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10 p, 3.0 MB |
Applicability and validation of different prognostic scores in allogeneic hematopoietic cell transplant (HCT) in the post-transplant cyclophosphamide era
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Salas, María Queralt (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez Lobato, Luis Gerardo (Hospital Clínic i Provincial de Barcelona) ;
Charry, Paola (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó, Maria (Hospital Clínic i Provincial de Barcelona) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Solano, María Teresa (Hospital Clínic i Provincial de Barcelona) ;
Arcarons, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Cid, Joan (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lozano, Miquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rosiñol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Esteve, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Martínez, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
We investigated the predictive capacity of six prognostic indices [Karnofsky Performance Status (KPS), Hematopoietic Cell Transplant-Specific Comorbidity Index (HCT-CI), Disease Risk Index (DRI), European Bone Marrow Transplantation (EBMT) and Revised Pre-Transplantation Assessment of Mortality (rPAM) Scores and Endothelial Activation and Stress Index (EASIX)] in 205 adults undergoing post-transplant cyclophosphamide (PTCy)-based allo-HCT. [...]
2023 -  10.1016/j.htct.2023.07.008
Hematology, Transfusion and Cell Therapy, 2023
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10 p, 1.0 MB |
Case report : Challenges in immune reconstitution following hematopoietic stem cell transplantation for CTLA-4 insufficiency-like primary immune regulatory disorders
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Margarit-Soler, Adriana (Hospital Sant Joan de Déu (Manresa)) ;
Deyà-Martínez, Ángela (Hospital Clínic i Provincial de Barcelona) ;
Canizales, Juan Torres (Hospital Clínic i Provincial de Barcelona) ;
Vlagea, Alexandru (Hospital Clínic i Provincial de Barcelona) ;
García-García, Ana (Hospital Clínic i Provincial de Barcelona) ;
Marsal, Júlia (Hospital Sant Joan de Déu (Manresa)) ;
Trabazo del Castillo, María (Hospital Sant Joan de Déu (Manresa)) ;
Planas, Sílvia (Hospital Sant Joan de Déu (Manresa)) ;
Simó, Sílvia (Hospital Sant Joan de Déu (Manresa)) ;
Esteve-Sole, Ana (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó Grande, María (Hospital Clínic i Provincial de Barcelona) ;
Badell Serra, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rovira Tarrats, Montserrat (Hospital Clínic i Provincial de Barcelona) ;
Fernandez Aviles, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Alsina Manrique, Laia (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Cytotoxic T-lymphocyte antigen-4 (CTLA-4) haploinsufficiency is a T-cell hyperactivation disorder that can manifest with both immunodeficiency and immune dysregulation. Approximately one-third of patients may present mild symptoms and remain stable under supportive care. [...]
2022 - 10.3389/fimmu.2022.1070068
Frontiers in immunology, Vol. 13 (december 2022)
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3.
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10 p, 1.3 MB |
General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs) : A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
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Jessop, Helen (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Farge, Dominique (McGill University) ;
Saccardi, Riccardo (Careggi University Hospital (Florència, Itàlia)) ;
Alexander, Tobias (Charité - Universitätsmedizin Berlin) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sharrack, Basil (University of Sheffield) ;
Greco, Raffaella (San Raffaele Scientific Institute) ;
Wulffraat, Nico (Wilhelmina Kinderziekenhuis) ;
Moore, John (St Vincent's Hospital (Sydney)) ;
Kazmi, Majid (King's College Hospital NHS Foundation Trust) ;
Badoglio, Manuela (EBMT Paris study office) ;
Adams, Geert (EBMT Executive Office) ;
Verhoeven, Bregje (EBMT Executive Office) ;
Murray, John (Christie Hospital NHS Foundation Trust) ;
Snowden, John A (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Universitat Autònoma de Barcelona
Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting in a poor long-term prognosis in terms of survival or disability. [...]
