Results overview: Found 4 records in 0.02 seconds.
Articles, 4 records found
Articles 4 records found  
1.
11 p, 1.9 MB Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies / Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ; Persyn, Elodie (King's College London) ; Tomppo, Liisa (Department of Neurology, Helsinki University Hospital, Helsinki, Finland) ; Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ; Bakker, Mark K (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ; Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ; Li, Linxin (Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK) ; Bell, Steven (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ; Tozer, Daniel J (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Griessenauer, Christoph J (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ; Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ; Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rundek, Tatjana (Evelyn F McKnight Brain Institute, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA) ; Grewal, Raji P (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ; Lindgren, Arne (Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden) ; Meschia, James F (Department of Neurology, Mayo Clinic, Jacksonville, FL, USA) ; Salomaa, Veikko (Finnish Institute for Health and Welfare (Helsinki, Finlàndia)) ; Havulinna, Aki (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ; Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Mitchell, Braxton D (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ; Kittner, Steven J (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ; Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ; Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ; Strbian, Daniel (Clinical Neurosciences, University of Helsinki, Helsinki, Finland) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ; Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ; Rost, Natalia (Massachusetts General Hospital) ; Lemmens, Robin (VIB Center for Brain & Disease Research, Department of Neurology, University Hospitals Leuven, Leuven, Belgium) ; Rothwell, Peter M (Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK) ; Anderson, Christopher D (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ; Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ; Lewis, Cathryn M (Social, Genetic, and Developmental Psychiatry Centre, King's College London, London, UK) ; Markus, Hugh S (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ; Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361  
2.
10 p, 736.9 KB Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage : a systematic review and meta-analysis of individual patient data / Al-Shahi Salman, Rustam (Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK) ; Frantzias, Joseph (King's College Hospital) ; Lee, Robert J (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK) ; Lyden, Patrick D (Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA) ; Battey, Thomas W K (Massachusetts General Hospital) ; Ayres, Alison M (Massachusetts General Hospital) ; Goldstein, Joshua N (Massachusetts General Hospital) ; Mayer, Stephan A (Department of Neurology, Henry Ford Health System, Detroit, MI, USA) ; Steiner, Thorsten (Heidelberg University Hospital (Alemanya)) ; Wang, Xia (The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia) ; Arima, Hisatomi (The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia) ; Hasegawa, Hitoshi (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Oishi, Makoto (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Godoy, Daniel A (Intensive Care Unit, Hospital Interzonal de Agudos "San Juan Bautista", Catamarca, Argentina) ; Masotti, Luca (Internal Medicine, Santa Maria Nuova Hospital, Florence, Italy) ; Dowlatshahi, Dar (Department of Medicine (Neurology), University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada) ; Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Molina, Carlos A (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jang, Dong-Kyu (Department of Neurosurgery, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea) ; Dávalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Castillo, José (Department of Neurology, University Clinical Hospital of Santiago, Santiago de Compostela, Spain) ; Yao, Xiaoying (Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ; Claassen, Jan (Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA) ; Volbers, Bastian (Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland) ; Kazui, Seiji (Kazui Medical Office, Ikeda, Osaka, Japan) ; Okada, Yasushi (Department of Cerebrovascular Medicine and Neurology, National Hospital Organisation Kyushu Medical Centre, Fukuoka, Japan) ; Fujimoto, Shigeru (Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan) ; Toyoda, Kazunori (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan) ; Li, Qi (Department of Neurology, ThE First Affiliated Hospital of Chongqing Medical University, Chongqing, China) ; Khoury, Jane (University of Cincinnati Medical Centre, Cincinnati, OH, USA) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sabín, José Álvarez (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Prats-Sánchez, Luis (Institut d'Investigació Biomèdica Sant Pau) ; Cai, Chunyan (Centre for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA) ; Kate, Mahesh