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19 p, 2.4 MB |
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano-Sagrera, Gerard (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sitlani, Collen M. (University of Washington) ;
Bone, William P. (University of Pennsylvania) ;
Martín Bórnez, Miguel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voight, Benjamin F. (University of Pennsylvania Perelman School of Medicine) ;
Morrison, Alanna C. ;
Damrauer, Scott M. ;
de Vries, Paul S. ;
Smith, Nicholas L. ;
Sabater-Lleal, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Dehghan, Abbas ;
Heath, Adam S. ;
Reiner, Alex P. ;
Johnson, Andrew ;
Richmond, Anne ;
Peters, Annette ;
van Hylckama Vlieg, Astrid ;
McKnight, Barbara ;
Psaty, Bruce M. ;
Hayward, Caroline ;
Ward-Caviness, Cavin ;
O'Donnell, Cristopher ;
Chasman, Daniel ;
Strachan, David P. ;
Tregouet, David A. ;
Mook-Kanamori, Dennis ;
Gill, Dipender ;
Thibord, Florian ;
Asselbergs, Folkert W. ;
Leebeek, Frank W. G. ;
Rosendaal, Frits R. ;
Davies, Gail ;
Homuth, Georg ;
Temprano, Gerard ;
Campbell, Harry ;
Taylor, Herman A. ;
Bressler, Jan ;
Huffman, Jennifer E. ;
Rotter, Jerome I. ;
Yao, Jie ;
Wilson, James F. ;
Bis, Joshua C. ;
Hahn, Julie M. ;
Desch, Karl C. ;
Wiggins, Kerri L. ;
Raffield, Laura M. ;
Bielak, Lawrence F. ;
Yanek, Lisa R. ;
Kleber, Marcus E. ;
Mueller, Martina ;
Kavousi, Maryam ;
Mangino, Massimo ;
Liu, Melissa ;
Brown, Michael R. ;
Conomos, Matthew P. ;
Jhun, Min-A. ;
Chen, Ming-Huei ;
de Maat, Moniek P. M. ;
Pankratz, Nathan ;
Smith, Nicholas L. ;
Peyser, Patricia A. ;
Elliot, Paul ;
Wei, Peng ;
Wild, Philipp S. ;
Morange, Pierre E. ;
van der Harst, Pim ;
Yang, Qiong ;
Le, Ngoc-Quynh ;
Marioni, Riccardo ;
Li, Ruifang ;
Damrauer, Scott M. ;
Cox, Simon R. ;
Trompet, Stella ;
Felix, Stephan B. ;
Völker, Uwe ;
Tang, Weihong ;
Koenig, Wolfgang ;
Jukema, J. Wouter ;
Guo, Xiuqing ;
Lindstrom, Sara ;
Wang, Lu ;
Smith, Erin N. ;
Gordon, William ;
van Hylckama Vlieg, Astrid ;
de Andrade, Mariza ;
Brody, Jennifer A. ;
Pattee, Jack W. ;
Haessler, Jeffrey ;
Brumpton, Ben M. ;
Suchon, Pierre ;
Chen, Ming-Huei ;
Turman, Constance ;
Germain, Marine ;
Wiggins, Kerri L. ;
MacDonald, James ;
Braekkan, Sigrid K. ;
Armasu, Sebastian M. ;
Pankratz, Nathan ;
Jackson, Rabecca D. ;
Nielsen, Jonas B. ;
Giulianini, Franco ;
Puurunen, Marja K. ;
Ibrahim, Manal ;
Heckbert, Susan R. ;
Bammler, Theo K. ;
Frazer, Kelly A. ;
McCauley, Bryan M. ;
Taylor, Kent ;
Pankow, James S. ;
Reiner, Alexander P. ;
