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16 p, 1.6 MB Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse / Manassero, Giusi (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Repetto, Ivan E. (Neuroscience Institute of the Cavalieri-Ottolenghi Foundation (Torí, Itàlia)) ; Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valsecchi, Valeria (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Bonny, Christophe (CHUV-University Hospital. Division of Medical Genetics (Lausanne, Suïssa)) ; Rossi, Ferdinando (University of Turin. Department of Neuroscience (Torí, Itàlia)) ; Vercelli, Alessandro (University of Turin. Department of Neuroscience (Torí, Itàlia))
Background: Current tools for analgesia are often only partially successful, thus investigations of new targets for pain therapy stimulate great interest. Consequent to peripheral nerve injury, c-Jun N-terminal kinase (JNK) activity in cells of the dorsal root ganglia (DRGs) and spinal cord is involved in triggering neuropathic pain. [...]
2012 - 10.1186/1744-8069-8-39
Molecular pain, Vol. 8, N. 39 (May 2012) , p. 1-16
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