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12 p, 9.5 MB |
Single-cell transcriptomic profiling reveals a pathogenic role of cytotoxic CD4+ T cells in giant cell arteritis
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Carmona, Elio G. (Hospital Universitario San Cecilio (Granada)) ;
Callejas Rubio, Jose Luis (Hospital Universitario San Cecilio (Granada)) ;
Raya, Enrique (Hospital Universitario San Cecilio (Granada)) ;
Ríos-Fernández, Raquel (Hospital Universitario San Cecilio (Granada)) ;
Villanueva-Martín, Gonzalo (Institute of Parasitology and Biomedicine López-Neyra) ;
Cid, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Hernández-Rodríguez, José (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Timmermann, Bernd (Max Planck Institute for Molecular Genetics) ;
Ortego-Centeno, Norberto (Universidad de Granada. Departamento de Medicina) ;
Martín, Javier (Spanish National Research Council) ;
Márquez, Ana (Instituto de Parasitología y Biomedicina "López-Neyra")
Giant cell arteritis (GCA) is a systemic vasculitis mediated by an aberrant immunological response against the blood vessel wall. Although the pathogenic mechanisms that drive GCA have not yet been elucidated, there is strong evidence that CD4 T cells are key drivers of the inflammatory process occurring in this vasculitis. [...]
2024 -  10.1016/j.jaut.2023.103124
Journal of Autoimmunity, Vol. 142 (january 2024) , p. 103124
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14 p, 1.2 MB |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
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López-Isac, Elena (Institute of Parasitology and Biomedicine López-Neyra) ;
Acosta-Herrera, Marialbert (Institute of Parasitology and Biomedicine López-Neyra) ;
Kerick, Martin (Institute of Parasitology and Biomedicine López-Neyra) ;
Assassi, Shervin (The University of Texas Health Science Center-Houston) ;
Satpathy, Ansuman (Stanford University) ;
Granja, Jeffrey (Stanford University) ;
Mumbach, Maxwell (Stanford University) ;
Beretta, Lorenzo (Referral Center for Systemic Autoimmune Diseases) ;
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron) ;
Carreira, Patricia E. (Hospital Universitario 12 de Octubre) ;
Ortego-Centeno, Norberto (San Cecilio Clinic University Hospital) ;
Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Bossini-Castillo, Lara (Wellcome Trust Sanger Institute (Regne Unit)) ;
Carmona, F. David (Universidad de Granada) ;
Orozco, Gisela (The University of Manchester) ;
Hunzelmann, Nicolas (University of Cologne) ;
Distler, Jörg H. W. (University of Erlangen-Nuremberg) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Lunardi, Claudio (Università degli Studi di Verona) ;
Moroncini, Gianluca (Università Politecnica delle Marche and Ospedali Riuniti) ;
Gabrielli, Armando (Università Politecnica delle Marche and Ospedali Riuniti) ;
de Vries-Bouwstra, Jeska (Leiden University Medical Center) ;
Wijmenga, Cisca (University of Groningen) ;
Koeleman, Bobby (University Medical Center Utrecht) ;
Nordin, Annika (Karolinska Institutet (Estocolm, Suècia)) ;
Padyukov, Leonid (Karolinska Institutet (Estocolm, Suècia)) ;
Hoffmann-Vold, Anna-Maria (Oslo University Hospital) ;
Lie, Benedicte A. (University of Oslo and Oslo University Hospital) ;
Ríos, Raquel (San Cecilio Clinic University Hospital) ;
Callejas Rubio, Jose Luis (San Cecilio Clinic University Hospital) ;
Vargas-Hitos, José Antonio (Hospital Virgen de las Nieves (Granada, Andalusia)) ;
García-Portales, Rosa (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Camps, María Teresa (Carlos Haya Hospital) ;
Fernández-Nebro, Antonio (Carlos Haya Hospital) ;
González-Escribano, Maria Francisca (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García-Hernández, Francisco Jose (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Castillo, María Jesús (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Aguirre, Mª Angeles (Hospital Reina Sofía/IMIBIC) ;