Gabrielsen, Maiken E. ;
Deleuze, Jean-François ;
O'Donnell, Chris J. ;
Kim, Jihye ;
McKnight, Barbara ;
Kraft, Peter ;
Hansen, John-Bjarne ;
Rosendaal, Frits R. ;
Heit, John A. ;
Psaty, Bruce M. ;
Tang, Weihong ;
Kooperberg, Charles ;
Hveem, Kristian ;
Ridker, Paul M. ;
Morange, Pierre-Emmanuel ;
Johnson, Andrew D. ;
Kabrhel, Christopher ;
Trégouët, David-Alexandre ;
Smith, Nicholas L. ;
Malik, Rainer ;
Chauhan, Ganesh ;
Traylor, Matthew ;
Sargurupremraj, Muralidharan ;
Okada, Yukinori ;
Mishra, Aniket ;
Rutten-Jacobs, Loes ;
Giese, Anne-Katrin ;
van der Laan, Sander W. ;
Gretarsdottir, Solveig ;
Anderson, Christopher D. ;
Chong, Michael ;
Adams, Hieab HH. ;
Ago, Tetsuro ;
Almgren, Peter ;
Amouyel, Philippe ;
Ay, Hakan ;
Bartz, Traci M. ;
Benavente, Oscar R. ;
Bevan, Steve ;
Boncoraglio, Giorgio B. ;
Brown, Robert D. ;
Butterworth, Aadam S. ;
Carrera, Caty ;
Carty, Cara L. ;
Chen, Wei-Min ;
Cole, John W. ;
Correa, Adolfo ;
Cotlarciuc, Ioanna ;
Cruchaga, Carlos ;
Danesh, John ;
de Bakker, Paul I. W. ;
DeStefano, Anita L. ;
den Hoed, Marcel ;
Duan, Qing ;
Engelter, Stefan T. ;
Falcone, Guido J. ;
Gottesman, Rebecca F. ;
Grewal, Raji P. ;
Gudnason, Vilmundur ;
Gustafsson, Stefan ;
Haessler, Jeffrey ;
Harris, Tamara B. ;
Hassan, Ahamad ;
Havulinna, Aki S. ;
Heckbert, Susan R. ;
Holliday, Elizabeth G. ;
Howard, George ;
Hsu, Fang-Chi ;
Hyacinth, Hyacinth I. ;
Arfan Ikram, M. ;
Ingelsson, Erik ;
Irvin, Marguerite R. ;
Jian, Xueqiu ;
Jiménez-Conde, Jordi ;
Johnson, Julie A. ;
Jukema, J. Wouter ;
Kanai, Masahiro ;
Keene, Keith L. ;
Kissela, Brett M. ;
Kleindorfer, Dawn O. ;
Kooperberg, Charles ;
Kubo, Michiaki ;
Lange, Leslie A. ;
Langefeld, Carl D. ;
Langenberg, Claudia ;
Launer, Lenore J. ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Leys, Didier ;
Lewis, Cathryn M. ;
Lin, Wei-Yu ;
Lindgren, Arne G. ;
Lorentzen, Erik ;
Magnusson, Patrik K. ;
Maguire, Jane ;
Manichaikul, Ani ;
McArdle, Patrick F. ;
Meschia, James F. ;
Mitchell, Braxton D. ;
Mosley, Thomas H. ;
Nalls, Michael A. ;
Ninomiya, Toshiharu ;
O'Donnell, Martin J. ;
Psaty, Bruce M. ;
Pulit, Sara L. ;
Rannikmäe, Kristiina ;
Reiner, Alexander P. ;
Rexrode, Kathryn M. ;
Rice, Kenneth ;
Rich, Stephen S. ;
Ridker, Paul M. ;
Rost, Natalia S. ;
Rothwell, Peter M. ;
Rotter, Jerome I. ;
Rundek, Tatjana ;
Sacco, Ralph L. ;
Sakaue, Saori ;
Sale, Michele M. ;
Salomaa, Veikko ;
Sapkota, Bishwa R. ;
Schmidt, Reinhold ;
Schmidt, Carsten O. ;
Schminke, Ulf ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Sudlow, Cathie L. M. ;
