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17 p, 921.2 KB |
Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes
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Sauta, Elisabetta (Humanitas Clinical and Research Center (Itàlia)) ;
Robin, Marie (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Bersanelli, Mateo (Department of Biomedical Sciences. Humanitas University) ;
Travaglino, Erica (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Meggendorfer, Manje (Mll Munich Leukemia Laboratory) ;
Zhao, Lin-Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis (França)) ;
Caballero Berrocal, Juan Carlos (Hematology Department. Hospital Universitario de Salamanca) ;
Sala, Claudia (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Maggioni, Giulia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bernardi, Massimo (University Vita-Salute San Raffaele (Itàlia)) ;
Di Grazia, Carmen (Irccs Ospedale Policlinico San Martino) ;
Vago, Luca (University Vita-Salute San Raffaele (Itàlia)) ;
Rivoli, Giulia (Irccs Ospedale Policlinico San Martino) ;
Borin, Lorenza (Ospedale San Gerardo) ;
D'Amico, Saverio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Tentori, Cristina Astrid (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Ubezio, Marta (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Campagna, Alessia (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Russo, Antonio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Mannina, Daniele (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Lanino, Luca (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Chiusolo, Patrizia (Università Cattolica Del Sacro Cuore) ;
Giaccone, Luisa (Department of Molecular Biotechnology and Health Sciences. University of Turin) ;
Voso, Maria Teresa (Tor Vergata University) ;
Riva, Maria (Asst Grande Ospedale Metropolitano Niguarda) ;
Oliva, Esther Natalie (Grande Ospedale Metropolitano Bianchi Melacrino Morelli) ;
Zampini, Matteo (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Riva, Elena (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Nibourel, Olivier (Chu Lille) ;
Bicchieri, Marinela (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Bolli, Niccolo (Department of Oncology and Hemato-Oncology. University of Milan) ;
Rambaldi, Alessandro (Azienda Ospedaliera Papa Giovanni Xxiii) ;
Passamonti, Francesco (Department of Medicine and Surgery. University of Insubria) ;
Savevski, Victor (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia)) ;
Santoro, Armando (Department of Biomedical Sciences. Humanitas University) ;
Germing, Ulrich (Department of Hematology. Heinrich-Heine-University. University Clinic) ;
Kordasti, Shahram (Hematology Department. DISCLIMO-Università Politecnica Delle Marche) ;
Santini, Valeria (University of Florence) ;
Diez-Campelo, María (Hospital Universitario de Salamanca) ;
Sanz, Guillermo (Hospital Universitari i Politècnic La Fe (València)) ;
Sole, F (Institut de Recerca Contra la Leucèmia Josep Carreras) ;
Kern, Wolfgang (Mll Munich Leukemia Laboratory) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Arenillas, Leonor (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Fenaux, Pierre (Department of Hematology and Bone Marrow Transplantation. Hôpital Saint-Louis) ;
Haferlach, Torsten (Mll Munich Leukemia Laboratory) ;
Castellani, Gastone (Experimental. Diagnostic and Specialty Medicine. Dimes) ;
Della Porta, Matteo Giovanni (Department of Biomedical Sciences. Humanitas University)
PURPOSEMyelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). [...]
2023 -  10.1200/JCO.22.01784
Journal of Clinical Oncology, Vol. 41 Núm. 15 (20 2023) , p. 2827-2842
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14 p, 9.2 MB |
Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1 -Mutant Myelodysplastic Syndromes With Ringed Sideroblasts
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Ademà, Vera (The University of Texas MD Anderson Cancer Center) ;
Ma, Feiyang (University of Michigan) ;
Kanagal-Shamanna, Rashmi (The University of Texas MD Anderson Cancer Center) ;
Thongon, Natthakan (The University of Texas MD Anderson Cancer Center) ;
Montalban-Bravo, Guillermo (The University of Texas) ;
Yang, Hui (The University of Texas) ;
Peslak, Scott A. (Children's Hospital of Philadelphia (Pennsilvània)) ;
Wang, Feng (The University of Texas MD Anderson Cancer Center) ;
Acha, Pamela (Universitat Autònoma de Barcelona) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lockyer, Pamela (The University of Texas MD Anderson Cancer Center) ;
Cassari, Margherita (University of Florence) ;
Maciejewski, Jaroslaw P. (Cleveland Clinic Foundation) ;
Visconte, Valeria (Cleveland Clinic Foundation) ;
Gañán-Gómez, Irene (The University of Texas MD Anderson Cancer Center) ;
Song, Yuanbin (Sun Yat-sen University Cancer Center) ;
Bueso-Ramos, Carlos (The University of Texas MD Anderson Cancer Center) ;
Pellegrini, Matteo (University of California) ;
Tan, Tuyet M. (Univerity of California San Diego) ;
Bejar, Rafael (Univerity of California San Diego) ;
Carew, Jennifer S. (University of Arizona Cancer Center) ;
Halene, Stephanie (Yale University School of Medicine) ;
Santini, Valeria (University of Florence) ;
Al-Atrash, Gheath (The University of Texas MD Anderson Cancer Center) ;
Clise-Dwyer, Karen (The University of Texas MD Anderson Cancer Center) ;
Garcia-Manero, Guillermo (The University of Texas MD Anderson Cancer Center) ;
Blobel, Gerd A. (Children's Hospital of Philadelphia (Pennsilvània)) ;
Colla, Simona (The University of Texas MD Anderson Cancer Center)
SF3B1 -mutant MDS-RS is associated with buildup of erythroid progenitor cells upregulating EIF2AK1-associated heme deficiency response and autophagy genes. Targeting EIF2AK1 relieves the dysregulated progenitor phenotype. [...]