Gómez-Gracia, Inmaculada (Hospital Reina Sofía/IMIBIC) ;
Fernández-Gutiérrez, B. (San Carlos Clinic Hospital) ;
Rodríguez-Rodríguez, L. (San Carlos Clinic Hospital) ;
García de la Peña, Paloma (Madrid Norte Sanchinarro Hospital) ;
Vicente-Rabaneda, Esther Francisca (Hospital Universitario de la Princesa (Madrid)) ;
Andréu, José Luis (Puerta de Hierro Hospital-Majadahonda) ;
Fernández de Castro, Mónica (Puerta de Hierro Hospital-Majadahonda) ;
López-Longo, Francisco Javier (Hospital General Universitario Gregorio Marañón) ;
Martínez, Lina Patricia (Hospital General Universitario Gregorio Marañón) ;
Fonollosa, Vicenç (Hospital Universitari Vall d'Hebron) ;
Guillén, Alfredo Chávez (Hospital Universitari Vall d'Hebron) ;
Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Tolosa-Vilella, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pros, Ana (Hospital del Mar (Barcelona, Catalunya)) ;
Rodríguez-Carballeira, M. (Hospital Universitari MútuaTerrassa) ;
Narváez, Francisco J. (Hospital Universitari de Bellvitge) ;
Rubio Rivas, Manuel (Hospital Universitari de Bellvitge) ;
Ortiz-Santamaría, None (Hospital Granollers) ;
Madroñero, A.B. (Hospital General Universitario San Jorge (Osca, Aragó)) ;
González-Gay, M.A. (Universidad de Cantabria) ;
Díaz, B. (Hospital Universitario Central de Asturias) ;
Trapiella, L. (Hospital Universitario Central de Asturias) ;
Sousa, A. (Hospital Xeral-Complexo Hospitalario Universitario de Vigo) ;
Egurbide, M.V. (Hospital Universitario Cruces) ;
Fanlo-Mateo, P. (Hospital Virgen del Camino (Pamplona)) ;
Sáez-Comet, L. (Hospital Universitario Miguel Servet (Saragossa)) ;
Díaz, F. (Hospital Universitario de Canarias) ;
Hernández, None (Hospital Universitario de Canarias) ;
Beltrán, E. (Hospital General Universitario de Valencia) ;
Román-Ivorra, J.A. (Hospital Universitari i Politècnic La Fe de València) ;
Grau, E. (Hospital Universitari i Politècnic La Fe de València) ;
Alegre-Sancho, Juan José (Hospital Universitari Doctor Peset) ;
Freire, M. (Complexo Hospitalario Universitario de Vigo) ;
Blanco-García, F.J (INIBIC-Hospital Universitario A Coruña) ;
Oreiro, N. (INIBIC-Hospital Universitario A Coruña) ;
Witte, T. (Hannover Medical School) ;
Kreuter, A. (Ruhr University Bochum) ;
Riemekasten, G. (University of Lübeck) ;
Airò, Paolo (Service of Rheumatology and Clinic Immunology Spedali Civili) ;
Magro-Checa, César (Leiden University Medical Center) ;
Voskuyl, A.E. (Amsterdam UMC. University Medical Center) ;
Vonk, Madelon C. (Radboud University Nijmegen Medical Center) ;
Hesselstrand, Roger (Lund University) ;
Proudman, Susanna (Royal Adelaide Hospital and University of Adelaide) ;
Stevens, Wendy (St. Vincent's Hospital) ;
Nikpour, Mandana (The University of Melbourne at St. Vincent's Hospital) ;
Zochling, Jane M. (University of Tasmania) ;
Sahhar, Joanne (Monash Medical Centre) ;
Roddy, Janet (Cincinnati Children's Hospital Medical Center (CCHMC). Center for Fetal and Placental Research) ;
Nash, Peter (Sunshine Coast Rheumatology) ;
Tymms, Kathleen (Canberra Rheumatology) ;
Rischmueller, Maureen (The Queen Elizabeth Hospital) ;
Lester, S. (The Queen Elizabeth Hospital) ;
Vyse, Timothy (King's College London) ;
Herrick, Ariane (NIHR Manchester Biomedical Research Centre) ;
Worthington, Jane (The University of Manchester) ;
Denton, Christopher P (Royal Free and University College Medical School) ;
Allanore, Yannick (Paris Descartes University) ;
Brown, Matthew A. (Princess Alexandra Hospital) ;
Radstake, Timothy R. D. J. (University Medical Center Utrecht) ;
Fonseca, Carmen (Royal Free and University College Medical School) ;
Chang, Howard Y. (Stanford University) ;
Mayes, Maureen D (The University of Texas Health Science Center-Houston) ;
Martín, Javier (Institute of Parasitology and Biomedicine López-Neyra) ;
Universitat Autònoma de Barcelona
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. [...]