Tanislav, Christian ;
Tatlisumak, Turgut ;
Taylor, Kent D. ;
Thijs, Vincent N. S. ;
Thorleifsson, Gudmar ;
Thorsteinsdottir, Unnur ;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Amin, Najaf ;
Aparicio, Hugo S. ;
Arnett, Donna K. ;
Attia, John ;
Beiser, Alexa S. ;
Berr, Claudine ;
Buring, Julie E. ;
Bustamante, Mariana ;
Caso, Valeria ;
Cheng, Yu-Ching ;
Hoan Choi, Seung ;
Chowhan, Ayesha ;
Cullell, Natalia ;
Dartigues, Jean-François ;
Delavaran, Hossein ;
Delgado, Pilar ;
Dörr, Marcus ;
Engström, Gunnar ;
Ford, Ian ;
Gurpreet, Wander S. ;
Hamsten, Anders ;
Heitsch, Laura ;
Hozawa, Aatsushi ;
Ibanez, Laura ;
Ilinca, Andrea ;
Ingelsson, Martin ;
Iwasaki, Motoki ;
Jackson, Rebecca D. ;
Jood, Katarina ;
Jousilahti, Pekka ;
Kaffashian, Sara ;
Kalra, Lalit ;
Kamouchi, Masahiro ;
Kitazono, Takanari ;
Kjartansson, Olafur ;
Kloss, Manja ;
Koudstaal, Peter J. ;
Krupinski, Jerzy ;
Labovitz, Daniel L. ;
Laurie, Cathy C. ;
Levi, Christhoper R. ;
Li, Linxin ;
Lind, Lars ;
Lindgren, Cecilia M. ;
Lioutas, Vasileios ;
Mei Liu, Yong ;
Lopez, Oscar L. ;
Makoto, Hirata ;
Martinez-Majander, Nicolas ;
Matsuda, Koichi ;
Minegishi, Naoko ;
Montaner, Joan ;
Morris, Andrew P. ;
Muiño, Elena ;
Müller-Nurasyid, Martina ;
Norrving, Bo ;
Ogishima, Soichi ;
Parati, Eugenio A. ;
Reddy Peddareddygari, Leema ;
Pedersen, Nancy L. ;
Pera, Joanna ;
Perola, Markus ;
Pezzini, Alessandro ;
Pileggi, Silvana ;
Rabionet, Raquel ;
Riba-Llena, Iolanda ;
Ribasés, Marta ;
Romero, Jose R. ;
Roquer, Jaume ;
Rudd, Anthony G. ;
Sarin, Antti-Pekka ;
Sarju, Ralhan ;
Sarnowski, Chloe ;
Sasaki, Makoto ;
Satizabal, Claudia L. ;
Satoh, Mamoru ;
Sattar, Naveed ;
Sawada, Norie ;
Sibolt, Gerli ;
Sigurdsson, Ásgeir ;
Smith, Albert ;
Sobue, Kenji ;
Soriano-Tárraga, Carolina ;
Stanne, Tara ;
Colin Stine, O. ;
Stott, David J. ;
Strauch, Konstantin ;
Takai, Takako ;
Tanaka, Hideo ;
Tanno, Kozo ;
Teumer, Alexander ;
Tomppo, Liisa ;
Torres-Aguila, Nuria P. ;
Touze, Emmanuel ;
Tsugane, Shoichiro ;
Uitterlinden, Aandre G. ;
Valdimarsson, Einar M. ;
van der Lee, Sven J. ;
Völzke, Henry ;
Wakai, Kenji ;
Weir, David ;
Williams, Stephen R. ;
Wolfe, Charles D.A. ;
Wong, Quenna ;
Xu, Huichun ;
Yamaji, Taiki ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W.T. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, BradfordB. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joana M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin ;
Universitat Autònoma de Barcelona
Multi-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes. [...]
