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14 p, 251.1 KB |
Cancer-Associated Thrombosis : Beyond Clinical Practice Guidelines-A Multidisciplinary (SEMI-SEOM-SETH) Expert Consensus
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Pachón, Vanessa (Department of Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain) ;
Trujillo-Santos, Javier (Department of Internal Medicine, Hospital Universitario Santa Lucía, Cartagena, Spain) ;
Domènech, Pere (Thrombosis and Haemostasis Unit, Hospital Universitario Bellvitge, L'Hospitalet de Llobregat, Catalonia, Spain) ;
Gallardo, Enrique (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Font, Carmen (Department of Medical Oncology, Hospital Clinic, Barcelona, Spain) ;
González-Porras, José Ramón (Hematology Service, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain) ;
Pérez-Segura, Pedro (Department of Oncology, Hospital Clínico San Carlos, Madrid, Spain) ;
Maestre, Ana (Department of Internal Medicine, Hospital del Vinalopó, Elche, Spain) ;
Mateo, José (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz, Andrés (Department of Oncology, Hospital Universitario Gregorio Marañón, Madrid, Spain) ;
Peris, María Luisa (Department of Internal Medicine, Hospital Provincial de Castellón, Castellón, Spain) ;
Lecumberri, Ramón (Hematology Service, Clínica Universidad de Navarra, IDISNA, CIBER-CV, Pamplona, Spain) ;
Universitat Autònoma de Barcelona
Despite the growing interest and improved knowledge about venous thromboembolism in cancer patients in the last years, there are still many unsolved issues. Due to the limitations of the available literature, evidence-based clinical practice guidelines are not able to give solid recommendations for challenging scenarios often present in the setting of cancer-associated thrombosis (CAT). [...]
2018 -  10.1055/s-0038-1675577
TH Open: Companion Journal to Thrombosis and Haemostasis, Vol. 2 (november 2018) , p. e373-e386
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24 p, 1.4 MB |
Intestinal mucosal mast cells : key modulators of barrier function and homeostasis
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Albert-Bayo, Mercé (Hospital Universitario Vall d'Hebron. Laboratory of Translational Mucosal Immunology) ;
Paracuellos, Irene (Hospital Universitario Vall d'Hebron. Laboratory of Translational Mucosal Immunology) ;
González-Castro, Ana M. (Hospital Universitario Vall d'Hebron. Laboratory of Translational Mucosal Immunology) ;
Rodríguez-Urrutia, Amanda (Universitat Autònoma de Barcelona) ;
University of Barcelona ;
Alonso Cotoner, Carmen (Hospital Universitari Vall d'Hebron) ;
Santos, Javier (Hospital Universitari Vall d'Hebron) ;
Vicario Pérez, María (Vall d'Hebron Institut de Recerca)
The gastrointestinal tract harbours the largest opulation of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides. [...]
2019 - 10.3390/cells8020135
Cells, Vol. 8 (2019) , p. 1-24
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11 p, 2.3 MB |
Decreased TESK1-mediated cofilin 1 phosphorylation in the jejunum of IBS-D patients may explain increased female predisposition to epithelial dysfunction
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Rodiño-Janeiro, Bruno K. (Vall d'Hebron Institut de Recerca) ;
Martínez, Cristina (Vall d'Hebron Institut de Recerca) ;
Fortea, Marina (Vall d'Hebron Institut de Recerca) ;
Lobo Álvarez, Beatriz (Vall d'Hebron Institut de Recerca) ;
Pigrau Pastor, Marc (Vall d'Hebron Institut de Recerca) ;
Nieto, Adoración (Vall d'Hebron Institut de Recerca) ;
González-Castro, Ana María (Vall d'Hebron Institut de Recerca) ;
Salvo Romero, Eloísa (Vall d'Hebron Institut de Recerca) ;
Guagnozzi, Danila (Vall d'Hebron Institut de Recerca) ;
Pardo-Camacho, Cristina (Vall d'Hebron Institut de Recerca) ;
Iribarren, Cristina (Vall d'Hebron Institut de Recerca) ;
Azpiroz Vidaur, Fernando (Vall d'Hebron Institut de Recerca) ;
Alonso Cotoner, Carmen (Vall d'Hebron Institut de Recerca) ;
Santos, Javier (Vall d'Hebron Institut de Recerca) ;
Vicario Pérez, María (Vall d'Hebron Institut de Recerca)
Disturbed intestinal epithelial barrier and mucosal micro-inflammation characterize irritable bowel syndrome (IBS). Despite intensive research demonstrating ovarian hormones modulation of IBS severity, there is still limited knowledge on the mechanisms underlying female predominance in this disorder. [...]
