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1.
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11 p, 21.0 MB |
Analysis of Tumor Microenvironment Changes after Neoadjuvant Chemotherapy with or without Bevacizumab in Advanced Ovarian Cancer (GEICO-89T/MINOVA Study)
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Tavira, Beatriz (Cancer Center Clínica Universidad de Navarra) ;
Iscar, Teresa (Cancer Center Clínica Universidad de Navarra) ;
Manso, Luis (Hospital 12 de Octubre (Madrid)) ;
Santaballa, Ana (Hospital Universitari i Politècnic La Fe (València)) ;
Gil-Martin, Marta (Institut Català d'Oncologia - Hospital Duran i Reynals) ;
García García, Yolanda (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iglesias, Maria (Hospital Son Llátzer) ;
de Juan Ferre, Ana (Hospital Marqués de Valdecilla) ;
Barretina-Ginesta, Maria-Pilar (Institut Català d'Oncologia) ;
Manzano, Aranzazu (Hospital Clínico San Carlos (Madrid)) ;
Gaba, Lydia (Hospital Clínic i Provincial de Barcelona) ;
Rubio, Maria Jesus (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
de Andrea, Carlos E. (Centro de Investigación Biomédica en Red de Cáncer) ;
González-Martín, Antonio (Cancer Center Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
The aim of our study was to elucidate the impact of bevacizumab added to neoadjuvant chemotherapy (NACT) on the tumor immune microenvironment and correlate the changes with the clinical outcome of the patients. [...]
2023 -  10.1158/1078-0432.CCR-23-0771
Clinical Cancer Research, Vol. 30 (august 2023) , p. 176-186
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2.
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17 p, 911.8 KB |
Multicenter Real-World Data of Subsequent Chemotherapy after Progression to PARP Inhibitors in a Maintenance Relapse Setting
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Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gil-Martín, Marta (Hospital Universitari de Bellvitge) ;
Gaba, Lydia (Hospital Clínic i Provincial de Barcelona) ;
Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Taus, Álvaro (Hospital del Mar (Barcelona, Catalunya)) ;
Fina, Claudia (Institut Català d'Oncologia) ;
Masvidal, Maria (Hospital Universitari de Reus) ;
Murata, Paola (Hospital Universitari Arnau de Vilanova) ;
Fernández-Plana, Julen (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Martínez Bueno, Alejandro (Hospital Quirón Dexeux) ;
Pérez, Cristina (Xarxa Sanitària i Social Santa Tecla) ;
García García, Yolanda (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rodriguez, Valerie (Hospital de Tortosa Verge de la Cinta) ;
Cros Costa, Sara (Hospital General de Granollers) ;
Parera, Marta (Hospital Universitari de Vic) ;
Zanui, Montserrat (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Catot, Silvia (Xarxa Assistencial Universitària de Manresa) ;
Pardo, Beatriz (Hospital Universitari de Bellvitge) ;
Plaja, Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barretina-Ginesta, Maria-Pilar (Institut Català d'Oncologia)
Since the irruption of PARPi in the therapeutic armamentarium for ovarian cancer, concerns regarding post-progression treatment outcomes have emerged, owing to known crossed-resistance mechanisms between PARPi and platinum. [...]
2022 - 10.3390/cancers14184414
Cancers, Vol. 14 (september 2022)
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3.
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12 p, 923.8 KB |
Small Cell Carcinoma of the Vagina : First Systematic Review of Case Reports and Proposal of a Management Algorithm
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Capote, Sira (Fundació Hospital de l'Esperit Sant) ;
Domènech, Marta (Institut Català d'Oncologia) ;
Valdivieso, Lorena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tuset, Victoria (Institut Català d'Oncologia) ;
Sanchez, Myriam (Fundació Hospital de l'Esperit Sant) ;
Carballas, Elvira (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teruel, Iris (Institut Català d'Oncologia) ;
Durany Lara, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Moragas, Gloria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina, Carlos (Fundació Hospital de l'Esperit Sant) ;
Lleberia, Judith (Fundació Hospital de l'Esperit Sant) ;
Martínez-Roman, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romeo, Margarita (Institut Català d'Oncologia) ;
Universitat Autònoma de Barcelona
Literature search in PubMed and Scopus was performed using the terms "small cell carcinoma" and "vagina. " English-language case reports of primary SmCCV up to January 2022 were included. Twenty-nine articles describing 44 cases met our inclusion criteria. [...]
2022 - 10.1097/LGT.0000000000000712
Journal of Lower Genital Tract Disease, Vol. 27 (october 2022) , p. 56-67
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4.
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17 p, 1.4 MB |
Immune Response and Effects of COVID-19 Vaccination in Patients with Lung Cancer-COVID Lung Vaccine Study
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Hernandez, Ainhoa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boigues Pons, Marc (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cucurull, Marc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Notario, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pous, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torres, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Benitez, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodriguez, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Moran, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina)
During the SARS-CoV-2 pandemic, lung cancer patients have been considered an especially vulnerable population and have been prioritized for vaccination. However, several aspects (degree of immunity, potential interaction with active anticancer therapy, safety, and tolerability of the vaccines) remained unclear. [...]
2022 - 10.3390/cancers15010137
Cancers, Vol. 15, Num. 1 (January 2022) , art. 137
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5.
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10 p, 3.7 MB |
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
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Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Felip, Eudald (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bernat-Peguera, Adrià (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ezeonwumelu, I.J (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teruel, Iris (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Clotet Sala, Bonaventura (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
SAMHD1 is a deoxynucleotide triphosphate (dNTP) triphosphohydrolase which has been proposed as a putative prognostic factor in haematological cancers and certain solid tumours, although with controversial data. [...]
2023 - 10.3389/fimmu.2023.1112761
Frontiers in immunology, Vol. 14 (february 2023)
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6.
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20 p, 1.9 MB |
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types
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Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-Chamorro, Lucía (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gómez, Maica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Vidal, Edurne (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Romeo, Margarita (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Morán, Teresa (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Layos, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Pérez-Roca, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Pedro Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ballana, Ester (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ample evidence exists connecting dNTP pool dysregulation to cancer and genomic instability. SAMHD1, the unique dNTP triphosphohydrolase described in humans, has been proposed to play a key role in hematological cancers, although its value in advanced solid tumors has not yet been explored. [...]
2022 - 10.20944/preprints202201.0141.v1
Cancers, Vol. 14 Núm. 3 (january 2022)
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7.
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18 p, 288.5 KB |
Translational research opportunities regarding homologous recombination in ovarian cancer
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Romeo, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pardo, Juan Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 - 10.3390/ijms19103249
International journal of molecular sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249
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