigenòmica) ;
Galstyan, Anahit (Centre de Recerca en Agrigenòmica) ;
Paulišić, Sandi (Centre de Recerca en Agrigenòmica) ;
Then, Christiane (Centre de Recerca en Agrigenòmica) ;
Ferrández-Ayela, Almudena (Universidad Miguel Hernández. Instituto de Bioingeniería) ;
Lorenzo-Orts, Laura (Centre de Recerca en Agrigenòmica) ;
Roig-Villanova, Irma (Centre de Recerca en Agrigenòmica) ;
Wang,Xuewen (University of London. Royal Holloway. School of Biological Sciences) ;
Micol, Jose Luis (Universidad Miguel Hernández. Instituto de Bioingeniería) ;
Ponce, Maria Rosa (Universidad Miguel Hernández. Instituto de Bioingeniería) ;
Devlin, Paul F. (University of London. Royal Holloway. School of Biological Sciences) ;
Martínez-García, Jaime F. (Centre de Recerca en Agrigenòmica)
When plants grow in close proximity basic resources such as light can become limiting. Under such conditions plants respond to anticipate and/or adapt to the light shortage, a process known as the shade avoidance syndrome (SAS). [...]
2016 - 10.1242/dev.130211
Development, Vol. 143, issue 9 (May 2016) , p. 1623-1631
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