2019 - 10.1038/s41467-019-12760-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 4955
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16 p, 998.9 KB |
Tocilizumab in visual involvement of giant cell arteritis : a multicenter study of 471 patients
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Loricera, Javier ;
Castañeda, Santos ;
Moriano, Clara ;
Narváez, Javier (Hospital Universitari de Bellvitge) ;
Aldasoro, Vicente ;
Maiz, Olga ;
Melero, Rafael ;
Villa, Ignacio ;
Vela, Paloma ;
Romero-Yuste, Susana ;
Callejas Rubio, Jose Luis ;
de Miguel, Eugenio ;
Galíndez Agirregoikoa, Eva ;
Sivera, Francisca ;
Fernández-López, Jesús C. ;
Galisteo Lencastre Da Veiga, Carlos (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ferraz-Amaro, Iván ;
Sánchez-Martín, Julio ;
Sánchez-Bilbao, Lara ;
Calderón-Goercke, Mónica ;
Casado, Alfonso ;
Hernández, José L. ;
Gonzalez-Gay, MA ;
Blanco, Ricardo ;
Universitat Autònoma de Barcelona
Visual involvement is the most feared complication of giant cell arteritis (GCA). Information on the efficacy of tocilizumab (TCZ) for this complication is scarce and controversial. We assessed a wide series of GCA treated with TCZ, to evaluate its role in the prevention of new visual complications and its efficacy when this manifestation was already present before the initiation of TCZ. [...]
2022 - 10.1177/1759720X221113747
Therapeutic Advances in Musculoskeletal Disease, Vol. 14 (july 2022)
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12 p, 10.1 MB |
Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis
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Kerick, Martin (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Acosta-Herrera, Marialbert (Systemic Autoimmune Disease Unit. Hospital Universitario San Cecilio de Granada. Instituto de Investigación Biosanitaria Ibs.GRANADA) ;
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron) ;
Callejas Rubio, Jose Luis (Hospital Universitario San Cecilio de Granada) ;
Assassi, Shervin (University of Texas Health Science Center at Houston) ;
Carreira, Patricia E (Hospital Universitario 12 de Octubre (Madrid). Servicio de Reumatología) ;
Castellvi, Ivan (Institut d'Investigació Biomèdica Sant Pau) ;
Ríos, Raquel (Hospital Universitario San Cecilio de Granada. Servicio de Medicina Interna) ;
García-Portales, Rosa (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Fernández-Nebro, Antonio (Hospital Regional de Málaga. Servicio de Reumatología) ;
García-Hernández, Francisco Jose (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Aguirre, Mª Angeles (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Fernández-Gutiérrez, Benjamín (Hospital Clínico San Carlos. Servicio de Reumatología) ;
Rodríguez-Rodríguez, Luis (Hospital Clínico San Carlos. Servicio de Reumatología) ;
de la Peña-Lefebvre, Paloma García (Hospital Universitario HM Sanchinarro. Servicio de Reumatología) ;
Vicente-Rabaneda, Esther Francisca (Hospital Universitario de La Princesa. Servicio de Reumatología) ;
Andréu, José Luis (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Fernández de Castro, Mónica (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
López-Longo, Francisco Javier (Hospital General Universitario Gregorio Marañón) ;
Fonollosa, Vicente (Hospital Universitari Vall d'Hebron) ;
Guillén-Del-Castillo, Alfredo (Hospital Universitari Vall d'Hebron) ;
Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Tolosa, Carlos (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pros, Anna (Hospital del Mar (Barcelona, Catalunya)) ;
Beltran Catalan, Emma (Hospital del Mar (Barcelona, Catalunya)) ;
Rodríguez-Carballeira, Mónica (Hospital Universitari Mútua Terrasa. Servei de Medicina Interna) ;
Narváez, Francisco Javier (Hospital Universitari de Bellvitge. Servei de Reumatologia) ;
Rubio Rivas, Manuel (Hospital Universitari de Bellvitge. Servei de Reumatologia) ;
Ortiz-Santamaría, Vera (Hospital General de Granollers. Servei de Reumatologia) ;
Madroñero, Ana Belén (Hospital General San Jorge (Osca). Servicio de Medicina Interna) ;
Gonzalez-Gay, MA (Universidad de Cantabria. Epidemiology. Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases. DIVAL) ;
