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16 p, 898.0 KB |
Diagnosis and treatment of Chiari malformation type 1 in children : the International Consensus Document
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Massimi, Luca (Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Peretta, Paola (AOU Citta' della Salute e della Scienza di Torino) ;
Erbetta, Alessandra (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Solari, Alessandra (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Farinotti, Mariangela (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Ciaramitaro, Palma (AOU Citta' della Salute e della Scienza di Torino) ;
Saletti, Veronica (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Caldarelli, Massimo (Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Canheu, Alexandre Casagrande (Universidade Estadual de Londrina) ;
Celada, Carlo ("Associazione Italiana Siringomielia e Arnold Chiari", Garino) ;
Chiapparini, Luisa (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Chieffo, Daniela (Fondazione Policlinico Universitario A Gemelli IRCCS and UCSC) ;
Cinalli, Giuseppe (Santobono-Pausilipon Children's Hospital) ;
Di Rocco, Federico (Université de Lyon) ;
Furlanetto, Marika (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Giordano, Flavio (Meyer Pediatric Hospital, Florence) ;
Jallo, George (Johns Hopkins All Children's Hospital) ;
James, Syril (Necker Enfants Malades Hospital) ;
Lanteri, Paola (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Lemarchand, Christian (Conseil Scientifique APAISER S&C, Treillières, France) ;
Messing-Jünger, Martina (Asklepios Kinderklinik) ;
Parazzini, Cecilia (Children Hospital V. Buzzi) ;
Paternoster, Giovanna (Necker Enfants Malades Hospital) ;
Piatelli, Gianluca (Gaslini Children's Hospital) ;
Poca, Maria. A. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Prabahkar, Prab (Great Ormond Street Hospital for Children, Londres) ;
Ricci, Federica (AOU Citta' della Salute e della Scienza di Torino) ;
Righini, Andrea (Children Hospital V. Buzzi) ;
Sala, Francesco (Great Ormond Street Hospital for Children (Londres)) ;
Sahuquillo Barris, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Stoodley, Marcus (Macquarie University Clinical Associates) ;
Talamonti, Giuseppe (ASST Niguarda) ;
Thompson, Dominic (Great Ormond Street Hospital for Children (Londres)) ;
Triulzi, Fabio (University of Milan) ;
Zucchelli, Mino (IRCCS Istituto delle Scienze Neurologiche di Bologna) ;
Valentini, Laura (Fondazione IRCCS Istituto Neurologico Carlo Besta) ;
Universitat Autònoma de Barcelona
Chiari malformation type 1 (CM1) is a rare condition where agreed classification and treatment are still missing. The goal of this study is to achieve a consensus on the diagnosis and treatment of CM1 in children. [...]
2021 -  10.1007/s10072-021-05317-9
Neurological Sciences, Vol. 43 (june 2021) , p. 1311-1326
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10 p, 4.1 MB |
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
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Rubio-Perez, Carlota (Vall d'Hebron Institut d'Oncologia) ;
Planas-Rigol, Ester (Vall d'Hebron Institut d'Oncologia) ;
Trincado, Juan L. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bonfill-Teixidor, Ester (Vall d'Hebron Institut d'Oncologia) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Moutinho, Catia (Centre de Regulació Genòmica) ;
Serna, Garazi (Vall d'Hebron Institut d'Oncologia) ;
Pedrosa, Leire (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Iurlaro, Raffaella (Vall d'Hebron Institut d'Oncologia) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Escudero, Laura (Vall d'Hebron Institut d'Oncologia) ;
Cordero, Esteban (Universitat Autònoma de Barcelona) ;
Cicuendez, Marta (Universitat Autònoma de Barcelona) ;
Ruiz, Sara (Centre de Regulació Genòmica) ;
Parra, Genís (Centre de Regulació Genòmica) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Gonzalez, Josep (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Tabernero, Josep (Centro de Investigación Biomédica en Red de Cáncer) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats)
Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (ICI) and the degree and phenotype of the immune cell infiltration has been used to predict response to ICI. [...]
2021 - 10.1038/s41467-021-21789-x
Nature communications, Vol. 12 (march 2021)
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11 p, 753.1 KB |
Lactate and the Lactate-to-Pyruvate Molar Ratio Cannot Be Used as Independent Biomarkers for Monitoring Brain Energetic Metabolism : A Microdialysis Study in Patients with Traumatic Brain Injuries
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Sahuquillo Barris, Juan (Hospital Universitari Vall d'Hebron) ;
Merino, Maria-Angels (Hospital Universitari Vall d'Hebron) ;
Sánchez-Guerrero, Angela (Hospital Universitari Vall d'Hebron) ;
Arikan Abelló, Fuat (Hospital Universitari Vall d'Hebron) ;
Vidal-Jorge, Marian (Hospital Universitari Vall d'Hebron) ;
Martínez-Valverde, Tamara (Hospital Universitari Vall d'Hebron) ;
Rey Pérez, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riveiro, Marilyn (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poca Pastor, María Antonia (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
For decades, lactate has been considered an excellent biomarker for oxygen limitation and therefore of organ ischemia. The aim of the present study was to evaluate the frequency of increased brain lactate levels and the LP ratio (LPR) in a cohort of patients with severe or moderate traumatic brain injury (TBI) subjected to brain microdialysis monitoring to analyze the agreement between these two biomarkers and to indicate brain energy metabolism dysfunction. [...]