2019 - 10.1038/s41409-019-0430-7
Bone marrow transplantation, Vol. 54 Núm. 7 (january 2019) , p. 933-942
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10 p, 582.3 KB |
Response to Novel Drugs before and after Allogeneic Stem Cell Transplantation in Patients with Relapsed Multiple Myeloma
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López Corral, Lucia (Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca) ;
Caballero Velazquez, Teresa (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
López-Godino, Oriana (Hospital Universitario Morales Meseguer y Centro Regional de Hemodonación. IMIB. Universidad de Murcia) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pérez-Vicente, Sabina (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Fernandez Aviles, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Krsnik, Isabel (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Morillo, Daniel (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Heras, Inmaculada (Hospital Universitario Morales Meseguer y Centro Regional de Hemodonación. IMIB. Universidad de Murcia) ;
Morgades, Mireia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rifon, Jose (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Sampol, Antonia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Iniesta, Francisca (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Ocio, Enrique M. (Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca) ;
Martin, Jesús (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Rovira Tarrats, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cabero, Martín (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Castilla-Llorente, Cristina (Hematology Department. Gustave Roussy Cancer Center) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Torres-Juan, Marta (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Moraleda, José María (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Martinez, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Vázquez, Alejandro (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Gutiérrez-García, Gonzalo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Caballero, Dolores (Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca) ;
San-Miguel, J (Clínica Universidad de Navarra. Centro de Investigación Médica Aplicada) ;
Mateos, M. V (Complejo Asistencial Universitario de Salamanca. Instituto de Investigación Biomédica de Salamanca) ;
Pérez-Simón, José Antonio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Universitat Autònoma de Barcelona
Multiple myeloma (MM) remains as an incurable disease and, although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative approach, most patients ultimately relapse, and their treatment remains challenging. [...]
2019 - 10.1016/j.bbmt.2019.04.026
Biology of blood and marrow transplantation, Vol. 25 Núm. 9 (september 2019) , p. 1703-1712
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6 p, 378.5 KB |
Quantitative PCR Is Faster, More Objective, and More Reliable Than Immunohistochemistry for the Diagnosis of Cytomegalovirus Gastrointestinal Disease in Allogeneic Stem Cell Transplantation
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Suárez-Lledó, M. (Hospital Clínic i Provincial de Barcelona) ;
Marcos, Maria Angeles (Institut de Salut Global de Barcelona) ;
Cuatrecasas, Miriam (Hospital Clínic i Provincial de Barcelona) ;
Bombi, J. A. (Hospital Clínic i Provincial de Barcelona) ;
Fernandez Aviles, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Magnano, Laura (Hospital Clínic i Provincial de Barcelona) ;
Martínez-Cibrián, N. (Hospital Clínic i Provincial de Barcelona) ;
Llobet, N. (Hospital Clínic i Provincial de Barcelona) ;
Rosiñol Dachs, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gutiérrez-García, Gonzalo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Jorge, S. (Hospital Clínic i Provincial de Barcelona) ;
Martínez Muñoz, Carmen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urbano Ispizua, Álvaro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Diagnosis of gastrointestinal (GI) cytomegalovirus (CMV) disease relies on the presence of GI symptoms and detection of CMV, mainly by immunohistochemistry (IHC), in GI biopsy specimens. Thus, in a symptomatic patient, a positive CMV-IHC result is accepted as a diagnosis of CMV disease. [...]
2019 - 10.1016/j.bbmt.2019.07.016
Biology of blood and marrow transplantation, Vol. 25 Núm. 11 (november 2019) , p. 2281-2286
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16 p, 1.5 MB |
The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever
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Rodríguez Lobato, Luis Gerardo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez-Roca, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Castaño-Díez, Sandra (Hospital Clínic i Provincial de Barcelona) ;
Palomino-Mosquera, Alicia (Hospital Clínic i Provincial de Barcelona) ;
Gutiérrez-García, Gonzalo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pedraza, Alexandra (Hospital Clínic i Provincial de Barcelona) ;
Suárez-Lledó, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rovira Tarrats, Montserrat (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Martínez, Carmen (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández deLarrea, Carlos (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cibeira, María Teresa (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lozano, Ester (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Marín, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Cid Colom, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Lozano, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Moreno-Castaño, Ana Belén (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Palomo, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Diaz-Ricart, Maribel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gallego-Fabrega, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Hernando, Adelina (Hospital Clínic i Provincial de Barcelona) ;
Segura Matute, Susana (Hospital Clínic i Provincial de Barcelona) ;
Carreras, Enric (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urbano Ispizua, Álvaro. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernandez Aviles, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Background Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. [...]
