1.
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13 p, 828.8 KB |
Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions
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Villatoro, Sergi (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-de-las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri-Ramírez, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón-Ibañez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Moya-Horno, Irene (Hospital General de Catalunya) ;
García-Peláez, Beatrtiz (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Malapelle, Umberto (University of Naples Federico II) ;
Balada-Bel, Ariadna (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Campos, Raquel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Remei (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Blasco, Ana (Hospital General Universitari de València) ;
Catalán, María J. (Grup Quirónsalud (Barcelona, Catalunya)) ;
González, Xavier (Hospital General de Catalunya) ;
Troncone, Giancarlo (University of Naples Federico II) ;
Karachaliou, Niki (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations and guide treatment decisions. [...]
2019 - 10.1002/1878-0261.12574
Molecular Oncology, Vol. 13 Núm. 12 (january 2019) , p. 2633-2645
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2.
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11 p, 918.0 KB |
Brief Research Report : Anti-SARS-CoV-2 Immunity in Long Lasting Responders to Cancer Immunotherapy Through mRNA-Based COVID-19 Vaccination
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Sisteré-Oró, Marta (Universitat Pompeu Fabra) ;
Wortmann, Diana D. J. (Universitat Pompeu Fabra) ;
Andrade, Naína (Universitat Pompeu Fabra) ;
Aguilar-Hernández, Andrés (Hospital Quiron-Dexeus Barcelona) ;
Mayo de las Casas, Clara (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Casabal, Florencia Garcia (Hospital Quiron-Dexeus Barcelona) ;
Torres, Susana (Hospital Quiron-Dexeus Barcelona) ;
Bona Salinas, Eduardo (Hospital Quiron-Dexeus Barcelona) ;
Raventos Soler, Laura (Hospital Quiron-Dexeus Barcelona) ;
Arcas, Andrea (Hospital Quiron-Dexeus Barcelona) ;
Esparre, Carlos (Hospital Quiron-Dexeus Barcelona) ;
Garcia, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Valarezo, Joselyn (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Güerri-Fernández, Robert (Hospital del Mar (Barcelona, Catalunya)) ;
Gonzalez-Cao, Maria (Hospital Quiron-Dexeus Barcelona) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Cancer patients (CPs) have been identified as particularly vulnerable to SARS-CoV-2 infection, and therefore are a priority group for receiving COVID-19 vaccination. From the patients with advanced solid tumors, about 20% respond very efficiently to immunotherapy with anti-PD1/PD-L1 antibodies and achieve long lasting cancer responses. [...]
2022 - 10.3389/fimmu.2022.908108
Frontiers in immunology, Vol. 13 (july 2022)
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3.
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17 p, 2.3 MB |
Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection
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D'Ambrosi, Silvia (Amsterdam UMC. University Medical Center) ;
Giannoukakos, Stavros (Centro de Investigación Biomédica de la Universidad de Granada) ;
Antunes-Ferreira, Mafalda (Amsterdam UMC. University Medical Center) ;
Pedraz-Valdunciel, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bracht, Jillian (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Potie, Nicolas (Centro de Investigación Biomédica de la Universidad de Granada) ;
Giménez-Capitán, Ana (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Hackenberg, Michael (Centro de Investigación Biomédica de la Universidad de Granada) ;
Fernandez Hilario, Alberto (Universidad de Granada) ;
Molina-Vila, Miguel Ángel (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Würdinger, Thomas (Amsterdam UMC. University Medical Center) ;
Koppers-Lalic, Danijela (Leiden University) ;
Universitat Autònoma de Barcelona
Despite the diversity of liquid biopsy transcriptomic repertoire, numerous studies often exploit only a single RNA type signature for diagnostic biomarker potential. This frequently results in insufficient sensitivity and specificity necessary to reach diagnostic utility. [...]
2023 - 10.3390/ijms24054881
International journal of molecular sciences, Vol. 24 (march 2023)
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4.