2018 - 10.1038/s41598-018-20540-9
Scientific reports (Nature Publishing Group), Vol. 8 (2018) , art. 2255
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22 p, 609.1 KB |
A Review of Microbiota and Irritable Bowel Syndrome : Future in Therapies
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Rodiño-Janeiro, Bruno K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vicario, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso-Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pascua-García, Roberto (Servicio de Atención Primaria de Celanova, Orense, Spain) ;
Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Irritable bowel syndrome (IBS), one of the most frequent digestive disorders, is characterized by chronic and recurrent abdominal pain and altered bowel habit. The origin seems to be multifactorial and is still not well defined for the different subtypes. [...]
2018 - 10.1007/s12325-018-0673-5
Advances in Therapy, Vol. 35 (march 2018) , p. 289-310
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21 p, 382.1 KB |
La cronología radiocarbónica de las primeras manifestaciones megalíticas en el sureste de la Península Ibérica : las necrópolis de Las Churuletas, La Atalaya y Llano del Jautón (Purchena, Almería)
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Aranda Jiménez, Gonzalo (Universidad de Granada. Departamento de Prehistoria y Arqueología) ;
Lozano Medina, Águeda (Universidad de Granada. Departamento de Prehistoria y Arqueología) ;
Camalich Massieu, María Dolores (Universidad de La Laguna. Departamento de Geografía e Historia) ;
Martín Socas, Dimas (Universidad de La Laguna. Departamento de Geografía e Historia) ;
Rodríguez Santos, Francisco Javier (Universidad de Cantabria. Instituto Internacional de Investigaciones Prehistóricas de Cantabria) ;
Trujillo Mederos, Aioze (Universidad de La Laguna. Departamento de Geografía e Historia) ;
Santana Cabrera, Jonathan (Durham University. Department of Archeology) ;
Nonza-Micaelli, Angelique (Université de Corse) ;
Clop i Garcia, Xavier (Universitat Autònoma de Barcelona. Departament de Prehistòria)
Por primera vez en el estudio del fenómeno megalítico del sureste de la Península Ibérica se ha obtenido una serie radiocarbónica para el análisis de sus manifestaciones más antiguas. Se han datado 30 restos antropológicos de sepulturas tipo rundgräber y de tumbas de cámara y corredor pertenecientes a las necrópolis de Las Churuletas, La Atalaya y Llano de El Jautón. [...]
For the first time in the study of the southeastern Iberian megalithic phenomenon, a series of 30 radiocarbon dates has been obtained for some of the oldest monuments. Two types of tombs, circular chambers (rundgräber) and graves with chamber and passage, from three necropolises, Las Churuletas, La Atalaya and El Llano de El Jautón, have been dated using human remains. [...]
2017 - 10.3989/tp.2017.12194
Trabajos de prehistoria, Vol. 74, núm. 2 (2017) , p. 257-277
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12 p, 494.4 KB |
Optimizing the use of linaclotide in patients with constipation-predominant irritable bowel syndrome : an expert consensus report
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Rey, Enrique (Hospital Universitario Clínico de San Carlos, Madrid, Spain) ;
Mearin, Fermín (Barcelona, Spain) ;
Alcedo, Javier (Zaragoza, Spain) ;
Ciriza, Constanza (Madrid, Spain) ;
Delgado-Aros, Silvia (Neuro-Enteric Translational Science (NETS) Research Group, Barcelona, Spain) ;
Freitas, Teresa (Porto, Portugal) ;
Mascarenhas, Miguel (CUF Porto Hospital, Porto, Portugal) ;
Mínguez, Miguel (Valencia, Spain) ;
Santos, Javier (Universitat Autònoma de Barcelona. Department de Medicina) ;
Serra Pueyo, Jordi (Barcelona, Spain)
Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic or recurrent abdominal pain in association with defecation or a change in bowel habits. A predominant disorder of bowel habits, IBS is classified into three main subtypes: constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D) and IBS alternating between constipation and diarrhea (IBS-M). [...]
