Home > Search Results: Salvadores, M.
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Articles, 2 records found
Articles 2 records found  
1.
19 p, 3.0 MB Mutational signatures are markers of drug sensitivity of cancer cells / Levatić, Jurica (Institute for Research in Biomedicine (IRB Barcelona)) ; Salvadores, Marina (Institute for Research in Biomedicine (IRB Barcelona)) ; Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Supek, Fran (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Genomic analyses have revealed mutational footprints associated with DNA maintenance gone awry, or with mutagen exposures. Because cancer therapeutics often target DNA synthesis or repair, we asked if mutational signatures make useful markers of drug sensitivity. [...]
2022 - 10.1038/s41467-022-30582-3
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 2926  
Detailed record - Creative Commons
2.
16 p, 2.5 MB Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns / Salvadores, Marina (Institut de Recerca Biomèdica de Lleida) ; Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Supek, F. (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
Cell lines are commonly used as cancer models. The tissue of origin provides context for understanding biological mechanisms and predicting therapy response. We therefore systematically examined whether cancer cell lines exhibit features matching the presumed cancer type of origin. [...]
2020 - 10.1126/sciadv.aba1862
Science advances, Vol. 6 Núm. 27 (july 2020) , p. eaba1862  
Detailed record - Creative Commons

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