2014 - 10.1371/journal.pone.0102540
PloS one, Vol. 9 (july 2014)
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6 p, 916.0 KB |
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
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De Mattos-Arruda, Leticia (Universitat Autònoma de Barcelona) ;
Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ;
Ng, Charlotte K. Y. (Memorial Sloan Kettering Cancer Center) ;
Weigelt, Britta (Memorial Sloan Kettering Cancer Center) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Torrejon, Davis (Vall d'Hebron Institut d'Oncologia) ;
Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Raventós, Carolina (Vall d'Hebron Institut d'Oncologia) ;
Tang, Jiabin (Memorial Sloan Kettering Cancer Center) ;
Guerini-Rocco, Elena (Memorial Sloan Kettering Cancer Center) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lois, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marín, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Piscuoglio, Salvatore (Memorial Sloan Kettering Cancer Center) ;
Towers, Russel (Department of Surgery, Memorial Sloan Kettering Cancer Center) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona) ;
Carles, Joan (Vall d'Hebron Institut d'Oncologia) ;
Rodon, Jordi (Vall d'Hebron Institut d'Oncologia) ;
González-Cao, María (Quirón Dexeus University Hospital) ;
Tabernero, Josep (Universitat Autònoma de Barcelona) ;
Felip, Enriqueta (Universitat Autònoma de Barcelona) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Berger, Michael F. (Memorial Sloan Kettering Cancer Center) ;
Cortés, Javier (Universitat Autònoma de Barcelona) ;
Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center) ;
Seoane Suárez, Joan (Universitat Autònoma de Barcelona)
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. [...]
2015 - 10.1038/ncomms9839
Nature communications, Vol. 6 (november 2015)
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21 p, 3.3 MB |
Malignant infarction of the middle cerebral artery in a porcine model. A pilot study
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Arikan Abelló, Fuat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-Valverde, Tamara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez-Guerrero, Ángela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Campos, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteves, Marielle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gándara, Dario F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torné, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castro, Lidia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dalmau Bueno, Antoni (Animal Breeding and Genetics Program (Girona)) ;
Tibau, Joan (Animal Breeding and Genetics Program, Monells (Girona)) ;
Sahuquillo Barris, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Interspecies variability and poor clinical translation from rodent studies indicate that large gyrencephalic animal stroke models are urgently needed. We present a proof-of-principle study describing an alternative animal model of malignant infarction of the middle cerebral artery (MCA) in the common pig and illustrate some of its potential applications. [...]
2017 - 10.1371/journal.pone.0172637
PloS one, Vol. 12 (february 2017)
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11 p, 2.2 MB |
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
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Escudero, Laura (Vall d'Hebron Institut d'Oncologia) ;
Llort, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Diaz-Navarro, Ander (Centro de Investigación Biomédica en Red de Cáncer) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Rubio-Perez, Carlota (Vall d'Hebron Institut d'Oncologia) ;
Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ;
Caratù, Ginevra (Vall d'Hebron Institut d'Oncologia) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez-Méndez, Élida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lesende-Rodríguez, Iván (Universidade da Coruña) ;
Hladun, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gros, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona) ;
Puente, Xose S. (Centro de Investigación Biomédica en Red de Cáncer) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Gallego, Soledad (Universitat Autònoma de Barcelona) ;
Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats)
The molecular characterisation of medulloblastoma, the most common paediatric brain tumour, is crucial for the correct management and treatment of this heterogenous disease. However, insufficient tissue sample, the presence of tumour heterogeneity, or disseminated disease can challenge its diagnosis and monitoring. [...]
2020 - 10.1038/s41467-020-19175-0
Nature communications, Vol. 11 (october 2020)
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30 p, 5.9 MB |
Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury : A Review of the Evidence
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Jha, Ruchira M. (University of Pittsburgh) ;
Bell, Josh (Biogen (Estats Units d'Amèrica)) ;
Citerio, Giuseppe (Ospedale San Gerardo (Itàlia)) ;
Hemphill, J. Claude (University of California) ;
Kimberly, W. Taylor (Massachusetts General Hospital (Boston)) ;
Narayan, Raj K. (North Shore University Hospital) ;
Sahuquillo Barris, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sheth, Kevin N. (Yale University School of Medicine) ;
Simard, J. Marc (University of Maryland School of Medicine) ;
Universitat Autònoma de Barcelona
Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. [...]
2020 - 10.3390/ijms21020409
International journal of molecular sciences, Vol. 21 (january 2020)
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14 p, 1.9 MB |
Considerations in the Use of Gravitational Valves in the Management of Hydrocephalus. Some Lessons Learned with the Dual-Switch Valve
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Poca Pastor, María Antonia (Universitat Autònoma de Barcelona. Departament de Cirurgia) ;
Gándara, Dario F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosas, Katiuska (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alcina, Aloma (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
López-Bermeo, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia)
In the past decade, there has been a clear trend towards better outcomes in patients with hydrocephalus, especially those with normal pressure hydrocephalus (NPH). This is partly due to the availability of more sophisticated hardware and a better understanding of implants. [...]
2021 - 10.3390/jcm10020246
Journal of clinical medicine, Vol. 10 (january 2021)
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22 p, 1.6 MB |
Neurodevelopmental profile in children with benign external hydrocephalus syndrome. A pilot cohort study
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Maruccia, Federica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gomariz, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosas, Katiuska (Hospital Universitari Vall d'Hebron) ;
Durduran, Turgut (Institut de Ciències Fotòniques) ;
Paredes Carmona, Fernando (Hospital Arnau de Vilanova (Lleida, Catalunya)) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona)
Purpose The management of children with benign external hydrocephalus (BEH) remains controversial. Most BEH children do well in the long-term, but a substantial number have temporary or permanent psychomotor delays. [...]
2021 - 10.1007/s00381-021-05201-z
Child's Nervous System, 10 May 2021
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