Results overview: Found 3 records in 0.02 seconds.
Articles, 3 records found
Articles 3 records found  
1.
16 p, 3.3 MB Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis / Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ; Rinas, Melanie (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ; Wirbel, Jakob (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ; Pertsovskaya, Inna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pliaka, Vicky (School of Mechanical Engineering, National Technical University of Athens) ; Messinis, Dimitris E. (ProtATonce) ; Vila, Gemma (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sakellaropoulos, Theodore (National Technical University of Athens) ; Faigle, Wolfgang (University of Zurich) ; Stridh, Pernilla (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Behrens, Janina R. (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ; Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Martin, Roland (University Hospital Zurich (Suïssa)) ; Paul, Friedemann (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ; Alexopoulos, Leonidas G. (ProtATonce) ; Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Saez-Rodriguez, Julio (Heidelberg University Hospital (Alemanya))
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects. [...]
2021 - 10.1186/s13073-021-00925-8
Genome Medicine, Vol. 13 (July 2021) , art. 117  
2.
13 p, 1.8 MB Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations / Brammeld, Jonathan S. (Wellcome Trust Sanger Institute (Regne Unit)) ; Petljak, Mia (Wellcome Trust Sanger Institute (Regne Unit)) ; Martincorena, Inigo (Wellcome Trust Sanger Institute (Regne Unit)) ; Williams, Steven P. (Wellcome Trust Sanger Institute (Regne Unit)) ; García Alonso, Luz (European Molecular Biology Laboratory (Regne Unit)) ; Dalmases, Alba (Hospital del Mar (Barcelona, Catalunya)) ; Bellosillo Paricio, Beatriz (Hospital del Mar (Barcelona, Catalunya)) ; Robles-Espinoza, Carla Daniela (Universidad Nacional Autónoma de México) ; Price, Stacey (Wellcome Trust Sanger Institute (Regne Unit)) ; Barthorpe, Syd (Wellcome Trust Sanger Institute (Regne Unit)) ; Tarpey, Patrick (Wellcome Trust Sanger Institute (Regne Unit)) ; Alifrangis, Constantine (Wellcome Trust Sanger Institute (Regne Unit)) ; Bignell, Graham (Wellcome Trust Sanger Institute (Regne Unit)) ; Vidal, Joana (Institut Hospital del Mar d'Investigacions Mèdiques) ; Young, Jamie (Wellcome Trust Sanger Institute (Regne Unit)) ; Stebbings, Lucy (Wellcome Trust Sanger Institute (Regne Unit)) ; Beal, Kathryn (Wellcome Trust Sanger Institute (Regne Unit)) ; Stratton, Michael R. (Wellcome Trust Sanger Institute (Regne Unit)) ; Saez-Rodriguez, Julio (University Hospital Aachen (Alemanya)) ; Garnett, Mathew (Wellcome Trust Sanger Institute (Regne Unit)) ; Montagut, Clara (Institut Hospital del Mar d'Investigacions Mèdiques) ; Iorio, Francesco (European Molecular Biology Laboratory (Regne Unit)) ; McDermott, Ultan (Wellcome Trust Sanger Institute (Regne Unit)) ; Universitat Autònoma de Barcelona
Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases, this is the consequence of specific gene mutations that have the potential to be targeted to resensitize the tumor. [...]
2017 - 10.1101/gr.213546.116
Genome research, Vol. 27 (april 2017) , p. 613-625  
3.
14 p, 1.6 MB Efficient randomization of biological networks while preserving functional characterization of individual nodes / Iorio, Francesco (European Bioinformatics Institute. European Molecular Biology Laboratory) ; Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ; Gobbi, Andrea (Fondazione Bruno Kessler) ; Cokelaer, Thomas (Institut Pasteur. The Center of Bioinformatics, Biostatistics and Integrative Biology) ; Jurman, Giuseppe. (Fondazione Bruno Kessler) ; Saez-Rodriguez, Julio (RWTH Aachen University. Joint Research Centre for Computational Biomedicine)
Background: Networks are popular and powerful tools to describe and model biological processes. Many computational methods have been developed to infer biological networks from literature, high-throughput experiments, and combinations of both. [...]
2016 - 10.1186/s12859-016-1402-1
BMC bioinformatics, Vol. 17 (2016) , art. 542  

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1 Saez-Rodriguez, J
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