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10 p, 654.4 KB |
Multiplex Detection of Clinically Relevant Mutations in Liquid Biopsies of Cancer Patients Using a Hybridization-Based Platform
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Giménez-Capitán, Ana (Grup Quirónsalud (Barcelona, Catalunya)) ;
Bracht, Jillian (Universitat Autònoma de Barcelona) ;
García Mosquera, Juan José (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
García, Beatriz (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón Ibáñez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-De-Las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Aguilar-Hernández, Andrés (Grup Quirónsalud (Barcelona, Catalunya)) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Johnson, Eric (NanoString Technologies) ;
Huang, Chun-Ying (NanoString Technologies) ;
Gerlach, Jay L. (NanoString Technologies) ;
Warren, Sarah (NanoString Technologies) ;
Beechem, Joseph M. (NanoString Technologies) ;
Teixidó, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel. (Grup Quirónsalud (Barcelona, Catalunya))
BACKGROUND: With the advent of precision oncology, liquid biopsies are quickly gaining acceptance in the clinical setting. However, in some cases, the amount of DNA isolated is insufficient for Next-Generation Sequencing (NGS) analysis. [...]
2021 - 10.1093/clinchem/hvaa248
Clinical Chemistry, Vol. 67 Núm. 3 (january 2021) , p. 554-563
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5.
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18 p, 4.5 MB |
Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin : Increased Cytotoxicity and Impairment of Cell Migration and Invasion
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Manguinhas, Rita (Universidade de Lisboa) ;
Fernandes, Ana S. (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ;
Costa, João G. (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ;
Saraiva, Nuno (Universidade Lusófona de Humanidades e Tecnologias, Lisboa) ;
Camões, Sérgio P. (Universidade de Lisboa) ;
Gil, Nuno (Lung Cancer Unit, Champalimaud Centre for the Unknown, Lisboa) ;
Rosell, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Castro, Matilde (Universidade de Lisboa) ;
Miranda, Joana P. (Universidade de Lisboa) ;
Oliveira, Nuno G. (Universidade de Lisboa)
Elevated expression levels of the apurinic/apyrimidinic endonuclease 1 (APE1) have been correlated with the more aggressive phenotypes and poor prognosis of non-small cell lung cancer (NSCLC). This study aimed to assess the impact of the inhibition of the redox function of APE1 with E3330 either alone or in combination with cisplatin in NSCLC cells. [...]
2020 - 10.3390/antiox9060550
Antioxidants, Vol. 9 (june 2020)
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6.
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12 p, 4.7 MB |
Analysis of extracellular vesicle mRNA derived from plasma using the nCounter platform
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Bracht, Jillian (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Giménez-Capitán, Ana (Quirón Dexeus University Hospital. Pangaea Oncology, Laboratory of Oncology) ;
Huang, Chung-Ying (NanoString Technologies, Seattle, WA USA) ;
Potie, Nicolas (Biotechnology Institute, Centro de Investigacion Biomedica, PTS. Bioinformatics Laboratory) ;
Pedraz-Valdunciel, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Warren, Sarah (NanoString Technologies, Seattle, WA USA) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital. Pangaea Oncology, Laboratory of Oncology)
Extracellular vesicles (EVs) are double-layered phospholipid membrane vesicles that are released by most cells and can mediate intercellular communication through their RNA cargo. In this study, we tested if the NanoString nCounter platform can be used for the analysis of EV-mRNA. [...]
2021 - 10.1038/s41598-021-83132-0
Scientific reports, Vol. 11 (february 2021)
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7.