2022 -  10.1111/jth.15698
Journal of Thrombosis and Haemostasis, Vol. 20 Núm. 6 (01 2022) , p. 1331-1349
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17 p, 693.0 KB |
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
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Jaworek, Thomas ;
Xu, Huichun ;
Gaynor, Brady ;
Cole, John W. ;
Rannikmae, Kristiina ;
Stanne, Tara M. ;
Tomppo, Liisa ;
Abedi, Vida ;
Amouyel, Philippe ;
Armstrong, Nicole D. ;
Attia, John ;
Bell, Steven ;
Benavente, Oscar R. ;
Boncoraglio, Giorgio B. ;
Butterworth, Adam ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Chen, Zhengming ;
Chong, Michael ;
Cruchaga, Carlos ;
Cushman, Mary ;
Danesh, John ;
Debette, Stéphanie ;
Duggan, David J. ;
Durda, Jon Peter ;
Engstrom, Gunnar ;
Enzinger, Chris ;
Faul, Jessica D. ;
Fecteau, Natalie S. ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Gieger, Christian ;
Giese, Anne-Katrin ;
Grewal, Raji P. ;
Grittner, Ulrike ;
Havulinna, Aki S. ;
Heitsch, Laura ;
Hochberg, Marc C. ;
Holliday, Elizabeth ;
Hu, Jie ;
Ilinca, Andreea ;
Irvin, Marguerite R. ;
Jackson, Rebecca D. ;
Jacob, Mina A. ;
Rabionet, Raquel ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Johnson, Julie A. ;
Kamatani, Yoichiro ;
Kardia, Sharon L.R. ;
Koido, Masaru ;
Kubo, Michiaki ;
Lange, Leslie ;
Lee, Jin-Moo ;
Lemmens, Robin ;
Levi, Christopher R. ;
Li, Jiang ;
Li, Liming ;
Lin, Kuang ;
Lopez, Haley ;
Luke, Sothear ;
Maguire, Jane ;
McArdle, Patrick F. ;
McDonough, Caitrin W. ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Metso, Tiina ;
Müller-Nurasyid, Martina ;
Dichgans, Martin ;
O'Donnell, Martin ;
Peddareddygari, Leema R. ;
Pera, Joanna ;
Perry, James A. ;
Peters, Annette ;
Putaala, Jukka ;
Ray, Debashree ;
Rexrode, Kathryn ;
Ribasés Haro, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosand, Jonathan ;
Rothwell, Peter M. ;
Rundek, Tatjana ;
Ryan, Kathleen A. ;
Sacco, Ralph L. ;
Salomaa, Veikko ;
Sánchez-Mora, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Schmidt, Reinhold ;
Sharma, Pankaj ;
Slowik, Agnieszka ;
Smith, Jennifer A. ;
Smith, Nicholas L. ;
Wassertheil-Smoller, Sylvia ;
Söderholm, Martin ;
Stine, O. Colin ;
Strbian, Daniel ;
Sudlow, Cathie L.M. ;
Tatlisumak, Turgut ;
Terao, Chikashi ;
Thijs, Vincent ;
Torres-Aguila, Nuria P.. ;
Trégouët, David-Alexandre ;
Tuladhar, Anil M. ;
Veldink, Jan ;
Walters, Robin G. ;
Weir, David R. ;
Woo, Daniel ;
Worrall, Bradford B. ;
Hong, Charles C. ;
Ross, Owen A. ;
Zand, Ramin ;
de Leeuw, Frank-Erik ;
Lindgren, Arne G. ;
Paré, Guillaume ;
Anderson, Christopher D. ;
Markus, Hugh S. ;
Jern, Christina ;
Malik, Rainer ;
Dichgans, Martin ;
Mitchell, Braxton D. ;
Kittner, Steven J. ;
Universitat Autònoma de Barcelona
Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic variants to risk of early-onset ischemic stroke. [...]
