Resultats globals: 11 registres trobats en 0.02 segons.
Articles, 10 registres trobats
Documents de recerca, 1 registres trobats
Articles 10 registres trobats  
1.
13 p, 1.1 MB Protein aggregation into insoluble deposits protects from oxidative stress / Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Ventura i Zamora, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity of protein conformational states, however the identity of the specific species responsible for the cellular damage is still unclear. [...]
2017 - 10.1016/j.redox.2017.03.027
Redox Biology, Vol. 12 (Aug. 2017) , p. 699-711  
2.
6 p, 5.8 MB Centrality in the host–pathogen interactome is associated with pathogen fitness during infection / Crua Asensio, Núria (Hospital Universitari Vall d'Hebron) ; Muñoz Giner, Elisabet (Hospital Universitari Vall d'Hebron) ; Sánchez de Groot, Natalia (Universitat Pompeu Fabra) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host–pathogen interactome is directly related to pathogen fitness during infection. [...]
2017 - 10.1038/ncomms14092
Nature Communications, Vol. 8 (January 2017) , art. 14092  
3.
11 p, 2.0 MB Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? / Sánchez de Groot, Natalia (Laboratory of Molecular Biology. Medical Research Council) ; Torrent Burgas, Marc (Laboratory of Molecular Biology. Medical Research Council) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. [...]
2015 - 10.1007/s00018-015-2038-4
Cellular and Molecular Life Sciences, Vol. 72, Issue 24 (December 2015) , p. 4795-4805  
4.
9 p, 626.3 KB Proteome response at the edge of protein aggregation / Sanchez de Groot, Natalia (MRC Laboratory of Molecular Biology) ; Gomes, Ricardo A. (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Villar Pique, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ; Madan Babu, M. (MRC Laboratory of Molecular Biology) ; Varela Coelho, Ana (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. [...]
2015 - 10.1098/rsob.140221
Open biology, Vol. 5, issue 2 (Feb. 2015) , art. 140221  
5.
12 p, 2.1 MB Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation / López Rodríguez, Laura Catalina (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Varea, Olga (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Navarro Cantero, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Carrodeguas Villar, José Alberto (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sancho Sanz, Javier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular)
Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus. [...]
2016 - 10.3390/ijms17060964
International Journal of Molecular Sciences, Vol. 17 Núm. 6 (june 2016)  
6.
3 p, 212.6 KB Resposta cel·lular a un mal plegament de proteïnes / Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Una de les principals línies de recerca del grup és l'estudi del mal plegament i l'agregació de proteïnes relacionades amb la malaltia. Estudien aquest fenomen des d'un punt de vista biofísic, per conèixer les propietats de les proteïnes que estan involucrades en aquest esdeveniment, i també utilitzant models vius, per entendre la seva relació amb les malalties i les funcions cel·lulars.
2015
UAB divulga, Octubre 2015  
7.
11 p, 1.6 MB Using bacterial inclusion bodies to screen for amyloid aggregation inhibitors / Villar Piqué, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Espargaró Colomé, Alba (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sabaté, Raimon (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: The amyloid-β peptide (Aβ42) is the main component of the inter-neuronal amyloid plaques characteristic of Alzheimer's disease (AD). The mechanism by which Aβ42 and other amyloid peptides assemble into insoluble neurotoxic deposits is still not completely understood and multiple factors have been reported to trigger their formation. [...]
2012 - 10.1186/1475-2859-11-55
Microbial cell factories, Vol. 11, N. 55 (May 2012) , p. 1-11  
8.
15 p, 658.6 KB Prediction of "hot spots" of aggregation in disease-linked polypeptides / Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vendrell i Roca, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Background: The polypeptides involved in amyloidogenesis may be globular proteins with a defined 3D-structure or natively unfolded proteins. The first class includes polypeptides such as β2-microglobulin, lysozyme, transthyretin or the prion protein, whereas β-amyloid peptide, amylin or α-synuclein all belong to the second class. [...]
2005 - 10.1186/1472-6807-5-18
BMC Structural biology, Vol. 5, N. 18 (September 2005) , p. 1-15  
9.
17 p, 815.0 KB AGGRESCAN : a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides / Conchillo-Solé, Óscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Vendrell i Roca, Josep (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura i Zamora, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases. On the biotechnological side, protein production is often hampered by the accumulation of recombinant proteins into aggregates. [...]
2007 - 10.1186/1471-2105-8-65
BMC Bioinformatics, Vol. 8, N. 65 (February 2007) , p. 1-17
5 documents
10.
17 p, 1.6 MB Protein aggregation profile of the bacterial cytosol / Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Background: protein misfolding is usually deleterious for the cell, either as a consequence of the loss of protein function or the buildup of insoluble and toxic aggregates. The aggregation behavior of a given polypeptide is strongly influenced by the intrinsic properties encoded in its sequence. [...]
2010 - 10.1371/journal.pone.0009383
PLoS one, Vol. 5, N. 2 (February 2010) , p. e9383  

Documents de recerca 1 registres trobats  
1.
85 p, 4.3 MB Sequential and structural deteminants of protein aggregation / Sánchez de Groot, Natalia ; Vendrell i Roca, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura Zamora, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
The project entitled "Sequential and structural determinants of protein aggregation" aims to study the factors that control protein deposition but also tries to develop new strategies to facilitate its comprehension. [...]
Bellaterra: Universitat Autònoma de Barcelona, 2010
2 documents

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