Díaz, Bernardino (Hospital Universitario Central de Asturias. Servicio de Medicina Interna) ;
Trapiella, Luis (Hospital Universitario Central de Asturias. Servicio de Medicina Interna) ;
Egurbide, María Victoria (Hospital Universitario de Cruces. Servicio de Medicina Interna) ;
Fanlo-Mateo, Patricia (Hospital Virgen del Camino (Pamplona)) ;
Sáez-Comet, Luis (Hospital Universitario Miguel Servet (Saragossa)) ;
Díaz, F. (Hospital Universitario de Canarias. Servicio de Reumatología) ;
Román-Ivorra, José Andrés (Hospital Universitari i Politècnic La Fe (València). Servicio de Reumatología) ;
Alegre-Sancho, Juan José (Hospital Doctor Peset. Servicio de Reumatología) ;
Freire, Mercedes (Complejo Hospitalario Universitario de Vigo. Unidad de Trombosis y Vasculitis. Servicio de Medicina Interna) ;
Garcia, Francisco J.B. (Hospital A Coruña. Instituto de Investigación Biomédica de A Coruña. Servicio de Reumatología) ;
Oreiro, Natividad (Hospital A Coruña. Instituto de Investigación Biomédica de A Coruña. Servicio de Reumatología) ;
Witte, Torsten (Department of Clinical Immunology. Hannover Medical School) ;
Kreuter, Alexander (Department of Dermatology. Josefs-Hospital. Ruhr University Bochum) ;
Riemekasten, Gabriela (Clinic of Rheumatology. University of Lübeck) ;
Airò, Paolo (Service of Rheumatology and Clinic Immunology Spedali Civili) ;
Magro-Checa, César (Department of Rheumatology. Leiden University Medical Center) ;
Voskuyl, A.E. (Department of Rheumatology. VU University Medical Center) ;
Vonk, Madelon C. (Department of Rheumatology. Radboud University Nijmegen Medical Center) ;
Hesselstrand, Roger (Department of Rheumatology. Lund University) ;
Nordin, Annika (Division of Rheumatology. Department of Medicine. Karolinska University Hospital. Karolinska Institute) ;
Lunardi, Claudio (Department of Medicine. Università degli Studi di Verona) ;
Gabrielli, Armando (Istituto di Clinica Medica Generale. Ematologia ed Immunologia Clinica. Università Politecnica delle Marche) ;
Hoffmann-Vold, A. (Department of Rheumatology. Oslo University Hospital) ;
Distler, J.H.W. (Department of Internal Medicine 3. Institute for Clinical Immunology. University of Erlangen-Nuremberg) ;
Padyukov, Leonid (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Koeleman, B.P.C. (Department of Genetics. University Medical Center Utrecht) ;
Proudman, Susanna M. (Rheumatology Unit. Royal Adelaide Hospital and University of Adelaide) ;
Nikpour, Mandana (The University of Melbourne at St. Vincent's Hospital) ;
Stevens, W. (The University of Melbourne at St. Vincent's Hospital) ;
Zochling, J. (Menzies Research Institute Tasmania. University of Tasmania) ;
Sahhar, J. (Department Rheumatology. Monash Medical Centre) ;
Roddy, J. (Rheumatology. Royal Perth Hospital) ;
Nash, P. (Research Unit. Sunshine Coast Rheumatology) ;
Tymms, K. (Canberra Rheumatology) ;
Rischmueller, Maureen (Department Rheumatology. The Queen Elizabeth Hospital) ;
Lester, Susan Elizabeth (Department Rheumatology. The Queen Elizabeth Hospital) ;
Vigone, Barbara (Referral Center for Systemic Autoimmune Diseases. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano) ;
Pers, Jacques-Olivier (Centre Hospitalier Universitaire de Brest. Hospital de la Cavale Blanche) ;
Saraux, Alain (Centre Hospitalier Universitaire de Brest. Hospital de la Cavale Blanche) ;
Devauchelle-Pensec, Valérie (Centre Hospitalier Universitaire de Brest. Hospital de la Cavale Blanche) ;
Cornec, Divi (Centre Hospitalier Universitaire de Brest. Hospital de la Cavale Blanche) ;
Jousse-Joulin, Sandrine (Centre Hospitalier Universitaire de Brest. Hospital de la Cavale Blanche) ;
Lauwerys, Bernard (Pôle de pathologies rhumatismales systémiques et inflammatoires. Institut de Recherche Expérimentale et Clinique. Université catholique de Louvain) ;
Ducreux, Julie (Pôle de pathologies rhumatismales systémiques et inflammatoires. Institut de Recherche Expérimentale et Clinique. Université catholique de Louvain) ;
Maudoux, Anne-Lise (Pôle de pathologies rhumatismales systémiques et inflammatoires. Institut de Recherche Expérimentale et Clinique. Université catholique de Louvain) ;