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11 p, 2.1 MB |
Src-Homology 2 Domain-Containing Phosphatase 2 in Resected EGFR Mutation-Positive Lung Adenocarcinoma
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Ito, Masaoki (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codony-Servat, Jordi (Institut Universitari Dexeus) ;
Giménez-Capitán, Ana (Institut Universitari Dexeus) ;
Serra-Mitjans, Mireia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Pérez-Ochoa, Francisco (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Llige, David (Institut Germans Trias i Pujol) ;
Chaib, Imane (Institut Germans Trias i Pujol) ;
Rami-Porta, Ramon (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Obiols, Carme (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Call, Sergi (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Iglesias, Manuela (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Belda, José (Belda Sanchis) (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Tarroch-Sarasa, Xavier (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Karachaliou, Niki (Institut Universitari Dexeus) ;
Molina-Vila, Miguel Ángel (Institut Universitari Dexeus) ;
Okada, Morihito (Hiroshima University. Department of Surgical Oncology) ;
Rosell, Rafael (Institut Germans Trias i Pujol)
EGFR mutation-positive lung adenocarcinoma (LUAD) displays impaired phosphorylation of ERK and Src-homology 2 domain-containing phosphatase 2 (SHP2) in comparison with EGFR wild-type LUADs. We hypothesize that SHP2 expression could be predictive in patients positive with resected EGFR mutation versus patients with EGFR wild-type LUAD. [...]
2020 - 10.1016/j.jtocrr.2020.100084
JTO Clinical and Research Reports, Vol. 1 Núm. 4 (august 2020)
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8.
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9.
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13 p, 2.2 MB |
Monitoring EGFR -T790M mutation in serum/plasma for prediction of response to third-generation EGFR inhibitors in patients with lung cancer
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Morán, Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Felip, Eudald (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bosch-Barrera, J (Hospital Universitari de Girona Doctor Josep Trueta) ;
de Aguirre, Itziar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mesia, Carles (Institut Català d'Oncologia) ;
Carcereny, Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roa, Diana (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sais, Elia (Hospital Universitari de Girona Doctor Josep Trueta) ;
García García, Yolanda (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Blanco, Remei (Consorci Sanitari de Terrassa. Departament d'Oncologia) ;
Sanchez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villacorta, Claudia Rosa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Queralt, C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Velarde, Jose María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Osimertinib is efficacious in lung cancer patients with epidermal growth factor receptor (EGFR) mutations and acquired resistance (AR) to EGFR tyrosine kinase inhibitors due to EGFR -T790M mutation (T790M). [...]
2018 - 10.18632/oncotarget.25478
Oncotarget, Vol. 9 (june 2018) , p. 27074-27086
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10.
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14 p, 2.2 MB |
Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer
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Aguado, Cristina (Quirón Dexeus University Hospital) ;
Teixidó, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Román, Ruth (Quirón Dexeus University Hospital) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Giménez-Capitán, Ana (Quirón Dexeus University Hospital) ;
Marin, Elba (Hospital Clínic i Provincial de Barcelona) ;
Cabrera, Carlos (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Castillo, Sergi (Hospital General de Granollers) ;
Muñoz, Silvia (Hospital General de Granollers) ;
Arcocha, Ainara (Hospital Clínic i Provincial de Barcelona) ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Aldeguer, Erika (Quirón Dexeus University Hospital) ;
Rodríguez, Sonia (Quirón Dexeus University Hospital) ;
Moya, Irene (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri, Santiago (Quiron Salud Group) ;
Cardona Zorrilla, Andrés Felipe (Clínica del Country) ;
Palmero, Ramon (L'Hospitalet) ;
Sainz, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ;
Mesa-Guzmán, Miguel (Universidad Pública de Navarra) ;
Lozano, Maria D. (Universidad Pública de Navarra) ;
Aguilar-Hernández, Andrés (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Gonzalvo, Elena (Hospital Clínic i Provincial de Barcelona) ;
Leenders, William P. J. (Radboud Institute for Molecular Life Sciences) ;
Rosell, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Montuenga, Luis M. (Universidad Pública de Navarra) ;
Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona)
We studied MET alterations in 474 advanced non-small-cell lung cancer (NSCLC) patients by nCounter, an RNA-based technique. We identified 3% with MET Δex14 mRNA and 3. 5% with very-high MET mRNA expression, a surrogate of MET amplification. [...]
2020 - 10.1002/1878-0261.12861
Molecular Oncology, Vol. 15 (december 2020) , p. 350-363
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