2022 - 10.1158/2643-3230.BCD-21-0220
Blood Cancer Discovery, Vol. 3 (august 2022) , p. 554-567
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20 p, 525.5 KB |
Managing hematological cancer patients during the COVID-19 pandemic : an ESMO-EHA Interdisciplinary Expert Consensus
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Buske, Christian (University Hospital of Ulm (Alemanya)) ;
Dreyling, M. (Department of Medicine III at LMU Hospital) ;
Álvarez Larrán, Alberto (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Apperley, Jane (Imperial College London) ;
Arcaini, Luca (University of Pavia) ;
Besson, Caroline (UVSQ. Inserm. CESP) ;
Bullinger, Lars (Charité - Universitätsmedizin Berlin) ;
Corradini, Paolo (University of Milan) ;
Della Porta, Matteo Giovanni (Humanitas University) ;
Dimopoulos, Meletios (National and Kapodistrian University of Athens) ;
D'Sa, Shirley (University College London Hospitals NHS Foundation Trust) ;
Eich, H.T. (University of Muenster) ;
Foà, R. (Sapienza University) ;
Ghia, P. (Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele) ;
da Silva, M.G. (Portuguese Institute of Oncology) ;
Gribben, J. (Queen Mary University of London) ;
Hajek, Roman (University of Ostrava) ;
Harrison, C. (Guy's and St Thomas' NHS Foundation Trust) ;
Heuser, M. (Hannover Medical School) ;
Kiesewetter, Barbara (Medical University of Vienna) ;
Kiladjian, Jean-Jacques (Université de Paris) ;
Kroeger, Nicolaus (University Hospital Hamburg-Eppendorf) ;
Moreau, Philippe (University Hospital Hotel-Dieu) ;
Passweg, Jakob R. (University Hospital Basel (Basilea, Suïssa)) ;
Peyvandi, Flora (University of Milan) ;
Rea, Delphine (Hôpital Saint-Louis) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Robak, Tadeusz (Medical University of Lodz) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Santini, Valeria (University of Florence) ;
Sanz, G. (CIBERONC. IS Carlos III) ;
Sonneveld, P. (Erasmus MC Cancer Institute) ;
Von Lilienfeld-Toal, M. (Hans Knöll Institute) ;
Wendtner, Clemens-Martin (Ludwig-Maximilian University) ;
Pentheroudakis, G. (European Society for Medical Oncology) ;
Passamonti, Francesco (University of Insubria)
Background: The COVID-19 pandemic has created enormous challenges for the clinical management of patients with hematological malignancies (HMs), raising questions about the optimal care of this patient group. [...]
2022 - 10.1016/j.esmoop.2022.100403
ESMO open, Vol. 7 Núm. 2 (april 2022) , p. 100403
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15 p, 1.6 MB |
The ABNL-MARRO 001 study : a phase 1-2 study of randomly allocated active myeloid target compound combinations in MDS/MPN overlap syndromes
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Moyo, Tamara K. (Vanderbilt University School of Medicine) ;
Mendler, Jason H (University of Rochester Medical Center) ;
Itzykson, Raphael (Paris Diderot University) ;
Kishtagari, Ashwin (Vanderbilt University School of Medicine) ;
Solary, Eric (Institut Gustave Roussy. Université Paris-Saclay) ;
Seegmiller, Adam C. (Vanderbilt University School of Medicine) ;
Gerds, Aaron T. (Cleveland Clinic) ;
Ayers, Gregory D. (Vanderbilt University School of Medicine) ;
Dezern, Amy E. (Johns Hopkins University) ;
Nazha, Aziz (Cleveland Clinic) ;
Valent, Peter (Ludwig Boltzmann Institute for Hematology and Oncology. Medical University of Vienna) ;
Onida, Francesco (University of Milan) ;
Van Azizan de Loosdrecht, Arjan A. (Amsterdam UMC. University Medical Center) ;
Pleyer, Lisa (Salzburg Cancer Research Institute Center for Clinical Cancer and Immunology Trials) ;
Xicoy Cirici, Blanca (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tibes, Raoul (Mayo Clinic) ;
Geissler, Klaus (Sigmund Freud University) ;
Komrokji, Rami S. (H. Lee Moffitt Cancer Center) ;
Zhang, Jing (University of Wisconsin-Madison) ;
Germing, Ulrich (Department of Hematology. Oncology. and Clinical Immunology. University of Duesseldorf) ;
Steensma, David P. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Wiseman, Daniel H. (University of Manchester) ;
Pfeilstöecker, Michael (Hanusch Hospital and Ludwig Boltzmann Institute for Hematology and Oncology) ;
Elena, Chiara (University of Pavia) ;
Cross, Nicholas C P (University of Southampton) ;
Luebbert, Michael (University of Freiburg) ;
Mesa, Ruben A. (Mays Cancer Center at UT Health San Antonio MD Anderson) ;
Montalban-Bravo, Guillermo (MD Anderson Cancer Center) ;
Sanz, G.F. (Hospital Universitari i Politècnic La Fe (València)) ;
Platzbecker, Uwe (University Hospital Leipzig) ;
Patnaik, Mrinal M. (Mayo Clinic) ;
Padron, Eric (H. Lee Moffitt Cancer Center) ;
Santini, Valeria (University of Florence) ;
Fenaux, Pierre (Paris Diderot University) ;
Savona, Michael R. (Vanderbilt University School of Medicine) ;
Universitat Autònoma de Barcelona
Background: Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life. [...]
2022 - 10.1186/s12885-022-10073-w
BMC Cancer, Vol. 22 Núm. 1 (december 2022) , p. 1013
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