Vasconcelos, Carlos (Centro Hospitalar do Porto) ;
Tavares, Ana (Centro Hospitalar do Porto) ;
Neves, Esmeralda (Centro Hospitalar do Porto) ;
Faria, Raquel (Centro Hospitalar do Porto) ;
Brandão, Mariana (Centro Hospitalar do Porto) ;
Campar, Ana (Centro Hospitalar do Porto) ;
Marinho, António (Centro Hospitalar do Porto) ;
Farinha, Fátima (Centro Hospitalar do Porto) ;
Almeida, Isabel (Centro Hospitalar do Porto) ;
Gonzalez-Gay, MA (Universidad de Cantabria. Epidemiology. Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases. DIVAL) ;
Blanco, Ricardo (Universidad de Cantabria. Epidemiology. Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases. DIVAL) ;
Corrales Martínez, Universidad de Cantabria. Epidemiology. Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases. DIVAL ;
Cervera, Ricard (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Pintó, Ignasi (Hospital Clínic i Provincial de Barcelona) ;
Espinosa, Gerard (Hospital Clínic i Provincial de Barcelona) ;
Lories, Rik (Katholieke Universiteit Leuven) ;
De Langhe, Ellen (Katholieke Universiteit Leuven) ;
Belz, Doreen (Department of Dermatology. University of Cologne) ;
Witte, Torsten (Department of Clinical Immunology. Hannover Medical School) ;
Baerlecken, Niklas (Department of Clinical Immunology. Hannover Medical School) ;
Stummvoll, Georg (Medical University Vienna) ;
Zauner, Michael (Medical University Vienna) ;
Lehner, Michaela (Medical University Vienna) ;
Collantes Estevéz, Eduardo (Servicio Andaluz de Salud. Hospital Universitario "Reina Sofía" (Còrdova)) ;
Ortega Castro, Rafaela (Servicio Andaluz de Salud. Hospital Universitario "Reina Sofía" (Còrdova)) ;
Escudero Contreras, Alejandro (Servicio Andaluz de Salud. Hospital Universitario "Reina Sofía" (Còrdova)) ;
Castro-Villegas, Ma Carmen (Servicio Andaluz de Salud. Hospital Universitario San Cecilio de Granada) ;
Fernández Roldán, María Concepción (Servicio Andaluz de Salud. Hospital Universitario San Cecilio de Granada) ;
Ortego, Norberto (Universidad de Granada. Facultad de Medicina) ;
Raya, Enrique (Servicio Andaluz de Salud. Hospital Virgen de las Nieves) ;
Jiménez Moleón, Inmaculada (Servicio Andaluz de Salud. Hospital Virgen de las Nieves) ;
de Ramon, Enrique (Servicio Andaluz de Salud. Hospital Regional Universitario de Málaga) ;
Díaz Quintero, Isabel (Servicio Andaluz de Salud. Hospital Regional Universitario de Málaga) ;
Meroni, Pier Luigi (Università degli studi di Milano) ;
Gerosa, Maria (Università degli studi di Milano) ;
Schioppo, Tommaso (Università degli studi di Milano) ;
Artusi, Carolina (Università degli studi di Milano) ;
Chizzolini, Carlo (Hospitaux Universitaires de Genève) ;
Zuber, Aleksandra (Hospitaux Universitaires de Genève) ;
Wynar, Donatirnne (Hospitaux Universitaires de Genève) ;
Kovács, Laszló (University of Szeged) ;
Balog, Attila (University of Szeged) ;
Deák, Magdolna (University of Szeged) ;
Bocskai, Márta (University of Szeged) ;
Dulic, Sonja (University of Szeged) ;
Kádár, Gabriella (University of Szeged) ;
Hiepe, Falk (Charite) ;
Gerl, Velia (Charite) ;
Thiel, Silvia (Charite) ;
rodriguez Maresca, Manuel (Andalusian Public Health System Biobank) ;
López-Berrio, Antonio (Andalusian Public Health System Biobank) ;
Aguilar-Quesada, Rocío (Andalusian Public Health System Biobank) ;
Navarro-Linares, Héctor (Andalusian Public Health System Biobank) ;
Hunzelmann, Nicolas (Department of Dermatology. University of Cologne) ;
Moroncini, Gianluca (Department of Clinical and Molecular Science. Università Politecnica delle Marche e Ospedali Riuniti) ;
de Vries-Bouwstra, Jeska K. (Department of Rheumatology. Leiden University Medical Center) ;
Orozco, Gisela (NIHR Manchester Biomedical Research Center. Manchester University NHS Foundation Trust. Manchester) ;
Barton, Anne (NIHR Manchester Biomedical Research Center. Manchester University NHS Foundation Trust. Manchester) ;
Herrick, Ariane (Division of Musculoskeletal and Dermatological Sciences. The University of Manchester. Northern care Alliance NHS Foundation Trust. Manchester Academic Health Science Centre) ;
Terao, Chikashi (Laboratory for Statistical and Translational Genetics. RIKEN Center for Integrative Medical Sciences) ;
