Resultados globales: 16 registros encontrados en 0.02 segundos.
Artículos, Encontrados 15 registros
Documentos de investigación, Encontrados 1 registros
Artículos Encontrados 15 registros  1 - 10siguiente  ir al registro:
1.
13 p, 5.2 MB Discovering putative prion-like proteins in Plasmodium falciparum : a computational and experimental analysis / Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sant'Anna, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Biosca, Arnau (Institut de Bioenginyeria de Catalunya) ; Fernàndez Busquets, Xavier (Institut de Bioenginyeria de Catalunya) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prions are a singular subset of proteins able to switch between a soluble conformation and a self-perpetuating amyloid state. Traditionally associated with neurodegenerative diseases, increasing evidence indicates that organisms exploit prion-like mechanisms for beneficial purposes. [...]
2018 - 10.3389/fmicb.2018.01737
Frontiers in microbiology, Vol. 9 (Aug. 2018) , art. 1737  
2.
7.9 MB Computational analysis of candidate prion-like proteins in bacteria and their role / Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez de Groot, Natalia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion proteins were initially associated with diseases such as Creutzfeldt Jakob and transmissible spongiform encephalopathies. However, deeper research revealed them as versatile tools, exploited by the cells to execute fascinating functions, acting as epigenetic elements or building membrane free compartments in eukaryotes. [...]
2015 - 10.3389/fmicb.2015.01123
Frontiers in microbiology, Vol. 6 (Oct. 2015) , art. 1123  
3.
20 p, 3.5 MB The fitness cost and benefit of phase-separated protein deposits / Sanchez de Groot, Natalia (Centre de Regulació Genòmica) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ravarani, Charles N.J. (Medical Research Council Laboratory of Molecular Biology) ; Trusina, Ala (Niels Bohr Institute) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Babu, Madam M. (Medical Research Council Laboratory of Molecular Biology)
Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. [...]
2019 - 10.15252/msb.20178075
Molecular systems biology, Vol. 15, issue 4 (April 2019) , art. e8075  
4.
12 p, 2.4 MB A coordinated response at the transcriptome and interactome level is required to ensure uropathogenic escherichia coli survival during bacteremia / Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Localized infections or disruption of the skin barrier can enable the entry of bacteria into the bloodstream, possibly leading to acute inflammation and sepsis. There is currently no holistic view on how bacteria can survive and spread in the bloodstream. [...]
2019 - 10.3390/microorganisms7090292
Microorganisms, Vol. 7, Issue 9 (September 2019) , art. 292  
5.
10 p, 1.3 MB Characterization of Amyloid Cores in Prion Domains / Sant'Anna, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fernández Gallegos, Ma. Rosario (María Rosario) (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Batlle Carreras, Cristina (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Navarro Cantero, Susana (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Serpell, Louise (University of Sussex. School of Life Sciences) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Amyloids consist of repetitions of a specific polypeptide chain in a regular cross-β-sheet conformation. Amyloid propensity is largely determined by the protein sequence, the aggregation process being nucleated by specific and short segments. [...]
2016 - 10.1038/srep34274
Scientific reports, Vol. 6 (2016) , art. 34274  
6.
13 p, 1.1 MB Protein aggregation into insoluble deposits protects from oxidative stress / Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity of protein conformational states, however the identity of the specific species responsible for the cellular damage is still unclear. [...]
2017 - 10.1016/j.redox.2017.03.027
Redox biology, Vol. 12 (Aug. 2017) , p. 699-711  
7.
6 p, 5.8 MB Centrality in the host-pathogen interactome is associated with pathogen fitness during infection / Crua Asensio, Núria (Hospital Universitari Vall d'Hebron) ; Muñoz Giner, Elisabet (Hospital Universitari Vall d'Hebron) ; Sánchez de Groot, Natalia (Universitat Pompeu Fabra) ; Torrent Burgas, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. [...]
2017 - 10.1038/ncomms14092
Nature communications, Vol. 8 (January 2017) , art. 14092  
8.
11 p, 2.0 MB Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases? / Sánchez de Groot, Natalia (Laboratory of Molecular Biology. Medical Research Council) ; Torrent Burgas, Marc (Laboratory of Molecular Biology. Medical Research Council) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. [...]
2015 - 10.1007/s00018-015-2038-4
Cellular and Molecular Life Sciences, Vol. 72, Issue 24 (December 2015) , p. 4795-4805  
9.
9 p, 626.3 KB Proteome response at the edge of protein aggregation / Sanchez de Groot, Natalia (MRC Laboratory of Molecular Biology) ; Gomes, Ricardo A. (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Villar Pique, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ; Madan Babu, M. (MRC Laboratory of Molecular Biology) ; Varela Coelho, Ana (Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. [...]
2015 - 10.1098/rsob.140221
Open biology, Vol. 5, issue 2 (Feb. 2015) , art. 140221  
10.
12 p, 2.1 MB Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation / López Rodríguez, Laura Catalina (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Varea, Olga (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Navarro Cantero, Susanna (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Carrodeguas Villar, José Alberto (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Sánchez de Groot, Natalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sancho Sanz, Javier (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular)
Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus. [...]
2016 - 10.3390/ijms17060964
International journal of molecular sciences, Vol. 17 Núm. 6 (june 2016)  

Artículos : Encontrados 15 registros   1 - 10siguiente  ir al registro:
Documentos de investigación Encontrados 1 registros  
1.
85 p, 4.3 MB Sequential and structural deteminants of protein aggregation / Sánchez de Groot, Natalia ; Vendrell i Roca, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura Zamora, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
The project entitled "Sequential and structural determinants of protein aggregation" aims to study the factors that control protein deposition but also tries to develop new strategies to facilitate its comprehension. [...]
Bellaterra: Universitat Autònoma de Barcelona, 2010
2 documentos

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