P (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; McCourt, Rebecca (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; Venkatasubramanian, Chitra (Division of Stroke and Neurocritical Care, Stanford University, Palo Alto, CA, USA) ; Diringer, Michael N (Department of Neurology and Neurological Surgery, Washington University, St Louis, MO, USA) ; Ikeda, Yukio (Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan) ; Worthmann, Hans (Department of Neurology, Hannover Medical School, Hannover, Germany) ; Ziai, Wendy C (Johns Hopkins University School of Medicine, Department of Neurology, Anaesthesia and Critical Care Medicine, Division of Neurocritical Care, Baltimore, MD, USA) ; d'Esterre, Christopher D (Department of Radiology, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada) ; Aviv, Richard I (Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Raab, Peter (Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany) ; Murai, Yasuo (Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan) ; Zazulia, Allyson R (Department of Neurology and Neurological Surgery, Washington University, St Louis, MO, USA) ; Butcher, Kenneth S (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; Seyedsaadat, Seyed Mohammad (Department of Radiology, Mayo Clinic, Rochester, MN, USA) ; Grotta, James C (Memorial Hermann Hospital (Houston, Estats Units d'Amèrica)) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Broderick, Joseph (University of Cincinnati Medical Centre, Cincinnati, OH, USA) ; Yamamoto, Haruko (Center for Advanced Clinical and Translational Sciences, National Cerebral and Cerebrovascular Center, Suita, Osaka, Japan) ; Staykov, Dimitre (Department of Neurology, Hospital of the Brothers of St John, Eisenstadt, Austria) ; Connolly, E Sander (Department of Neurosurgery, Columbia University, College of Physicians and Surgeons, New York, NY, USA) ; Selim, Magdy (Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA) ; Leira, Rogelio (Department of Neurology, University Clinical Hospital of Santiago, Santiago de Compostela, Spain) ; Moon, Byung Hoo (Department of Neurosurgery, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea) ; Demchuk, Andrew M (Department of Clinical Neurosciences and Department of Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada) ; Di Napoli, Mario (Neurological Service, San Camillo de'Lellis General Hospital, Rieti, Italy) ; Fujii, Yukihiko (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Anderson, Craig S (The George Institute for Global Health, China at Peking University Health Science Center, Beijing, China) ; Rosand, Jonathan (Massachusetts General Hospital) ; Universitat Autònoma de Barcelona
Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography. [...]
2018 - 10.1016/S1474-4422(18)30253-9
The Lancet neurology, Vol. 17 (october 2018) , p. 885-894  
3.
13 p, 2.7 MB White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts - The MRI-GENIE study / Schirmer, Markus D. (Massachusetts General Hospital) ; Dalca, Adrian V. (Massachusetts Institute of Technology) ; Sridharan, Ramesh (Massachusetts Institute of Technology) ; Giese, Anne-Katrin (Massachusetts General Hospital) ; Donahue, Kathleen L. (Massachusetts General Hospital) ; Nardin, Marco J. (Massachusetts General Hospital) ; Mocking, Steven J.T. (Massachusetts General Hospital) ; McIntosh, Elissa C. (Massachusetts General Hospital) ; Frid, Petrea (Lund University) ; Wasselius, Johan (Lund University) ; Cole, John W. (University of Maryland School of Medicine) ; Holmegaard, Lukas (University of Gothenburg) ; Jern, Christina (University of Gothenburg) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lemmens, Robin (Leuven Research Institute for Neuroscience and Disease) ; Lindgren, Arne G. (Lund University) ; Meschia, James F. (Mayo Clinic, Florida) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Rundek, Tatjana (Miller School of Medicine) ; Sacco, Ralph L. (Miller School of Medicine) ; Schmidt, Reinhold (Medical University Graz) ; Sharma, Pankaj (Royal Holloway University of London) ; Slowik, Agnieszka (Jagiellonian University Medical College) ; Thijs, Vincent (Florey Institute of Neuroscience and Mental Health) ; Woo, Daniel (University of Cincinnati College of Medicine) ; Vagal, Achala (University of Cincinnati College of Medicine) ; Xu, Huichun (University of Maryland School of Medicine) ; Kittner, Steven J. (University of Maryland School of Medicine) ; McArdle, Patrick F. (University of Maryland School of Medicine) ; Mitchell, Braxton D. (University of Maryland School of Medicine) ; Rosand, Jonathan (Massachusetts General Hospital) ; Worrall, Bradford B. (University of Virginia) ; Wu, Ona (Massachusetts General Hospital) ; Golland, Polina (Massachusetts Institute of Technology) ; Rost, Natalia S. (Massachusetts General Hospital) ; Universitat Autònoma de Barcelona
White matter hyperintensity (WMH) burden is a critically important cerebrovascular phenotype linked to prediction of diagnosis and prognosis of diseases, such as acute ischemic stroke (AIS). However, current approaches to its quantification on clinical MRI often rely on time intensive manual delineation of the disease on T2 fluid attenuated inverse recovery (FLAIR), which hinders high-throughput analyses such as genetic discovery. [...]
