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11 p, 2.5 MB |
The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains
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Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pujols, Jordi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vasili, Eftychia (Max Planck Institute for Experimental Medicine) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Santos, Jaime (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Manglano-Artuñedo, Zoe (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Outeiro, Tiago F. (Scientific Employee With a Honorary Contract. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intraneuronal proteinaceous inclusions known as Lewy bodies and Lewy neurites. [...]
2022 -  10.1016/j.jbc.2022.101902
Journal of Biological Chemistry, Vol. 298, Issue 5 (May 2022) , art. 101902
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3.
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12 p, 2.1 MB |
A fermented milk product containing B. lactis CNCM i-2494 improves the tolerance of a plant-based diet in patients with disorders of gut-brain interactions
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Le Nevé, Boris (Danone Nutricia Research) ;
Martinez-De la Torre, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tap, Julien (Danone Nutricia Research) ;
Nieto Ruiz, Adoración (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Derrien, Muriel (Danone Nutricia Research) ;
Cotillard, Aurélie (Danone Nutricia Research) ;
Faurie, Jean-Michel (Danone Nutricia Research) ;
Barba Orozco, Elizabeth (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mego Silva, Marianela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Dornic, Quentin (Danone Nutricia Research) ;
Butler, John (Lawson Health Research Institute) ;
Merino, Xavi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pinsach Batet, Ferran (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pozuelo, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Guarner, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Manichanh, Chaysavanh (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Azpiroz Vidaur, Fernando (Universitat Autònoma de Barcelona. Departament de Medicina)
Healthy, plant-based diets, rich in fermentable residues, may induce gas-related symptoms. The aim of this exploratory study was to assess the effects of a fermented milk product, containing probiotics, on the tolerance of a healthy diet in patients with disorders of gut-brain interactions (DGBI), complaining of excessive flatulence. [...]
2021 - 10.3390/nu13124542
Nutrients, Vol. 13 Núm. 12 (december 2021) , p. 4542
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4.
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25 p, 1.8 MB |
Impact of Morbid Obesity and Obesity Phenotype on Outcomes After Transcatheter Aortic Valve Replacement
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McInerney, Angela (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Tirado-Conte, Gabriela (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Rodes-Cabau, Josep (Laval University) ;
Campelo-Parada, Francisco (Rangueil University Hospital) ;
Tafur Soto, Jose D. (Ochsner Medical Center) ;
Barbanti, Marco (University of Catania) ;
Muñoz-Garcia, Erika (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Arif, Mobeena (Toronto University. St. Michael's Hospital) ;
Lopez, Diego (Hospital Clínico Universitario (Galícia)) ;
Toggweiler, Stefan (Luzerner Kantonsspital) ;
Veiga, Gabriela (Instituto de Investigación Sanitaria Valdecilla (País Basc)) ;
Pylko, Anna (National Institute of Cardiology) ;
Sevilla Ruiz, Teresa (Hospital Clínico Universitario (Valladolid)) ;
Compagnone, Miriam (University Hospital of Bologna) ;
Regueiro, Ander (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Serra, Viçent (Hospital Universitari Vall d'Hebron) ;
Carnero, Manuel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Oteo, Juan F. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rivero, Fernando (Instituto de Investigación Hospital Universitario de la Princesa) ;
Barbosa Ribeiro, Henrique (Heart Institute (Instituto de Coraçāo)) ;
Guimaraes, Leonardo (Laval University) ;
Matta, Anthony (Rangueil University Hospital) ;
Giraldo Echavarria, Natalia (Ochsner Medical Center) ;
Valvo, Roberto (University of Catania) ;
Moccetti, Federico (Luzerner Kantonsspital) ;
Muñoz-Garcia, Antonio J. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Lopez-Pais, Javier (Hospital Clínico Universitario (Galícia)) ;
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Campanha Borges, Diego Carter (Heart Institute (Instituto de Coraçāo)) ;
Dumont, Eric (Laval University. Quebec Heart and Lung Institute) ;
Gonzalo, Nieves (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Criscione, Enrico (University of Catania) ;
Dabrowski, Maciej (National Institute of Cardiology) ;
Alfonso, Fernando (Instituto de Investigación Hospital Universitario de la Princesa) ;
de la Torre Hernández, Jose M. (Instituto de Investigación Sanitaria Valdecilla (Santander, Cantabria)) ;
Cheema, Asim N. (University of Toronto) ;
Amat-Santos, Ignacio J. (Hospital Clínico Universitario (Valladolid)) ;
Saia, Francesco (University Hospital of Bologna) ;
Escaned, Javier (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Nombela-Franco, Luis (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
There is a paucity of outcome data on patients who are morbidly obese (MO) undergoing transcatheter aortic valve replacement. We aimed to determine their periprocedural and midterm outcomes and investigate the impact of obesity phenotype. [...]