2020 - 10.1371/journal.pone.0241778
PloS one, Vol. 15 Núm. 11 November (november 2020) , p. e0241778
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13 p, 1.0 MB |
Post-transplant cyclophosphamide after matched sibling, unrelated and haploidentical donor transplants in patients with acute myeloid leukemia : A comparative study of the ALWP EBMT
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Sanz, Jaime (Centro de Investigación Biomédica en Red de Cáncer) ;
Galimard, J. E. (EBMT Paris Office. Hospital Saint Antoine) ;
Labopin, Myriam (Department of Hematology. Hopital Saint Antoine. Sorbonne University) ;
Afanasyev, B. (First State Pavlov Medical University of St. Petersburg. Raisa Gorbacheva Mem. Research Institute for Paediatric Oncology. Hematology. and Transplantation) ;
Angelucci, Emanuele (Department of Haematology. IRCCS Ospedale Policlinico San Martino) ;
Ciceri, Fabio (Haematology and BMT) ;
Blaise, Didier (Programme de Transplantation and Therapie Cellulaire. Centre de Recherche en Cancérologie de Marseille. Institut Paoli Calmettes) ;
Cornelissen, J. J. (Department of Hematology. Erasmus MC Cancer Institute. University Medical Center Rotterdam) ;
Meijer, E. (Department of Hematology (Br 250). VU University Medical Center) ;
Diez-Martin, J. L. (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Koc, Y. (Stem Cell Transplant Unit. Medical Park Hospitals) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castagna, L. (Transplantation Unit. Department of Oncology and Haematology. Istituto Clinico Humanitas) ;
Savani, B. N. (Vanderbilt University Medical Center) ;
Ruggeri, Annalisa (Ospedale Pediatrico Bambino Gesù (Roma, Itàlia)) ;
Nagler, Arnon (ALWP of the EBMT Office. Saint Antoine Hospital) ;
Mohty, Mohamad (Department of Hematology. Hopital Saint Antoine. Sorbonne University) ;
Universitat Autònoma de Barcelona
Background: The use of post-transplant cyclophosphamide (PTCy) is highly effective in preventing graft-versus-host disease (GVHD) in the haploidentical (Haplo) transplant setting and is being increasingly used in matched sibling (MSD) and matched unrelated (MUD) transplants. [...]
2020 - 10.1186/s13045-020-00882-6
Journal of hematology & oncology, Vol. 13 Núm. 1 (june 2020) , p. 46
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24 p, 2.3 MB |
Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases : updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)
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Sharrack, Basil (NIHR Neurosciences Biomedical Research Centre. University of Sheffield) ;
Saccardi, Riccardo (Careggi University Hospital (Florència, Itàlia)) ;
Alexander, Tobias (Charité - Universitätsmedizin Berlin) ;
Badoglio, Manuela (EBMT Paris study office. Department of Haematology. Saint Antoine Hospital. INSERM UMR 938. Sorbonne University) ;
Burman, Joachim (Department of Neuroscience. Uppsala University) ;
Farge-Bancel, Dominique (EA 3518. Université Denis Diderot) ;
Greco, Raffaella (IRCCS San Raffaele Scientific Institute (Milà, Itàlia). Hematology and Bone Marrow Transplantation Unit) ;
Jessop, Helen (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Kazmi, Majid (King's College Hospital NHS Foundation Trust) ;
Kirgizov, Kirill Igorevich (N.N. Blokhin National Medical Center of Oncology. Institute of Pediatric Oncology and Hematology) ;
Labopin, Myriam (EBMT Paris study office. Department of Haematology. Saint Antoine Hospital. INSERM UMR 938. Sorbonne University) ;
Mancardi, Giovanni Luigi (University of Genova and Clinical Scientific Institutes Maugeri. Department of Neuroscience) ;
Martin, Roland (University Hospital Zurich (Suïssa)) ;
Moore, John (St. Vincent's Health Network. Haematology Department.) ;
Muraro, Paolo Antonio (Imperial College London) ;
Rovira Tarrats, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sormani, Maria Pia (IRCCS Ospedale Policlinico San Martino) ;
