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1.
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23 p, 1.5 MB |
The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults
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Alonso Cotoner, Carmen (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Abril-Gil, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Albert-Bayo, Mercé (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mall, John-P. Ganda (Linköping University. Department of Biomedical and Clinical Sciences) ;
Expósito, Elba (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González-Castro, Ana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo, Beatriz (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Santos, Javier (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Chronic diarrhea is a frequent presenting symptom, both in primary care medicine and in specialized gastroenterology units. It is estimated that more than 5% of the global population suffers from chronic diarrhea. [...]
2021 -  10.1007/s12325-021-01676-z
Advances in Therapy, march 2021, p. 1-23
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2.
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18 p, 1.5 MB |
Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain
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Fernández-Cooke, Elisa (Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)) ;
Grasa, Carlos D. (Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz) ;
Domínguez-Rodríguez, Sara (Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12)) ;
Barrios Tascón, Ana (Department of Pediatrics, Hospital Universitario Infanta Sofia) ;
Sánchez-Manubens, Judith (Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona) ;
Anton, Jordi (Pediatric Rheumatology Department, Hospital Sant Joan de Déu) ;
Mercader, Beatriz (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia)) ;
Villalobos, Enrique (Department of Pediatrics, Hospital Infantil Universitario Niño Jesús) ;
Camacho, Marisol (Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Department of Pediatrics, Hospital Virgen del Rocío) ;
Navarro Gómez, María Luisa (Hospital General Universitario Gregorio Marañón) ;
Oltra Benavent, Manuel (Hospital Universitari i Politècnic La Fe de Valencia) ;
Giralt, Gemma (Hospital Universitari Vall d'Hebron) ;
Bustillo, Matilde (Pediatric Infectious Disease Unit, Department of Pediatrics, Hospital Universitario Miguel Servet) ;
Bello Naranjo, Ana María (Department of Pediatrics, Hospital Universitario Materno-Infantil de Las Palmas de Gran Canaria) ;
Rocandio, Beatriz (Department of Pediatrics, Hospital Universitario de Donostia) ;
Rodríguez-González, Moisés (Department of Pediatrics, Hospital Universitario Puerta Del Mar de Cádiz) ;
Núñez Cuadros, Esmeralda (Department of Pediatrics, Hospital Regional Universitario de Málaga) ;
Aracil Santos, Javier (Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz) ;
Moreno, David (Department of Pediatrics, Hospital Regional Universitario de Málaga) ;
Calvo, Cristina (Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz) ;
Universitat Autònoma de Barcelona
Introduction: COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). [...]
2021 - 10.3389/fped.2020.617039
Frontiers in Pediatrics, Vol. 8 (january 2021)
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3.
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43 p, 2.2 MB |
Immune-Checkpoint Inhibitors in B-Cell Lymphoma
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Armengol, Marc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribeiro, ML (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Serrano, Miranda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
For years, immunotherapy has been considered a viable and attractive treatment option for patients with cancer. Among the immunotherapy arsenal, the targeting of intratumoral immune cells by immune-checkpoint inhibitory agents has recently revolutionised the treatment of several subtypes of tumours. [...]
2021 - 10.3390/cancers13020214
Cancers, Vol. 13 Núm. 214 (2021) , p. 43
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4.
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12 p, 2.4 MB |
Inhibition of α-synuclein aggregation and mature fibril disassembling with a minimalistic compound, ZPDm
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Peña Díaz, Samuel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pinheiro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Santos, Jaime (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès i Goitiz, Irantzu (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro Cantero, Susana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conde Gimenez, María (Universidad de Zaragoza. Instituto Aragonés de Investigaciones Sanitarias) ;
García, Jesús (Institut de Recerca Biomèdica de Lleida) ;
Salvatella, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Dalfo Capella, Esther (Universitat Autònoma de Barcelona. Facultat de Medicina) ;
Sancho, Javier (Universidad de Zaragoza. Instituto Aragonés de Investigaciones Sanitarias) ;
Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Synucleinopathies are a group of disorders characterized by the accumulation of α-Synuclein amyloid inclusions in the brain. Preventing α-Synuclein aggregation is challenging because of the disordered nature of the protein and the stochastic nature of fibrillogenesis, but, at the same time, it is a promising approach for therapeutic intervention in these pathologies. [...]
2020 - 10.3389/fbioe.2020.588947
Frontiers in Bioengineering and Biotechnology, Vol. 8 (October 2020) , art. 588947
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5.
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12 p, 1.4 MB |
DispHred : a server to predict pH-dependent order-disorder transitions in intrinsically disordered proteins
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Santos, Jaime (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pintado Grima, Carlos (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Santos-Suárez, Juan (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
The natively unfolded nature of intrinsically disordered proteins (IDPs) relies on several physicochemical principles, of which the balance between a low sequence hydrophobicity and a high net charge appears to be critical. [...]
2020 - 10.3390/ijms21165814
International journal of molecular sciences, Vol. 21, Issue 16 (August 2020) , art. 5814
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6.
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12 p, 653.9 KB |
HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy
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Blanch Lombarte, Oscar (Institut Germans Trias i Pujol) ;
Santos, José Ramón (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Peña, Ruth (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Jiménez Moyano, Esther (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Prado, Julia G. (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Virological failure (VF) to boosted PIs with a high genetic barrier is not usually linked to the development of resistance-associated mutations in the protease gene. From a cohort of 520 HIV-infected subjects treated with lopinavir/ritonavir or darunavir/ritonavir monotherapy, we retrospectively identified nine patients with VF. [...]