Allanore, Yannick (Department of Rheumatology A. Hospital Cochin) ;
Fonseca, Carmen (Center for Rheumatology. Royal Free and University College Medical School) ;
Alarcón-Riquelme, Marta E (Center for Genomics and Oncological Research (GENYO). Pfizer-University of Granada-Andalusian Regional Government) ;
Radstake, Timothy R.D.J. (Department of Rheumatology and Clinical Immunology. University Medical Center Utrecht) ;
Beretta, Lorenzo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano) ;
Denton, Christopher P. (Center for Rheumatology. Royal Free and University College Medical School) ;
Mayes, Maureen D. (University of Texas McGovern Medical School) ;
Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra")
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. [...]
2022 - 10.1038/s41525-022-00327-8
npj Genomic Medicine, Vol. 7 Núm. 1 (december 2022) , p. 57
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12 p, 637.7 KB |
Tocilizumab in refractory Caucasian Takayasu's arteritis : a multicenter study of 54 patients and literature review
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Prieto-Peña, Diana (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Bernabeu, Pilar (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Vela, Paloma (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Narváez, Javier (Hospital Universitari de Bellvitge) ;
Fernández-López, Jesus C. (Complejo H. Universitario de A Coruña) ;
Freire-González, Mercedes (Complejo H. Universitario de A Coruña) ;
González-Álvarez, Beatriz (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Solans, Roser (Hospital Universitari Vall d'Hebron) ;
Callejas Rubio, Jose Luis (Hospital Universitario San Cecilio (Granada)) ;
Ortego, Norberto (Hospital Universitario San Cecilio (Granada)) ;
Fernández-Díaz, Carlos (IIS-Princesa) ;
Rubio, Esteban (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
García-Morillo, Salvador (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Minguez, Mauricio (Hospital San Juan de Alicante) ;
Fernández-Carballido, Cristina (Hospital San Juan de Alicante) ;
de Miguel, Eugenio (Hospital Universitario La Paz (Madrid)) ;
Melchor, Sheila (Hospital Universitario) ;
Salgado, Eva (Complejo H. Universitario de Ourense) ;
Bravo, Beatriz (Hospital Universitario Virgen de las Nieves (Granada)) ;
Romero-Yuste, Susana (Complejo H. Universitario de Pontevedra) ;
Salvatierra, Juan (Hospital Universitario San Cecilio (Granada)) ;
Hidalgo, Cristina (Complejo Universitario de Salamanca) ;
Manrique, Sara (Hospital Regional Universitario de Málaga) ;
Romero-Gómez, Carlos (Hospital Regional Universitario de Málaga) ;
Moya, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Álvarez-Rivas, Noelia (Hospital Universitario San Agustín (Avilés)) ;
Mendizabal, Javier (Complejo Hospitalario de Navarra) ;
Ortiz-Sanjuán, Francisco (Hospital Universitari i Politècnic La Fe (València)) ;
Pérez de Pedro, Iván (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Alonso-Valdivielso, José L. (Hospital Universitario de Burgos) ;
Perez-Sanchez, Laura (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Roldán, Rosa (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Fernandez-Llanio, Nagore (Hospital Arnau de Vilanova (València)) ;
Gómez de la Torre, Ricardo (Hospital Universitario Central de Asturias) ;
Suarez, Silvia (Hospital Universitario Central de Asturias) ;
Montesa Cabrera, María Jesús (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Delgado Sánchez, Mónica (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Loricera, Javier (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Atienza-Mateo, Belén (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Castañeda, Santos (IIS-Princesa) ;
Gonzalez-Gay, MA (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Blanco, Ricardo (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Objective: To assess the efficacy and safety of tocilizumab (TCZ) in Caucasian patients with refractory Takayasu's arteritis (TAK) in clinical practice. Methods: A multicenter study of Caucasian patients with refractory TAK who received TCZ. [...]