2022 - 10.1212/WNL.0000000000201006
Neurology, Vol. 99 (october 2022) , p. e1738-e1754
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11 p, 1.9 MB |
Genetic basis of lacunar stroke : a pooled analysis of individual patient data and genome-wide association studies
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Traylor, Matthew (Clinical Pharmacology and The Barts Heart Centre and NIHR Barts Biomedical Research Centre, Barts Health NHS Trust, William Harvey Research Institute, Queen Mary University of London, London, UK) ;
Persyn, Elodie (King's College London) ;
Tomppo, Liisa (Helsinki University Hospital (Finlàndia)) ;
Klasson, Sofia (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Abedi, Vida (Department of Molecular and Functional Genomics, Weis Center for Research, Geisinger Health System, Danville, PA, USA) ;
Bakker, Mark K. (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Torres, Nuria (Institut d'Investigació Biomèdica Sant Pau) ;
Li, Linxin (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Bell, Steven (Unversity of Cambridge) ;
Rutten-Jacobs, Loes (Product Development Personalized Health Care, F Hoffmann-La Roche, Basel, Switzerland) ;
Tozer, Daniel J. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Griessenauer, Christoph J. (Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria) ;
Zhang, Yanfei (Genomic Medicine Institute, Geisinger Health System, Danville, PA, USA) ;
Pedersen, Annie (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Sharma, Pankaj (Institute of Cardiovascular Research, Royal Holloway University of London, London, UK) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami. Miller School of Medicine) ;
Grewal, Raji P. (Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ, USA) ;
Lindgren, Arne (Lund University (Lund, Suècia)) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Salomaa, Veikko (Finnish Institute for Health and Welfare (Helsinki, Finlàndia)) ;
Havulinna, Aki S (Institute for Molecular Medicine Finland (FIMM HiLIFE), Helsinki, Finland) ;
Kourkoulis, Christina (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Crawford, Katherine (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Marini, Sandro (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Mitchell, Braxton D. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Kittner, Steven J. (Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA) ;
Rosand, Jonathan (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Dichgans, Martin (Munich Cluster for Systems Neurology (SyNergy), Munich, Germany) ;
Jern, Christina (Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zand, Ramin (Neuroscience Institute, Geisinger Health System, Danville, PA, USA) ;
Ruigrok, Ynte (Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands) ;
Rost, Natalia (Massachusetts General Hospital (Boston)) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Rothwell, Peter M. (University of Oxford. Nuffield Department of Clinical Neuroscience) ;
Anderson, Christopher D. (Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA) ;
Wardlaw, Joanna (Centre for Clinical Brain Sciences, UK Dementia Research Institute and Row Fogo Centre for Research into the Ageing Brain, University of Edinburgh, Edinburgh, UK) ;
Lewis, Cathryn M. (King's College London. Social, Genetic, and Developmental Psychiatry Centre) ;
Markus, Hugh S. (Clinical Neurosciences, University of Cambridge, Cambridge, UK) ;
Universitat Autònoma de Barcelona
The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. We sought to identify novel associations and provide mechanistic insights into the disease. [...]
