Resultados globales: 12 registros encontrados en 0.02 segundos.
Artículos, Encontrados 11 registros
Documentos de investigación, Encontrados 1 registros
Artículos Encontrados 11 registros  1 - 10siguiente  ir al registro:
1.
Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Escuela, Alfonso M. (Universidad de Las Palmas de Gran Canaria) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteomes by the alternative selection of exonic sequences. Alterations in this mechanism are associated with most cancers, enhancing their proliferation and survival, and can be employed as cancer biomarkers. [...]
2019 - 10.1021/acs.analchem.9b03898
Analytical chemistry, Vol. 91, Issue 23 (December 2019) , p. 15138-15146  
2.
25 p, 1.7 MB Advanced Evanescent-Wave Optical Biosensors for the Detection of Nucleic Acids : An Analytic Perspective / Sánchez Huertas, César (Royal Melbourne Institute of Technology University) ; Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ; Mitchell, Arnan (Royal Melbourne Institute of Technology University) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Evanescent-wave optical biosensors have become an attractive alternative for the screening of nucleic acids in the clinical context. They possess highly sensitive transducers able to perform detection of a wide range of nucleic acid-based biomarkers without the need of any label or marker. [...]
2019 - 10.3389/fchem.2019.00724
Frontiers in chemistry, Vol. 7 (October 2019) , art. 724  
3.
53 p, 6.1 MB Aptamer-peptide conjugates as a new strategy to modulate human α-thrombin binding affinity / Aviñó, Anna (Institut de Química Avançada de Catalunya) ; Jorge, Andreia F. (Universidade de Coimbra) ; Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Cova, Tania F.G.G. (Universidade de Coimbra) ; Pais, Alberto (Universidade de Coimbra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Fàbrega, Carme (Institut de Química Avançada de Catalunya)
Aptamers are single-stranded RNA or DNA molecules that specifically recognize their targets and have proven valuable for functionalizing sensitive biosensors. α-thrombin is a trypsin-like serine proteinase which plays a crucial role in haemostasis and thrombosis. [...]
2019 - 10.1016/j.bbagen.2019.06.014
Biochimica et Biophysica Acta - General Subjects, Vol. 1863, Issue 10 (October 2019) , p. 1619-1630  
4.
38 p, 3.1 MB Prospects of optical biosensors for emerging label-free RNA analysis / Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia) ; Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
RNA is critical in countless cellular processes, and researchers are constantly discovering new types and attributing them different roles. Consequently, a growing interest in efficient RNA analysis has arisen. [...]
2016 - 10.1016/j.trac.2016.02.018
TrAC - Trends in Analytical Chemistry, Vol. 80 (June 2016) , p. 177-189  
5.
32 p, 1.1 MB Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. [...]
2016 - 10.1016/j.bios.2015.11.023
Biosensors and bioelectronics, Vol. 78 (April 2016) , p. 118-125  
6.
8 p, 201.2 KB Simple, low-cost and timely optical biosensors for the detection of epigenetics biomarkers : the future of cancer diagnosis / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
The cancer burden continues to grow with enormous physical, emotional, and financial pressure on individuals, families, communities, and health systems. Early detection and effective treatment are crucial. [...]
2017
European Medical Journal Oncology, Vol. 5, Núm. 1 (October 2017) , p. 54-61  
7.
Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Aviñó, Anna (Institut de Química Avançada de Catalunya) ; Kurachi, Cristina (Institut Català de Nanociència i Nanotecnologia) ; Piqué, Albert (Institut Català de Nanociència i Nanotecnologia) ; Sandoval, Juan (Institut de Recerca Biomèdia Bellvitge) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats (ICREA)) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Cancer diagnosis continuously evolves due to the better understanding of tumorigenic processes. DNA-methylation is consolidated as an effective biomarker for cancer prognosis and diagnostic even in tumors of unknown origin. [...]
2018 - 10.1016/j.bios.2018.08.027
Biosensors and bioelectronics, Vol. 120 (November 2018) , p. 47-54  
8.
25 p, 1.1 MB Label-free plasmonic biosensors for point-of-care diagnostics : a review / Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Introduction: Optical biosensors, particularly those based on nanoplasmonics technology, have emerged in recent decades as a potential solution for disease diagnostics and therapy follow-up at the point-of-care (POC). [...]
2018 - 10.1080/14737159.2019.1554435
Expert review of molecular diagnostics, Vol. 19, Issue 1 (December 2018) , p. 71-81
2 documentos
9.
8 p, 985.7 KB Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Domínguez Zotes, Santos (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. [...]
2017 - 10.1038/srep41368
Scientific reports, Vol. 7 (January 2017) , art. 41368  
10.
10 p, 957.5 KB Direct and Label-Free Quantification of Micro-RNA-181a at Attomolar Level in Complex Media Using a Nanophotonic Biosensor / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Fariña, David (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Micro-RNA signatures have emerged as advantageous biomarkers for disease prediction opening the route for the development of more direct and accurate therapies. There is an urgent need for reliable tools which can offer fast, highly sensitive, and selective detection of multiple miRNAs in complex matrices as opposed to the conventional techniques. [...]
2016 - 10.1021/acssensors.6b00162
ACS Sensors, Vol. 1, Núm. 6 (June 2016) , p. 748-756  

Artículos : Encontrados 11 registros   1 - 10siguiente  ir al registro:
Documentos de investigación Encontrados 1 registros  
1.
217 p, 6.6 MB Nanophotonic biosensors for deciphering cell regulation pathways / Sánchez Huertas, César ; Lechuga, Laura M., dir. ; Villaverde, Antoni ; Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia
La presente Tesis Doctoral se centra en el desarrollo de metodologías analíticas de carácter innovador para el estudio de diferentes rutas de regulación genética. Éstas nuevas técnicas de análisis se presentan como una atractiva alternativa para conseguir un diagnóstico y seguimiento de terapia del cáncer más precisos e informativos. [...]
This Doctoral Thesis focuses on the development of innovative biosensor devices as alternative analytical techniques for the evaluation of different gene regulating pathways in order to obtain a more informative and accurate diagnosis and follow-up therapy of cancer. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  

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