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16 p, 3.3 MB Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis / Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ; Rinas, Melanie (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ; Wirbel, Jakob (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ; Pertsovskaya, Inna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Pliaka, Vicky (School of Mechanical Engineering, National Technical University of Athens) ; Messinis, Dimitris E. (ProtATonce) ; Vila, Gemma (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Sakellaropoulos, Theodore (National Technical University of Athens) ; Faigle, Wolfgang (University of Zurich) ; Stridh, Pernilla (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Behrens, Janina R. (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ; Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Martin, Roland (University Hospital Zurich (Suïssa)) ; Paul, Friedemann (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ; Alexopoulos, Leonidas G. (ProtATonce) ; Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Saez-Rodriguez, Julio (Heidelberg University Hospital (Alemanya))
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects. [...]
2021 - 10.1186/s13073-021-00925-8
Genome Medicine, Vol. 13 (July 2021) , art. 117  
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