2021 - 10.1016/S1474-4422(21)00031-4
The Lancet neurology, Vol. 20 (may 2021) , p. 351-361
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13 p, 818.2 KB |
Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack : a pooled analysis of individual patient data from cohort studies
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Wilson, Duncan (New Zealand Brain Research Institute, Christchurch, New Zealand) ;
Ambler, Gareth (Department of Statistical Science, University College London, London, UK) ;
Lee, Keon-Joo (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University School of Medicine, Seongnam, South Korea) ;
Lim, Jae-Sung (Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea) ;
Shiozawa, Masayuki (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan) ;
Koga, Masatoshi (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan) ;
Li, Linxin (University of Oxford. Centre for Prevention of Stroke and Dementia) ;
Lovelock, Caroline (University of Oxford. Centre for Prevention of Stroke and Dementia) ;
Chabriat, Hugues (Département Hospitalo-Universtaire NeuroVasc, University Paris Diderot, and INSERM U1141, Paris, France) ;
Hennerici, Michael (Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany) ;
Wong, Yuen Kwun (Division of Neurology, Department of Medicine, The University of Hong Kong, Hong Kong) ;
Mak, Henry Ka Fung (Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong) ;
Prats-Sánchez, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Domeño, Alejandro (Institut d'Investigació Biomèdica Sant Pau) ;
Inamura, Shigeru (Department of Neurosurgery, Kushiro City General Hospital, Kushiro, Japan) ;
Yoshifuji, Kazuhisa (Department of Neurosurgery, Kushiro City General Hospital, Kushiro, Japan) ;
Arsava, Ethem Murat (Harvard Medical School) ;
Horstmann, Solveig (Heidelberg University Hospital (Alemanya)) ;
Purrucker, Jan (Heidelberg University Hospital (Alemanya)) ;
Lam, Bonnie Yin Ka (Therese Pei Fong Chow Research Centre for Prevention of Dementia) ;
Wong, Adrian (Therese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong) ;
Kim, Young Dae (Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea) ;
Song, Tae-Jin (Department of Neurology, Ewha Womans University College of Medicine, Seoul, South Korea) ;
Schrooten, Maarten (Center for Brain and Disease Research, VIB, Leuven, Belgium) ;
Lemmens, Robin (Experimental Neurology and Leuven Institute for Neuroscience and Disease, Katholieke Universiteit Leuven, University of Leuven, Laboratory of Neurobiology, Leuven, Belgium) ;
Eppinger, Sebastian (Department of Neurology, Medical University of Graz, Graz, Austria) ;
Gattringer, Thomas (Department of Neurology, Medical University of Graz, Graz, Austria) ;
Uysal, Ender (Department of Neurology, Demiroglu Bilim University, Istanbul, Turkey) ;
Tanriverdi, Zeynep (Department of Neurology, Demiroglu Bilim University, Istanbul, Turkey) ;
Bornstein, Natan M. (Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel) ;
Assayag, Einor Ben (Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel) ;
Hallevi, Hen (Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel) ;
Tanaka, Jun (Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Saga, Japan) ;
Hara, Hideo (Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Saga, Japan) ;
Coutts, Shelagh B. (Calgary Stroke Program, Department of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada) ;
Hert, Lisa (Department of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Basel, Switzerland) ;
Polymeris, Alexandros (Department of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Basel, Switzerland) ;
Seiffge, David J. (Bern University Hospital) ;
Lyrer, Philippe (Department of Neurology and Stroke Centre, University Hospital Basel and University of Basel, Basel, Switzerland) ;
Algra, Ale (Department of Neurology and Neurosurgery, Utrecht Stroke Centre, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands) ;
Kappelle, Jaap (Department of Neurology and Neurosurgery, Utrecht Stroke Centre, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands) ;
Al-Shahi Salman, Rustam (Centre for Clinical Brain Sciences, School of Clinical Sciences, University of Edinburgh, Edinburgh, UK) ;
Jäger, Hans Rolf (Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK) ;
Lip, Gregory Y H. (Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark) ;
Mattle, Heinrich P. (Bern University Hospital) ;
Panos, Leonidas D. (Bern University Hospital) ;
