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14 p, 2.0 MB |
p53 Controls Meiotic Prophase Progression and Crossover Formation
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Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
López-Panadés, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roig, Ignasi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Meiosis initiates with the formation of double strand breaks (DSBs) throughout the genome. To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (DDR) pathway ATM-CHK2-p53 can detect the persistence of unrepaired DBSs and activate the recombination-dependent arrest at the pachytene stage. [...]
2022 - 10.3390/ijms23179818
International journal of molecular sciences, Vol. 23, Issue 17 (September 2022) , p. 9818
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3.
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21 p, 3.4 MB |
The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice
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Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huang, Yan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Guillot-Ferriols, Maria Teresa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Roda, Mònica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Guixé, Anna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roig, Ignasi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Mammalian oogonia proliferate without completing cytokinesis, forming cysts. Within these, oocytes differentiate and initiate meiosis, promoting double-strand break (DSBs) formation, which are repaired by homologous recombination (HR) causing the pairing and synapsis of the homologs. [...]
2020 - 10.1371/journal.pgen.1009067
PLoS Genetics, Vol. 16 (November 2020)
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4.
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16 p, 12.4 MB |
H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells
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Testa, Erika. (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Nardozi, Daniela (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Antinozzi, Cristina (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Faieta, Monica (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Di Cecca, Stefano (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Caggiano, Cinzia (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione) ;
Fukuda, Tomoyuki (Niigata University Graduate School of Medical and Dental Sciences. Department of Cellular Physiology) ;
Bonanno, Elena (Università degli Studi di Roma "Tor Vergata". Unità di Anatomia patologica) ;
Zhenkun, Lou (Mayo Clinic. Department of Oncology.) ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Di Giacomo, Monica (European Molecular Biology Laboratory) ;
Barchi, Marco (Università degli Studi di Roma "Tor Vergata". Dipartimento di Biomedicina e Prevenzione)
In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. [...]
2018 - 10.1242/jcs.214411
Journal of Cell Science, Vol. 131, issue 6 (2018) , p. jcs214411
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14 p, 6.4 MB |
ATR is required to complete meiotic recombination in mice
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Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Rojas, Cristina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Fuentes Lazaro, Judit (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas) ;
Garcia-Caldés, Montserrat (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622
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12 p, 7.0 MB |
ATR is a multifunctional regulator of male mouse meiosis
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Widger, Alexander (The Francis Crick Institute) ;
Mahadevaiah, Shantha K. (Francis Crick Institute) ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Elinati, Elias (The Francis Crick Institute) ;
Zohren, Jasmin (The Francis Crick Institute) ;
Hirota, Takayuki (The Francis Crick Institute) ;
Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maldonado Linares, Andros (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Stanzione, Marcello (TU Dresden. Faculty of Medicine) ;
Ojarikre, Obah (The Francis Crick Institute) ;
Maciulyte, Valdone (The Francis Crick Institute) ;
De Rooij, Dirk G.. (University of Amsterdam. Center for Reproductive Medicine) ;
Tóth, Attila (TU Dresden. Faculty of Medicine) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Turner, James M. A. (Francis Crick Institute)
Meiotic cells undergo genetic exchange between homologs through programmed DNA double-strand break (DSB) formation, recombination and synapsis. In mice, the DNA damage-regulated phosphatidylinositol-3-kinase-like kinase (PIKK) ATM regulates all of these processes. [...]
2018 - 10.1038/s41467-018-04850-0
Nature communications, Vol. 9 (2018) , art. 2621
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7.
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24 p, 25.7 MB |
p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes
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Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martínez Marchal, Ana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Castillo Ècija, Helena (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845
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13 p, 6.6 MB |
Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
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Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ;
Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ;
Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961
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19 p, 1001.5 KB |
The ATM signaling network in development and disease
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Stracker, Travis H. (Institut de Recerca Biomèdica de Lleida) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Knobel, Philip A. (Institut de Recerca Biomèdica) ;
Marjanović, Marko (Institut de Recerca Biomèdica) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the appropriate cellular programs to maintain genome integrity. This includes the coordination of cell cycle checkpoints, transcription, translation, DNA repair, metabolism, and cell fate decisions, such as apoptosis or senescence (Jackson and Bartek, 2009). [...]
2013 - 10.3389/fgene.2013.00037
Frontiers in genetics, Vol. 4 (March 2013) , art. 37
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27 p, 21.8 MB |
The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes
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Pacheco, Sarai (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Marcet-Ortega, Marina (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Lange, Julian (Memorial Sloan Kettering Cancer Center) ;
Jasin, Maria (Memorial Sloan Kettering Cancer Center) ;
Keeney, Scott (Memorial Sloan Kettering Cancer Center) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017
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