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19 p, 4.7 MB |
Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer
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Hermanova, Ivana (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Zúñiga-García, Patricia (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Caro-Maldonado, Alfredo (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Fernandez-Ruiz, Sonia (CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain) ;
Salvador, Fernando (Cancer Science Program, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Spain) ;
Martín-Martín, Natalia (CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain) ;
Zabala-Letona, Amaia (CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain) ;
Nuñez-Olle, Marc (Cancer Science Program, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Spain) ;
Torrano, Verónica (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ;
Camacho, Laura (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Talamillo, Ana (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Carreira, Suzanne (The Institute of Cancer Research, London, UK) ;
Gurel, Bora (The Institute of Cancer Research, London, UK) ;
Cortazar, Ana R. (CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain) ;
Guiu, Marc (Cancer Science Program, Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Spain) ;
López, Jose I. (Department of Pathology, Cruces University Hospital, Biocruces Institute, University of the Basque Country, Barakaldo, Spain) ;
Martinez-Romero, Anabel (Institut d'Investigació Biomèdica de Bellvitge) ;
Astobiza, Ianire (CIBERONC (Centro de Investigación Biomédica en Red de Cáncer), Madrid, Spain) ;
Valcarcel-Jimenez, Lorea (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Lorente, Mar (Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain) ;
Arruabarrena-Aristorena, Amaia (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Velasco, Guillermo (Instituto de Investigaciones Sanitarias San Carlos, Madrid, Spain) ;
Gomez-Muñoz, Antonio (Biochemistry and Molecular Biology Department, University of the Basque Country, Bilbao, Spain) ;
Suárez-Cabrera, Cristian (Unidad de Oncología Molecular, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain) ;
Lodewijk, Iris (Unidad de Oncología Molecular, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain) ;
Flores, Juana M. (Department of Animal Medicine and Surgery, School of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain) ;
Sutherland, James D. (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
Barrio, Rosa (Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Derio, Spain) ;
de Bono, Johann S. (The Royal Marsden National Health Service Foundation Trust, London, UK) ;
Paramio, Jesús M. (Unidad de Oncología Molecular, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain) ;
Trka, Jan (Department of Paediatric Haematology/Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic) ;
Graupera, Mariona (Institut d'Investigació Biomèdica de Bellvitge) ;
Gomis, Roger R. (Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain) ;
Carracedo, Arkaitz (Ikerbasque, Basque Foundation for Science, Bilbao, Spain)
This study unravels an unprecedented murine model of lethal metastatic prostate cancer, based on the combined deletion of Pten and Lkb1. Importantly, minimal activity of LKB1 is sufficient to hamper prostate cancer cell aggressiveness, thus redefining the relationship between gene dosage and tumor suppression. [...]
2020 -  10.1084/jem.20191787
The Journal of Experimental Medicine, Vol. 217 (march 2020)
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15 p, 450.0 KB |
Experimental and Clinical Treatment of Chagas Disease : A Review
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Sales Junior, Policarpo Ademar (Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil) ;
Molina, Israel (Hospital Universitari Vall d'Hebron) ;
Fonseca Murta, Silvane Maria (Centro de Pesquisas René Rachou, FIOCRUZ, Belo Horizonte, Minas Gerais, Brazil) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Salvador, Fernando (Hospital Universitari Vall d'Hebron) ;
Corrêa-Oliveira, Rodrigo (Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil) ;
Carneiro, Cláudia Martins (Laboratório de Imunopatologia, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil) ;
Universitat Autònoma de Barcelona
Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million people in Latin America, and its incidence is increasing in nonendemic countries owing to rising international immigration and nonvectorial transmission routes such as blood donation. [...]
2017 - 10.4269/ajtmh.16-0761
The American Journal of Tropical Medicine and Hygiene, Vol. 97 (october 2017) , p. 1289-1303
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