Snowden, John A. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Snowden, John A (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
McGrath, Eoin (EBMT Executive Office) ;
Bambi, Franco (Ospedale Pediatrico. Azienda Ospedaliero Universitaria Meyer (A.O.U. Meyer)) ;
Sanchez-Guijo, Fermin (Instituto de Investigación Biomédica de Salamanca) ;
Worel, Nina (Blood Group Serology and Transfusion Medicine. Medical University of Vienna) ;
Abinun, Mario (Great North Children's Hospital. Institute of Cellular Medicine. Newcastle University) ;
Arnold, Renate (Charité - Universitätsmedizin Berlin) ;
Brierley, Charlotte (Oxford University Hospitals NHS Foundation Trust) ;
Castilla-Llorente, Cristina (Unité de transplantation des cellules souches. Département d'Hématologie Gustave Roussy) ;
Cooper, Nichola (Hammersmith Hospital (Londres)) ;
Daikeler, Thomas D. (University Hospital Basel (Basilea, Suïssa)) ;
del Papa, Nicoletta (Ospedale Gaetano Pini. Department of Rheumatology) ;
Farge-Bancel, Dominique (EA 3518. Université Denis Diderot) ;
Finke, Jürgen M. (Department of Medicine-Hematology and Oncology. University of Freiburg) ;
Hagglund, Hans G. (Department of Hematology. Uppsala University Hospital) ;
Henes, Jörg Christoph (University Hospital of Tübingen (Alemanya)) ;
Hiepe, Falk (Charité - Universitätsmedizin Berlin) ;
Kiely, David G. (Sheffield Teaching Hospitals NHS Foundation Trust (Sheffield, Regne Unit)) ;
Marjanovic, Z. (Department of Haematology. Saint Antoine Hospital) ;
Martin, Roland (Neuroimmunology and MS Research. Neurology Clinic. University Hospital) ;
Martin, Thierry (Department of Clinical Immunology. National Referral Center for Autoimmune Diseases. Strasbourg University Hospital) ;
Ma, D. (Haematology Department. St. Vincent's Health Network) ;
Moore, J. (Haematology Department. St. Vincent's Health Network) ;
Miller, P. (Anthony Nolan Research Institute) ;
Muraro, P. (Imperial College London) ;
Oliveira, M. C. (Division of Clinical Immunology. Ribeirão Preto Medical School. University of São Paulo) ;
Polushin, A. (Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology. Hematology and Transplantation First State Pavlov Medical University of Saint Petersburg) ;
Onida, F. (Haematology-BMT Centre. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico. Università degli Studi di Milano) ;
Simoes, B. (Division of Hematology. Ribeirão Preto Medical School. University of São Paulo) ;
Puyade, M. (Centre Hospitalier Universitaire de Poitiers) ;
Resnick, I. (University Hospital St. Marina) ;
Rovira Argelagués, Montserrat (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Saccardi, R. (Careggi University Hospital (Florència, Itàlia)) ;
Saif, M. (Department of Clinical Haematology. Manchester Royal Infirmary) ;
Sakellari, Ioanna (Bone Marrow Transplantation Unit. George Papanicolaou General Hospital) ;
Sharrack, B. (NIHR Neurosciences Biomedical Research Centre. University of Sheffield) ;
Snarski, E. (Department of Hematology. Oncology and Internal Medicine. Medical University of Warsaw) ;
Scherer, H. U. (Department of Rheumatology. Leiden University Medical Centre) ;
Sossa, C. (Division of Hematology and Hematopoietic Stem Cell Transplantation. Hematology and Stem Cell Transplantation Unit. Clinica FOSCAL) ;
de Vries-Bouwstra, J. (Department of Rheumatology. Leiden University Medical Centre) ;
Wulffraat, N. (Divisie Kinderen. Cluster Immunologie. Reumatologie. Hematologie en Infectiologie. Wilhelmina Kinderziekenhuis) ;
Zaccara, E. (Osp. G. Pini. Department of Rheumatology) ;
Universitat Autònoma de Barcelona
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. [...]
2020 - 10.1038/s41409-019-0684-0
Bone marrow transplantation, Vol. 55 Núm. 2 (january 2020) , p. 283-306
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