2021 - 10.1177/1759720X211020917
Therapeutic Advances in Musculoskeletal Disease, Vol. 13 (2021)
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Complete Genome Sequence of a Tomato Isolate of Parietaria Mottle Virus from Italy
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Martínez, Carolina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Aramburu, José ;
Rubio, Luis (Instituto Valenciano de Investigaciones Agrarias) ;
Galipienso, Luis (Instituto Valenciano de Investigaciones Agrarias)
We report here the complete genome sequence of isolate T32 of parietaria mottle virus (PMoV) infecting tomato plants in Turin, Italy, obtained by Sanger sequencing. T32 shares 90. 48 to 96. 69% nucleotide identity with other two PoMV isolates, CR8 and Pe1, respectively, whose complete genome sequences are available.
2015 - 10.1128/genomeA.01452-15
Genome announcements, Vol. 3, Issue 6 (December 2015) , art. e01452-15
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8 p, 676.9 KB |
Off-label use of rituximab for systemic lupus erythematosus in Europe
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Rydén-Aulin, Monica (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Boumpas, Dimitrios (Kapodestrian University of Athens) ;
Bultink, Irene (Amsterdam Rheumatology and Immunology Center) ;
Callejas Rubio, Jose Luis (Hospital Universitario San Cecilio (Granada)) ;
Caminal-Montero, Luis (Hospital Universitario Central de Asturias) ;
Castro, Antoni (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Colodro Ruiz, Agustín ;
Doria, Andrea (University of Padova) ;
Dörner, Thomas (Charite Universitaetsmedizin Berlin) ;
González-Echávarri, Cristina (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Gremese, Elisa (Institute of Rheumatology and Affine Sciences (IRSA), Catholic University of the Sacred Heart) ;
Houssiau, Frederic A. (Université Catholique de Louvain) ;
Huizinga, Tom ;
Inanç, Murat (Istanbul University) ;
Isenberg, David (University College London) ;
Iuliano, Annamaria (San Camillo Forlanini Hospital) ;
Jacobsen, Søren (University of Copenhagen) ;
Jimenéz-Alonso, Juan (Hospital Universitario Virgen de las Nieves (Granada)) ;
Kovács, Lászlo (University of Szeged. Albert Szent-Györgyi Health Centre) ;
Mariette, Xavier (Université Paris-Sud) ;
Mosca, Marta (Rheumatology Unit, Pisa) ;
Nived, Ola (Skåne University Hospital (Suècia)) ;
Oristrell, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ramos-Casals, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rascón, Javier ;
Ruiz-Irastorza, Guillermo (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Sáez-Comet, Luis (Hospital Universitario Miguel Servet (Saragossa)) ;
Salvador Cervelló, Gonzalo (Hospital Universitari i Politècnic La Fe (València)) ;
Sebastiani, Gian Domenico (Ospedale San Camillo) ;
Squatrito, Danilo (University of Florence) ;
Szücs, Gabriella (Institute of Medicine, University of Debrecen) ;
Voskuyl, Alexandre (Amsterdam Rheumatology and Immunology Center (ARC)) ;
van Vollenhoven, Ronald (Amsterdam Rheumatology and Immunology Center ARC)
Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the off-label use of RTX in Europe and compare the characteristics of patients receiving RTX with those receiving conventional therapy. [...]
2016 - 10.1136/lupus-2016-000163
Lupus Science & Medicine, Vol. 3 (september 2016)
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