Mas, Jean-Louis (Department of Neurology, Sainte-Anne Hospital, Paris Descartes University, INSERM U1266, Paris, France) ;
Legrand, Laurence (Sainte-Anne Hospital, Paris Descartes University, INSERM U1266, Paris, France) ;
Karayiannis, Christopher (Peninsula Clinical School, Peninsula Health, Monash University, Melbourne, VIC, Australia) ;
Phan, Thanh (Stroke and Ageing Research Group, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia) ;
Gunkel, Sarah (Department of Neurology, University Hospital of Würzburg, Josef-Schneider Strasse 11, Würzburg, Germany) ;
Christ, Nicolas (Department of Neurology, University Hospital of Würzburg, Josef-Schneider Strasse 11, Würzburg, Germany) ;
Abrigo, Jill (Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong) ;
Leung, Thomas (Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong) ;
Chu, Winnie (Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong) ;
Chappell, Francesca (UK Dementia Institute at the University of Edinburgh, School of Clinical Sciences, University of Edinburgh, Edinburgh, UK) ;
Makin, Stephen (Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK) ;
Hayden, Derek (The Neurovascular Research Unit and Health Research Board, Stroke Clinical Trials Network Ireland, University College Dublin, Dublin, Ireland) ;
Williams, David J. (Beaumont Hospital (Dublín, Irlanda)) ;
Kooi, M. Eline (Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands) ;
van Dam-Nolen, Dianne H. K. (University Medical Centre (Rotterdam, Netherlands)) ;
Barbato, Carmen (University College London Hospitals NHS Trust) ;
Browning, Simone (University College London Hospitals NHS Trust) ;
Wiegertjes, Kim (Radboud University Medical Centre. Department of Neurology) ;
Tuladhar, Anil M. (Radboud University Medical Center (Nijmegen, Països Baixos)) ;
Maaijwee, Noortje (Lucerne State Hospital (Suïssa)) ;
Guevarra, Christine (National Neuroscience Institute (Singapore)) ;
Yatawara, Chathuri (National Neuroscience Institute (Singapore)) ;
Mendyk, Anne-Marie (University of Lille) ;
Delmaire, Christine (University of Lille) ;
Köhler, Sebastian (Maastricht University. Department of Psychiatry and Neuropsychology) ;
van Oostenbrugge, Robert (Maastricht University Medical Centre) ;
Zhou, Ying (Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China) ;
Xu, Chao (Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China) ;
Hilal, Saima (National University Health System (Singapore)) ;
Gyanwali, Bibek (National University Health System (Singapore)) ;
Chen, Christopher (National University Health System (Singapore)) ;
Lou, Min (Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China) ;
Staals, Julie (Department of Neurology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre, Maastricht, Netherlands) ;
Bordet, Régis (University of Lille, Inserm, CHU de Lille, Degenerative and vascular cognitive disorders U1171, Lille, France) ;
Kandiah, Nagaendran (Department of Neurology, National Neuroscience Institute, Singapore, Singapore) ;
de Leeuw, Frank-Erik (Radboud University Medical Centre. Department of Neurology) ;
Simister, Robert (University College London Hospitals NHS Trust) ;
van der Lugt, Aad (Department of Radiology and Nuclear Medicine, Erasmus Medical Centre, University Medical Centre, Rotterdam, Netherlands) ;
Kelly, Peter J. (The Neurovascular Research Unit and Health Research Board, Stroke Clinical Trials Network Ireland, University College Dublin, Dublin, Ireland) ;
Wardlaw, Joanna (University of Edinburgh. UK Dementia Institute) ;
Soo, Yannie (Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong) ;
Fluri, Felix (University Hospital of Würzburg (Würzburg, Alemanya)) ;
Srikanth, Velandai (Peninsula Clinical School, Peninsula Health, Monash University, Melbourne, VIC, Australia) ;
Calvet, David (Department of Neurology, Sainte-Anne Hospital, Paris Descartes University, INSERM U1266, Paris, France) ;
Jung, Simon (Bern University Hospital) ;
Kwa, Vincent I H. (Department of Neurology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands) ;
Engelter, Stefan T. (Neurology and Neurorehabilitation, University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland) ;
Peters, Nils (Neurology and Neurorehabilitation, University Department of Geriatric Medicine Felix Platter, University of Basel, Basel, Switzerland) ;
Smith, Eric E. (Calgary Stroke Program, Department of Clinical Neurosciences, Radiology and Community Health Sciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada) ;