2020 - 10.1093/jac/dkaa228
Journal of Antimicrobial Chemotherapy, Vol. 75 (june 2020) , p. 2535-2546
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7.
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11 p, 1.4 MB |
Computational prediction of protein aggregation : advances in proteomics, conformation-specific algorithms and biotechnological applications
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Santos, Jaime (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pallarès i Goitiz, Irantzu (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein aggregation is a widespread phenomenon that stems from the establishment of non-native intermolecular contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic property of polypeptide chains, indissociable from protein structure and function. [...]
2020 - 10.1016/j.csbj.2020.05.026
Computational and Structural Biotechnology Journal, Vol. 18 (June 2020) , p. 1403-1413
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8.
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14 p, 251.1 KB |
Cancer-Associated Thrombosis : Beyond Clinical Practice Guidelines-A Multidisciplinary (SEMI-SEOM-SETH) Expert Consensus
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Pachón, Vanessa (Department of Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain) ;
Trujillo-Santos, Javier (Department of Internal Medicine, Hospital Universitario Santa Lucía, Cartagena, Spain) ;
Domènech, Pere (Hospital Universitari de Bellvitge) ;
Gallardo, Enrique (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Font, Carmen (Hospital Clínic i Provincial de Barcelona) ;
González-Porras, José Ramón (Hematology Service, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain) ;
Pérez-Segura, Pedro (Hospital Clínico San Carlos (Madrid)) ;
Maestre, Ana (Department of Internal Medicine, Hospital del Vinalopó, Elche, Spain) ;
Mateo, José (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz Martin, Andrés (Hospital General Universitario Gregorio Marañón) ;
Peris, María Luisa (Department of Internal Medicine, Hospital Provincial de Castellón, Castellón, Spain) ;
Lecumberri, Ramón (Hematology Service, Clínica Universidad de Navarra, IDISNA, CIBER-CV, Pamplona, Spain) ;
Universitat Autònoma de Barcelona
Despite the growing interest and improved knowledge about venous thromboembolism in cancer patients in the last years, there are still many unsolved issues. Due to the limitations of the available literature, evidence-based clinical practice guidelines are not able to give solid recommendations for challenging scenarios often present in the setting of cancer-associated thrombosis (CAT). [...]
2018 - 10.1055/s-0038-1675577
TH Open: Companion Journal to Thrombosis and Haemostasis, Vol. 2 (november 2018) , p. e373-e386
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9.
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4 p, 481.9 KB |
Ambrisentan use in a HIV-1 infected patient with end-stage renal disease and pulmonary hypertension : minimal removal by hemodialysis - a case report
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Santos, José Ramón (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Merino Ribas, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Haefeli, Walter E. (Heidelberg University Hospital. Department of Clinical Pharmacology and Pharmacoepidemiology) ;
Miranda, Cristina (Fundacio Lluita contra la SIDA, Barcelona, Spain) ;
Prats, Marisol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bancu, Ioana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bailón, Lucía (Fundacio Lluita contra la SIDA, Barcelona, Spain) ;
Moltó, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Ambrisentan is a selective endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH). Little is known about ambrisentan removal by hemodialysis in patients with end-stage renal disease (ESRD). [...]
2020 - 10.1186/s12882-019-1659-5
BMC Nephrology, Vol. 21 (january 2020)
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10.
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11 p, 767.5 KB |
Estimated Effect of COVID-19 Lockdown on Skin Tumor Size and Survival : An Exponential Growth Model Estimación del efecto en el tamaño y la supervivencia de los tumores cutáneos debido al confinamiento por COVID-19: modelo basado en un crecimiento exponencial
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Tejera-Vaquerizo, A. (Servicio de Dermatología. Instituto Dermatológico GlobalDerm) ;
Cañueto, J. (Servicio de Dermatología. Hospital Universitario de Salamanca) ;
Toll, A. (Hospital Clínic i Provincial de Barcelona) ;
Santos-Juanes, J. (Servicio de Dermatología. Hospital Universitario Central de Asturias) ;
Jaka, Ane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrandiz-Pulido, Carla (Hospital Universitari Vall d'Hebron) ;
Sanmartín, O. (Fundació Institut Valencià d'Oncologia) ;
Ribero, S. (Departamento de Dermatología. Hospital Universitario de Turín) ;
Moreno-Ramírez, D. (Unidad de Melanoma. Servicio de Dermatología Médico-Quirúrgica. Hospital Universitario Virgen Macarena) ;
Almazán, F. (Unidad de Gestión Clínica de Dermatología. Hospital Universitario San Cecilio) ;
Fuente, M.J. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Podlipnik, S. (Hospital Clínic i Provincial de Barcelona) ;
Nagore, E. (Fundació Institut Valencià d'Oncologia) ;
Universitat Autònoma de Barcelona
Background and objectives: Spain is in a situation of indefinite lockdown due to the ongoing coronavirus disease 2019 (COVID-19) pandemic. One of the consequences of this lockdown is delays in medical and surgical procedures for common diseases. [...]
2020 - 10.1016/j.ad.2020.05.001
Actas Dermo-Sifiliograficas, 2020
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