2021 - 10.1161/JAHA.120.019051
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 10 (may 2021)
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8 p, 1.7 MB |
Blastocystis sp. Carriage and Irritable Bowel Syndrome : Is the Association Already Established?
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Salvador, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Goterris, Lidia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Sulleiro, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bailo, Begoña (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Carmena, David (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bosch-Nicolau, Pau (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espinosa-Pereiro, Juan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fuentes, Isabel (National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Madrid, Spain; (B.B.); (D.C.); (I.F.)) ;
Molina, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
The intestinal protist Blastocystis sp. is one of the most common intestinal parasites observed in humans, and has a worldwide distribution, being more prevalent in developing countries. Although this parasite has been described decades ago, the pathogenic potential it is still not understood completely. [...]
2021 - 10.3390/biology10040340
Biology, Vol. 10 (april 2021)
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29 p, 1.5 MB |
Effect of resource spatial correlation and hunter-fisher-gatherer mobility on social cooperation in Tierra del Fuego
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Santos, José Ignacio (Universidad de Burgos, Escuela Politécnica Superior) ;
Pereda, María (Universidad de Burgos. Escuela Politécnica Superior) ;
Zurro Hernández, Débora (Consejo Superior de Investigaciones Científicas (Espanya)) ;
Álvarez, Myrian (Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina)) ;
Caro, Jorge (Universitat Autònoma de Barcelona. Departament de Sociologia) ;
Galán, José Manuel (Universidad de Burgos) ;
Briz i Godino, Ivan (University of York. Department of Archaeology)
This article presents an agent-based model designed to explore the development of cooperation in hunter-fisher-gatherer societies that face a dilemma of sharing an unpredictable resource that is randomly distributed in space. [...]
2015 - 10.1371/journal.pone.0121888
PloS one, Vol. 10 (april 2015)
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7 p, 469.0 KB |
Epidemiological and clinical profile of adult patients with Blastocystis sp. infection in Barcelona, Spain
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Salvador, Fernando (Hospital Universitari Vall d'Hebron) ;
Sulleiro, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Alonso Cotoner, Carmen (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Santos, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Fuentes, Isabel (Instituto de Salud Carlos III, National Centre of Microbiology, Madrid, Spain) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)
Blastocystis spp. are among the most frequently observed intestinal parasites in humans. Despite the discovery of Blastocystis approximately 100 years ago, limited information is available regarding its pathogenesis, genetic diversity, and available treatment options. [...]