Yakushiji, Yusuke (Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Nabeshima, Saga, Japan) ;
Orken, Dilek Necioglu (Department of Neurology, Demiroglu Bilim University, Istanbul, Turkey) ;
Fazekas, Franz (Department of Neurology, Medical University of Graz, Graz, Austria) ;
Thijs, Vincent (University Hospitals Leuven (Bèlgica)) ;
Heo, Ji Hoe (Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea) ;
Mok, Vincent (Therese Pei Fong Chow Research Centre for Prevention of Dementia, Gerald Choa Neuroscience Centre, Lui Che Woo Institute of Innovative Medicine, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong) ;
Veltkamp, Roland (Heidelberg University Hospital (Alemanya)) ;
Ay, Hakan (Harvard Medical School) ;
Imaizumi, Toshio (Department of Neurosurgery, Kushiro City General Hospital, Kushiro, Japan) ;
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ;
Lau, Kui Kai (Division of Neurology, Department of Medicine, The University of Hong Kong, Hong Kong) ;
Jouvent, Eric (Département Hospitalo-Universtaire NeuroVasc, University Paris Diderot, and INSERM U1141, Paris, France) ;
Rothwell, Peter M. (University of Oxford. Centre for Prevention of Stroke and Dementia) ;
Toyoda, Kazunori (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan) ;
Bae, Hee-Joon (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University School of Medicine, Seongnam, South Korea) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Werring, David J. (Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, UK) ;
Universitat Autònoma de Barcelona
Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. [...]
2019 - 10.1016/S1474-4422(19)30197-8
The Lancet neurology, Vol. 18 (july 2019) , p. 653-665
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Genome-wide association meta-analysis of functional outcome after ischemic stroke
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Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Pedersen, Annie (Department of Clinical Neuroscience. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg) ;
Lorentzen, Erik (Sahlgrenska University Hospital (Suècia)) ;
Stanne, Tara M. (Institute of Biomedicine) ;
Bevan, Steve (Bioinformatics Core Facility. University of Gothenburg) ;
Olsson, Maja (Institute of Biomedicine) ;
Cole, John W. ;
Fernandez-Cadenas, Israel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Hankey, Graeme J. (Medical School. The University of Western Australia, Perth; Department of Neurology) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jood, Katarina (Department of Clinical Genetics and Genomics) ;
Lee, Jin-Moo (Department of Neurology. Washington University School of Medicine, St. Louis, MO) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R (School of Medicine and Public Health) ;
Mitchell, Braxton D. (Priority Research Centre for Stroke and Traumatic Brain Injury. University of Newcastle) ;
Norrving, Bo (Skåne University Hospital (Suècia)) ;
Rannikmäe, Kristiina (University of Maryland. Department of Medicine) ;
Rost, Natalia S. (Geriatric Research. Education. and Clinical Center. Veterans Affairs Medical Center) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Rothwell, Peter M. (Broad Institute of MIT and Harvard) ;
Scott, Rodney (University of Virginia. Departments of Neurology and Health Evaluation Sciences) ;
Strbian, Daniel (Massachusetts General Hospital (Boston)) ;
Sturm, Jonathan W. (VIB. Center for Brain and Disease Research) ;
Sudlow, Cathie (University of Maryland. Department of Medicine) ;
Traylor, Matthew (University of Oxford. Nuffield Department of Clinical Neurosciences.) ;
Thijs, Vincent (University of Cambridge. Department of ClinicalNeurosciences) ;
Tatlisumak, Turgut (Stroke Division. Florey Institute for Neuroscience and Mental Health. University of Melbourne) ;
Woo, Daniel (Austin Health. Department of Neurology) ;
Worrall, Bradford B. (University of Cincinnati. Department of Neurology and Rehabilitation) ;
Maguire, Jane M. (HunterMedical Research Centre. PRC Stroke and Brain Injury) ;
Lindgren, Arne (Skåne University Hospital (Suècia)) ;
Jern, Christina (University of Lincoln. School of Life Sciences) ;
Universitat Autònoma de Barcelona
ObjectiveTo discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. MethodsThe study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. [...]
2019 - 10.1212/WNL.0000000000007138
Neurology, Vol. 92 Núm. 12 (19 2019) , p. E1271-E1283
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