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14 p, 7.6 MB Activation of regulated cell death in the lung of piglets infected with virulent PRRSV-1 Lena strain occurs earlier and mediated by cleaved Caspase-8 / Sánchez-Carvajal, Jose María (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Ruedas-Torres, Inés (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Carrasco, Librado (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Pallarés Martínez, Francisco José (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology) ; Mateu de Antonio, Enrique María (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ; Rodríguez-Gómez, Irene Magdalena (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology, Faculty of Veterinary Medicine) ; Gómez-Laguna, Jaime (University of Córdoba. Department of Anatomy and Comparative Pathology and Toxicology)
PRRSV-1 virulent strains cause high fever, marked respiratory disease and severe lesions in lung and lymphoid organs. Regulated cell death (RCD), such as apoptosis, necroptosis and pyroptosis, is triggered by the host to interrupt viral replication eliminating infected cells, however, although it seems to play a central role in the immunopathogenesis of PRRSV, there are significant gaps regarding their sequence and activation upon PRRSV-infection. [...]
2021 - 10.1186/s13567-020-00882-x
Veterinary research, Vol. 52 (january 2021)  
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