2016 - 10.1186/s13071-016-1827-4
Parasites & vectors, Vol. 9 (october 2016)
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14 p, 3.4 MB |
miR-16 and miR-103 impact 5-HT receptor signalling and correlate with symptom profile in irritable bowel syndrome
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Wohlfarth, Carolin (University of Heidelberg) ;
Schmitteckert, Stefanie (University of Heidelberg) ;
Härtle, Janina D. (University of Heidelberg) ;
Houghton, Lesley A. (Mayo Clinic) ;
Dweep, Harsh (National Centre for Toxicological Research) ;
Fortea, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Assadi, Ghazaleh (Karolinska Institutet (Estocolm, Suècia)) ;
Braun, Alexander (University of Heidelberg) ;
Mederer, Tanja (University of Heidelberg) ;
Pöhner, Sarina (University of Heidelberg) ;
Becker, Philip P. (University of Heidelberg) ;
Fischer, Christine (University of Heidelberg) ;
Granzow, Martin (University of Heidelberg) ;
Mönnikes, Hubert (Martin-Luther-Hospital) ;
Mayer, Emeran A. (University of California) ;
Sayuk, Gregory (Washington University School of Medicine) ;
Boeckxstaens, Guy (University Hospitals Leuven (Bèlgica)) ;
Wouters, Mira M. (University Hospitals Leuven (Bèlgica)) ;
Simrén, Magnus (University of Gothenburg) ;
Lindberg, Greger (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Ohlsson, Bodil (Skåne University Hospital (Suècia)) ;
Schmidt, Peter Thelin (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Dlugosz, Aldona (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Agreus, Lars (Karolinska Institutet (Estocolm, Suècia)) ;
Andreasson, Anna (Stockholm University) ;
D'Amato, Mauro (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Burwinkel, Barbara (University of Heidelberg) ;
Bermejo, Justo Lorenzo (University of Heidelberg) ;
Röth, Ralph (University of Heidelberg) ;
Lasitschka, Felix (University of Heidelberg) ;
Vicario Perez, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Metzger, Marco (Branch of the Fraunhofer Institute Interfacial Engineering and Biotechnology) ;
Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rappold, Gudrun A. (University of Heidelberg) ;
Martinez, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Niesler, Beate (University of Heidelberg) ;
Universitat Autònoma de Barcelona
2017 - 10.1038/s41598-017-13982-0
Scientific reports (Nature Publishing Group), Vol. 7 (october 2017)
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9.
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10 p, 897.3 KB |
Emergence and evolution of cooperation under resource Ppressure
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Pereda, María (Universidad Carlos III de Madrid. Departamento de Matemáticas) ;
Zurro Hernández, Débora (Universitat Pompeu Fabra. Departament d'Humanitats) ;
Santos, José I. (Universidad de Burgos. Departamento de Ingeniería Civil) ;
Briz i Godino, Ivan (University of York. Department of Archaeology) ;
Álvarez, Myrian (CONICET-CADIC) ;
Caro, Jorge (Universitat Autònoma de Barcelona. Departament de Sociologia) ;
Galán, José M. (Universidad de Burgos. Departamento de Ingeniería Civil)
We study the influence that resource availability has on cooperation in the context of hunter-gatherer societies. This paper proposes a model based on archaeological and ethnographic research on resource stress episodes, which exposes three different cooperative regimes according to the relationship between resource availability in the environment and population size. [...]
2017 - 10.1038/srep45574
Scientific reports (Nature Publishing Group), Vol. 7 (03 2017)
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10.
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14 p, 1.4 MB |
Hunter-gatherer mobility and technological landscapes in southernmost South America : a statistical learning approach
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Briz i Godino, Ivan (University of York. Department of Archaeology) ;
Ahedo, Virginia (Universidad de Burgos. Departamento de Ingeniería Civil) ;
Álvarez, Myrian (CONICET-Centro Austral de Investigaciones Científicas) ;
Pal, Nélida (CONICET-Centro Austral de Investigaciones Científicas) ;
Turnes, Lucas (CONICET-Centro Austral de Investigaciones Científicas) ;
Santos, José Ignacio (Universidad de Burgos. Departamento de Ingeniería Civil) ;
Zurro Hernández, Débora (Universitat Pompeu Fabra. Departament d'Humanitats) ;
Caro Saiz, Jorge (Universitat Autònoma de Barcelona. Departament de Sociologia) ;
Galán, José Manuel (Universidad de Burgos. Departamento de Ingeniería Civil)
The present work aims to quantitatively explore and understand the relationship between mobility types (nautical versus pedestrian), specific technological traits and shared technological knowledge in pedestrian hunter-gatherer and nautical hunter-fisher-gatherer societies from the southernmost portion of South America. [...]
2018 - 10.1098/rsos.180906
Royal Society Open Science, Vol. 5 (october 2018)
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