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11 p, 1.0 MB Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703 / Schmidt, Manuel (Mologen AG (Berlin, Alemanya)) ; Hagner, Nicole (Freie Universitaet) ; Marco Valle, Alberto (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; König-Merediz, Sven A. (Vivotecnia) ; Schroff, Matthias (Mologen AG (Berlin, Alemanya)) ; Wittig, Burghardt (Freie Universitaet)
Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine–guanine motifs (CpG ODN), are recognized by the innate immune system as "danger signals. " CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or other backbone modifications for metabolic stability, which cause toxicities in mice and primates. [...]
2015 - 10.1089/nat.2015.0533
Nucleic Acid Therapeutics, Vol. 25 (june 2015) , p. 130-140  

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