2017 - 10.1007/s12325-016-0473-8
Advances in Therapy, Vol. 34 (january 2017) , p. 587-598
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14 p, 2.6 MB |
miR-16 and miR-125b are involved in barrier function dysregulation through the modulation of claudin-2 and cingulin expression in the jejunum in IBS with diarrhoea
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Martínez, Cristina (Hospital Universitari Vall d'Hebron) ;
Rodiño-Janeiro, Bruno K (Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Lobo, Beatriz (Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Stanifer, Megan L (University of Heidelberg) ;
Klaus, Bernd (European Molecular Biology Laboratory (EMBL)) ;
Granzow, Martin (Institute of Human Genetics, University of Heidelberg) ;
González-Castro, Ana M (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salvo-Romero, Eloisa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso-Cotoner, Carmen (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ;
Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Roeth, Ralph (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ;
Rappold, Gudrun (Institute of Human Genetics, University of Heidelberg) ;
Huber, Wolfgang (European Molecular Biology Laboratory (EMBL)) ;
González-Silos, Rosa (Institute of Medical Biometry and Informatics, University of Heidelberg) ;
Lorenzo, Justo (Institute of Medical Biometry and Informatics, University of Heidelberg) ;
Torres, Inés de (Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona) ;
Azpiroz Vidaur, Fernando (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ;
Boulant, Steeve (Research Group 'Cellular Polarity and Viral Infection' (F140), German Cancer Research Center (DKFZ)) ;
Vicario, María (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network) ;
Niesler, Beate (nCounter Core Facility, Institute of Human Genetics, University of Heidelberg) ;
Santos, Javier (COST Action BM1106 Genes in Irritable Bowel Syndrome (GENIEUR) European Research Network)
Micro-RNAs (miRNAs) play a crucial role in controlling intestinal epithelial barrier function partly by modulating the expression of tight junction (TJ) proteins. We have previously shown differential messenger RNA (mRNA) expression correlated with ultrastructural abnormalities of the epithelial barrier in patients with diarrhoea-predominant IBS (IBS-D). [...]
2017 - 10.1136/gutjnl-2016-311477
Gut, Vol. 66 (january 2017) , p. 1537-1538
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18 p, 4.8 MB |
The Emergence of mesolithic cemeteries in SW Europe : insights from the El Collado (Oliva, Valencia, Spain) radiocarbon record
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Gibaja, Juan F. (Juan Francisco) (Consejo Superior de Investigaciones Científicas. Institución Milá y Fontanals) ;
Subirà, M. Eulàlia (Maria Eulàlia) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Terradas, Xavier (Consejo Superior de Investigaciones Científicas. Institución Milá y Fontanals) ;
Santos, F. Javier (Universidad de Sevilla. Centro Nacional de Aceleradores) ;
Agulló, Lidia (Universidad de Sevilla. Centro Nacional de Aceleradores) ;
Gómez-Martínez, Isabel (Universidad de Sevilla. Centro Nacional de Aceleradores) ;
Allièse, Florence (Université Paris-Sorbonne) ;
Fernández-López de Pablo, Javier (Universitat Rovira i Virgili. Àrea de Prehistòria)
Located on the Iberian Mediterranean coast, El Collado is an open-air site where a rescue excavation was conducted over two seasons in 1987 and 1988. The archaeological work excavated a surface area of 143m2 where 14 burials were discovered, providing skeletal remains from 15 individuals. [...]
2015 - 10.1371/journal.pone.0115505
PloS one, Vol. 10, issue 1 (Jan. 2015) , e0115505
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18 p, 945.8 KB |
Role of Corticotropin-releasing Factor in Gastrointestinal Permeability
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Rodiño-Janeiro, Bruno K (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso-Cotoner, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pigrau Pastor, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lobo, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vicario, María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular physiological conditions, the intestinal micro-flora and the epithelial barrier are well prepared to process daily a huge amount of food-derived antigens and non-immunogenic particles. [...]
2015 - 10.5056/jnm14084
Journal of Neurogastroenterology and Motility, Vol. 21 (january 2015) , p. 33-50
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8 p, 1.0 MB |
Anal gas evacuation and colonic microbiota in patients with flatulence : effect of diet
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Manichanh, Chaysavanh (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eck, Anat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Varela, Encarna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roca, Joaquim (Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Cientificas) ;
Clemente, José C (University of Colorado at Boulder, and Howard Hughes Medical Institute) ;
González, Antonio (University of Colorado at Boulder, and Howard Hughes Medical Institute) ;
Knights, Dan (University of Colorado at Boulder, and Howard Hughes Medical Institute) ;
Knight, Rob (University of Colorado at Boulder, and Howard Hughes Medical Institute) ;
Estrella, Sandra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guyonnet, Denis (Danone Research) ;
Accarino, Ana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santos, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malagelada, Juan-R (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guarner, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Azpiroz Vidaur, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To characterise the influence of diet on abdominal symptoms, anal gas evacuation, intestinal gas distribution and colonic microbiota in patients complaining of flatulence. Patients complaining of flatulence (n=30) and healthy subjects (n=20) were instructed to follow their usual diet for 3 days (basal phase) and to consume a high-flatulogenic diet for another 3 days (challenge phase). [...]
2013 - 10.1136/gutjnl-2012-303013
Gut, Vol. 63 (june 2013) , p. 401-408
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