2019 - 10.1016/j.nicl.2019.101884
NeuroImage, Vol. 23 (may 2019)  
4.
11 p, 168.8 KB Genetic variants in CETP increase risk of intracerebral hemorrhage / Anderson, Christopher D. (Broad Institute of MIT and Harvard) ; Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Phuah, Chia-Ling (Broad Institute of MIT and Harvard) ; Radmanesh, Farid (Broad Institute of MIT and Harvard) ; Brouwers, H. Bart (Broad Institute of MIT and Harvard) ; Battey, Thomas W. K. (Broad Institute of MIT and Harvard) ; Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ; Peloso, Gina M. (Broad Institute of MIT and Harvard) ; Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ; Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ; Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ; Selim, Magdy (Beth Israel Deaconess Medical Center) ; Meschia, James F. (Mayo Clinic) ; Brown, Devin L. (University of Michigan Health System) ; Worrall, Bradford B. (University of Virginia Health System) ; Silliman, Scott L. (University of Florida College of Medicine) ; Tirschwell, David L. (University of Washington) ; Flaherty, Matthew L. (University of Cincinnati College of Medicine) ; Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ; Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ; Schmidt, Helena (Medical University Graz) ; Hansen, Björn M. (Skåne University Hospital) ; Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ; Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ; Rannikmae, Kristiina (University of Edinburgh) ; Samarasekera, Neshika (University of Edinburgh) ; Salman, Rustam Al-Shahi (University of Edinburgh) ; Sudlow, Catherine L. (University of Edinburgh) ; Deary, Ian J. (University of Edinburgh) ; Morotti, Andrea (Neurology Clinic, University of Brescia) ; Pezzini, Alessandro (Neurology Clinic, University of Brescia) ; Pera, Joanna (Jagiellonian University Medical College) ; Urbanik, Andrzej (Jagiellonian University Medical College) ; Pichler, Alexander (Medical University of Graz) ; Enzinger, Christian (Medical University of Graz) ; Norrving, Bo (Skåne University Hospital) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado Martínez, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Lindgren, Arne (Skåne University Hospital) ; Slowik, Agnieszka (Jagiellonian University Medical College) ; Schmidt, Reinhold (Medical University of Graz) ; Kidwell, Chelsea S. (University of Arizona) ; Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ; Waddy, Salina P. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ; Langefeld, Carl D. (Wake Forest University) ; Abecasis, Goncalo (University of Michigan School of Public Health) ; Willer, Cristen J. (University of Michigan Medical School) ; Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ; Woo, Daniel (University of Cincinnati College of Medicine) ; Rosand, Jonathan (Broad Institute of MIT and Harvard) ; Universitat Autònoma de Barcelona. Departament de Neurologia
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of neurology, Vol. 80 (october 2016) , p. 730-740  

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7 Rosand, J.
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