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11 p, 912.1 KB Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing / Corominas Galbany, Jordi (Radboud University Medical Center) ; Klein, Marieke (Radboud University Medical Center) ; Zayats, Tetyana (University of Bergen) ; Rivero, Olga (University of Würzburg) ; Ziegler, Georg C. (University of Würzburg) ; Pauper, Marc (Radboud University Medical Center) ; Neveling, Kornelia (Radboud University Medical Center) ; Poelmans, Geert (Radboud University Medical Center) ; Jansch, Charline (University of Würzburg) ; Svirin, Evgeniy (I.M. Sechenov First Moscow State Medical University) ; Geissler, Julia (University Hospital of Würzburg) ; Weber, Heike (University Hospital of Frankfurt (Alemanya)) ; Reif, Andreas (University Hospital of Frankfurt (Alemanya)) ; Arias-Vásquez, Alejandro (Radboud University Medical Center) ; Galesloot, Tessel E. (Radboud University Medical Center) ; Kiemeney, Lambertus A. L. M. (Radboud University Medical Center) ; Buitelaar, Jan (Radboud University Medical Center) ; Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Cormand, Bru (Institut de Recerca Sant Joan de Déu) ; Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hveem, Kristian (Norwegian University of Science and Technology) ; Gabrielsen, Maiken Elvestad (Norwegian University of Science and Technology) ; Hoffmann, Per (University of Basel) ; Cichon, Sven (University Hospital Basel (Basilea, Suïssa)) ; Haavik, Jan (Haukeland University Hospital (Bergen, Noruega)) ; Johansson, Stefan E (University of Bergen) ; Jacob, Christian P. (University of Würzburg) ; Romanos, Marcel (University Hospital of Würzburg) ; Franke, Barbara (Radboud University Medical Center) ; Lesch, Klaus-Peter (Maastricht University)
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of underlying genetic risk factors. We hypothesized that combining linkage analysis and whole-exome sequencing (WES) in multi-generation pedigrees with multiple affected individuals can point toward novel ADHD genes. [...]
2018 - 10.1038/s41380-018-0210-6
Molecular psychiatry, Vol. 25 (august 2018) , p. 2047-2057  
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