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13 p, 2.8 MB Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects / Forteza, R. (University of Miami) ; Ahsan, M. K. (Universitat Autònoma de Barcelona) ; Arango, Diego (Universitat Autònoma de Barcelona) ; Ameen, N. A. (Yale University) ; Salas, P. J. (University of Miami) ; Vall d'Hebron Institut de Recerca (VHIR)
Loss-of-function mutations in the nonconventional myosin Vb (Myo5b) result in microvillus inclusion disease (MVID) and massive secretory diarrhea that often begins at birth. Myo5b mutations disrupt the apical recycling endosome (ARE) and membrane traffic, resulting in reduced surface expression of apical membrane proteins. [...]
2019 - 10.1091/mbc.E18-07-0415
Molecular biology of the cell, Vol. 30 Núm. 26 (2019) , p. 3076-3089  

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